A double-blind comparison of moclobemide and thioridazine versus moclobemide and placebo in the treatment of refractory, severe depression.

abstract：PURPOSE/BACKGROUND:Lithium, a common medication used in bipolar disorder treatment, can exert an inhibitory effect on sodium and potassium channels and potentially cause cardiac electrical conduction disturbance and corrected QT (QTc) prolongation. This study aimed to examine whether lithium at therapeutic levels can c...

journal_title：Journal of clinical psychopharmacology

authors： Chen PH,Kao YH,Chang CK,Lin YK,Lin YF,Chen YJ

更新日期：2020-01-01 00:00:00

abstract：:The aim of the study was to determine whether baseline pain was associated with discernible clinical features and treatment outcomes for patients with major depressive disorder (MDD) receiving 6-week fluoxetine treatment. A total of 131 inpatients with acutely ill MDD were enrolled to receive 20 mg of fluoxetine daily...

journal_title：Journal of clinical psychopharmacology

authors： Lin HS,Wang FC,Lin CH

更新日期：2015-12-01 00:00:00

abstract：:Physician-rating scales remain the standard in antidepressant clinical trials. The current study aimed to examine the discrepancies between physician-rating scales and self-rating scales for symptoms and functioning, before and after treatment, in newly hospitalized patients. A total of 131 acutely ill inpatients with...

journal_title：Journal of clinical psychopharmacology

authors： Lin CH,Lu MJ,Wong J,Chen CC

更新日期：2014-12-01 00:00:00

abstract：:Despite a recognized need for the inclusion of women of childbearing age in drug studies, many such studies include only men. This practice is due mainly to the added risk of teratogenicity and to cyclic variations in the menstrual phase and hormonal state. The methodological and ethical problems associated with drug ...

journal_title：Journal of clinical psychopharmacology

authors： Halbreich U,Carson SW

更新日期：1989-10-01 00:00:00

abstract：:We examined kinetic and dynamic factors to determine the pharmacological and behavioral safety and tolerability of low versus high doses of an opiate antagonist, naltrexone (50 mg/day vs. 100 mg/day), and acamprosate (2 g/day vs. 3 g/day), a functional N-methyl-D-aspartate receptor antagonist, both independently and c...

journal_title：Journal of clinical psychopharmacology

authors： Johnson BA,O'Malley SS,Ciraulo DA,Roache JD,Chambers RA,Sarid-Segal O,Couper D

更新日期：2003-06-01 00:00:00

abstract：:Some of the selective serotonin reuptake inhibitors (SSRI)-induced motor side effects are mediated by stimulating 5-HT2 receptors in the basal ganglia, probably because serotonin inhibits the subsequent neuronal dopamine release. We hypothesized that nefazodone, a serotonin 2 antagonist/reuptake inhibitor (SARI) that ...

journal_title：Journal of clinical psychopharmacology

authors： Avila A,Cardona X,Martin-Baranera M,Maho P,Sastre F,Bello J

更新日期：2003-10-01 00:00:00

abstract：:The dose range of estazolam for hypnotic effects was studied in seven men and eight women (mean age 30.3 +/- 8.6 years) who complained of insomnia and had polysomnographic evidence of disturbed sleep. Patients slept in the laboratory and were monitored using standard polysomnographic techniques. Four consecutive night...

journal_title：Journal of clinical psychopharmacology

authors： Roehrs T,Zorick F,Lord N,Koshorek GL,Roth T

更新日期：1983-06-01 00:00:00

abstract：:The Taq1A polymorphism in the dopamine D2 receptor (DRD2) gene could be related to the response to antipsychotics. We examined the effects of the Taq1A polymorphism on the plasma monoamine metabolites during the treatment of schizophrenia with aripiprazole, a DRD2 partial agonist. Thirty Japanese patients with schizop...

journal_title：Journal of clinical psychopharmacology

authors： Miura I,Takeuchi S,Katsumi A,Mori A,Kanno K,Yang Q,Mashiko H,Numata Y,Niwa S

更新日期：2012-02-01 00:00:00

abstract：:Although a relatively common behavior, treatment data for pathological skin picking (PSP) are limited. The current study sought to examine the efficacy and tolerability of lamotrigine in adults with PSP and to examine neurocognitive predictors of treatment response. Thirty-two subjects (29 female subjects [90.6%]; mea...

journal_title：Journal of clinical psychopharmacology

authors： Grant JE,Odlaug BL,Chamberlain SR,Kim SW

更新日期：2010-08-01 00:00:00

abstract：:Recognition of social anxiety disorder (social phobia) as a common and disabling condition has led to new advances in its pharmacotherapy. Limitations with selective seroton reuptake inhibitors (side effects) and behavior therapy (scarcity of trained therapists), coupled with the tendency for patients with the disorde...

