Accuracy of Clinician Assessments of Medication Status in the Emergency Setting: A Comparison of Clinician Assessment of Antipsychotic Usage and Plasma Level Determination.

abstract：:Medication nonadherence in severe mental disorders is an important clinical issue, but estimates vary between studies. There is a need for valid self-reports for both research and clinical practice. This study examined the level of adherence to prescribed medication in outpatients with severe mental disorders and eval...

journal_title：Journal of clinical psychopharmacology

authors： Jónsdóttir H,Opjordsmoen S,Birkenaes AB,Engh JA,Ringen PA,Vaskinn A,Aamo TO,Friis S,Andreassen OA

更新日期：2010-04-01 00:00:00

abstract：:Central nervous system depressant drugs (CNS-Ds) are known to impair cognitive functions. Overdose of these drugs is common, and most of the hospital-treated patients are discharged within 24 to 48 hours. No previous studies have examined whether they have residual impairment at the time of discharge. Our aim was to e...

journal_title：Journal of clinical psychopharmacology

authors： Dassanayake TL,Michie PT,Jones A,Carter G,Mallard T,Whyte I

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:This study investigated extended release quetiapine (quetiapine XR) associated changes in functional MRI (fMRI) measures of task-induced amygdalar activation and resting state connectivity in anxious unipolar major depressive disorder (AMDD). METHODS:Anxious unipolar major depressive disorder patients (n = ...

journal_title：Journal of clinical psychopharmacology

authors： Altinay M,Karne H,Beall E,Anand A

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The combination of olanzapine and valproic acid (VPA) is regularly prescribed in the treatment of bipolar or schizoaffective disorders. The VPA has been shown to reduce olanzapine concentration, but the mechanism behind this interaction remains unknown. We aimed to investigate the effect of VPA on olanzapine...

journal_title：Journal of clinical psychopharmacology

authors： Tveito M,Smith RL,Høiseth G,Molden E

更新日期：2019-11-01 00:00:00

abstract：AIMS:The aim of this study was the evaluation of the possible relationship between pharmacokinetics and the safety of aripiprazole as well as its influence on blood pressure (BP), heart rate (HR), and corrected QT (QTc) interval. METHODS:The study population comprised 157 healthy volunteers from 6 bioequivalence clini...

journal_title：Journal of clinical psychopharmacology

authors： Belmonte C,Ochoa D,Román M,Cabaleiro T,Talegón M,Sánchez-Rojas SD,Abad-Santos F

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:This post hoc meta-analysis evaluated the efficacy and safety of desvenlafaxine 50 and 100 mg versus placebo across age groups and severity of depression at baseline in patients with major depressive disorder. METHODS:Data from placebo and desvenlafaxine 50-mg and 100-mg dose arms were pooled from 9 short-term...

journal_title：Journal of clinical psychopharmacology

authors： Mosca D,Zhang M,Prieto R,Boucher M

更新日期：2017-04-01 00:00:00

abstract：:The Taq1A polymorphism in the dopamine D2 receptor (DRD2) gene could be related to the response to antipsychotics. We examined the effects of the Taq1A polymorphism on the plasma monoamine metabolites during the treatment of schizophrenia with aripiprazole, a DRD2 partial agonist. Thirty Japanese patients with schizop...

journal_title：Journal of clinical psychopharmacology

authors： Miura I,Takeuchi S,Katsumi A,Mori A,Kanno K,Yang Q,Mashiko H,Numata Y,Niwa S

更新日期：2012-02-01 00:00:00

abstract：:The objective of this study was to assemble expert clinical experience and judgment regarding the treatment of panic disorder in a systematic, quantitative manner, particularly with respect to changes during the past 5 years. A panel of 73 internationally recognized experts in the field of pharmacotherapy of anxiety a...

journal_title：Journal of clinical psychopharmacology

authors： Uhlenhuth EH,Balter MB,Ban TA,Yang K

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Sexual dysfunction (SD) is an important underestimated adverse effect of antidepressant drugs. Patients, in fact, if not directly questioned, tend to scarcely report them. The aim of the present meta-analysis was to quantify SD caused by antidepressants on the basis of studies where sexual functioning was pu...

journal_title：Journal of clinical psychopharmacology

authors： Serretti A,Chiesa A

更新日期：2009-06-01 00:00:00

abstract：:Despite a recognized need for the inclusion of women of childbearing age in drug studies, many such studies include only men. This practice is due mainly to the added risk of teratogenicity and to cyclic variations in the menstrual phase and hormonal state. The methodological and ethical problems associated with drug ...

