Efficacy of the novel anxiolytic pregabalin in social anxiety disorder: a placebo-controlled, multicenter study.

abstract：:The aim of this study was to compare the disposition of the tricyclic antidepressant clomipramine (C) in Japanese and Swedish patients receiving continuous treatment. Therapeutic drug monitoring data for C and the active metabolite N-desmethylclomipramine (DC) in Japanese patients receiving monotherapy (N = 12) and in...

journal_title：Journal of clinical psychopharmacology

authors： Shimoda K,Jerling M,Böttiger Y,Yasuda S,Morita S,Bertilsson L

更新日期：1999-10-01 00:00:00

abstract：PURPOSE/BACKGROUND:Extensive research has been conducted comparing the metabolic characteristics of older second-generation antipsychotics (SGAs); minimal data exist comparing the long-term metabolic effects of SGAs approved in the last 10 years. METHODS/PROCEDURES:A retrospective chart review of patients treated with...

journal_title：Journal of clinical psychopharmacology

authors： Greger J,Aladeen T,Lewandowski E,Wojcik R,Westphal E,Rainka M,Capote H

更新日期：2021-01-01 00:00:00

abstract：:A randomized, double-blind, placebo-controlled study was conducted to assess the efficacy of risperidone in the treatment of developmental stuttering in 16 adults. Eight subjects received placebo and eight received risperidone at 0.5 mg once daily at night, increased to a maximum of 2 mg/day. After 6 weeks of treatmen...

journal_title：Journal of clinical psychopharmacology

authors： Maguire GA,Riley GD,Franklin DL,Gottschalk LA

更新日期：2000-08-01 00:00:00

abstract：:The sex prevalence of schizophrenia is approximately equal, and yet clinical trials of new therapeutic drugs have been conducted, for the most part, with male participants. The authors reviewed the percentage of women in schizophrenia clinical trials of the new "atypical" antipsychotic medications. MEDLINE and Cochran...

journal_title：Journal of clinical psychopharmacology

authors： Chaves AC,Seeman MV

更新日期：2006-10-01 00:00:00

abstract：:Olanzapine is an atypical antipsychotic effective in the treatment of schizophrenic patients. After a 2- to 9-day placebo lead-in, 79 inpatients with schizophrenia according to DSM-III-R criteria were placed on an olanzapine dosage of 10 mg/day or 1 mg/day for up to 6 weeks. Blood samples were obtained weekly during t...

journal_title：Journal of clinical psychopharmacology

authors： Perry PJ,Sanger T,Beasley C

更新日期：1997-12-01 00:00:00

abstract：:The long-term use of the serotonin-releaser and uptake-inhibitor 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") has been associated with memory impairments and increased liability to depressive mood and anxiety attacks. It is unclear, however, whether these psychologic deviations are reflected in alterations of t...

journal_title：Journal of clinical psychopharmacology

authors： Gamma A,Buck A,Berthold T,Vollenweider FX

更新日期：2001-02-01 00:00:00

abstract：:Alprazolam administered for 43 days in doses of 6 to 10 mg/day had an antidepressant effect in four of nine depressed patients. Decreases in slow wave sleep, increases in rapid eye movement (REM) latency, and decreases in REM minutes and percent and REM sleep eye movements were found in the group as a whole. The drug ...

journal_title：Journal of clinical psychopharmacology

authors： Zarcone VP Jr,Benson KL,Greene KA,Csernansky JG,Faull KF

更新日期：1994-02-01 00:00:00

abstract：:The present study was conducted to derive pediatric mianserin pharmacokinetic parameters, which were compared to those from healthy young adults, and to obtain preliminary information regarding the utility of mianserin for the management of hyperkinesis in children. The sample consisted of six prepubescent children wi...

journal_title：Journal of clinical psychopharmacology

authors： Winsberg BG,Camp-Bruno JA,Vink J,Timmer CJ,Sverd J

更新日期：1987-06-01 00:00:00

abstract：PURPOSE:The neuropeptide oxytocin (OXT) has a variety of physiological functions in maternal behavior and attachment including sexual behavior. Based on animal research and our previous human studies, we set out to investigate intranasal administration of OXT and hypothesized that OXT should be able to modulate sexual ...

journal_title：Journal of clinical psychopharmacology

authors： Kruger THC,Deiter F,Zhang Y,Jung S,Schippert C,Kahl KG,Heinrichs M,Schedlowski M,Hartmann U

更新日期：2018-06-01 00:00:00

abstract：:There have been many attempts to find predictors of the therapeutic response to the clomipramine treatment of obsessive-compulsive disorder. The majority of studies have failed to identify such predictors. Possible reasons for this failure include the small sample size of most studies, samples homogeneous with respect...

