Efficacy of Desvenlafaxine Compared With Placebo in Major Depressive Disorder Patients by Age Group and Severity of Depression at Baseline.

abstract：BACKGROUND:Depression, the leading cause of nonfatal disease burden, has a strong correlation with suicide and affects approximately 7% of the general elderly population. Adverse drug reactions in older patients are particularly important because of reduced drug metabolism, polypharmacy, drug-drug interactions, and dru...

journal_title：Journal of clinical psychopharmacology

authors： Kim S,Ko YJ,Park K,Yang BR,Kim MS,Park BJ

更新日期：2019-07-01 00:00:00

abstract：:The assessment of adverse effects of psychiatric medications is important in clinical and research settings because they are often associated with medication discontinuation, symptom exacerbation, and reduced quality of life. Currently available assessment tools are either limited with regard to the number and variety...

journal_title：Journal of clinical psychopharmacology

authors： Nugent KL,Spahr E,Toroney J,Mojtabai R,Nettles C,Turner LW,Fenton A,Spivak A,Cullen BA,Everett A,Eaton WW

更新日期：2015-06-01 00:00:00

abstract：:Drug delivery systems capable of delivering free (unconjugated) curcuminoids is of great therapeutic significance, since the absorption of bioactive and permeable form plays a key factor in mediating the efficacy of a substance which undergoes rapid biotransformation. Considering the recent understanding on the relati...

journal_title：Journal of clinical psychopharmacology

authors： Pandaran Sudheeran S,Jacob D,Natinga Mulakal J,Gopinathan Nair G,Maliakel A,Maliakel B,Kuttan R,Im K

更新日期：2016-06-01 00:00:00

abstract：:In this multicenter, parallel-group, placebo-controlled, fixed-dose study, the efficacy, safety, dosing characteristics, and discontinuation of clonazepam were analyzed in patients with panic disorder. Four hundred thirteen patients were randomly assigned to receive placebo or one of five fixed daily doses of clonazep...

journal_title：Journal of clinical psychopharmacology

authors： Rosenbaum JF,Moroz G,Bowden CL

更新日期：1997-10-01 00:00:00

abstract：PURPOSE:The antidepressant venlafaxine is largely O-desmethylated by CYP2D6, whereas CYP2C19 mediates an alternative metabolic route of venlafaxine through N-desmethylation. The aim of this study was to investigate the combined effect of genotype-predicted CYP2D6 and CYP2C19 phenotypes on serum concentrations of venlaf...

journal_title：Journal of clinical psychopharmacology

authors： Kringen MK,Bråten LS,Haslemo T,Molden E

更新日期：2020-03-01 00:00:00

abstract：:The ability of the Hamilton Rating Scale for Anxiety, the Hamilton Rating Scale for Depression, and 50 items from the self-rated Hopkins Symptom Checklist to discriminate generalized anxiety disorder from major depressive disorder was examined for over 3,000 patients entering studies in three drug development projects...

journal_title：Journal of clinical psychopharmacology

authors： Copp JE,Schwiderski UE,Robinson DS

更新日期：1990-06-01 00:00:00

abstract：:The aim of the study was to determine whether baseline pain was associated with discernible clinical features and treatment outcomes for patients with major depressive disorder (MDD) receiving 6-week fluoxetine treatment. A total of 131 inpatients with acutely ill MDD were enrolled to receive 20 mg of fluoxetine daily...

journal_title：Journal of clinical psychopharmacology

authors： Lin HS,Wang FC,Lin CH

更新日期：2015-12-01 00:00:00

abstract：:The purpose of this study was to determine the pharmacokinetic behavior of triazolam in children. Nine healthy children, aged 6 to 9 years, received oral triazolam (0.025 mg/kg suspended in Kool-Aid, Kraft General Foods, Chicago, IL) before dental treatment. Plasma triazolam concentrations were measured by gas chromat...

journal_title：Journal of clinical psychopharmacology

authors： Karl HW,Milgrom P,Domoto P,Kharasch ED,Coldwell SE,Weinstein P,Leroux B,Awamura K,Mautz D

更新日期：1997-06-01 00:00:00

abstract：:Uninstitutionalized young adults with chronic mental disorders and social disabilities pose a new challenge in community psychiatry. These attention-seeking, help-rejecting young men and women spend most of their lives in the community and differ markedly from older deinstitutionalized chronic psychiatric patients. Ma...

journal_title：Journal of clinical psychopharmacology

authors： Pepper B

更新日期：1985-06-01 00:00:00

abstract：:Meta-analyses have found conflicting evidence on the link between antipsychotics and cerebrovascular events (CVEs). The primary aim of this study was to evaluate the association between any antipsychotic prescription and CVEs in Italian elderly; second, to compare the effect of typical and atypical antipsychotics on C...

