Abstract:
:Zolpidem is an imidazopyridine hypnotic that is biochemically distinct from classic benzodiazepine agonists in that it may be selective for the BZ1 receptor subtype and shows a different pattern of distribution of binding sites. The present study compared the learning, recall, performance, subject-rated and observer-rated effects of zolpidem, triazolam, and temazepam in 11 healthy humans. Placebo, zolpidem (5, 10, and 20 mg/70 kg), triazolam (0.125, 0.25, and 0.50 mg/70 kg), and temazepam (15, 30, and 60 mg/70 kg) were administered orally in a randomized, double-blind, cross-over design. Zolpidem, triazolam, and temazepam produced orderly dose- and time-related impairment of learning, recall, and performance, and increased subject- and observer-rated estimates of strength of drug effect. The absolute magnitude of these effects at peak effect were comparable across the three compounds. The time to maximal drug effect was faster with zolpidem (0.5-1.0 hours) than with triazolam (1.5-2.0 hours) or temazepam (2-3 hours). These results suggest that despite the somewhat unique benzodiazepine receptor-binding profile of zolpidem, its behavioral and subject-rated effects are similar to those of benzodiazepine hypnotics (i.e., triazolam and temazepam).
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Rush CR,Griffiths RRdoi
10.1097/00004714-199604000-00007subject
Has Abstractpub_date
1996-04-01 00:00:00pages
146-57issue
2eissn
0271-0749issn
1533-712Xjournal_volume
16pub_type
临床试验,杂志文章,随机对照试验abstract::Pregabalin is a novel compound in development for the treatment of anxiety disorders. The safety and efficacy of pregabalin for the treatment of social anxiety disorder was evaluated in a double-blind, multicenter clinical trial in which 135 patients were randomized to 10 weeks of double-blind treatment with either pr...
journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章
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更新日期:1997-06-01 00:00:00
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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