US psychiatric residents' treatment of patients with bipolar disorder.

abstract：:As many as 45% of patients with major depression also meet diagnostic criteria for bipolar (BP) II disorder. Although the use of a concurrent mood-stabilizing drug has been suggested in treating BP II depression, antidepressant monotherapy has received less attention. The efficacy and safety of venlafaxine were examin...

journal_title：Journal of clinical psychopharmacology

authors： Amsterdam J

更新日期：1998-10-01 00:00:00

abstract：:Forty bipolar depressed inpatients underwent three consecutive cycles of total sleep deprivation (TSD). At the beginning of the study, 20 patients were free of psychotropic drugs and 20 had been receiving lithium medication for at least 6 months. Mood was rated on the Hamilton Rating Scale for Depression before and af...

journal_title：Journal of clinical psychopharmacology

authors： Benedetti F,Colombo C,Barbini B,Campori E,Smeraldi E

更新日期：1999-06-01 00:00:00

abstract：:This study aimed to assess whether exposure to anticholinergic and sedative medications and its evolution was associated with increased risk of in-hospital falls and all-cause mortality. Furthermore, results were compared with 2 definitions of drug burden index (DBI) against the outcomes.This observational, multicentr...

journal_title：Journal of clinical psychopharmacology

authors： Dauphinot V,Faure R,Omrani S,Goutelle S,Bourguignon L,Krolak-Salmon P,Mouchoux C

更新日期：2014-10-01 00:00:00

abstract：:The reinforcing effects of methylphenidate (20-40 mg), d-amphetamine (10-20 mg), and placebo were assessed in eight healthy, non-sleep-deprived, non-drug-abusing outpatient volunteers. A modified progressive-ratio schedule was used to assess drug reinforcement in which a sampling session always preceded a self-adminis...

journal_title：Journal of clinical psychopharmacology

authors： Rush CR,Essman WD,Simpson CA,Baker RW

更新日期：2001-06-01 00:00:00

abstract：:Phenomenological, physiological, biochemical, and receptor binding measures are useful as dependent variables in affective disorders research. Abnormalities of these measures can result from up-regulation and supersensitivity of cholinergic systems and disturbances of cholinergic-monoaminergic interaction. These devia...

journal_title：Journal of clinical psychopharmacology

authors： Dilsaver SC

更新日期：1986-04-01 00:00:00

abstract：:There have been an increased number of recent reports on orgasm-related sexual dysfunction coincident with selective serotonin reuptake inhibitor (SSRI) treatment. In contrast, it has also been reported that SSRIs improve sexual dysfunction. Low doses of clomipramine and paroxetine, potent 5-hydroxytryptamine reuptake...

journal_title：Journal of clinical psychopharmacology

authors： Lee HS,Song DH,Kim CH,Choi HK

更新日期：1996-10-01 00:00:00

abstract：:Fluoxetine, a selective serotonin reuptake inhibitor, is currently being evaluated as a potential treatment for cocaine abuse. This 4-week inpatient study evaluated the pharmacologic interaction between fluoxetine and cocaine in healthy adult male volunteers (N = 5) with histories of cocaine abuse. Oral capsules were ...

journal_title：Journal of clinical psychopharmacology

authors： Walsh SL,Preston KL,Sullivan JT,Fromme R,Bigelow GE

更新日期：1994-12-01 00:00:00

abstract：:A double-blind controlled study comparing the effects of bupropion to doxepin in outpatients with primary depression was conducted to evaluate efficacy and safety differences between the two drugs. Following a 7-day placebo washout period, patients could be treated for up to 13 weeks on either treatment. Antidepressan...

journal_title：Journal of clinical psychopharmacology

authors： Feighner J,Hendrickson G,Miller L,Stern W

更新日期：1986-02-01 00:00:00

abstract：:The Taq1A polymorphism in the dopamine D2 receptor (DRD2) gene could be related to the response to antipsychotics. We examined the effects of the Taq1A polymorphism on the plasma monoamine metabolites during the treatment of schizophrenia with aripiprazole, a DRD2 partial agonist. Thirty Japanese patients with schizop...

journal_title：Journal of clinical psychopharmacology

authors： Miura I,Takeuchi S,Katsumi A,Mori A,Kanno K,Yang Q,Mashiko H,Numata Y,Niwa S

更新日期：2012-02-01 00:00:00

abstract：:The efficacy of continuation therapy with tricyclic antidepressants has been established in a number of controlled trials. This study investigated the efficacy of continuation therapy with a relatively new antidepressant, amoxapine, using a double-blind controlled comparison with amitriptyline. Subjects met DSM-III cr...

