Effects of adding cognitive therapy to fluoxetine dose increase on risk of relapse and residual depressive symptoms in continuation treatment of major depressive disorder.

abstract：:Seventeen hospitalized psychotic patients were treated with a fixed oral dose of haloperidol, 5 mg twice daily for 28 days. Most were chronic schizophrenics with an acute exacerbation of their illness. All patients also received benztropine 3 mg twice daily during the last 11 days of the study, regardless of the prese...

journal_title：Journal of clinical psychopharmacology

authors： Shostak M,Perel JM,Stiller RL,Wyman W,Curran S

更新日期：1987-12-01 00:00:00

abstract：:The current study uses utility analysis to assess economic and quality-of-life benefits of risperidone in patients with chronic schizophrenia. A retrospective analysis was performed on Positive and Negative Syndrome Symptoms (PANSS) data obtained from the published Canadian multicenter risperidone trial (part of the N...

journal_title：Journal of clinical psychopharmacology

authors： Chouinard G,Albright PS

更新日期：1997-08-01 00:00:00

abstract：:We compared acute effects of single intravenous administrations of metoclopramide (40 mg) and placebo in a double-blind crossover study involving 81 patients with tardive dyskinesia. Metoclopramide produced significantly greater reduction in mean total Abnormal Involuntary Movement Scale score as well as in ratings fo...

journal_title：Journal of clinical psychopharmacology

authors： Doongaji DR,Jeste DV,Jape NM,Sheth AS,Apte JS,Vahia VN,Desai AB,Parikh MD,Rathi LG,Ghandi MH,Parikh RM,Thatte S,Bharadwaj J

更新日期：1982-12-01 00:00:00

abstract：:Platelet monoamine oxidase (MAO) activity was studied in bipolar and schizophrenic patients treated with lithium and was found to be increased as a nonspecific drug effect. Greater MAO increase in manic patients was correlated with lesser clinical improvement. There was no correlation of MAO activity with short-term o...

journal_title：Journal of clinical psychopharmacology

authors： Huang LG,Bowden CL

更新日期：1984-12-01 00:00:00

abstract：PURPOSE:The use of smokeless tobacco/nicotine products is common among athletes, but clear evidence for their positive or negative effect on sports performance is lacking. Nicotine is a psychoactive substance involved in numerous neuronal processes including cortical excitability. The aim of this study was to evaluate ...

journal_title：Journal of clinical psychopharmacology

authors： Zandonai T,Pizzolato F,Tam E,Bruseghini P,Chiamulera C,Cesari P

更新日期：2020-09-01 00:00:00

abstract：:Two cases of mania following the discontinuation of treatment with isocarboxazid are described. Although this phenomenon has been reported by several investigators to occur after cessation of tricyclic antidepressant therapy, there exists only one isolated report of hypomania after discontinuation of monoamine oxidase...

journal_title：Journal of clinical psychopharmacology

authors： Rothschild AJ

更新日期：1985-12-01 00:00:00

abstract：:In normal subjects after a single oral dose, haloperidol half-life has been reported to range 14.5-36.7 hours (or up to 1.5 days). After chronic administration, half-lives of up to 21 days have been reported. The objective of this study was to evaluate specific factors that might account for differences in haloperidol...

journal_title：Journal of clinical psychopharmacology

authors： de Leon J,Diaz FJ,Wedlund P,Josiassen RC,Cooper TB,Simpson GM

更新日期：2004-12-01 00:00:00

abstract：PURPOSE/BACKGROUND:The use of clozapine, particularly in young people, is often limited by early treatment-emergent adverse effects including drowsiness and lethargy. Concerns about adverse effects, medication adherence, and the need for blood monitoring often impede the use of clozapine in this population, leading to ...

journal_title：Journal of clinical psychopharmacology

authors： Ballon JS,Ashfaq H,Noordsy DL

更新日期：2018-06-01 00:00:00

abstract：:The effects of daily buprenorphine treatment (4 or 8 mg/day, sublingual) on reports of subjective effects after single intravenous doses of morphine (10 mg), cocaine (30 mg), and saline placebo were studied on an inpatient clinical research ward in 26 men concurrently dependent on opioids and cocaine (DSM-III-R). Late...

journal_title：Journal of clinical psychopharmacology

authors： Teoh SK,Mello NK,Mendelson JH,Kuehnle J,Gastfriend DR,Rhoades E,Sholar W

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Depression, the leading cause of nonfatal disease burden, has a strong correlation with suicide and affects approximately 7% of the general elderly population. Adverse drug reactions in older patients are particularly important because of reduced drug metabolism, polypharmacy, drug-drug interactions, and dru...