journal_title：Journal of clinical psychopharmacology

authors： Ackerman DL,Greenland S,Bystritsky A,Morgenstern H,Katz RJ

更新日期：1994-08-01 00:00:00

abstract：:Molindone hydrochloride, a dihydroindolone neuroleptic, is structurally distinct from other classes of neuroleptics. Molindone exhibits many similarities to other neuroleptics, including dopamine receptor blockade, antipsychotic efficacy, and extrapyramidal side effects. Despite these similarities, molindone also has ...

journal_title：Journal of clinical psychopharmacology

authors： Owen RR Jr,Cole JO

更新日期：1989-08-01 00:00:00

abstract：:Over the past 10 years, knowledge gained about the pharmacokinetic profiles of valproate and carbamazepine has increased the clinical effectiveness of their use. Much of the information has been gained through their use as successful antiepileptic medications. As these agents begin to play an increasing role as mood-s...

journal_title：Journal of clinical psychopharmacology

authors： Wilder BJ

更新日期：1992-02-01 00:00:00

abstract：INTRODUCTION:Zonisamide is an anticonvulsant medication with GABAergic, glutamatergic, and monoaminergic effects. Zonisamide has also been shown to reduce alcohol intake in rodents and in risky drinkers in the context of a laboratory study. This pilot clinical trial evaluated the safety, tolerability, and efficacy of z...

journal_title：Journal of clinical psychopharmacology

authors： Arias AJ,Feinn R,Oncken C,Covault J,Kranzler HR

更新日期：2010-06-01 00:00:00

abstract：:Patients with major depressive disorder remain at risk for relapse following remission and often continue to experience subthreshold symptoms. This study compared the rate of relapse of major depressive disorder and the prevalence of residual depressive symptoms during the continuation phase for patients treated with ...

journal_title：Journal of clinical psychopharmacology

authors： Perlis RH,Nierenberg AA,Alpert JE,Pava J,Matthews JD,Buchin J,Sickinger AH,Fava M

更新日期：2002-10-01 00:00:00

abstract：INTRODUCTION:Although medication with antipsychotic for the psychosis prodrome has often caused some ethical issues, recent studies have shown that some novel antipsychotics are safer and more tolerable for young people. This study aimed to investigate whether the administration of aripiprazole would not only relieve t...

journal_title：Journal of clinical psychopharmacology

authors： Kobayashi H,Morita K,Takeshi K,Koshikawa H,Yamazawa R,Kashima H,Mizuno M

更新日期：2009-10-01 00:00:00

abstract：:Lithium augmentation, the most studied augmentation strategy for depression, has not been evaluated in patients with a history of non-response to multiple antidepressants. The objective of this study was to assess the efficacy of lithium augmentation for patients with a history of treatment resistant depression who al...

journal_title：Journal of clinical psychopharmacology

authors： Nierenberg AA,Papakostas GI,Petersen T,Montoya HD,Worthington JJ,Tedlow J,Alpert JE,Fava M

更新日期：2003-02-01 00:00:00

abstract：:The aim of the study was to determine whether baseline pain was associated with discernible clinical features and treatment outcomes for patients with major depressive disorder (MDD) receiving 6-week fluoxetine treatment. A total of 131 inpatients with acutely ill MDD were enrolled to receive 20 mg of fluoxetine daily...

journal_title：Journal of clinical psychopharmacology

authors： Lin HS,Wang FC,Lin CH

更新日期：2015-12-01 00:00:00

abstract：:Lithium is clinically available for the treatment of mood disorders. However, it has remained unclear how lithium acts on the brain to produce its effects. The aim of this study was to evaluate the effects of chronic lithium on human brain activity using positron emission tomography and clarify the correlation between...

journal_title：Journal of clinical psychopharmacology

authors： Kohno T,Shiga T,Toyomaki A,Kusumi I,Matsuyama T,Inoue T,Katoh C,Koyama T,Tamaki N

更新日期：2007-12-01 00:00:00

abstract：:A growing number of anticonvulsant drugs are receiving attention as possible mood stabilizers. This attention is based mainly on the assumption that the antimanic efficacy of anticonvulsants makes them suitable as mood stabilizers. However, their antidepressant properties have received less scrutiny. In this review, c...

journal_title：Journal of clinical psychopharmacology

authors： Ernst CL,Goldberg JF

更新日期：2003-04-01 00:00:00

abstract：:The measurement of plasma clozapine concentrations is useful in assessing compliance, optimizing therapy, and minimizing toxicity. We measured plasma clozapine and norclozapine (N-desmethylclozapine) concentrations in samples from 3782 patients (2648 male, 1127 female). No clozapine was detected in 291 samples (227 pa...

