Placebo-controlled trial of zonisamide for the treatment of alcohol dependence.

abstract：:The aim of this study was to estimate the long-term effectiveness of olanzapine as adjunctive therapy in patients with bipolar disorder who exhibited an inadequate response to mood stabilizers. Twenty-three Research Diagnostic Criteria (RDC) patients with bipolar I and II were assessed by means of the Schedule for Aff...

journal_title：Journal of clinical psychopharmacology

authors： Vieta E,Reinares M,Corbella B,Benabarre A,Gilaberte I,Colom F,Martínez-Arán A,Gastó C,Tohen M

更新日期：2001-10-01 00:00:00

abstract：PURPOSE/BACKGROUND:The study objective was to compare the impact of being treated by paliperidone palmitate (PP) or risperidone long-acting injection (RLAI) on the length of stay on initial hospitalization, rehospitalization risk, and treatment duration in schizophrenic patients. METHODS:We conducted an observational ...

journal_title：Journal of clinical psychopharmacology

authors： Limosin F,Belhadi D,Comet D,Pacou M,Bouju S,Van Impe K,Guillon P

更新日期：2018-02-01 00:00:00

abstract：CONTEXT:Major depressive disorder causes significant morbidity and mortality. Current therapies fail to fully treat both emotional and physical symptoms of major depressive disorder. OBJECTIVE:To evaluate duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine, on improvement of emotional and painful phy...

journal_title：Journal of clinical psychopharmacology

authors： Goldstein DJ,Lu Y,Detke MJ,Wiltse C,Mallinckrodt C,Demitrack MA

更新日期：2004-08-01 00:00:00

abstract：:This study evaluated the impact of using long-acting injectable (LAI) antipsychotics for a longer treatment duration versus a short duration on health care resource utilization among Medicaid-insured schizophrenia patients. Schizophrenia patients 13 years or older initiating LAI antipsychotics were identified from the...

journal_title：Journal of clinical psychopharmacology

authors： Bera R,Offord S,Zubek D,Lau G,Lin J,Karson C

更新日期：2014-02-01 00:00:00

abstract：:We compared acute effects of single intravenous administrations of metoclopramide (40 mg) and placebo in a double-blind crossover study involving 81 patients with tardive dyskinesia. Metoclopramide produced significantly greater reduction in mean total Abnormal Involuntary Movement Scale score as well as in ratings fo...

journal_title：Journal of clinical psychopharmacology

authors： Doongaji DR,Jeste DV,Jape NM,Sheth AS,Apte JS,Vahia VN,Desai AB,Parikh MD,Rathi LG,Ghandi MH,Parikh RM,Thatte S,Bharadwaj J

更新日期：1982-12-01 00:00:00

abstract：:The cholinergic-adrenergic balance hypothesis of affective disorders suggests that, in the areas of the brain that regulate mood, depression may represent a relative predominance of central cholinergic tone over adrenergic tone and that mania may represent the converse. Currently, converging lines of investigation fro...

journal_title：Journal of clinical psychopharmacology

authors： Risch SC,Kalin NH,Janowsky DS

更新日期：1981-07-01 00:00:00

abstract：:Phencyclidine (PCP) abuse has diminished since PCP's intrusion into American culture in the late 1970s. One of its legacies is the assumption that it provokes violent behavior in humans with predictable regularity. This assumption is so accepted that ingestion of the drug both accidentally and knowingly prior to commi...

journal_title：Journal of clinical psychopharmacology

authors： Brecher M,Wang BW,Wong H,Morgan JP

更新日期：1988-12-01 00:00:00

abstract：OBJECTIVE:This prospective study sought to compare the acute effects of haloperidol, amisulpride, and quetiapine on serum markers of bone formation and resorption in relatively young patients with minimal previous exposure to antipsychotic drugs. METHODS:Patients included in the study were randomly assigned to receive...

journal_title：Journal of clinical psychopharmacology

authors： Liang Y,Su YA,Zhao ZG,Gao N,Huang JZ,Tang MQ,Li KQ,Yang FD,Yu X,Si TM

更新日期：2015-10-01 00:00:00

abstract：:The 2-mg dexamethasone suppression test (DST), performed in a drug-free acute exacerbation phase of illness shortly after admission, differentiated between major depression with psychosis and stringently diagnosed chronic schizophrenia. This has practical significance because effective drug treatment in each diagnosti...

journal_title：Journal of clinical psychopharmacology

authors： Clower CG

更新日期：1986-12-01 00:00:00

abstract：:This article presents incidence estimates and relative risks for a number of adverse clinical events reported by outpatients being treated with either trazodone or fluoxetine. Data were collected via an innovative method of patient self-monitoring. Many of the suggested differences between the two drugs are quite cons...

