Carbamazepine augmentation in lithium-refractory bipolar patients: a prospective study on long-term prophlyactic effectiveness.


:Twenty-two patients affected by bipolar or schizoaffective disorder, in whom carbamazepine was added to lithium after recurrence when on maintenance with lithium alone, were followed up prospectively for 2 to 13 years. The number of episodes, hospitalizations, and cumulative affective morbidity was markedly reduced after carbamazepine augmentation. Seventeen patients presented a better course during combined treatment than during lithium alone, and of these 15 had no further recurrences. Four patients did not appear to improve after carbamazepine augmentation, whereas one featured reemergence of affective episodes after having derived satisfactory benefit from combination for 7 years (delayed tolerance). Carbamazepine augmentation was associated with a reduction of lithium doses in some patients, including a subgroup who had not tolerated lithium at usual therapeutic levels. Carbamazepine significantly reduced serum thyrotropin concentrations, which were abnormally high in approximately one half of patients when on lithium alone. Total serum thyroxine concentrations were also decreased after carbamazepine augmentation, but free thyroid hormone concentrations did not change. Other significant carbamazepine-induced changes in laboratory tests included increases in total cholesterol concentrations and decreases in white blood cell counts.


J Clin Psychopharmacol


Bocchetta A,Chillotti C,Severino G,Ardau R,Del Zompo M




Has Abstract


1997-04-01 00:00:00












  • Blood levels of haloperidol and thioridazine during maintenance neuroleptic treatment of schizophrenic outpatients.

    abstract::Plasma and red blood cell levels of haloperidol, thioridazine, and thioridazine's main metabolite mesoridazine were measured in schizophrenic outpatients during treatment with fixed doses of haloperidol or thioridazine for several months. These drug levels were compared to those in schizophrenic inpatients treated wit...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Shvartsburd A,Sajadi C,Morton V,Mirabi M,Gordon J,Smith RC

    更新日期:1984-08-01 00:00:00

  • Efficacy and safety of venlafaxine in the treatment of bipolar II major depressive episode.

    abstract::As many as 45% of patients with major depression also meet diagnostic criteria for bipolar (BP) II disorder. Although the use of a concurrent mood-stabilizing drug has been suggested in treating BP II depression, antidepressant monotherapy has received less attention. The efficacy and safety of venlafaxine were examin...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Amsterdam J

    更新日期:1998-10-01 00:00:00

  • Hospitalization resource utilization and costs among Medicaid insured patients with schizophrenia with different treatment durations of long-acting injectable antipsychotic therapy.

    abstract::This study evaluated the impact of using long-acting injectable (LAI) antipsychotics for a longer treatment duration versus a short duration on health care resource utilization among Medicaid-insured schizophrenia patients. Schizophrenia patients 13 years or older initiating LAI antipsychotics were identified from the...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Bera R,Offord S,Zubek D,Lau G,Lin J,Karson C

    更新日期:2014-02-01 00:00:00

  • 12-month follow-up study of drug treatment in pathological gamblers: a primary outcome study.

    abstract:BACKGROUND:Pathological gambling (PG) is a relatively common and highly disabling impulse control disorder. A range of psychotherapeutic agents including selective serotonin reuptake inhibitors, antiepileptic drugs, and opioid antagonists are shown to be effective in the short-term treatment of PG. The use of a wide ra...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Dannon PN,Lowengrub K,Musin E,Gonopolsky Y,Kotler M

    更新日期:2007-12-01 00:00:00

  • Review of the use of topiramate for treatment of bipolar disorders.

    abstract::Lithium alone or in combination with other psychotherapeutic drugs has long been the gold standard of management for bipolar disorder (BD). Recognition of its limitations in the acute and chronic management of BD has led to the development of alternative therapies. One such approach involves the use of antiepileptic d...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,评审


    authors: Suppes T

    更新日期:2002-12-01 00:00:00

  • Alprazolam kinetics in patients with renal insufficiency.

    abstract::Alprazolam kinetics following a single 1.0-mg oral dose of alprazolam were compared between seven dialysis-dependent patients with chronic renal failure and seven healthy controls matched for age, sex, and weight. There were no significant differences between patients and controls in alprazolam half-life (11.5 vs. 11....

