Pharmacokinetic and pharmacodynamic evaluation of the inhibition of alprazolam by citalopram and fluoxetine.

abstract：:Phencyclidine (PCP) abuse has diminished since PCP's intrusion into American culture in the late 1970s. One of its legacies is the assumption that it provokes violent behavior in humans with predictable regularity. This assumption is so accepted that ingestion of the drug both accidentally and knowingly prior to commi...

journal_title：Journal of clinical psychopharmacology

authors： Brecher M,Wang BW,Wong H,Morgan JP

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Bipolar disorder is a serious mental disorder. This study investigated whether early improvement at week 1 or 2 could predict treatment outcomes at week 4 in clinical populations with acute mania. METHODS:We conducted a naturalistic study, recruiting inpatients with bipolar mania for acute treatment. Sympto...

journal_title：Journal of clinical psychopharmacology

authors： Li DJ,Lin CH,Lu MJ

更新日期：2017-08-01 00:00:00

abstract：:The purpose of this study was to assess the effect of bupropion on cytochrome P450 2D6 (CYP2D6) activity. Twenty-one subjects completed this repeated-measures study in which dextromethorphan (30-mg oral dose) was administered to smokers at baseline and after 17 days of treatment with either bupropion sustained-release...

journal_title：Journal of clinical psychopharmacology

authors： Kotlyar M,Brauer LH,Tracy TS,Hatsukami DK,Harris J,Bronars CA,Adson DE

更新日期：2005-06-01 00:00:00

abstract：:Methadone is a synthetic opioid that binds to the κ-opioid receptor with a low affinity. This study tested the hypotheses that the genetic polymorphisms in the κ-opioid receptor 1 (OPRK1) gene region are associated with methadone treatment responses in a Taiwan methadone maintenance treatment (MMT) cohort. Seventeen s...

journal_title：Journal of clinical psychopharmacology

authors： Wang SC,Tsou HH,Chung RH,Chang YS,Fang CP,Chen CH,Ho IK,Kuo HW,Liu SC,Shih YH,Wu HY,Huang BH,Lin KM,Chen AC,Hsiao CF,Liu YL

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:We examined the influence of prior antidepressant treatment trials on the likelihood of depressive relapse, and time to depressive relapse, during maintenance therapy of bipolar II disorder in treatment-responsive subjects who had recovered from a major depressive episode. METHODS:Data were derived from a p...

journal_title：Journal of clinical psychopharmacology

authors： Amsterdam JD,Kim TT

更新日期：2019-07-01 00:00:00

abstract：:In this study, the authors examined the relationship between steady-state haloperidol blood levels and clinical response in patients with acute psychotic mania. Fifty-four inpatients with acute mania were randomly assigned to receive either haloperidol 25 mg/day or haloperidol 5 mg/day. Each subject also received a co...

journal_title：Journal of clinical psychopharmacology

authors： Chou JC,Czobor P,Dacpano G,Richardson N,Tuma I,Trujillo M,Cooper TB,Volavka J

更新日期：2001-08-01 00:00:00

abstract：:The aim of this article was to analyze systematically literature information published in English (between 1966 and January 2011) on the efficacy of antidepressants in pediatric obsessive-compulsive disorder. Data were identified through different databases by using variously combined patterns of search terms. Searche...

journal_title：Journal of clinical psychopharmacology

authors： Gentile S

更新日期：2011-10-01 00:00:00

abstract：:In a prospective study of all geriatric patients treated with tricyclic antidepressants over an 18-month period, a lower incidence of adverse psychiatric reactions than literature based on chart reviews has suggested was found. In only three of the 43 patients studied (7%) did a picture consistent with toxic delirium ...

journal_title：Journal of clinical psychopharmacology

authors： Meyers BS,Mei-Tal V

更新日期：1983-02-01 00:00:00

abstract：:Patients with obsessive-compulsive disorder (OCD) have been shown to be preferentially responsive to serotonin (5-HT) uptake-inhibiting antidepressants including clomipramine, fluoxetine, fluvoxamine, and sertraline. The nontricyclic antidepressant, trazodone, also possesses serotonin reuptake inhibiting properties an...

journal_title：Journal of clinical psychopharmacology

authors： Pigott TA,L'Heureux F,Rubenstein CS,Bernstein SE,Hill JL,Murphy DL

更新日期：1992-06-01 00:00:00

abstract：:Seven patients with AIDS-related cognitive and emotional deficits had neuropsychologic testing and then were treated with methylphenidate or dextroamphetamine in individualized doses. Three patients showed marked functional improvement and 5 of the 7 became more spontaneous, reactive, and animated. Additional neuropsy...

journal_title：Journal of clinical psychopharmacology

authors： Angrist B,d'Hollosy M,Sanfilipo M,Satriano J,Diamond G,Simberkoff M,Weinreb H