journal_title：Journal of clinical psychopharmacology

authors： Franchi C,Sequi M,Tettamanti M,Bonometti F,Nobili A,Fortino I,Bortolotti A,Merlino L,Pasina L,Djade CD,Marengoni A

更新日期：2013-08-01 00:00:00

abstract：:There have been an increased number of recent reports on orgasm-related sexual dysfunction coincident with selective serotonin reuptake inhibitor (SSRI) treatment. In contrast, it has also been reported that SSRIs improve sexual dysfunction. Low doses of clomipramine and paroxetine, potent 5-hydroxytryptamine reuptake...

journal_title：Journal of clinical psychopharmacology

authors： Lee HS,Song DH,Kim CH,Choi HK

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Some studies have shown that low dose of neuroleptic addition to ongoing antiobsessive treatment might be effective in treatment resistant obsessive-compulsive disorder (OCD). The primary purpose of this study was to evaluate the efficacy of low-dose quetiapine in clomipramine and serotonin reuptake inhibito...

journal_title：Journal of clinical psychopharmacology

authors： Sevincok L,Topuz A

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:The present study aimed to assess the level of agreement between clinicians' routine assessments of medication status and plasma levels of commonly prescribed antipsychotic medications in patients presenting to an emergency room with an exacerbation of psychosis. METHODS:We studied 105 patients presenting to a...

journal_title：Journal of clinical psychopharmacology

authors： Lopez LV,Shaikh A,Merson J,Greenberg J,Suckow RF,Kane JM

更新日期：2017-06-01 00:00:00

abstract：:Effects of venlafaxine, an antidepressant acting by selective serotonin and norepinephrine reuptake inhibition with a potency ratio of 5:1, were assessed in a standardized, actual driving test, a battery of psychomotor tests (Critical Flicker/Fusion Frequency, Critical Tracking, Divided Attention), and a 45-minute vig...

journal_title：Journal of clinical psychopharmacology

authors： O'Hanlon JF,Robbe HW,Vermeeren A,van Leeuwen C,Danjou PE

更新日期：1998-06-01 00:00:00

abstract：:In recent years, the use of antipsychotics has been widely debated for reasons concerning their safety in elderly patients affected with dementia. To update the use of antipsychotics in elderly demented people, a MEDLINE search was conducted using the following terms: elderly, conventional and atypical antipsychotics,...

journal_title：Journal of clinical psychopharmacology

authors： Gareri P,De Fazio P,Manfredi VG,De Sarro G

更新日期：2014-02-01 00:00:00

abstract：:A case of treatment-resistant catatonic stupor responding to combined lithium-neuroleptic medications is described. As there are no reports in the literature of combined lithium-neuroleptic medications being effective for this potentially life-threatening disorder, the course of recovery is detailed and the risks and ...

journal_title：Journal of clinical psychopharmacology

authors： Climo LH

更新日期：1985-06-01 00:00:00

abstract：:In a recent study, the authors gauged the net effectiveness of imipramine to be 53%; that is, of 110 patients having panic disorder with agoraphobia who started a course of imipramine at a fixed, targeted, weight-adjusted dose of 2.25 mg x kg(-1) x day(-1), 59 adhered to the regimen and showed a marked and stable resp...

journal_title：Journal of clinical psychopharmacology

authors： Mavissakalian MR,Perel JM

更新日期：2000-10-01 00:00:00

abstract：:This 12-week, double-blind, multicenter trial evaluated the efficacy of venlafaxine extended release (ER), sertraline, and placebo in adult outpatients (N = 538) with a primary diagnosis of posttraumatic stress disorder (PTSD), as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, sy...

journal_title：Journal of clinical psychopharmacology

authors： Davidson J,Rothbaum BO,Tucker P,Asnis G,Benattia I,Musgnung JJ

更新日期：2006-06-01 00:00:00

abstract：:Trichotillomania (TTM) is characterized by repetitive hair pulling resulting in hair loss. Data on the pharmacological treatment of TTM are limited. This study examined the opioid antagonist, naltrexone, in adults with TTM who had urges to pull their hair. Fifty-one individuals with TTM were randomized to naltrexone o...

journal_title：Journal of clinical psychopharmacology

authors： Grant JE,Odlaug BL,Schreiber LR,Kim SW

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Craving, an urge or increased desire to take a drug, is part of a cluster of behavioral, cognitive, and physiological phenomena that can develop after substance use. Self-reported cravings for heroin and cocaine are compared in opioid dependent patients while receiving maintenance treatment with slow-release ...

journal_title：Journal of clinical psychopharmacology

authors： Falcato L,Beck T,Reimer J,Verthein U

更新日期：2015-04-01 00:00:00

abstract：:An antidepressant for use in the patient receiving concomitant drug treatment, over-the-counter medications, or herbal products should lack cytochrome P-450 (CYP) 3A4 inductive or inhibitory activity to provide the least likelihood of a drug-drug interaction. This study addresses the potential of 4 diverse antidepress...