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Ochs HR,Greenblatt DJ,Labedzki L,Smith RB

    更新日期:1986-10-01 00:00:00

  • Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts.

    abstract::Nitrous oxide (laughing gas) has shown early promise as a rapidly acting antidepressant in patients with treatment-resistant major depression and is currently investigated in several clinical trials. Because nitrous oxide is rarely administered outside operating rooms or dental practices, most psychiatrists are not fa...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,评审


    authors: Nagele P,Zorumski CF,Conway C

    更新日期:2018-04-01 00:00:00

  • Alprazolam treatment of postcoronary bypass anxiety and depression.

    abstract::The effectiveness of alprazolam in treating symptoms of anxiety and depression in 60 patients undergoing coronary bypass surgery was assessed in a double-blind, placebo-controlled study. The results indicate that alprazolam treatment for anxiety following coronary bypass surgery, particularly symptoms occurring in the...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Freeman AM 3rd,Fleece L,Folks DG,Sokol RS,Hall KR,Pacifico AD,McGiffin DC,Kirklin JK,Zorn GL,Karp RB

    更新日期:1986-02-01 00:00:00

  • A Pilot Study of a Topical Intervention for Treatment of Female Sexual Dysfunction.

    abstract:PURPOSE/BACKGROUND:Many investigators reported that pharmacological treatment of female sexual dysfunction (FSD) has been a promising field yet to be explored. The purpose of this pilot study was to investigate the efficacy and safety of a topical cream containing small concentrations of three vasodilators with differe...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Gomaa AA,Abdel Aziz NM,Thabet RH,Fouly HA,Altellawy SH,Gomaa GA

    更新日期:2018-02-01 00:00:00

  • International Study of Expert Judgement on Therapeutic Use of Benzodiazepines and Other Psychotherapeutic Medications: V. Treatment strategies in panic disorder, 1992-1997.

    abstract::The objective of this study was to assemble expert clinical experience and judgment regarding the treatment of panic disorder in a systematic, quantitative manner, particularly with respect to changes during the past 5 years. A panel of 73 internationally recognized experts in the field of pharmacotherapy of anxiety a...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Uhlenhuth EH,Balter MB,Ban TA,Yang K

    更新日期:1998-12-01 00:00:00

  • Quetiapine Extended Release Open-Label Treatment Associated Changes in Amygdala Activation and Connectivity in Anxious Depression: An fMRI Study.

    abstract:BACKGROUND:This study investigated extended release quetiapine (quetiapine XR) associated changes in functional MRI (fMRI) measures of task-induced amygdalar activation and resting state connectivity in anxious unipolar major depressive disorder (AMDD). METHODS:Anxious unipolar major depressive disorder patients (n = ...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Altinay M,Karne H,Beall E,Anand A

    更新日期:2016-12-01 00:00:00

  • Trends in the adoption of medications for alcohol dependence.

    abstract::Increasing attention is being paid to the development and dissemination of effective pharmacotherapies for the treatment of alcohol and other drug dependence. However, numerous structural and philosophical barriers impede the widespread adoption of these treatment approaches in everyday clinical practice. Research is ...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,meta分析,评审


    authors: Ducharme LJ,Knudsen HK,Roman PM

    更新日期:2006-12-01 00:00:00

  • Reinforcing and subject-rated effects of methylphenidate and d-amphetamine in non-drug-abusing humans.

    abstract::The reinforcing effects of methylphenidate (20-40 mg), d-amphetamine (10-20 mg), and placebo were assessed in eight healthy, non-sleep-deprived, non-drug-abusing outpatient volunteers. A modified progressive-ratio schedule was used to assess drug reinforcement in which a sampling session always preceded a self-adminis...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Rush CR,Essman WD,Simpson CA,Baker RW

    更新日期:2001-06-01 00:00:00

  • Psychological strategies for discontinuing benzodiazepine treatment.

    abstract::Successful discontinuation of therapeutic drugs requires patients to negotiate two potentially difficult phases. First, they must complete the drug discontinuation procedure itself, which may entail coping with rebound and withdrawal symptoms as well as anxiety due to stopping a treatment on which they depend psycholo...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,评审


    authors: Spiegel DA

    更新日期:1999-12-01 00:00:00

  • Acute Effects of Haloperidol, Amisulpride, and Quetiapine on Bone Turnover Markers in Patients With Schizophrenia.