journal_title：Journal of clinical psychopharmacology

authors： Kim S,Ko YJ,Park K,Yang BR,Kim MS,Park BJ

更新日期：2019-07-01 00:00:00

abstract：:There have been many attempts to find predictors of the therapeutic response to the clomipramine treatment of obsessive-compulsive disorder. The majority of studies have failed to identify such predictors. Possible reasons for this failure include the small sample size of most studies, samples homogeneous with respect...

journal_title：Journal of clinical psychopharmacology

authors： Ackerman DL,Greenland S,Bystritsky A,Morgenstern H,Katz RJ

更新日期：1994-08-01 00:00:00

abstract：:Twenty-four healthy male and female subjects, who participated in this randomized, double-blind, crossover study, received single nighttime doses of zaleplon 10 mg (therapeutic dose), zaleplon 20 mg, zolpidem 10 mg (therapeutic dose), zolpidem 20 mg, triazolam 0.25 mg (positive control), and placebo. Subjective behavi...

journal_title：Journal of clinical psychopharmacology

authors： Troy SM,Lucki I,Unruh MA,Cevallos WH,Leister CA,Martin PT,Furlan PM,Mangano R

更新日期：2000-06-01 00:00:00

abstract：:A role for serotonin in season affective disorder (SAD) has been explored with a variety of serotonergic pharmacologic agents. The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms. In a small, open-label pilot study, the authors observed the oppo...

journal_title：Journal of clinical psychopharmacology

authors： Turner EH,Schwartz PJ,Lowe CH,Nawab SS,Feldman-Naim S,Drake CL,Myers FS,Barnett RL,Rosenthal NE

更新日期：2002-04-01 00:00:00

abstract：:An antidepressant for use in the patient receiving concomitant drug treatment, over-the-counter medications, or herbal products should lack cytochrome P-450 (CYP) 3A4 inductive or inhibitory activity to provide the least likelihood of a drug-drug interaction. This study addresses the potential of 4 diverse antidepress...

journal_title：Journal of clinical psychopharmacology

authors： DeVane CL,Donovan JL,Liston HL,Markowitz JS,Cheng KT,Risch SC,Willard L

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:To conduct a systematic review examining the relationships between olanzapine dose, clinical outcome, dopamine occupancy, and plasma concentration; and to evaluate the potential for therapeutic drug monitoring. METHODS:A search using Embase, Medline, and Pubmed was conducted; and the literature was systemati...

journal_title：Journal of clinical psychopharmacology

authors： Bishara D,Olofinjana O,Sparshatt A,Kapur S,Taylor D,Patel MX

更新日期：2013-06-01 00:00:00

abstract：:The purpose of this study was to assess the effect of bupropion on cytochrome P450 2D6 (CYP2D6) activity. Twenty-one subjects completed this repeated-measures study in which dextromethorphan (30-mg oral dose) was administered to smokers at baseline and after 17 days of treatment with either bupropion sustained-release...

journal_title：Journal of clinical psychopharmacology

authors： Kotlyar M,Brauer LH,Tracy TS,Hatsukami DK,Harris J,Bronars CA,Adson DE

更新日期：2005-06-01 00:00:00

abstract：:The selection of appropriate subjects is a critical element of successful clinical trials. Failure to properly identify, select, and retain subjects in clinical trials of antidepressant medications may affect the ability to show separation from placebo. Little is known about which type of site, academic or nonacademic...

journal_title：Journal of clinical psychopharmacology

authors： Dording CM,Dalton ED,Pencina MJ,Fava M,Mischoulon D

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:We examined the influence of prior antidepressant treatment trials on the likelihood of depressive relapse, and time to depressive relapse, during maintenance therapy of bipolar II disorder in treatment-responsive subjects who had recovered from a major depressive episode. METHODS:Data were derived from a p...

journal_title：Journal of clinical psychopharmacology

authors： Amsterdam JD,Kim TT

更新日期：2019-07-01 00:00:00

abstract：:The assessment of adverse effects of psychiatric medications is important in clinical and research settings because they are often associated with medication discontinuation, symptom exacerbation, and reduced quality of life. Currently available assessment tools are either limited with regard to the number and variety...

journal_title：Journal of clinical psychopharmacology

authors： Nugent KL,Spahr E,Toroney J,Mojtabai R,Nettles C,Turner LW,Fenton A,Spivak A,Cullen BA,Everett A,Eaton WW

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Combination antipsychotics (CAs) are prescribed in schizophrenia despite limited evidence of efficacy. To explore the effect of switching from CA to monotherapy, we performed an exploratory analysis of the PROACTIVE (Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared with Injectables: Evaluati...