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Late-life depression, often in association with anxiety, affects approximately 15% of individuals older than 65 years. Selective serotonin reuptake inhibitors are the first-line treatment but could be responsible of an early exacerbation of anxiety, possibly reduced by a very gradual titration of drugs. The ...

journal_title：Journal of clinical psychopharmacology

authors： Gibiino S,Mori E,De Ronchi D,Serretti A

更新日期：2013-08-01 00:00:00

abstract：:Alcohol cue-induced brain activation has been studied extensively in alcoholics. However, little is known about the impact of standard treatment protocols on this phenomenon. The current study aimed at investigating the impact of the anticraving substance acamprosate on alcohol cue-related brain activity. Patients und...

journal_title：Journal of clinical psychopharmacology

authors： Langosch JM,Spiegelhalder K,Jahnke K,Feige B,Regen W,Kiemen A,Hennig J,Olbrich HM

更新日期：2012-10-01 00:00:00

abstract：:Minority women often have a unique set of beliefs and expectations about medical treatment. At this time, there is a dearth of research looking at how depressed minority women respond to pharmacological interventions for the sexual concomitants of depression. This was the first study to examine the impact of a medicat...

journal_title：Journal of clinical psychopharmacology

authors： Dobkin RD,Menza M,Marin H,Allen LA,Rousso R,Leiblum SR

更新日期：2006-02-01 00:00:00

abstract：:Switching antipsychotic regimen to agents with low weight gain potential has been suggested in patients who gain excessive weight on their antipsychotic therapy. In an open-label pilot study, we evaluated the metabolic and psychiatric efficacy of switching to aripiprazole in 15 (9 men, 6 women) outpatients with schizo...

journal_title：Journal of clinical psychopharmacology

authors： Kim SH,Ivanova O,Abbasi FA,Lamendola CA,Reaven GM,Glick ID

更新日期：2007-08-01 00:00:00

abstract：:Individual daily dosages of nortriptyline (NT) can be predicted from administration of a 50-mg or 100-mg single test dose, with a determination of the plasma level 24 hours later. Because the 50-mg or 100-mg test dose used in previous studies may cause unmanageable acute side effects in elderly patients, a 25-mg NT te...

journal_title：Journal of clinical psychopharmacology

authors： Schneider LS,Cooper TB,Staples FR,Sloane RB

更新日期：1987-10-01 00:00:00

abstract：:Hospital-treated deliberate self-poisoning (DSP) by central nervous system depressant drugs (CNS-D) has been associated with impairments in cognitive and psychomotor functions at the time of discharge. We aimed to replicate this finding and to compare recovery in the first month after discharge for CNS-D and CNS nonde...

journal_title：Journal of clinical psychopharmacology

authors： Oxley SO,Dassanayake TL,Carter GL,Whyte I,Jones AL,Cooper G,Michie PT

更新日期：2015-12-01 00:00:00

abstract：:A case of treatment-resistant catatonic stupor responding to combined lithium-neuroleptic medications is described. As there are no reports in the literature of combined lithium-neuroleptic medications being effective for this potentially life-threatening disorder, the course of recovery is detailed and the risks and ...

journal_title：Journal of clinical psychopharmacology

authors： Climo LH

更新日期：1985-06-01 00:00:00

abstract：PURPOSE/BACKGROUND:The aim of this study was to evaluate the effects of quetiapine XR and lithium on actigraphy-measured circadian parameters in patients with bipolar II depression. METHODS/PROCEDURES:This was an 8-week, open-label, prospective, randomized comparative study. The assessments included the 17-item Hamilt...

journal_title：Journal of clinical psychopharmacology

authors： Hwang JY,Choi JW,Kang SG,Hwang SH,Kim SJ,Lee YJ

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Some studies have shown that low dose of neuroleptic addition to ongoing antiobsessive treatment might be effective in treatment resistant obsessive-compulsive disorder (OCD). The primary purpose of this study was to evaluate the efficacy of low-dose quetiapine in clomipramine and serotonin reuptake inhibito...

journal_title：Journal of clinical psychopharmacology

authors： Sevincok L,Topuz A

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to use a visual analog scale (VAS) longitudinally measuring somnolence severity in patients with bipolar disorder. METHODS:A data set of patients with bipolar spectrum disorders who were randomized to lithium or quetiapine-IR for 16 weeks was used. The somnolence severity was measur...

journal_title：Journal of clinical psychopharmacology

authors： Gao K,Su M,Ganocy SJ,Goto T,Yuan C,Fang F,Conroy C,Brownrigg B,Serrano MB,Calabrese JR