journal_title：Journal of clinical psychopharmacology

authors： DeVane CL,Donovan JL,Liston HL,Markowitz JS,Cheng KT,Risch SC,Willard L

更新日期：2004-02-01 00:00:00

abstract：:Methadone is a synthetic opioid that binds to the κ-opioid receptor with a low affinity. This study tested the hypotheses that the genetic polymorphisms in the κ-opioid receptor 1 (OPRK1) gene region are associated with methadone treatment responses in a Taiwan methadone maintenance treatment (MMT) cohort. Seventeen s...

journal_title：Journal of clinical psychopharmacology

authors： Wang SC,Tsou HH,Chung RH,Chang YS,Fang CP,Chen CH,Ho IK,Kuo HW,Liu SC,Shih YH,Wu HY,Huang BH,Lin KM,Chen AC,Hsiao CF,Liu YL

更新日期：2014-04-01 00:00:00

abstract：:The objective of this study was twofold: (1) to describe the effects of risperidone on the quantitative electroencephalogram (EEG) in schizophrenic patients and (2) to explore the relationships between EEG changes and clinical improvement. The subjects were nine male schizophrenic patients participating in a placebo-c...

journal_title：Journal of clinical psychopharmacology

authors： Czobor P,Volavka J

更新日期：1993-10-01 00:00:00

abstract：:Switching antipsychotic regimen to agents with low weight gain potential has been suggested in patients who gain excessive weight on their antipsychotic therapy. In an open-label pilot study, we evaluated the metabolic and psychiatric efficacy of switching to aripiprazole in 15 (9 men, 6 women) outpatients with schizo...

journal_title：Journal of clinical psychopharmacology

authors： Kim SH,Ivanova O,Abbasi FA,Lamendola CA,Reaven GM,Glick ID

更新日期：2007-08-01 00:00:00

abstract：:Serum neuroleptic activity by radioreceptor assay and prolactin concentration were measured every 6 months for 2 years in 105 male schizophrenic outpatients. The patients took a variety of neuroleptics at clinically determined doses. As expected, when four dissimilar neuroleptics were examined together, there was no s...

journal_title：Journal of clinical psychopharmacology

authors： Young AS,Faraone SV,Brown WA

更新日期：1989-10-01 00:00:00

abstract：:Previous studies with functional magnetic resonance imaging (fMRI) demonstrated a differential brain activity and connectivity after treatment with donepezil in Alzheimer's disease (AD) when compared to healthy elders. Importantly however, there are no available studies where the placebo or control group included comp...

journal_title：Journal of clinical psychopharmacology

authors： Solé-Padullés C,Bartrés-Faz D,Lladó A,Bosch B,Peña-Gómez C,Castellví M,Rami L,Bargalló N,Sánchez-Valle R,Molinuevo JL

更新日期：2013-04-01 00:00:00

abstract：:Forty bipolar depressed inpatients underwent three consecutive cycles of total sleep deprivation (TSD). At the beginning of the study, 20 patients were free of psychotropic drugs and 20 had been receiving lithium medication for at least 6 months. Mood was rated on the Hamilton Rating Scale for Depression before and af...

journal_title：Journal of clinical psychopharmacology

authors： Benedetti F,Colombo C,Barbini B,Campori E,Smeraldi E

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Bipolar disorder (BPD) is a chronic and recurrent mood disorder characterized by episodes of mania, hypomania, and major depression. Based on available evidence, mitochondrial dysfunction, oxidative stress, and inflammation have important roles in the pathophysiology of bipolar depression. More specifically,...

journal_title：Journal of clinical psychopharmacology

authors： Mehrpooya M,Yasrebifar F,Haghighi M,Mohammadi Y,Jahangard L

更新日期：2018-10-01 00:00:00

abstract：:This study evaluated the impact of using long-acting injectable (LAI) antipsychotics for a longer treatment duration versus a short duration on health care resource utilization among Medicaid-insured schizophrenia patients. Schizophrenia patients 13 years or older initiating LAI antipsychotics were identified from the...

journal_title：Journal of clinical psychopharmacology

authors： Bera R,Offord S,Zubek D,Lau G,Lin J,Karson C

更新日期：2014-02-01 00:00:00

abstract：:Sexual dysfunctions (SDs) occur frequently in schizophrenia patients and have a huge impact on quality of life and compliance. They are often associated with antipsychotic medication. Nicotine consumption, negative or depressive symptoms, and physical illness are also discussed as contributing factors. Data on SD in f...

journal_title：Journal of clinical psychopharmacology

authors： Malik P,Kemmler G,Hummer M,Riecher-Roessler A,Kahn RS,Fleischhacker WW,EUFEST Study Group.

更新日期：2011-06-01 00:00:00