Abstract：
:On the basis of a previous report suggesting the effectiveness of the beta-adrenoceptor/5-HT1A antagonist pindolol to accelerate the antidepressant effect of a selective serotonin reuptake inhibitor (SSRI) and to produce a therapeutic effect in drug-resistant depressed patients, these open studies were undertaken to further explore the safety and efficacy of this strategy. In a first study, nine untreated unipolar depressed patients were given the SSRI paroxetine (20 mg/day) together with pindolol (2.5 mg thrice daily). One patient stopped taking pindolol because of increased irritability after 3 days. One week later, seven patients had their Hamilton Rating Scale for Depression Score decreased by more than 50%. In a second study, 19 drug-resistant unipolar depressed patients (9 on paroxetine, 5 on sertraline, 3 on fluoxetine, and 2 on moclobemide) were also given pindolol at the same regimen and were assessed weekly. Two patients (one on sertraline, one on moclobemide) stopped taking pindolol also because of increased irritability after 2 and 3 days, respectively. After 1 week of pindolol addition, 10 patients had a more than 50% decrease of their depression score. By day 14, all of the patients had a score of 10 or less, with the exception of those on sertraline. Improvement was maintained in all patients for at least 28 days on this combination. The results of these studies indicate that pindolol is safe when used in combination with an SSRI or moclobemide. Given the positive results obtained in this second open trial in 28 patients, this treatment strategy should be tested under double-blind conditions to establish its efficacy.
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Blier P,Bergeron Rdoi
10.1097/00004714-199506000-00011subject
Has Abstractpub_date
1995-06-01 00:00:00pages
217-22issue
3eissn
0271-0749issn
1533-712Xjournal_volume
15pub_type
临床试验,杂志文章abstract：:The purpose of this study was to determine the pharmacokinetic behavior of triazolam in children. Nine healthy children, aged 6 to 9 years, received oral triazolam (0.025 mg/kg suspended in Kool-Aid, Kraft General Foods, Chicago, IL) before dental treatment. Plasma triazolam concentrations were measured by gas chromat...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/00004714-199706000-00005
更新日期：1997-06-01 00:00:00
abstract：:Data from evening questionnaires, reports of side effects, laboratory findings, and all-night respiratory measurements were collected on the 99 chronic insomniacs examined in this multicenter study. These data were used to compare the clinical safety and desirability of a benzodiazepine hypnotic with a very short half...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1990-08-01 00:00:00
abstract：INTRODUCTION:One of the major enzymes of the cytochrome P450 drug-metabolizing system, CYP2D6, shows a high degree of genetic polymorphism and variability in activity. Based on the degree of CYP2D6 activity, individuals can be broadly classified as poor metabolizers (PMs) or extensive metabolizers (EMs); the metabolism...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0b013e3181acc4dd
更新日期：2009-08-01 00:00:00
abstract：:The pharmacokinetic parameters of clozapine and its two main metabolites, N-desmethylclozapine (norclozapine, active metabolite) and clozapine N-oxide, were evaluated, after oral administration, in 19 patients with chronic schizophrenia. Plasma and red blood cell (RBC) drug concentrations were determined by high-perfo...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/00004714-199812000-00010
更新日期：1998-12-01 00:00:00
abstract：:Several reports suggest that selective serotonin reuptake blockers are helpful in the treatment of panic disorder. The aim of the study was to compare fluvoxamine with placebo in 50 panic disorder patients by using an 8-week, double-blind, parallel-groups design. Weekly assessment included a panic attack diary (freque...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-10-01 00:00:00
abstract：:Recognition of social anxiety disorder (social phobia) as a common and disabling condition has led to new advances in its pharmacotherapy. Limitations with selective seroton reuptake inhibitors (side effects) and behavior therapy (scarcity of trained therapists), coupled with the tendency for patients with the disorde...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/01.jcp.0000150227.61501.00
更新日期：2005-02-01 00:00:00
abstract：:Lithium alone or in combination with other psychotherapeutic drugs has long been the gold standard of management for bipolar disorder (BD). Recognition of its limitations in the acute and chronic management of BD has led to the development of alternative therapies. One such approach involves the use of antiepileptic d...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,评审
doi：10.1097/00004714-200212000-00010