journal_title：Journal of clinical psychopharmacology

authors： Foster A,Buckley P,Lauriello J,Looney S,Schooler N

更新日期：2017-10-01 00:00:00

abstract：:Plasma and red blood cell levels of haloperidol, thioridazine, and thioridazine's main metabolite mesoridazine were measured in schizophrenic outpatients during treatment with fixed doses of haloperidol or thioridazine for several months. These drug levels were compared to those in schizophrenic inpatients treated wit...

journal_title：Journal of clinical psychopharmacology

authors： Shvartsburd A,Sajadi C,Morton V,Mirabi M,Gordon J,Smith RC

更新日期：1984-08-01 00:00:00

abstract：OBJECTIVES:It is unknown to which degree the effect of antidepressant drugs are related to baseline degree of depression, dose level, patient's age, or type of questionnaire used. We explored this for paroxetine. METHODS:We used placebo-controlled published and unpublished randomized, double-blind, clinical trials of ...

journal_title：Journal of clinical psychopharmacology

authors： Klemp M,Tvete IF,Gåsemyr J,Natvig B,Aursnes I

更新日期：2011-04-01 00:00:00

abstract：:Forty bipolar depressed inpatients underwent three consecutive cycles of total sleep deprivation (TSD). At the beginning of the study, 20 patients were free of psychotropic drugs and 20 had been receiving lithium medication for at least 6 months. Mood was rated on the Hamilton Rating Scale for Depression before and af...

journal_title：Journal of clinical psychopharmacology

authors： Benedetti F,Colombo C,Barbini B,Campori E,Smeraldi E

更新日期：1999-06-01 00:00:00

abstract：:A case of rhabdomyolysis is described, with onset following three intramuscular injections of loxapine and one injection of benztropine over a 7-hour period. The possible additive effects of intramuscular drug administration and psychotic episode-associated increased muscle membrane permeability are discussed. Because...

journal_title：Journal of clinical psychopharmacology

authors： Thase ME,Shostak M

更新日期：1984-02-01 00:00:00

abstract：:Little is known about the association between antidepressant treatment-emergent adverse events and symptom nonremission in major depressive disorder. The objective of the current analysis was to determine whether particular baseline symptoms or treatment-emergent symptoms (adverse events) during the first 2 weeks are ...

journal_title：Journal of clinical psychopharmacology

authors： Daly EJ,Trivedi MH,Fava M,Shelton R,Wisniewski SR,Morris DW,Stegman D,Preskorn SH,Rush AJ

更新日期：2011-02-01 00:00:00

abstract：PURPOSE/BACKGROUND:To add to limited evidence on the Abnormal Involuntary Movement Scale (AIMS) as a measure of tardive dyskinesia (TD) in clinical practice settings, the characteristics and correlates of AIMS scores were assessed. METHODS/PROCEDURES:Veterans with schizophrenia/schizoaffective, bipolar, or major depre...

journal_title：Journal of clinical psychopharmacology

authors： Caroff SN,Leong SH,Roberts CB,Berkowitz RM,Campbell EC

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Risperidone long-acting injectable (RLAI), the first second-generation depot antipsychotic, has extensively been studied before introduction. Thereafter, questions about the type of patients actually treated with RLAI in daily practice remain to be answered for making valid antipsychotic treatment comparison...

journal_title：Journal of clinical psychopharmacology

authors： Vehof J,Postma MJ,Bruggeman R,De Jong-Van Den Berg LT,Van Den Berg PB,Stolk RP,Burger H

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Dopaminergic dysfunction, namely, dopamine transporter (DAT) availability variations in patients with drug-naive schizophrenia after long-term treatment, is still not well understood. The aims of the study were to explore (i) whether the DAT availability in patients with drug-naive schizophrenia differed aft...

journal_title：Journal of clinical psychopharmacology

authors： Chang WH,Chen KC,Lee IH,Chi MH,Chen PS,Yao WJ,Chiu NT,Yang YK

更新日期：2017-02-01 00:00:00

abstract：:This study aimed to assess whether exposure to anticholinergic and sedative medications and its evolution was associated with increased risk of in-hospital falls and all-cause mortality. Furthermore, results were compared with 2 definitions of drug burden index (DBI) against the outcomes.This observational, multicentr...

journal_title：Journal of clinical psychopharmacology

authors： Dauphinot V,Faure R,Omrani S,Goutelle S,Bourguignon L,Krolak-Salmon P,Mouchoux C

更新日期：2014-10-01 00:00:00

abstract：:This study investigated the effects of antidepressant treatment on platelet activation in depressed patients with ischemic heart disease (IHD). Plasma levels of platelet alpha-granule release products beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were measured in 17 depressed patients with IHD who were treate...

journal_title：Journal of clinical psychopharmacology

authors： Pollock BG,Laghrissi-Thode F,Wagner WR

更新日期：2000-04-01 00:00:00