Postmarketing surveillance by patient self-monitoring: trazodone versus fluoxetine.

abstract：:Minority women often have a unique set of beliefs and expectations about medical treatment. At this time, there is a dearth of research looking at how depressed minority women respond to pharmacological interventions for the sexual concomitants of depression. This was the first study to examine the impact of a medicat...

journal_title：Journal of clinical psychopharmacology

authors： Dobkin RD,Menza M,Marin H,Allen LA,Rousso R,Leiblum SR

更新日期：2006-02-01 00:00:00

abstract：PURPOSE/BACKGROUND:The number of patients with acute synthetic cannabinoid intoxication (SCI) has increased in recent years although the prohibition of its legal sale and use in Turkey despite other countries allowing to some extent sale and use. The reported clinical findings of acute SCI are similar to the symptoms o...

journal_title：Journal of clinical psychopharmacology

authors： Altintop I

更新日期：2020-09-01 00:00:00

abstract：:Twenty-eight patients with a DSM-III diagnosis of agoraphobia with panic attacks who completed a 4-month combined drug and behavioral treatment program and who were then discharged on imipramine were interviewed 1 to 5 years after being discharged. At the time of follow-up, half of the patients were medication free, e...

journal_title：Journal of clinical psychopharmacology

authors： Nagy LM,Krystal JH,Charney DS,Merikangas KR,Woods SW

更新日期：1993-02-01 00:00:00

abstract：PURPOSE:This post hoc meta-analysis evaluated the efficacy and safety of desvenlafaxine 50 and 100 mg versus placebo across age groups and severity of depression at baseline in patients with major depressive disorder. METHODS:Data from placebo and desvenlafaxine 50-mg and 100-mg dose arms were pooled from 9 short-term...

journal_title：Journal of clinical psychopharmacology

authors： Mosca D,Zhang M,Prieto R,Boucher M

更新日期：2017-04-01 00:00:00

abstract：:Twenty-two patients affected by bipolar or schizoaffective disorder, in whom carbamazepine was added to lithium after recurrence when on maintenance with lithium alone, were followed up prospectively for 2 to 13 years. The number of episodes, hospitalizations, and cumulative affective morbidity was markedly reduced af...

journal_title：Journal of clinical psychopharmacology

authors： Bocchetta A,Chillotti C,Severino G,Ardau R,Del Zompo M

更新日期：1997-04-01 00:00:00

abstract：:There have been an increased number of recent reports on orgasm-related sexual dysfunction coincident with selective serotonin reuptake inhibitor (SSRI) treatment. In contrast, it has also been reported that SSRIs improve sexual dysfunction. Low doses of clomipramine and paroxetine, potent 5-hydroxytryptamine reuptake...

journal_title：Journal of clinical psychopharmacology

authors： Lee HS,Song DH,Kim CH,Choi HK

更新日期：1996-10-01 00:00:00

abstract：:The aims of this study were to examine whether pindolol, a serotonin (5-hydroxytryptamine [5-HT])-1A receptor antagonist, and mianserin, a 5-HT2A/C and alpha2-adrenoceptor (alpha2-AR) antagonist, may augment the clinical efficacy of fluoxetine, a selective serotonin reuptake inhibitor, and shorten the latency of onset...

journal_title：Journal of clinical psychopharmacology

authors： Maes M,Libbrecht I,van Hunsel F,Campens D,Meltzer HY

更新日期：1999-04-01 00:00:00

abstract：:The clinical features and pharmacokinetics of 22 lithium overdoses are described. Effectiveness of different treatment regimens regarding elimination of lithium is discussed. Origin of overdose was due to deliberate poisoning or precipitated by concomitant diseases, coadministration of drugs, or combination of both. T...

journal_title：Journal of clinical psychopharmacology

authors： Eyer F,Pfab R,Felgenhauer N,Lutz J,Heemann U,Steimer W,Zondler S,Fichtl B,Zilker T

更新日期：2006-06-01 00:00:00

abstract：:Concomitant use of acetylcholine esterase inhibitors (AChEIs) and anticholinergic drugs, such as urinary antispasmodics (UA), is generally considered as inappropriate because of their opposite pharmacological actions. However, prevalence and the duration or factors associated with concomitant use have not been previou...

journal_title：Journal of clinical psychopharmacology

authors： Torvinen-Kiiskinen S,Taipale H,Tanskanen A,Tiihonen J,Hartikainen S

更新日期：2014-12-01 00:00:00

abstract：:Dextromethorphan is a nonopioid antitussive metabolized by cytochrome P450 2D6 (CYP2D6) to an active metabolite, dextrorphan. CYP2D6 is polymorphically expressed in humans, with 5 to 10% of Caucasians being homozygous deficient for the active form of the enzyme. In a pilot study, the authors investigated the pharmacol...

