Abstract:
:The present study was conducted to derive pediatric mianserin pharmacokinetic parameters, which were compared to those from healthy young adults, and to obtain preliminary information regarding the utility of mianserin for the management of hyperkinesis in children. The sample consisted of six prepubescent children with hyperkinetic behavior disorders who had not responded, or had developed tolerance to, stimulant medication. Mianserin pharmacokinetics were derived from plasma samples obtained over a 36- to 50-hour period following a single oral dose which ranged from 0.28 to 0.72 mg/kg. Children evidenced a significantly faster elimination half-life and a significantly smaller apparent kinetic volume of distribution than did adults, whereas maximum plasma concentration, time to maximum concentration, and apparent oral plasma clearance were similar. Ratings of behavioral deviance were obtained from teachers and parents during placebo and mianserin titration to a maximum dose of 40 mg/day. Although half the children showed some decrease in hyperactivity ratings, the small sample size and high variability of response preclude conclusions regarding the efficacy of mianserin for childhood hyperkinesis. Possible side effects in our sample included akathisia, excitability, insomnia, and migraine-like headache, as well as cardiovascular effects of tachycardia and two instances of minor electrocardiographic change. Our pharmacokinetic findings will be of import should mianserin prove useful for such childhood disorders as depression and/or enuresis.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Winsberg BG,Camp-Bruno JA,Vink J,Timmer CJ,Sverd Jsubject
Has Abstractpub_date
1987-06-01 00:00:00pages
143-7issue
3eissn
0271-0749issn
1533-712Xjournal_volume
7pub_type
杂志文章abstract:OBJECTIVES:It is unknown to which degree the effect of antidepressant drugs are related to baseline degree of depression, dose level, patient's age, or type of questionnaire used. We explored this for paroxetine. METHODS:We used placebo-controlled published and unpublished randomized, double-blind, clinical trials of ...
journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,meta分析
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::In an open label study, two fixed doses of nifedipine (30 mg and 60 mg daily) were added to the usual antipsychotic drug treatments of 10 patients suffering from chronic schizophrenia. While no patient experienced significant improvements, statistically significant falls in Brief Psychiatric Rating Scales scores were ...
journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,评审
doi:
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更新日期:2018-06-01 00:00:00
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章
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更新日期:1984-08-01 00:00:00
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,评审
doi:10.1097/00004714-199604001-00006
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2009-02-01 00:00:00
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1097/00004714-199612000-00007
更新日期:1996-12-01 00:00:00
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-02-01 00:00:00
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-08-01 00:00:00