journal_title：Journal of clinical psychopharmacology

authors： Halbreich U,Carson SW

更新日期：1989-10-01 00:00:00

abstract：:This study evaluated the impact of using long-acting injectable (LAI) antipsychotics for a longer treatment duration versus a short duration on health care resource utilization among Medicaid-insured schizophrenia patients. Schizophrenia patients 13 years or older initiating LAI antipsychotics were identified from the...

journal_title：Journal of clinical psychopharmacology

authors： Bera R,Offord S,Zubek D,Lau G,Lin J,Karson C

更新日期：2014-02-01 00:00:00

abstract：:The objective of this study was to compare the efficacy of the alpha-2a agonist guanfacine with that of dextroamphetamine for the treatment of adult attention-deficit/hyperactivity disorder (ADHD). Seventeen adult outpatients who met DSM-IV criteria for ADHD participated in a double-blind, placebo-controlled, crossove...

journal_title：Journal of clinical psychopharmacology

authors： Taylor FB,Russo J

更新日期：2001-04-01 00:00:00

abstract：:The debilitation of schizophrenia (SCHZ) worsens markedly with comorbid cocaine dependence (CD) and alcohol abuse. To date, no medications have conclusively demonstrated effects against both SCHZ and CD (SCHZ + CD) simultaneously. Because of its dopamine-modulating properties, we hypothesized that aripiprazole would a...

journal_title：Journal of clinical psychopharmacology

authors： Beresford TP,Clapp L,Martin B,Wiberg JL,Alfers J,Beresford HF

更新日期：2005-08-01 00:00:00

abstract：:Newer atypical antipsychotics demonstrate superior effectiveness, with a diminished incidence of extrapyramidal side effects compared with older typical antipsychotics, but they have been associated with the development of obesity and new-onset diabetes. A small number of reports documenting modest hypertriglyceridemi...

journal_title：Journal of clinical psychopharmacology

authors： Meyer JM

更新日期：2001-08-01 00:00:00

abstract：:Concomitant use of acetylcholine esterase inhibitors (AChEIs) and anticholinergic drugs, such as urinary antispasmodics (UA), is generally considered as inappropriate because of their opposite pharmacological actions. However, prevalence and the duration or factors associated with concomitant use have not been previou...

journal_title：Journal of clinical psychopharmacology

authors： Torvinen-Kiiskinen S,Taipale H,Tanskanen A,Tiihonen J,Hartikainen S

更新日期：2014-12-01 00:00:00

abstract：PURPOSE/BACKGROUND:Lithium, a common medication used in bipolar disorder treatment, can exert an inhibitory effect on sodium and potassium channels and potentially cause cardiac electrical conduction disturbance and corrected QT (QTc) prolongation. This study aimed to examine whether lithium at therapeutic levels can c...

journal_title：Journal of clinical psychopharmacology

authors： Chen PH,Kao YH,Chang CK,Lin YK,Lin YF,Chen YJ

更新日期：2020-01-01 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder (PTSD). This 12-week, multicenter, double-blind study randomized patients to receive either tiagabine or placebo. Tiagabine (administered in divided doses) was initiated at 4 mg/d (2 m...

journal_title：Journal of clinical psychopharmacology

authors： Davidson JR,Brady K,Mellman TA,Stein MB,Pollack MH

更新日期：2007-02-01 00:00:00

abstract：:Age and sex may influence both efficacy and side effects of second-generation antipsychotics. Women and elderly patients tend to have a higher prevalence for several side effects. Higher plasma levels in these groups of patients may be one reason. We studied the hypothesis that steady-state olanzapine plasma concentra...

journal_title：Journal of clinical psychopharmacology

authors： Weiss U,Marksteiner J,Kemmler G,Saria A,Aichhorn W

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Despite initial reports of efficacy in bipolar depression, multicenter trials did not show aripiprazole to be better than placebo, possibly because the doses used were too high, leading to lower efficacy and high dropout rates. This study evaluated the effects of low-dose aripiprazole. Extensive clinical exp...

journal_title：Journal of clinical psychopharmacology

authors： Kelly T,Lieberman DZ

更新日期：2017-02-01 00:00:00

abstract：:The disposition of orally administered imipramine (IMI) was studied in 11 depressed alcoholic and 12 depressed nonalcoholic male inpatients. Subjects received 50 mg three times daily for at least 10 days to ensure steady state. Following a temporary discontinuation of therapy, several blood samples were drawn over a 4...

journal_title：Journal of clinical psychopharmacology

authors： Ciraulo DA,Alderson LM,Chapron DJ,Jaffe JH,Subbarao B,Kramer PA

更新日期：1982-02-01 00:00:00

abstract：:Little is known about the association between antidepressant treatment-emergent adverse events and symptom nonremission in major depressive disorder. The objective of the current analysis was to determine whether particular baseline symptoms or treatment-emergent symptoms (adverse events) during the first 2 weeks are ...