journal_title：Journal of clinical psychopharmacology

authors： Rostami-Hodjegan A,Amin AM,Spencer EP,Lennard MS,Tucker GT,Flanagan RJ

更新日期：2004-02-01 00:00:00

abstract：:The current study aimed at establishing the prevalence of impulse control disorders (ICDs) in patients with Parkinson disease (PD) and their association with demographic, drug-related, and disease-related characteristics. We performed a single-center cross-sectional study of 805 PD patients. Impulse control disorders ...

journal_title：Journal of clinical psychopharmacology

authors： Poletti M,Logi C,Lucetti C,Del Dotto P,Baldacci F,Vergallo A,Ulivi M,Del Sarto S,Rossi G,Ceravolo R,Bonuccelli U

更新日期：2013-10-01 00:00:00

abstract：:A case of treatment-resistant catatonic stupor responding to combined lithium-neuroleptic medications is described. As there are no reports in the literature of combined lithium-neuroleptic medications being effective for this potentially life-threatening disorder, the course of recovery is detailed and the risks and ...

journal_title：Journal of clinical psychopharmacology

authors： Climo LH

更新日期：1985-06-01 00:00:00

abstract：:A role for serotonin in season affective disorder (SAD) has been explored with a variety of serotonergic pharmacologic agents. The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms. In a small, open-label pilot study, the authors observed the oppo...

journal_title：Journal of clinical psychopharmacology

authors： Turner EH,Schwartz PJ,Lowe CH,Nawab SS,Feldman-Naim S,Drake CL,Myers FS,Barnett RL,Rosenthal NE

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Risperidone long-acting injectable (RLAI), the first second-generation depot antipsychotic, has extensively been studied before introduction. Thereafter, questions about the type of patients actually treated with RLAI in daily practice remain to be answered for making valid antipsychotic treatment comparison...

journal_title：Journal of clinical psychopharmacology

authors： Vehof J,Postma MJ,Bruggeman R,De Jong-Van Den Berg LT,Van Den Berg PB,Stolk RP,Burger H

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Bipolar disorder is a serious mental disorder. This study investigated whether early improvement at week 1 or 2 could predict treatment outcomes at week 4 in clinical populations with acute mania. METHODS:We conducted a naturalistic study, recruiting inpatients with bipolar mania for acute treatment. Sympto...

journal_title：Journal of clinical psychopharmacology

authors： Li DJ,Lin CH,Lu MJ

更新日期：2017-08-01 00:00:00

abstract：:Clinical studies that have evaluated serotonergic medications to reduce alcohol consumption have yielded conflicting results. These studies primarily treated patients with alcohol dependence, excluding those with a current depressive disorder, in an effort to differentiate any medication effects directly on drinking f...

journal_title：Journal of clinical psychopharmacology

authors： Pettinati HM,Volpicelli JR,Luck G,Kranzler HR,Rukstalis MR,Cnaan A

更新日期：2001-04-01 00:00:00

abstract：:In this 6-week, open-label trial, combat veterans meeting DSM-IV criteria for posttraumatic stress disorder (PTSD) were treated with the atypical antipsychotic quetiapine. The starting dose was 25 mg at bedtime with subsequent titration based on tolerability and clinical response. Primary outcome was measured using th...

journal_title：Journal of clinical psychopharmacology

authors： Hamner MB,Deitsch SE,Brodrick PS,Ulmer HG,Lorberbaum JP

更新日期：2003-02-01 00:00:00

abstract：:Age and sex may influence both efficacy and side effects of second-generation antipsychotics. Women and elderly patients tend to have a higher prevalence for several side effects. Higher plasma levels in these groups of patients may be one reason. We studied the hypothesis that steady-state olanzapine plasma concentra...

journal_title：Journal of clinical psychopharmacology

authors： Weiss U,Marksteiner J,Kemmler G,Saria A,Aichhorn W

更新日期：2005-12-01 00:00:00

abstract：:This study tested the association between tardive dyskinesia (TD) and polymorphic variations in (a) 2 cytochrome P450 (CYP) genes (CYP2D6 or CYP3A5), (b) 2 DRD2 variants (Ser311Cys and -141C Ins/del) and the Ser9Gly DRD3 variants, (c) 2 glutathione S-transferases (GSTT1 and GSTM1), and (d) variations in the PgP gene, ...

journal_title：Journal of clinical psychopharmacology

authors： de Leon J,Susce MT,Pan RM,Koch WH,Wedlund PJ

更新日期：2005-10-01 00:00:00

abstract：:There have been an increased number of recent reports on orgasm-related sexual dysfunction coincident with selective serotonin reuptake inhibitor (SSRI) treatment. In contrast, it has also been reported that SSRIs improve sexual dysfunction. Low doses of clomipramine and paroxetine, potent 5-hydroxytryptamine reuptake...

journal_title：Journal of clinical psychopharmacology

authors： Lee HS,Song DH,Kim CH,Choi HK

更新日期：1996-10-01 00:00:00