An open clinical trial of fluoxetine in the treatment of premature ejaculation.

abstract：:Depression in the elderly patient may present special challenges for the design of clinical treatment trials due to a complex antidepressant treatment history, individual contraindications to certain medications, medical comorbidity, as well as concurrent medications for other medical conditions. The chronic, relapsin...

journal_title：Journal of clinical psychopharmacology

authors： Lavori PW

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:Although medication with antipsychotic for the psychosis prodrome has often caused some ethical issues, recent studies have shown that some novel antipsychotics are safer and more tolerable for young people. This study aimed to investigate whether the administration of aripiprazole would not only relieve t...

journal_title：Journal of clinical psychopharmacology

authors： Kobayashi H,Morita K,Takeshi K,Koshikawa H,Yamazawa R,Kashima H,Mizuno M

更新日期：2009-10-01 00:00:00

abstract：:In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of cytochrome P450 (CYP) CYP2C19 and CYP2D6. Fifty-one Japanese patients (18 men and 33 women) were administered 10 to 250 mg/day of C by mouth and maintained on the same daily dose of C for at least 2...

journal_title：Journal of clinical psychopharmacology

authors： Yokono A,Morita S,Someya T,Hirokane G,Okawa M,Shimoda K

更新日期：2001-12-01 00:00:00

abstract：PURPOSE/BACKGROUND:The number of patients with acute synthetic cannabinoid intoxication (SCI) has increased in recent years although the prohibition of its legal sale and use in Turkey despite other countries allowing to some extent sale and use. The reported clinical findings of acute SCI are similar to the symptoms o...

journal_title：Journal of clinical psychopharmacology

authors： Altintop I

更新日期：2020-09-01 00:00:00

abstract：:Remifentanil is a short-acting, esterase-metabolized opioid analgesic. This study compared the abuse liability of remifentanil with that of fentanyl and placebo in a randomized, double-blind, crossover study. Twelve recreational users of opioids received increasing doses of remifentanil (0.6, 1.2, 1.8, 2.4, and 3.0 mi...

journal_title：Journal of clinical psychopharmacology

authors： Baylon GJ,Kaplan HL,Somer G,Busto UE,Sellers EM

更新日期：2000-12-01 00:00:00

abstract：:This discussion focuses on three basic areas relevant to tardive dyskinesia (TD). The first area includes an overview of some specific acts of negligence that have been the basis for successful malpractice cases involving TD. Some of these acts of negligence include inappropriate assessment of the patient, failure to ...

journal_title：Journal of clinical psychopharmacology

authors： Tancredi LR

更新日期：1988-08-01 00:00:00

abstract：:Patients with major depressive disorder remain at risk for relapse following remission and often continue to experience subthreshold symptoms. This study compared the rate of relapse of major depressive disorder and the prevalence of residual depressive symptoms during the continuation phase for patients treated with ...

journal_title：Journal of clinical psychopharmacology

authors： Perlis RH,Nierenberg AA,Alpert JE,Pava J,Matthews JD,Buchin J,Sickinger AH,Fava M

更新日期：2002-10-01 00:00:00

abstract：:Methamphetamine has become a major public health issue globally, particularly in the United States. Despite this, no effective pharmacotherapy for methamphetamine abuse has been developed to date. This 6-week, open-label pilot clinical trial examined the safety and tolerability of modafinil up to 400 mg/d in 8 methamp...

journal_title：Journal of clinical psychopharmacology

authors： McGaugh J,Mancino MJ,Feldman Z,Chopra MP,Gentry WB,Cargile C,Oliveto A

更新日期：2009-10-01 00:00:00

abstract：:Meta-analyses have found conflicting evidence on the link between antipsychotics and cerebrovascular events (CVEs). The primary aim of this study was to evaluate the association between any antipsychotic prescription and CVEs in Italian elderly; second, to compare the effect of typical and atypical antipsychotics on C...

journal_title：Journal of clinical psychopharmacology

authors： Franchi C,Sequi M,Tettamanti M,Bonometti F,Nobili A,Fortino I,Bortolotti A,Merlino L,Pasina L,Djade CD,Marengoni A

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Posttraumatic stress disorder (PTSD) is one of the chronic and disabling psychiatric disorders, particularly in combat veterans. In a case series, rivastigmine was suggested to be an effective augmentation in treatment of PTSD. The aim of the present study was to evaluate this finding in a randomized control...

journal_title：Journal of clinical psychopharmacology

authors： Rezaei Ardani A,Hosseini G,Fayyazi Bordbar MR,Talaei A,Mostafavi Toroghi H