journal_title：Journal of clinical psychopharmacology

authors： Kobak KA,Taylor LV,Warner G,Futterer R

更新日期：2005-02-01 00:00:00

abstract：:Methadone is a synthetic opioid that binds to the κ-opioid receptor with a low affinity. This study tested the hypotheses that the genetic polymorphisms in the κ-opioid receptor 1 (OPRK1) gene region are associated with methadone treatment responses in a Taiwan methadone maintenance treatment (MMT) cohort. Seventeen s...

journal_title：Journal of clinical psychopharmacology

authors： Wang SC,Tsou HH,Chung RH,Chang YS,Fang CP,Chen CH,Ho IK,Kuo HW,Liu SC,Shih YH,Wu HY,Huang BH,Lin KM,Chen AC,Hsiao CF,Liu YL

更新日期：2014-04-01 00:00:00

abstract：:In this multicenter, parallel-group, placebo-controlled, fixed-dose study, the efficacy, safety, dosing characteristics, and discontinuation of clonazepam were analyzed in patients with panic disorder. Four hundred thirteen patients were randomly assigned to receive placebo or one of five fixed daily doses of clonazep...

journal_title：Journal of clinical psychopharmacology

authors： Rosenbaum JF,Moroz G,Bowden CL

更新日期：1997-10-01 00:00:00

abstract：:Aripiprazole is widely used to treat schizophrenia. Plasma levels of aripiprazole and its active metabolite dehydroaripiprazole and their clinical responses in patients were explored. Forty-five (male/female: 19/26) patients with schizophrenia were treated with aripiprazole after a washout period of at least 3 days. T...

journal_title：Journal of clinical psychopharmacology

authors： Lin SK,Chen CK,Liu YL

更新日期：2011-12-01 00:00:00

abstract：:The disposition of orally administered imipramine (IMI) was studied in 11 depressed alcoholic and 12 depressed nonalcoholic male inpatients. Subjects received 50 mg three times daily for at least 10 days to ensure steady state. Following a temporary discontinuation of therapy, several blood samples were drawn over a 4...

journal_title：Journal of clinical psychopharmacology

authors： Ciraulo DA,Alderson LM,Chapron DJ,Jaffe JH,Subbarao B,Kramer PA

更新日期：1982-02-01 00:00:00

abstract：:In a recent study, the authors suggested that tachycardia, dry mouth, and sweating continued to burden patients with panic disorder with agoraphobia who have shown marked and stable response to 6 months of imipramine treatment at the fixed, weight-adjusted dose of 2.25 mg/kg/day. Although sexual dysfunction and weight...

journal_title：Journal of clinical psychopharmacology

authors： Mavissakalian M,Perel J,Guo S

更新日期：2002-04-01 00:00:00

abstract：PURPOSE/BACKGROUND:The use of clozapine, particularly in young people, is often limited by early treatment-emergent adverse effects including drowsiness and lethargy. Concerns about adverse effects, medication adherence, and the need for blood monitoring often impede the use of clozapine in this population, leading to ...

journal_title：Journal of clinical psychopharmacology

authors： Ballon JS,Ashfaq H,Noordsy DL

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Pharmacogenetic studies on clozapine (CLZ) have provided meaningful insights but have shown redundancies owing to wide interindividual variability and insufficient replication. The present study was designed to validate hitherto suggested candidate genes on CLZ pharmacokinetics and pharmacodynamics and explor...

journal_title：Journal of clinical psychopharmacology

authors： Lee ST,Ryu S,Kim SR,Kim MJ,Kim S,Kim JW,Lee SY,Hong KS

更新日期：2012-08-01 00:00:00

abstract：:There have been several case reports of improvement in tardive dyskinesia (TD) after treatment with calcium-blocking agents. We have conducted prior single-blind (rater-blind) studies of verapamil and diltiazem and found a statistically significant improvement in TD with verapamil, and a small improvement that did not...

journal_title：Journal of clinical psychopharmacology

authors： Duncan E,Adler L,Angrist B,Rotrosen J

更新日期：1990-12-01 00:00:00

abstract：:Transient amnesias, fugues, twilight states, automatisms, depersonalization, and furors or explosive disorders can occur in association with, or be caused by, various medications or substance-induced organic brain states. Agents capable of precipitating dissociative-like states include alcohol, barbiturates and simila...

journal_title：Journal of clinical psychopharmacology

authors： Good MI

更新日期：1989-04-01 00:00:00

abstract：:Twenty-four healthy male and female subjects, who participated in this randomized, double-blind, crossover study, received single nighttime doses of zaleplon 10 mg (therapeutic dose), zaleplon 20 mg, zolpidem 10 mg (therapeutic dose), zolpidem 20 mg, triazolam 0.25 mg (positive control), and placebo. Subjective behavi...

journal_title：Journal of clinical psychopharmacology

authors： Troy SM,Lucki I,Unruh MA,Cevallos WH,Leister CA,Martin PT,Furlan PM,Mangano R