    abstract:OBJECTIVE:This prospective study sought to compare the acute effects of haloperidol, amisulpride, and quetiapine on serum markers of bone formation and resorption in relatively young patients with minimal previous exposure to antipsychotic drugs. METHODS:Patients included in the study were randomly assigned to receive...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Liang Y,Su YA,Zhao ZG,Gao N,Huang JZ,Tang MQ,Li KQ,Yang FD,Yu X,Si TM

    更新日期:2015-10-01 00:00:00

  • Unaltered Dopamine Transporter Availability in Drug-Naive Patients With Schizophrenia After 6 Months of Antipsychotics Treatment: A Naturalistic Study.

    abstract:BACKGROUND:Dopaminergic dysfunction, namely, dopamine transporter (DAT) availability variations in patients with drug-naive schizophrenia after long-term treatment, is still not well understood. The aims of the study were to explore (i) whether the DAT availability in patients with drug-naive schizophrenia differed aft...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Chang WH,Chen KC,Lee IH,Chi MH,Chen PS,Yao WJ,Chiu NT,Yang YK

    更新日期:2017-02-01 00:00:00

  • Specific side effects of long-term imipramine management of panic disorder.

    abstract::In a recent study, the authors suggested that tachycardia, dry mouth, and sweating continued to burden patients with panic disorder with agoraphobia who have shown marked and stable response to 6 months of imipramine treatment at the fixed, weight-adjusted dose of 2.25 mg/kg/day. Although sexual dysfunction and weight...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mavissakalian M,Perel J,Guo S

    更新日期:2002-04-01 00:00:00

  • A 4-Year Retrospective Analysis of Patients Presenting at the Emergency Department With Synthetic Cannabinoid Intoxication in Turkey.

    abstract:PURPOSE/BACKGROUND:The number of patients with acute synthetic cannabinoid intoxication (SCI) has increased in recent years although the prohibition of its legal sale and use in Turkey despite other countries allowing to some extent sale and use. The reported clinical findings of acute SCI are similar to the symptoms o...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Altintop I

    更新日期:2020-09-01 00:00:00

  • Mania after withdrawal of isocarboxazid.

    abstract::Two cases of mania following the discontinuation of treatment with isocarboxazid are described. Although this phenomenon has been reported by several investigators to occur after cessation of tricyclic antidepressant therapy, there exists only one isolated report of hypomania after discontinuation of monoamine oxidase...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Rothschild AJ

    更新日期:1985-12-01 00:00:00

  • Effects of aripiprazole and the Taq1A polymorphism in the dopamine D2 receptor gene on the clinical response and plasma monoamine metabolites level during the acute phase of schizophrenia.

    abstract::The Taq1A polymorphism in the dopamine D2 receptor (DRD2) gene could be related to the response to antipsychotics. We examined the effects of the Taq1A polymorphism on the plasma monoamine metabolites during the treatment of schizophrenia with aripiprazole, a DRD2 partial agonist. Thirty Japanese patients with schizop...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章


    authors: Miura I,Takeuchi S,Katsumi A,Mori A,Kanno K,Yang Q,Mashiko H,Numata Y,Niwa S

    更新日期:2012-02-01 00:00:00

  • Increased lithium serum and red blood cell concentrations during ketorolac coadministration.

    abstract::Case reports of a lithium-ketorolac drug interaction have been published, but no formal investigation of this interaction has been conducted. The objective of the study presented here was to determine significant changes in lithium serum and red blood cell (RBC) concentrations after lithium and ketorolac (oral formula...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Cold JA,ZumBrunnen TL,Simpson MA,Augustin BG,Awad E,Jann MW

    更新日期:1998-02-01 00:00:00

  • Psychiatric side effects from topical ocular timolol, a beta-adrenergic blocker.

    abstract::Neuropsychiatric side effects have been reported with various systemic betablockers. Data submitted to the National Registry of Drug-Induced Ocular Side Effects appear to indicate similar adverse reactions secondary to topical ophthalmic timolol. One hundred sixty-three of 369 central nervous system cases (44%) report...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Shore JH,Fraunfelder FT,Meyer SM

    更新日期:1987-08-01 00:00:00

  • Risperidone-associated burning paraesthesia.