更新日期：2017-02-01 00:00:00

abstract：:Hyperprolactinemia mediated by antagonism of dopaminergic neurotransmission in the pituitary gland is a common adverse effect of antipsychotics. Recent studies have suggested that polymorphisms of dopamine receptors can affect the therapeutic response to antipsychotics. Thus, our aim was to evaluate whether 2 such pol...

journal_title：Journal of clinical psychopharmacology

authors： López-Rodríguez R,Román M,Novalbos J,Pelegrina ML,Ochoa D,Abad-Santos F

更新日期：2011-10-01 00:00:00

abstract：:Adverse events during selective serotonin reuptake inhibitor (SSRI) treatment are frequent and may lead to premature treatment discontinuation. If attrition is associated with early worsening of adverse effects or the frequency, intensity, or burden of adverse effects, interventions to maximize retention could be focu...

journal_title：Journal of clinical psychopharmacology

authors： Warden D,Trivedi MH,Wisniewski SR,Kurian B,Zisook S,Kornstein SG,Friedman ES,Miyahara S,Leuchter AF,Fava M,Rush AJ

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Despite initial reports of efficacy in bipolar depression, multicenter trials did not show aripiprazole to be better than placebo, possibly because the doses used were too high, leading to lower efficacy and high dropout rates. This study evaluated the effects of low-dose aripiprazole. Extensive clinical exp...

journal_title：Journal of clinical psychopharmacology

authors： Kelly T,Lieberman DZ

更新日期：2017-02-01 00:00:00

abstract：:Four patients with obsessive-compulsive disorder (DSM-III and RDC) were treated in an open trial with alprazolam. Moderate to marked improvement was noted in the degree of obsessionality, anxiety with motor tension, and secondary affective changes. The mixed anxiolytic-antidepressant properties of alprazolam are theor...

journal_title：Journal of clinical psychopharmacology

authors： Tollefson G

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:This study investigated extended release quetiapine (quetiapine XR) associated changes in functional MRI (fMRI) measures of task-induced amygdalar activation and resting state connectivity in anxious unipolar major depressive disorder (AMDD). METHODS:Anxious unipolar major depressive disorder patients (n = ...

journal_title：Journal of clinical psychopharmacology

authors： Altinay M,Karne H,Beall E,Anand A

更新日期：2016-12-01 00:00:00

abstract：:Although recent treatment guidelines for schizophrenia recommend that the prior antipsychotic agent should remain stable for at least 2 weeks when aripiprazole is introduced, there is no trial-based evidence to support this strategy. This study was designed to compare this strategy with another conventional one in pat...

journal_title：Journal of clinical psychopharmacology

authors： Takeuchi H,Suzuki T,Uchida H,Nakajima S,Nomura K,Kikuchi T,Manki H,Watanabe K,Kashima H

更新日期：2008-10-01 00:00:00

abstract：:This article reports results for patients who completed the 16-week maintenance phase of a double-blind clinical trial comparing buprenorphine (N = 43; average dose = 9.0 mg/day sublingually) with methadone (N = 43; average dose = 54 mg/day orally) in the outpatient treatment of opioid dependence. In addition to pharm...

journal_title：Journal of clinical psychopharmacology

authors： Strain EC,Stitzer ML,Liebson IA,Bigelow GE

更新日期：1996-02-01 00:00:00

abstract：PURPOSE/BACKGROUND:The study objective was to compare the impact of being treated by paliperidone palmitate (PP) or risperidone long-acting injection (RLAI) on the length of stay on initial hospitalization, rehospitalization risk, and treatment duration in schizophrenic patients. METHODS:We conducted an observational ...

journal_title：Journal of clinical psychopharmacology

authors： Limosin F,Belhadi D,Comet D,Pacou M,Bouju S,Van Impe K,Guillon P

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Late-life depression, often in association with anxiety, affects approximately 15% of individuals older than 65 years. Selective serotonin reuptake inhibitors are the first-line treatment but could be responsible of an early exacerbation of anxiety, possibly reduced by a very gradual titration of drugs. The ...

journal_title：Journal of clinical psychopharmacology

authors： Gibiino S,Mori E,De Ronchi D,Serretti A

更新日期：2013-08-01 00:00:00

abstract：:Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia and is linked to a need for mandatory hematological monitoring. Besides agranulocytosis, other hematological aberrations have resulted in premature termination in some cases. Considering clozapine's role in immunomodulation, we proceeded to...

journal_title：Journal of clinical psychopharmacology

authors： Lee J,Takeuchi H,Fervaha G,Powell V,Bhaloo A,Bies R,Remington G

更新日期：2015-10-01 00:00:00

abstract：:Pregabalin is a novel compound in development for the treatment of anxiety disorders. The safety and efficacy of pregabalin for the treatment of social anxiety disorder was evaluated in a double-blind, multicenter clinical trial in which 135 patients were randomized to 10 weeks of double-blind treatment with either pr...