更新日期：2000-06-01 00:00:00

abstract：:The cholinergic-adrenergic balance hypothesis of affective disorders suggests that, in the areas of the brain that regulate mood, depression may represent a relative predominance of central cholinergic tone over adrenergic tone and that mania may represent the converse. Currently, converging lines of investigation fro...

journal_title：Journal of clinical psychopharmacology

authors： Risch SC,Kalin NH,Janowsky DS

更新日期：1981-07-01 00:00:00

abstract：OBJECTIVE:The associations between prenatal exposure to antidepressants and preterm delivery and fetal growth restriction are controversial and poorly understood. We studied the relation between antidepressant use and these outcomes. METHODS:Analysis included women with nonmalformed infants interviewed in the Slone Ep...

journal_title：Journal of clinical psychopharmacology

authors： Toh S,Mitchell AA,Louik C,Werler MM,Chambers CD,Hernández-Díaz S

更新日期：2009-12-01 00:00:00

abstract：INTRODUCTION:One of the major enzymes of the cytochrome P450 drug-metabolizing system, CYP2D6, shows a high degree of genetic polymorphism and variability in activity. Based on the degree of CYP2D6 activity, individuals can be broadly classified as poor metabolizers (PMs) or extensive metabolizers (EMs); the metabolism...

journal_title：Journal of clinical psychopharmacology

authors： Nichols AI,Lobello K,Guico-Pabia CJ,Paul J,Preskorn SH

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Late-life depression, often in association with anxiety, affects approximately 15% of individuals older than 65 years. Selective serotonin reuptake inhibitors are the first-line treatment but could be responsible of an early exacerbation of anxiety, possibly reduced by a very gradual titration of drugs. The ...

journal_title：Journal of clinical psychopharmacology

authors： Gibiino S,Mori E,De Ronchi D,Serretti A

更新日期：2013-08-01 00:00:00

abstract：:The present study was conducted to derive pediatric mianserin pharmacokinetic parameters, which were compared to those from healthy young adults, and to obtain preliminary information regarding the utility of mianserin for the management of hyperkinesis in children. The sample consisted of six prepubescent children wi...

journal_title：Journal of clinical psychopharmacology

authors： Winsberg BG,Camp-Bruno JA,Vink J,Timmer CJ,Sverd J

更新日期：1987-06-01 00:00:00

abstract：:It was predicted that tiaspirone, a novel compound, would benefit schizophrenic patients since in animal experiments it is a potent dopamine blocker. Following a placebo washout period of 1 to 2 weeks, 14 patients were treated for 28 days with the drug in a single-blind, dose ranging trial. GAS, NOSIE, and BPRS scores...

journal_title：Journal of clinical psychopharmacology

authors： Moore NC,Meyendorff E,Yeragani V,LeWitt PA,Gershon S

更新日期：1987-04-01 00:00:00

abstract：:This 6-week, double-blind, placebo-controlled study evaluated paliperidone extended-release (ER) as both monotherapy and adjunctive therapy to mood stabilizers and/or antidepressants (MS/ADs) for schizoaffective disorder. Included subjects had a schizoaffective disorder diagnosis; a Positive and Negative Syndrome Scal...

journal_title：Journal of clinical psychopharmacology

authors： Canuso CM,Schooler N,Carothers J,Turkoz I,Kosik-Gonzalez C,Bossie CA,Walling D,Lindenmayer JP

更新日期：2010-10-01 00:00:00

abstract：:A multicenter, double-blind, 12-week, placebo-controlled trial of 411 randomized patients, predominantly women diagnosed with posttraumatic stress disorder, failed to show a difference between either dose of fluoxetine treatment and placebo. The mean changes from baseline (SD) measured by the Clinician-Administered PT...

journal_title：Journal of clinical psychopharmacology

authors： Martenyi F,Brown EB,Caldwell CD

更新日期：2007-04-01 00:00:00

abstract：:The aim of this post-hoc analysis was to determine whether early symptom improvement with extended release quetiapine (quetiapine XR) may predict treatment outcome in patients with major depressive disorder. Data were from 6, double-blind, placebo-controlled studies of quetiapine XR (2 fixed-dose and 2 flexible-dose m...

journal_title：Journal of clinical psychopharmacology

authors： McIntyre RS,Gorwood P,Thase ME,Liss C,Desai D,Chen J,Bauer M

更新日期：2015-12-01 00:00:00

abstract：:Seventeen hospitalized psychotic patients were treated with a fixed oral dose of haloperidol, 5 mg twice daily for 28 days. Most were chronic schizophrenics with an acute exacerbation of their illness. All patients also received benztropine 3 mg twice daily during the last 11 days of the study, regardless of the prese...

journal_title：Journal of clinical psychopharmacology

authors： Shostak M,Perel JM,Stiller RL,Wyman W,Curran S

更新日期：1987-12-01 00:00:00