    abstract::This report notes the incidence and quality of paraesthesiae related to treatment with risperidone, as well as potential implications for treatment. Possible pathophysiologic explanations are offered. ...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章


    authors: Heimberg C,Yearian AS

    更新日期:1996-12-01 00:00:00

  • Evaluation of the effects of duloxetine and escitalopram on 24-hour heart rate variability: a mechanistic study using heart rate variability as a pharmacodynamic measure.

    abstract::A decrease in heart rate variability (HRV) can indicate increased sympathetic nervous system activity and possibly increased norepinephrine levels. In this randomized, placebo- and escitalopram (ESC)-controlled, subject-blind, 2-period, crossover study, 26 healthy subjects 50 to 65 years old received duloxetine (DLX) ...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Chappell JC,Kovacs R,Haber H,Wright R,Mitchell MI,Detke M,Pangallo B

    更新日期:2013-04-01 00:00:00

  • Assessment of the prescription of antidepressant drugs in elderly nursing home patients: a clinical and laboratory follow-up investigation.

    abstract::The aim of the study was to investigate the use of antidepressant drugs among elderly people in nursing homes. Elderly residents who where found to have been prescribed at least one antidepressant drug according to the specific medication dispensing system were identified in 8 nursing homes in the county of Ostergötla...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,多中心研究


    authors: Chermá MD,Löfgren UB,Almkvist G,Hallert C,Bengtsson F

    更新日期:2008-08-01 00:00:00

  • Risperidone: an open-label, observational study of the efficacy, tolerability, and prescribing behavior in acutely exacerbated patients with schizophrenia.

    abstract:OBJECTIVE:Efficacy of atypical antipsychotic in acute schizophrenic episodes is still in debate. This study evaluated treatment practices over 7 years of initial treatment with oral risperidone in acutely exacerbated patients with schizophrenia and in a subgroup of highly agitated, tense, and aggressive patients. Addit...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Pajonk FG,Schreiner A,Peters S,Rettig K,Degner D,Rüther E

    更新日期:2005-08-01 00:00:00

  • Rating the raters: assessing the quality of Hamilton rating scale for depression clinical interviews in two industry-sponsored clinical drug trials.

    abstract:OBJECTIVE:The quality of clinical interviews conducted in industry-sponsored clinical drug trials is an important but frequently overlooked variable that may influence the outcome of a study. We evaluated the quality of Hamilton Rating Scale for Depression (HAM-D) clinical interviews performed at baseline in 2 similar ...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Engelhardt N,Feiger AD,Cogger KO,Sikich D,DeBrota DJ,Lipsitz JD,Kobak KA,Evans KR,Potter WZ

    更新日期:2006-02-01 00:00:00

  • Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers.

    abstract::An antidepressant for use in the patient receiving concomitant drug treatment, over-the-counter medications, or herbal products should lack cytochrome P-450 (CYP) 3A4 inductive or inhibitory activity to provide the least likelihood of a drug-drug interaction. This study addresses the potential of 4 diverse antidepress...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: DeVane CL,Donovan JL,Liston HL,Markowitz JS,Cheng KT,Risch SC,Willard L

    更新日期:2004-02-01 00:00:00

  • Concentration-response relationship for fluvoxamine using remission as an endpoint: a receiver operating characteristics curve analysis in major depression.

    abstract::Therapeutic drug monitoring studies of selective serotonin reuptake inhibitor (SSRI) antidepressants thus far failed to identify a clear concentration-response relationship in major depression. Majority of the previous studies defined clinical response as 50% or greater reduction from baseline in depression rating sca...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章


    authors: Suzuki Y,Fukui N,Sawamura K,Sugai T,Watanabe J,Ono S,Inoue Y,Ozdemir V,Someya T

    更新日期:2008-06-01 00:00:00

  • Olanzapine: a systematic review and meta-regression of the relationships between dose, plasma concentration, receptor occupancy, and response.

    abstract:OBJECTIVE:To conduct a systematic review examining the relationships between olanzapine dose, clinical outcome, dopamine occupancy, and plasma concentration; and to evaluate the potential for therapeutic drug monitoring. METHODS:A search using Embase, Medline, and Pubmed was conducted; and the literature was systemati...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,meta分析,评审


    authors: Bishara D,Olofinjana O,Sparshatt A,Kapur S,Taylor D,Patel MX

    更新日期:2013-06-01 00:00:00