journal_title：Journal of clinical psychopharmacology

authors： Pande AC,Feltner DE,Jefferson JW,Davidson JR,Pollack M,Stein MB,Lydiard RB,Futterer R,Robinson P,Slomkowski M,DuBoff E,Phelps M,Janney CA,Werth JL

更新日期：2004-04-01 00:00:00

abstract：:Plasma pemoline levels were measured in 6- to 12-year-old, severely hyperactive males coincident with onset of abnormal involuntary movements. Acute exposure to pemoline (2 mg/kg orally) was associated with choreoathetoid movements of face, limbs, and trunk in five of 20 subjects in an acute study of pemoline pharmaco...

journal_title：Journal of clinical psychopharmacology

authors： Sallee FR,Stiller RL,Perel JM,Everett G

更新日期：1989-04-01 00:00:00

abstract：:Paroxetine is a novel phenylpiperidine antidepressant agent that acts as a potent and selective inhibitor of serotonin reuptake. We report results of a 6-week, randomized, double-blind, multicenter study comparing paroxetine and fluoxetine in the treatment of major depression. One hundred seventy-eight inpatients, who...

journal_title：Journal of clinical psychopharmacology

authors： Tignol J

更新日期：1993-12-01 00:00:00

abstract：:The reinforcing effects of methylphenidate (20-40 mg), d-amphetamine (10-20 mg), and placebo were assessed in eight healthy, non-sleep-deprived, non-drug-abusing outpatient volunteers. A modified progressive-ratio schedule was used to assess drug reinforcement in which a sampling session always preceded a self-adminis...

journal_title：Journal of clinical psychopharmacology

authors： Rush CR,Essman WD,Simpson CA,Baker RW

更新日期：2001-06-01 00:00:00

abstract：:A study of medication compliance, side effects, and clinical change with the use of antidepressants in 32 Southeast Asian refugee patients seen at an urban mental health center is reported. Patients met criteria for either major depressive episode, posttraumatic stress disorder, or both. Only five of the 32 patients w...

journal_title：Journal of clinical psychopharmacology

authors： Kroll J,Linde P,Habenicht M,Chan S,Yang M,Vang T,Souvannasoth L,Nguyen T,Ly M,Nguyen H

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:Risperidone long-acting injectable (RLAI), the first second-generation depot antipsychotic, has extensively been studied before introduction. Thereafter, questions about the type of patients actually treated with RLAI in daily practice remain to be answered for making valid antipsychotic treatment comparison...

journal_title：Journal of clinical psychopharmacology

authors： Vehof J,Postma MJ,Bruggeman R,De Jong-Van Den Berg LT,Van Den Berg PB,Stolk RP,Burger H

更新日期：2008-12-01 00:00:00

abstract：:Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients and were robustly el...

journal_title：Journal of clinical psychopharmacology

authors： Daniel DG,Randolph C,Jaskiw G,Handel S,Williams T,Abi-Dargham A,Shoaf S,Egan M,Elkashef A,Liboff S

更新日期：1994-10-01 00:00:00

abstract：:Age and sex may influence both efficacy and side effects of second-generation antipsychotics. Women and elderly patients tend to have a higher prevalence for several side effects. Higher plasma levels in these groups of patients may be one reason. We studied the hypothesis that steady-state olanzapine plasma concentra...

journal_title：Journal of clinical psychopharmacology

authors： Weiss U,Marksteiner J,Kemmler G,Saria A,Aichhorn W

更新日期：2005-12-01 00:00:00

abstract：:Forty bipolar depressed inpatients underwent three consecutive cycles of total sleep deprivation (TSD). At the beginning of the study, 20 patients were free of psychotropic drugs and 20 had been receiving lithium medication for at least 6 months. Mood was rated on the Hamilton Rating Scale for Depression before and af...

journal_title：Journal of clinical psychopharmacology

authors： Benedetti F,Colombo C,Barbini B,Campori E,Smeraldi E

更新日期：1999-06-01 00:00:00

abstract：:In normal subjects after a single oral dose, haloperidol half-life has been reported to range 14.5-36.7 hours (or up to 1.5 days). After chronic administration, half-lives of up to 21 days have been reported. The objective of this study was to evaluate specific factors that might account for differences in haloperidol...

journal_title：Journal of clinical psychopharmacology

authors： de Leon J,Diaz FJ,Wedlund P,Josiassen RC,Cooper TB,Simpson GM

更新日期：2004-12-01 00:00:00