更新日期：2002-12-01 00:00:00
abstract：PURPOSE:The present study aimed to assess the level of agreement between clinicians' routine assessments of medication status and plasma levels of commonly prescribed antipsychotic medications in patients presenting to an emergency room with an exacerbation of psychosis. METHODS:We studied 105 patients presenting to a...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/JCP.0000000000000697
更新日期：2017-06-01 00:00:00
abstract：:Agonist replacement may be a viable treatment approach for managing stimulant use disorders. This study sought to determine the effects of D-amphetamine maintenance on methamphetamine self-administration in stimulant using human participants. We predicted that D-amphetamine maintenance would reduce methamphetamine sel...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000000207
更新日期：2014-12-01 00:00:00
abstract：INTRODUCTION:Zonisamide is an anticonvulsant medication with GABAergic, glutamatergic, and monoaminergic effects. Zonisamide has also been shown to reduce alcohol intake in rodents and in risky drinkers in the context of a laboratory study. This pilot clinical trial evaluated the safety, tolerability, and efficacy of z...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/JCP.0b013e3181db38bb
更新日期：2010-06-01 00:00:00
abstract：:The aim of this study was to compare the disposition of the tricyclic antidepressant clomipramine (C) in Japanese and Swedish patients receiving continuous treatment. Therapeutic drug monitoring data for C and the active metabolite N-desmethylclomipramine (DC) in Japanese patients receiving monotherapy (N = 12) and in...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/00004714-199910000-00002
更新日期：1999-10-01 00:00:00
abstract：:This UK multicenter, noncomparative, open-trial study assessed risperidone in 74 first-psychotic-episode patients (DSM-IV schizophrenia) treated with flexible doses. Treatment commenced at 1 mg/day, increasing to 2 mg after 3 days; then adjusted to 8 mg/day maximum. Treatment duration was 12 weeks (Phase 1) with follo...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1097/01.jcp.0000115663.45074.8a
更新日期：2004-04-01 00:00:00
abstract：:Weight gain is a problem commonly encountered with antipsychotic treatment and has become more apparent with increasing use of the newer atypical antipsychotics. The adipocyte-derived hormone, leptin, has been associated with body weight and energy homeostasis, and abnormal regulation of leptin could play a role in we...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/jcp.0b013e3180582412
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:Pathological gambling (PG) is a relatively common and highly disabling impulse control disorder. A range of psychotherapeutic agents including selective serotonin reuptake inhibitors, antiepileptic drugs, and opioid antagonists are shown to be effective in the short-term treatment of PG. The use of a wide ra...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/jcp.0b013e31815a4400
更新日期：2007-12-01 00:00:00
abstract：:Patients with obsessive-compulsive disorder (OCD) have been shown to be preferentially responsive to serotonin (5-HT) uptake-inhibiting antidepressants including clomipramine, fluoxetine, fluvoxamine, and sertraline. The nontricyclic antidepressant, trazodone, also possesses serotonin reuptake inhibiting properties an...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1992-06-01 00:00:00
abstract：:The ability of the Hamilton Rating Scale for Anxiety, the Hamilton Rating Scale for Depression, and 50 items from the self-rated Hopkins Symptom Checklist to discriminate generalized anxiety disorder from major depressive disorder was examined for over 3,000 patients entering studies in three drug development projects...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-199006001-00011
更新日期：1990-06-01 00:00:00
abstract：:The objective of this study was to investigate the efficacy of pirenzepine in the treatment of clozapine-induced hypersalivation. Pirenzepine is reported to counteract hypersalivation by its selective antagonistic activity on the M4-muscarinic receptor, which is stimulated by clozapine. Twenty patients with clozapine-...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-200112000-00012
更新日期：2001-12-01 00:00:00
abstract：:Platelet monoamine oxidase (MAO) activity was studied in bipolar and schizophrenic patients treated with lithium and was found to be increased as a nonspecific drug effect. Greater MAO increase in manic patients was correlated with lesser clinical improvement. There was no correlation of MAO activity with short-term o...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：:The objective of this study was twofold: (1) to describe the effects of risperidone on the quantitative electroencephalogram (EEG) in schizophrenic patients and (2) to explore the relationships between EEG changes and clinical improvement. The subjects were nine male schizophrenic patients participating in a placebo-c...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-10-01 00:00:00