journal_title：Journal of clinical psychopharmacology

authors： Daly EJ,Trivedi MH,Fava M,Shelton R,Wisniewski SR,Morris DW,Stegman D,Preskorn SH,Rush AJ

更新日期：2011-02-01 00:00:00

abstract：:The clinical features and pharmacokinetics of 22 lithium overdoses are described. Effectiveness of different treatment regimens regarding elimination of lithium is discussed. Origin of overdose was due to deliberate poisoning or precipitated by concomitant diseases, coadministration of drugs, or combination of both. T...

journal_title：Journal of clinical psychopharmacology

authors： Eyer F,Pfab R,Felgenhauer N,Lutz J,Heemann U,Steimer W,Zondler S,Fichtl B,Zilker T

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:Clozapine (CLZ) has been shown to have a beneficial effect on cognition in schizophrenia in some studies and a detrimental effect in others. The relative effect and exposure to CLZ and its major metabolite-N-desmethylclozapine (NDMC)-could explain these discrepancies. METHODS:Using a validated measure of glo...

journal_title：Journal of clinical psychopharmacology

authors： Rajji TK,Uchida H,Ismail Z,Ng W,Mamo DC,Remington G,Pollock BG,Mulsant BH

更新日期：2010-08-01 00:00:00

abstract：:Hyperprolactinemia mediated by antagonism of dopaminergic neurotransmission in the pituitary gland is a common adverse effect of antipsychotics. Recent studies have suggested that polymorphisms of dopamine receptors can affect the therapeutic response to antipsychotics. Thus, our aim was to evaluate whether 2 such pol...

journal_title：Journal of clinical psychopharmacology

authors： López-Rodríguez R,Román M,Novalbos J,Pelegrina ML,Ochoa D,Abad-Santos F

更新日期：2011-10-01 00:00:00

abstract：:This report notes the incidence and quality of paraesthesiae related to treatment with risperidone, as well as potential implications for treatment. Possible pathophysiologic explanations are offered. ...

journal_title：Journal of clinical psychopharmacology

authors： Heimberg C,Yearian AS

更新日期：1996-12-01 00:00:00

abstract：:The effects of daily buprenorphine treatment (4 or 8 mg/day, sublingual) on reports of subjective effects after single intravenous doses of morphine (10 mg), cocaine (30 mg), and saline placebo were studied on an inpatient clinical research ward in 26 men concurrently dependent on opioids and cocaine (DSM-III-R). Late...

journal_title：Journal of clinical psychopharmacology

authors： Teoh SK,Mello NK,Mendelson JH,Kuehnle J,Gastfriend DR,Rhoades E,Sholar W

更新日期：1994-02-01 00:00:00

abstract：:To assess the effect of carbamazepine (CBZ) upon total serum cholesterol, we examined 38 inpatients with affective illness and one with multiple personality disorder who received a course of CBZ monotherapy. CBZ therapy yielded significant increases in total serum cholesterol that became evident during the second week...

journal_title：Journal of clinical psychopharmacology

authors： Brown DW,Ketter TA,Crumlish J,Post RM

更新日期：1992-12-01 00:00:00

abstract：PURPOSE/BACKGROUND:The number of patients with acute synthetic cannabinoid intoxication (SCI) has increased in recent years although the prohibition of its legal sale and use in Turkey despite other countries allowing to some extent sale and use. The reported clinical findings of acute SCI are similar to the symptoms o...

journal_title：Journal of clinical psychopharmacology

authors： Altintop I

更新日期：2020-09-01 00:00:00

abstract：:Alcohol cue-induced brain activation has been studied extensively in alcoholics. However, little is known about the impact of standard treatment protocols on this phenomenon. The current study aimed at investigating the impact of the anticraving substance acamprosate on alcohol cue-related brain activity. Patients und...

journal_title：Journal of clinical psychopharmacology

authors： Langosch JM,Spiegelhalder K,Jahnke K,Feige B,Regen W,Kiemen A,Hennig J,Olbrich HM

更新日期：2012-10-01 00:00:00

abstract：:A role for serotonin in season affective disorder (SAD) has been explored with a variety of serotonergic pharmacologic agents. The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms. In a small, open-label pilot study, the authors observed the oppo...

journal_title：Journal of clinical psychopharmacology

authors： Turner EH,Schwartz PJ,Lowe CH,Nawab SS,Feldman-Naim S,Drake CL,Myers FS,Barnett RL,Rosenthal NE

更新日期：2002-04-01 00:00:00