journal_title：Journal of clinical psychopharmacology

authors： Zawertailo LA,Kaplan HL,Busto UE,Tyndale RF,Sellers EM

更新日期：1998-08-01 00:00:00

abstract：:Central nervous system depressant drugs (CNS-Ds) are known to impair cognitive functions. Overdose of these drugs is common, and most of the hospital-treated patients are discharged within 24 to 48 hours. No previous studies have examined whether they have residual impairment at the time of discharge. Our aim was to e...

journal_title：Journal of clinical psychopharmacology

authors： Dassanayake TL,Michie PT,Jones A,Carter G,Mallard T,Whyte I

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Depression, the leading cause of nonfatal disease burden, has a strong correlation with suicide and affects approximately 7% of the general elderly population. Adverse drug reactions in older patients are particularly important because of reduced drug metabolism, polypharmacy, drug-drug interactions, and dru...

journal_title：Journal of clinical psychopharmacology

authors： Kim S,Ko YJ,Park K,Yang BR,Kim MS,Park BJ

更新日期：2019-07-01 00:00:00

abstract：:The cholinergic-adrenergic balance hypothesis of affective disorders suggests that, in the areas of the brain that regulate mood, depression may represent a relative predominance of central cholinergic tone over adrenergic tone and that mania may represent the converse. Currently, converging lines of investigation fro...

journal_title：Journal of clinical psychopharmacology

authors： Risch SC,Kalin NH,Janowsky DS

更新日期：1981-07-01 00:00:00

abstract：:Molindone hydrochloride, a dihydroindolone neuroleptic, is structurally distinct from other classes of neuroleptics. Molindone exhibits many similarities to other neuroleptics, including dopamine receptor blockade, antipsychotic efficacy, and extrapyramidal side effects. Despite these similarities, molindone also has ...

journal_title：Journal of clinical psychopharmacology

authors： Owen RR Jr,Cole JO

更新日期：1989-08-01 00:00:00

abstract：:Second-generation antipsychotics (SGAs) have generally replaced classic neuroleptics in managing bipolar disorder because of their property of inducing extrapyramidal symptoms (EPS) less frequently than conventional agents. However, EPS and tardive dyskinesia both remain a concern especially in bipolar patients who ma...

journal_title：Journal of clinical psychopharmacology

authors： Gentile S

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Late-life depression, often in association with anxiety, affects approximately 15% of individuals older than 65 years. Selective serotonin reuptake inhibitors are the first-line treatment but could be responsible of an early exacerbation of anxiety, possibly reduced by a very gradual titration of drugs. The ...

journal_title：Journal of clinical psychopharmacology

authors： Gibiino S,Mori E,De Ronchi D,Serretti A

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Antipsychotic drugs are prescribed to approximately 30% to 40% of adults with intellectual disability (ID) and behavioral problems despite lack of evidence of effectiveness and potential adverse effects, including movement disorders. AIMS:The aim of this study was to examine the prevalence of movement disor...

journal_title：Journal of clinical psychopharmacology

authors： Scheifes A,Walraven S,Stolker JJ,Nijman HL,Tenback DE,Egberts TC,Heerdink ER

更新日期：2016-08-01 00:00:00

abstract：:Two experiments examined the effects of methylphenidate in male and female patients enrolled in an outpatient treatment program for primary cocaine dependence. The first study was a component of a double-blind efficacy trial wherein 57 patients were first tested in a human laboratory for their initial responsiveness t...

journal_title：Journal of clinical psychopharmacology

authors： Roache JD,Grabowski J,Schmitz JM,Creson DL,Rhoades HM

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:Clozapine (CLZ) has been shown to have a beneficial effect on cognition in schizophrenia in some studies and a detrimental effect in others. The relative effect and exposure to CLZ and its major metabolite-N-desmethylclozapine (NDMC)-could explain these discrepancies. METHODS:Using a validated measure of glo...

journal_title：Journal of clinical psychopharmacology

authors： Rajji TK,Uchida H,Ismail Z,Ng W,Mamo DC,Remington G,Pollock BG,Mulsant BH

更新日期：2010-08-01 00:00:00

abstract：:Platelet monoamine oxidase (MAO) activity was studied in bipolar and schizophrenic patients treated with lithium and was found to be increased as a nonspecific drug effect. Greater MAO increase in manic patients was correlated with lesser clinical improvement. There was no correlation of MAO activity with short-term o...