journal_title：Journal of clinical psychopharmacology

authors： Mason BJ,Kocsis JH,Frances AJ,Mann JJ

更新日期：1990-10-01 00:00:00

abstract：:Patients with obsessive-compulsive disorder (OCD) have been shown to be preferentially responsive to serotonin (5-HT) uptake-inhibiting antidepressants including clomipramine, fluoxetine, fluvoxamine, and sertraline. The nontricyclic antidepressant, trazodone, also possesses serotonin reuptake inhibiting properties an...

journal_title：Journal of clinical psychopharmacology

authors： Pigott TA,L'Heureux F,Rubenstein CS,Bernstein SE,Hill JL,Murphy DL

更新日期：1992-06-01 00:00:00

abstract：:This report notes the incidence and quality of paraesthesiae related to treatment with risperidone, as well as potential implications for treatment. Possible pathophysiologic explanations are offered. ...

journal_title：Journal of clinical psychopharmacology

authors： Heimberg C,Yearian AS

更新日期：1996-12-01 00:00:00

abstract：PURPOSE:The neuropeptide oxytocin (OXT) has a variety of physiological functions in maternal behavior and attachment including sexual behavior. Based on animal research and our previous human studies, we set out to investigate intranasal administration of OXT and hypothesized that OXT should be able to modulate sexual ...

journal_title：Journal of clinical psychopharmacology

authors： Kruger THC,Deiter F,Zhang Y,Jung S,Schippert C,Kahl KG,Heinrichs M,Schedlowski M,Hartmann U

更新日期：2018-06-01 00:00:00

abstract：:Hypersalivation is a frequent, disturbing, and uncomfortable adverse effect of clozapine therapy that frequently leads to noncompliance. The aim of this study was to examine the efficacy of metoclopramide (dopamine D2 antagonist, antiemetic medication) as an option for management of hypersalivation associated with clo...

journal_title：Journal of clinical psychopharmacology

authors： Kreinin A,Miodownik C,Mirkin V,Gaiduk Y,Yankovsky Y,Bersudsky Y,Lerner PP,Bergman J,Lerner V

更新日期：2016-06-01 00:00:00

abstract：:Neuropsychiatric side effects have been reported with various systemic betablockers. Data submitted to the National Registry of Drug-Induced Ocular Side Effects appear to indicate similar adverse reactions secondary to topical ophthalmic timolol. One hundred sixty-three of 369 central nervous system cases (44%) report...

journal_title：Journal of clinical psychopharmacology

authors： Shore JH,Fraunfelder FT,Meyer SM

更新日期：1987-08-01 00:00:00

abstract：:The objective of this study was to compare the efficacy of the alpha-2a agonist guanfacine with that of dextroamphetamine for the treatment of adult attention-deficit/hyperactivity disorder (ADHD). Seventeen adult outpatients who met DSM-IV criteria for ADHD participated in a double-blind, placebo-controlled, crossove...

journal_title：Journal of clinical psychopharmacology

authors： Taylor FB,Russo J

更新日期：2001-04-01 00:00:00

abstract：PURPOSE/BACKGROUND:Extensive research has been conducted comparing the metabolic characteristics of older second-generation antipsychotics (SGAs); minimal data exist comparing the long-term metabolic effects of SGAs approved in the last 10 years. METHODS/PROCEDURES:A retrospective chart review of patients treated with...

journal_title：Journal of clinical psychopharmacology

authors： Greger J,Aladeen T,Lewandowski E,Wojcik R,Westphal E,Rainka M,Capote H

更新日期：2021-01-01 00:00:00

abstract：:Trichotillomania (TTM) is characterized by repetitive hair pulling resulting in hair loss. Data on the pharmacological treatment of TTM are limited. This study examined the opioid antagonist, naltrexone, in adults with TTM who had urges to pull their hair. Fifty-one individuals with TTM were randomized to naltrexone o...

journal_title：Journal of clinical psychopharmacology

authors： Grant JE,Odlaug BL,Schreiber LR,Kim SW

更新日期：2014-02-01 00:00:00

abstract：:Lithium is clinically available for the treatment of mood disorders. However, it has remained unclear how lithium acts on the brain to produce its effects. The aim of this study was to evaluate the effects of chronic lithium on human brain activity using positron emission tomography and clarify the correlation between...

journal_title：Journal of clinical psychopharmacology

authors： Kohno T,Shiga T,Toyomaki A,Kusumi I,Matsuyama T,Inoue T,Katoh C,Koyama T,Tamaki N

更新日期：2007-12-01 00:00:00

abstract：:In a prospective study of all geriatric patients treated with tricyclic antidepressants over an 18-month period, a lower incidence of adverse psychiatric reactions than literature based on chart reviews has suggested was found. In only three of the 43 patients studied (7%) did a picture consistent with toxic delirium ...