journal_title：Journal of clinical psychopharmacology

authors： Fisher S,Bryant SG,Kent TA

更新日期：1993-08-01 00:00:00

abstract：:Adult attention deficit/hyperactivity disorder (ADHD) is an increasingly recognized disorder with associated psychiatric comorbidity and impairment. Although pharmacotherapy serves an important role in treating ADHD and other concurrent psychiatric disorders in children and adolescents, the use of pharmacotherapeutics...

journal_title：Journal of clinical psychopharmacology

authors： Wilens TE,Biederman J,Spencer TJ,Prince J

更新日期：1995-08-01 00:00:00

abstract：:The incidence of treatment-emergent extrapyramidal symptoms (EPSs) and tardive dyskinesia (TD) in schizophrenic patients, and the clinical characteristics associated with an increased risk of developing EPSs and TD were examined. Patients (N = 7728) in the 3-year, prospective, observational Schizophrenia Outpatient He...

journal_title：Journal of clinical psychopharmacology

authors： Novick D,Haro JM,Bertsch J,Haddad PM

更新日期：2010-10-01 00:00:00

abstract：:The reinforcing effects of methylphenidate (20-40 mg), d-amphetamine (10-20 mg), and placebo were assessed in eight healthy, non-sleep-deprived, non-drug-abusing outpatient volunteers. A modified progressive-ratio schedule was used to assess drug reinforcement in which a sampling session always preceded a self-adminis...

journal_title：Journal of clinical psychopharmacology

authors： Rush CR,Essman WD,Simpson CA,Baker RW

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Several lines of evidence implicate glutamatergic neurotransmission in the pathophysiology of obsessive compulsive disorder (OCD). Sarcosine is an endogenous antagonist of glycine transporter-1. By blocking glycine uptake, sarcosine may increase the availability of synaptic glycine and enhance N-methyl-d-asp...

journal_title：Journal of clinical psychopharmacology

authors： Wu PL,Tang HS,Lane HY,Tsai CA,Tsai GE

更新日期：2011-06-01 00:00:00

abstract：:Using the Karolinska Scales of Personality (KSP), we investigated the effect of the selective serotonin reuptake inhibitor citalopram on personality traits and the relationship between personality traits and peripheral indexes for central serotonergic function in patients with panic disorder at baseline and after 6 mo...

journal_title：Journal of clinical psychopharmacology

authors： Neuger J,Wistedt B,Aberg-Wistedt A,Stain-Malmgren R

更新日期：2002-08-01 00:00:00

abstract：:Unlike many other areas of medicine, psychiatric clinical trials have no gold standard laboratory tests with which to measure drug effects. Although reliable and valid psychometric measures are available, the standard analysis of such measures obscures the clinical relevance of drug effects. In this study, the authors...

journal_title：Journal of clinical psychopharmacology

authors： Faraone SV,Biederman J,Spencer TJ,Wilens TE

更新日期：2000-12-01 00:00:00

abstract：:Two cases of mania following the discontinuation of treatment with isocarboxazid are described. Although this phenomenon has been reported by several investigators to occur after cessation of tricyclic antidepressant therapy, there exists only one isolated report of hypomania after discontinuation of monoamine oxidase...

journal_title：Journal of clinical psychopharmacology

authors： Rothschild AJ

更新日期：1985-12-01 00:00:00

abstract：:Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia and is linked to a need for mandatory hematological monitoring. Besides agranulocytosis, other hematological aberrations have resulted in premature termination in some cases. Considering clozapine's role in immunomodulation, we proceeded to...

journal_title：Journal of clinical psychopharmacology

authors： Lee J,Takeuchi H,Fervaha G,Powell V,Bhaloo A,Bies R,Remington G

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Depression, the leading cause of nonfatal disease burden, has a strong correlation with suicide and affects approximately 7% of the general elderly population. Adverse drug reactions in older patients are particularly important because of reduced drug metabolism, polypharmacy, drug-drug interactions, and dru...

journal_title：Journal of clinical psychopharmacology

authors： Kim S,Ko YJ,Park K,Yang BR,Kim MS,Park BJ

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Researchers, by studying first-generation antipsychotics, have established an early prediction model, which had a favorable specificity but a low sensitivity. This study aims to optimize early prediction of treatment response for schizophrenia using a novel statistic method that can be done even under the Mic...