journal_title：Journal of clinical psychopharmacology

authors： Huang LG,Bowden CL

更新日期：1984-12-01 00:00:00

abstract：:The objective of this study was to investigate the efficacy of pirenzepine in the treatment of clozapine-induced hypersalivation. Pirenzepine is reported to counteract hypersalivation by its selective antagonistic activity on the M4-muscarinic receptor, which is stimulated by clozapine. Twenty patients with clozapine-...

journal_title：Journal of clinical psychopharmacology

authors： Bai YM,Lin CC,Chen JY,Liu WC

更新日期：2001-12-01 00:00:00

abstract：:Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia and is linked to a need for mandatory hematological monitoring. Besides agranulocytosis, other hematological aberrations have resulted in premature termination in some cases. Considering clozapine's role in immunomodulation, we proceeded to...

journal_title：Journal of clinical psychopharmacology

authors： Lee J,Takeuchi H,Fervaha G,Powell V,Bhaloo A,Bies R,Remington G

更新日期：2015-10-01 00:00:00

abstract：:A multicenter, double-blind, 12-week, placebo-controlled trial of 411 randomized patients, predominantly women diagnosed with posttraumatic stress disorder, failed to show a difference between either dose of fluoxetine treatment and placebo. The mean changes from baseline (SD) measured by the Clinician-Administered PT...

journal_title：Journal of clinical psychopharmacology

authors： Martenyi F,Brown EB,Caldwell CD

更新日期：2007-04-01 00:00:00

abstract：:Drug delivery systems capable of delivering free (unconjugated) curcuminoids is of great therapeutic significance, since the absorption of bioactive and permeable form plays a key factor in mediating the efficacy of a substance which undergoes rapid biotransformation. Considering the recent understanding on the relati...

journal_title：Journal of clinical psychopharmacology

authors： Pandaran Sudheeran S,Jacob D,Natinga Mulakal J,Gopinathan Nair G,Maliakel A,Maliakel B,Kuttan R,Im K

更新日期：2016-06-01 00:00:00

abstract：:Hypersalivation is a frequent, disturbing, and uncomfortable adverse effect of clozapine therapy that frequently leads to noncompliance. The aim of this study was to examine the efficacy of metoclopramide (dopamine D2 antagonist, antiemetic medication) as an option for management of hypersalivation associated with clo...

journal_title：Journal of clinical psychopharmacology

authors： Kreinin A,Miodownik C,Mirkin V,Gaiduk Y,Yankovsky Y,Bersudsky Y,Lerner PP,Bergman J,Lerner V

更新日期：2016-06-01 00:00:00

abstract：:This study was designed to investigate the relationship between subjective and objective effects of a benzodiazepine on the one hand, and the rate of increase of plasma concentration on the other. The pharmacokinetic variables of 10 normal volunteers were calculated following a single intravenous bolus injection of 1 ...

journal_title：Journal of clinical psychopharmacology

authors： Boulenger JP,Smokcum R,Lader M

更新日期：1984-02-01 00:00:00

abstract：:Methamphetamine has become a major public health issue globally, particularly in the United States. Despite this, no effective pharmacotherapy for methamphetamine abuse has been developed to date. This 6-week, open-label pilot clinical trial examined the safety and tolerability of modafinil up to 400 mg/d in 8 methamp...

journal_title：Journal of clinical psychopharmacology

authors： McGaugh J,Mancino MJ,Feldman Z,Chopra MP,Gentry WB,Cargile C,Oliveto A

更新日期：2009-10-01 00:00:00

abstract：:A role for serotonin in season affective disorder (SAD) has been explored with a variety of serotonergic pharmacologic agents. The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms. In a small, open-label pilot study, the authors observed the oppo...

journal_title：Journal of clinical psychopharmacology

authors： Turner EH,Schwartz PJ,Lowe CH,Nawab SS,Feldman-Naim S,Drake CL,Myers FS,Barnett RL,Rosenthal NE

更新日期：2002-04-01 00:00:00

abstract：:Consensus guidelines which are applicable in New Zealand and worldwide recommend that the duration of exposure to antipsychotics not exceed 12 weeks, unless justified for mental illnesses like schizophrenia and severe psychotic symptoms which require longer treatment. There has been limited information on time-to-firs...

journal_title：Journal of clinical psychopharmacology

authors： Ndukwe HC,Nishtala PS

更新日期：2016-12-01 00:00:00

abstract：:To identify factors associated with anticholinergic abuse in patients taking antipsychotics and anticholinergics and to document the extent of extrapyramidal side effects in anticholinergic abusers, 21 anticholinergic abusers were matched with 21 controls without a history of anticholinergic abuse for diagnosis and an...

journal_title：Journal of clinical psychopharmacology

authors： Wells BG,Marken PA,Rickman LA,Brown CS,Hamann G,Grimmig J

更新日期：1989-12-01 00:00:00