journal_title：Journal of clinical psychopharmacology

authors： Meyers BS,Mei-Tal V

更新日期：1983-02-01 00:00:00

abstract：PURPOSE/BACKGROUND:The use of clozapine, particularly in young people, is often limited by early treatment-emergent adverse effects including drowsiness and lethargy. Concerns about adverse effects, medication adherence, and the need for blood monitoring often impede the use of clozapine in this population, leading to ...

journal_title：Journal of clinical psychopharmacology

authors： Ballon JS,Ashfaq H,Noordsy DL

更新日期：2018-06-01 00:00:00

abstract：:In this nationwide population-based study, we examined whether haloperidol exposure is associated with a higher risk of mortality than are other antipsychotic medications. Patients who newly received monotherapy with chlorpromazine (n = 2133), haloperidol (n = 4454), quetiapine (n = 1513), and risperidone (n = 1046) b...

journal_title：Journal of clinical psychopharmacology

authors： Wang LJ,Lee SY,Yuan SS,Yang KC,Yang CJ,Lee TL,Shyu YC

更新日期：2016-02-01 00:00:00

abstract：:This investigation aimed to provide evidence on the lack of pharmacokinetic interaction of paroxetine (20 mg/d) and alprazolam (1 mg/d) in combined therapy. In addition, the central effects of both drugs when administered alone and in combination were assessed to rule out any relevant synergistic depressant central ef...

journal_title：Journal of clinical psychopharmacology

authors： Calvo G,García-Gea C,Luque A,Morte A,Dal-Ré R,Barbanoj M

更新日期：2004-06-01 00:00:00

abstract：:Many drugs, including alcohol and stimulants, demonstrably increase sociability and verbal interaction and are recreationally consumed in social settings. One drug, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), seems to produce its prosocial effects by increasing plasma oxytocin levels, and the oxytocin system ha...

journal_title：Journal of clinical psychopharmacology

authors： Bershad AK,Kirkpatrick MG,Seiden JA,de Wit H

更新日期：2015-06-01 00:00:00

abstract：:The pharmacokinetics of drugs with specific binding sites in the brain needs to be evaluated at these sites. In this study, we measured the time course of the selective serotonin reuptake inhibitor fluvoxamine in the human brain based on serotonin transporter (5-HTT) occupancy by positron emission tomography. Consecut...

journal_title：Journal of clinical psychopharmacology

authors： Takano A,Suhara T,Ichimiya T,Yasuno F,Suzuki K

更新日期：2006-04-01 00:00:00

abstract：:Many factors obscure the diagnosis of psychogenic disorders, especially anxiety and depression. The factors involved include an overlap of symptoms, discrepancies in diagnostic criteria, and the unreliability of self- and observer-reporting. Differentiation among the various personality disorders is, however, extremel...

journal_title：Journal of clinical psychopharmacology

authors： Cloninger CR

更新日期：1990-06-01 00:00:00

abstract：:Phencyclidine (PCP) abuse has diminished since PCP's intrusion into American culture in the late 1970s. One of its legacies is the assumption that it provokes violent behavior in humans with predictable regularity. This assumption is so accepted that ingestion of the drug both accidentally and knowingly prior to commi...

journal_title：Journal of clinical psychopharmacology

authors： Brecher M,Wang BW,Wong H,Morgan JP

更新日期：1988-12-01 00:00:00

abstract：:Uninstitutionalized young adults with chronic mental disorders and social disabilities pose a new challenge in community psychiatry. These attention-seeking, help-rejecting young men and women spend most of their lives in the community and differ markedly from older deinstitutionalized chronic psychiatric patients. Ma...

journal_title：Journal of clinical psychopharmacology

authors： Pepper B

更新日期：1985-06-01 00:00:00

abstract：:The assessment of adverse effects of psychiatric medications is important in clinical and research settings because they are often associated with medication discontinuation, symptom exacerbation, and reduced quality of life. Currently available assessment tools are either limited with regard to the number and variety...

journal_title：Journal of clinical psychopharmacology

authors： Nugent KL,Spahr E,Toroney J,Mojtabai R,Nettles C,Turner LW,Fenton A,Spivak A,Cullen BA,Everett A,Eaton WW

更新日期：2015-06-01 00:00:00

abstract：:The incidence of treatment-emergent extrapyramidal symptoms (EPSs) and tardive dyskinesia (TD) in schizophrenic patients, and the clinical characteristics associated with an increased risk of developing EPSs and TD were examined. Patients (N = 7728) in the 3-year, prospective, observational Schizophrenia Outpatient He...

journal_title：Journal of clinical psychopharmacology

authors： Novick D,Haro JM,Bertsch J,Haddad PM

更新日期：2010-10-01 00:00:00