abstract：:Eight schizophrenic patients received alprazolam in an open-label protocol. A partial reversal of negative symptoms was noted in six of the eight patients. Also, all eight experienced a decrease in anxiety. Alprazolam in doses of 5 to 7 mg/day yielded steady state plasma levels of 6 to 64 ng/ml. As the drug was well t...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：OBJECTIVE:Clozapine (CLZ) has been shown to have a beneficial effect on cognition in schizophrenia in some studies and a detrimental effect in others. The relative effect and exposure to CLZ and its major metabolite-N-desmethylclozapine (NDMC)-could explain these discrepancies. METHODS:Using a validated measure of glo...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0b013e3181e69060
更新日期：2010-08-01 00:00:00
abstract：:Serotonin 2C and 2A receptor (5-HT2C and 5-HT2A) antagonisms are hypothesized to play a role in the metabolic adverse effects induced by olanzapine and clozapine. Associations between polymorphisms in 5-HT2C and 5-HT2A receptor coding genes, HTR2C and HTR2A, with antipsychotic-induced weight gain have been reported. T...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0b013e31819302c3
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:Pharmacogenetic studies on clozapine (CLZ) have provided meaningful insights but have shown redundancies owing to wide interindividual variability and insufficient replication. The present study was designed to validate hitherto suggested candidate genes on CLZ pharmacokinetics and pharmacodynamics and explor...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0b013e31825ac35c
更新日期：2012-08-01 00:00:00
abstract：:Physician-rating scales remain the standard in antidepressant clinical trials. The current study aimed to examine the discrepancies between physician-rating scales and self-rating scales for symptoms and functioning, before and after treatment, in newly hospitalized patients. A total of 131 acutely ill inpatients with...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/JCP.0000000000000229
更新日期：2014-12-01 00:00:00
abstract：:Depression is a common disorder in pregnancy and associated with adverse effects for both mother and neonate. Pharmacological treatment and prevention options include mirtazapine. In a series of 56 cases, we investigated neonatal outcome after intrauterine exposure to mirtazapine and exposure through lactation in the ...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000000279
更新日期：2015-04-01 00:00:00
abstract：:Serotonin uptake inhibitors are generally considered activating antidepressants. To assess rates and temporal patterns of activation and sedation as well as dose-effect relationships, adverse event data were evaluated from a fixed-dose study comparing placebo and fluoxetine 5, 20, and 40 mg/day in the treatment of maj...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1992-10-01 00:00:00
abstract：:Using the Karolinska Scales of Personality (KSP), we investigated the effect of the selective serotonin reuptake inhibitor citalopram on personality traits and the relationship between personality traits and peripheral indexes for central serotonergic function in patients with panic disorder at baseline and after 6 mo...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/00004714-200208000-00011
更新日期：2002-08-01 00:00:00
abstract：:A growing number of anticonvulsant drugs are receiving attention as possible mood stabilizers. This attention is based mainly on the assumption that the antimanic efficacy of anticonvulsants makes them suitable as mood stabilizers. However, their antidepressant properties have received less scrutiny. In this review, c...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,评审
doi：10.1097/00004714-200304000-00011
更新日期：2003-04-01 00:00:00
abstract：:Paroxetine is a novel phenylpiperidine antidepressant agent that acts as a potent and selective inhibitor of serotonin reuptake. We report results of a 6-week, randomized, double-blind, multicenter study comparing paroxetine and fluoxetine in the treatment of major depression. One hundred seventy-eight inpatients, who...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1097/00004714-199312002-00003
更新日期：1993-12-01 00:00:00
abstract：:This article reports results for patients who completed the 16-week maintenance phase of a double-blind clinical trial comparing buprenorphine (N = 43; average dose = 9.0 mg/day sublingually) with methadone (N = 43; average dose = 54 mg/day orally) in the outpatient treatment of opioid dependence. In addition to pharm...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-199602000-00010
更新日期：1996-02-01 00:00:00