更新日期：2019-05-01 00:00:00

abstract：:In a double-blind study of 34 randomly assigned depressed inpatients, antidepressant-induced electroencephalogram (EEG) abnormalities were compared in amitriptyline-treated versus bupropion-treated patients. Drug-free baseline EEGs plus one or more repeat EEGs under pharmacokinetic steady state conditions were obtaine...

journal_title：Journal of clinical psychopharmacology

authors： Preskorn SH,Othmer SC,Lai CW,Othmer E

更新日期：1984-10-01 00:00:00

abstract：:The cholinergic-adrenergic balance hypothesis of affective disorders suggests that, in the areas of the brain that regulate mood, depression may represent a relative predominance of central cholinergic tone over adrenergic tone and that mania may represent the converse. Currently, converging lines of investigation fro...

journal_title：Journal of clinical psychopharmacology

authors： Risch SC,Kalin NH,Janowsky DS

更新日期：1981-07-01 00:00:00

abstract：:The study describes prescription patterns of psychotropic medications for patients treated for psychosis in psychiatric hospitals of Uganda. A cross-sectional quantitative survey of age, sex, diagnoses, and psychotropic medication of 682 psychiatric inpatients of the 2 national referral hospitals in Uganda was conduct...

journal_title：Journal of clinical psychopharmacology

authors： Rukat A,Musisi S,Ströhle A,Mundt AP

更新日期：2014-10-01 00:00:00

abstract：:In this nationwide population-based study, we examined whether haloperidol exposure is associated with a higher risk of mortality than are other antipsychotic medications. Patients who newly received monotherapy with chlorpromazine (n = 2133), haloperidol (n = 4454), quetiapine (n = 1513), and risperidone (n = 1046) b...

journal_title：Journal of clinical psychopharmacology

authors： Wang LJ,Lee SY,Yuan SS,Yang KC,Yang CJ,Lee TL,Shyu YC

更新日期：2016-02-01 00:00:00

abstract：:To assess the effect of carbamazepine (CBZ) upon total serum cholesterol, we examined 38 inpatients with affective illness and one with multiple personality disorder who received a course of CBZ monotherapy. CBZ therapy yielded significant increases in total serum cholesterol that became evident during the second week...

journal_title：Journal of clinical psychopharmacology

authors： Brown DW,Ketter TA,Crumlish J,Post RM

更新日期：1992-12-01 00:00:00

abstract：:A decrease in heart rate variability (HRV) can indicate increased sympathetic nervous system activity and possibly increased norepinephrine levels. In this randomized, placebo- and escitalopram (ESC)-controlled, subject-blind, 2-period, crossover study, 26 healthy subjects 50 to 65 years old received duloxetine (DLX) ...

journal_title：Journal of clinical psychopharmacology

authors： Chappell JC,Kovacs R,Haber H,Wright R,Mitchell MI,Detke M,Pangallo B

更新日期：2013-04-01 00:00:00

abstract：:Higher prevalence rates of metabolic syndrome (MetS) in patients with schizophrenia are getting more and more attention. Uric acid (UA) has been frequently reported to be associated with MetS in the general population. Sex difference in this relationship is inconsistent. As a selective antioxidant, UA has also been fo...

journal_title：Journal of clinical psychopharmacology

authors： Chiu CC,Chen CH,Huang MC,Chen PY,Tsai CJ,Lu ML

更新日期：2012-10-01 00:00:00

abstract：:Olanzapine therapeutic drug monitoring (TDM) is the measurement of plasma olanzapine to assess adherence and guide dosage. We have audited data from an olanzapine TDM service, 1999-2009. Multiple linear regression analysis was conducted to investigate the contribution of dose, age, sex, body weight, and smoking status...

journal_title：Journal of clinical psychopharmacology

authors： Patel MX,Bowskill S,Couchman L,Lay V,Taylor D,Spencer EP,Flanagan RJ

更新日期：2011-08-01 00:00:00

abstract：:Increasing attention is being paid to the development and dissemination of effective pharmacotherapies for the treatment of alcohol and other drug dependence. However, numerous structural and philosophical barriers impede the widespread adoption of these treatment approaches in everyday clinical practice. Research is ...

journal_title：Journal of clinical psychopharmacology

authors： Ducharme LJ,Knudsen HK,Roman PM

更新日期：2006-12-01 00:00:00

abstract：:Lithium is clinically available for the treatment of mood disorders. However, it has remained unclear how lithium acts on the brain to produce its effects. The aim of this study was to evaluate the effects of chronic lithium on human brain activity using positron emission tomography and clarify the correlation between...

journal_title：Journal of clinical psychopharmacology

authors： Kohno T,Shiga T,Toyomaki A,Kusumi I,Matsuyama T,Inoue T,Katoh C,Koyama T,Tamaki N

更新日期：2007-12-01 00:00:00