journal_title：Journal of clinical psychopharmacology

authors： Chang YC,Lane HY,Yang KH,Huang CL

更新日期：2006-12-01 00:00:00

abstract：:The present study was conducted to derive pediatric mianserin pharmacokinetic parameters, which were compared to those from healthy young adults, and to obtain preliminary information regarding the utility of mianserin for the management of hyperkinesis in children. The sample consisted of six prepubescent children wi...

journal_title：Journal of clinical psychopharmacology

authors： Winsberg BG,Camp-Bruno JA,Vink J,Timmer CJ,Sverd J

更新日期：1987-06-01 00:00:00

abstract：INTRODUCTION:Although medication with antipsychotic for the psychosis prodrome has often caused some ethical issues, recent studies have shown that some novel antipsychotics are safer and more tolerable for young people. This study aimed to investigate whether the administration of aripiprazole would not only relieve t...

journal_title：Journal of clinical psychopharmacology

authors： Kobayashi H,Morita K,Takeshi K,Koshikawa H,Yamazawa R,Kashima H,Mizuno M

更新日期：2009-10-01 00:00:00

abstract：PURPOSE/BACKGROUND:The Phase 3 program for RBP-7000, a once-monthly subcutaneous (SC) extended-release risperidone formulation approved for treatment of schizophrenia, consisted of a double-blind placebo-controlled trial (previously reported) and a 52-week open-label study of monthly RBP-7000 120 mg. The primary object...

journal_title：Journal of clinical psychopharmacology

authors： Andorn A,Graham J,Csernansky J,Newcomer JW,Shinde S,Muma G,Heidbreder C,Fava M

更新日期：2019-09-01 00:00:00

abstract：:Depression in the elderly patient may present special challenges for the design of clinical treatment trials due to a complex antidepressant treatment history, individual contraindications to certain medications, medical comorbidity, as well as concurrent medications for other medical conditions. The chronic, relapsin...

journal_title：Journal of clinical psychopharmacology

authors： Lavori PW

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to use a visual analog scale (VAS) longitudinally measuring somnolence severity in patients with bipolar disorder. METHODS:A data set of patients with bipolar spectrum disorders who were randomized to lithium or quetiapine-IR for 16 weeks was used. The somnolence severity was measur...

journal_title：Journal of clinical psychopharmacology

authors： Gao K,Su M,Ganocy SJ,Goto T,Yuan C,Fang F,Conroy C,Brownrigg B,Serrano MB,Calabrese JR

更新日期：2019-05-01 00:00:00

abstract：:Aripiprazole is widely used to treat schizophrenia. Plasma levels of aripiprazole and its active metabolite dehydroaripiprazole and their clinical responses in patients were explored. Forty-five (male/female: 19/26) patients with schizophrenia were treated with aripiprazole after a washout period of at least 3 days. T...

journal_title：Journal of clinical psychopharmacology

authors： Lin SK,Chen CK,Liu YL

更新日期：2011-12-01 00:00:00

abstract：:The correlation between vitamin D deficiency and depression has recently been put forward and resulted in controversial findings. The present study was conducted to find out the effect of 2 single injections of 150,000 and 300,000 IU of vitamin D on improving the depression in depressed patients with vitamin D deficie...

journal_title：Journal of clinical psychopharmacology

authors： Mozaffari-Khosravi H,Nabizade L,Yassini-Ardakani SM,Hadinedoushan H,Barzegar K

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:We examined the influence of prior antidepressant treatment trials on the likelihood of depressive relapse, and time to depressive relapse, during maintenance therapy of bipolar II disorder in treatment-responsive subjects who had recovered from a major depressive episode. METHODS:Data were derived from a p...

journal_title：Journal of clinical psychopharmacology

authors： Amsterdam JD,Kim TT

更新日期：2019-07-01 00:00:00

abstract：:In this review, the physiologic and pharmacologic effects of tricyclic antidepressants are discussed as they apply to an overdose situation. Systemic arterial hypotension is a frequent occurrence in major overdoses. Occasionally conventional resuscitative measures such as crystalloid or colloid infusion are inadequate...

journal_title：Journal of clinical psychopharmacology

authors： Buchman AL,Dauer J,Geiderman J

更新日期：1990-12-01 00:00:00

abstract：:The Taq1A polymorphism in the dopamine D2 receptor (DRD2) gene could be related to the response to antipsychotics. We examined the effects of the Taq1A polymorphism on the plasma monoamine metabolites during the treatment of schizophrenia with aripiprazole, a DRD2 partial agonist. Thirty Japanese patients with schizop...

journal_title：Journal of clinical psychopharmacology

authors： Miura I,Takeuchi S,Katsumi A,Mori A,Kanno K,Yang Q,Mashiko H,Numata Y,Niwa S

更新日期：2012-02-01 00:00:00