Cross-sectional comparison of fasting lipids in normoglycemic patients with schizophrenia during chronic treatment with olanzapine, risperidone, or typical antipsychotics.

abstract：:This UK multicenter, noncomparative, open-trial study assessed risperidone in 74 first-psychotic-episode patients (DSM-IV schizophrenia) treated with flexible doses. Treatment commenced at 1 mg/day, increasing to 2 mg after 3 days; then adjusted to 8 mg/day maximum. Treatment duration was 12 weeks (Phase 1) with follo...

journal_title：Journal of clinical psychopharmacology

authors： Huq ZU,RIS-GBR-32 Investigators.

更新日期：2004-04-01 00:00:00

abstract：:Many drugs, including alcohol and stimulants, demonstrably increase sociability and verbal interaction and are recreationally consumed in social settings. One drug, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), seems to produce its prosocial effects by increasing plasma oxytocin levels, and the oxytocin system ha...

journal_title：Journal of clinical psychopharmacology

authors： Bershad AK,Kirkpatrick MG,Seiden JA,de Wit H

更新日期：2015-06-01 00:00:00

abstract：:The ability of the Hamilton Rating Scale for Anxiety, the Hamilton Rating Scale for Depression, and 50 items from the self-rated Hopkins Symptom Checklist to discriminate generalized anxiety disorder from major depressive disorder was examined for over 3,000 patients entering studies in three drug development projects...

journal_title：Journal of clinical psychopharmacology

authors： Copp JE,Schwiderski UE,Robinson DS

更新日期：1990-06-01 00:00:00

abstract：:A study of medication compliance, side effects, and clinical change with the use of antidepressants in 32 Southeast Asian refugee patients seen at an urban mental health center is reported. Patients met criteria for either major depressive episode, posttraumatic stress disorder, or both. Only five of the 32 patients w...

journal_title：Journal of clinical psychopharmacology

authors： Kroll J,Linde P,Habenicht M,Chan S,Yang M,Vang T,Souvannasoth L,Nguyen T,Ly M,Nguyen H

更新日期：1990-08-01 00:00:00

abstract：:A decrease in heart rate variability (HRV) can indicate increased sympathetic nervous system activity and possibly increased norepinephrine levels. In this randomized, placebo- and escitalopram (ESC)-controlled, subject-blind, 2-period, crossover study, 26 healthy subjects 50 to 65 years old received duloxetine (DLX) ...

journal_title：Journal of clinical psychopharmacology

authors： Chappell JC,Kovacs R,Haber H,Wright R,Mitchell MI,Detke M,Pangallo B

更新日期：2013-04-01 00:00:00

abstract：:Side effect and health status changes were measured in 3 studies in which outpatients experiencing suboptimal efficacy or tolerability with their current antipsychotic were switched to 6 weeks of open-label ziprasidone. The studies differed only in the patient's prior antipsychotic; 1 study group was on olanzapine (n ...

journal_title：Journal of clinical psychopharmacology

authors： Weiden PJ,Daniel DG,Simpson G,Romano SJ

更新日期：2003-12-01 00:00:00

abstract：:Hypersalivation is a frequent, disturbing, and uncomfortable adverse effect of clozapine therapy that frequently leads to noncompliance. The aim of this study was to examine the efficacy of metoclopramide (dopamine D2 antagonist, antiemetic medication) as an option for management of hypersalivation associated with clo...

journal_title：Journal of clinical psychopharmacology

authors： Kreinin A,Miodownik C,Mirkin V,Gaiduk Y,Yankovsky Y,Bersudsky Y,Lerner PP,Bergman J,Lerner V

更新日期：2016-06-01 00:00:00

abstract：:This 12-week, double-blind, multicenter trial evaluated the efficacy of venlafaxine extended release (ER), sertraline, and placebo in adult outpatients (N = 538) with a primary diagnosis of posttraumatic stress disorder (PTSD), as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, sy...

journal_title：Journal of clinical psychopharmacology

authors： Davidson J,Rothbaum BO,Tucker P,Asnis G,Benattia I,Musgnung JJ

更新日期：2006-06-01 00:00:00

abstract：:In a recent study, the authors suggested that tachycardia, dry mouth, and sweating continued to burden patients with panic disorder with agoraphobia who have shown marked and stable response to 6 months of imipramine treatment at the fixed, weight-adjusted dose of 2.25 mg/kg/day. Although sexual dysfunction and weight...

journal_title：Journal of clinical psychopharmacology

authors： Mavissakalian M,Perel J,Guo S

更新日期：2002-04-01 00:00:00

abstract：:Patients with obsessive-compulsive disorder (OCD) have been shown to be preferentially responsive to serotonin (5-HT) uptake-inhibiting antidepressants including clomipramine, fluoxetine, fluvoxamine, and sertraline. The nontricyclic antidepressant, trazodone, also possesses serotonin reuptake inhibiting properties an...

journal_title：Journal of clinical psychopharmacology

authors： Pigott TA,L'Heureux F,Rubenstein CS,Bernstein SE,Hill JL,Murphy DL

更新日期：1992-06-01 00:00:00

abstract：:In this 6-week, open-label trial, combat veterans meeting DSM-IV criteria for posttraumatic stress disorder (PTSD) were treated with the atypical antipsychotic quetiapine. The starting dose was 25 mg at bedtime with subsequent titration based on tolerability and clinical response. Primary outcome was measured using th...

journal_title：Journal of clinical psychopharmacology

authors： Hamner MB,Deitsch SE,Brodrick PS,Ulmer HG,Lorberbaum JP

更新日期：2003-02-01 00:00:00

abstract：:This study tested the association between tardive dyskinesia (TD) and polymorphic variations in (a) 2 cytochrome P450 (CYP) genes (CYP2D6 or CYP3A5), (b) 2 DRD2 variants (Ser311Cys and -141C Ins/del) and the Ser9Gly DRD3 variants, (c) 2 glutathione S-transferases (GSTT1 and GSTM1), and (d) variations in the PgP gene, ...

journal_title：Journal of clinical psychopharmacology

authors： de Leon J,Susce MT,Pan RM,Koch WH,Wedlund PJ

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Antipsychotic drugs are well established to alter serum prolactin levels, often resulting in adverse effects including amenorrhea, galactorrhea, osteoporosis, and loss of libido. There is growing preclinical evidence that prolactin-elevating drugs can instigate the progression of precancerous lesions to brea...

journal_title：Journal of clinical psychopharmacology

authors： Rahman T,Patrick C,Ma C,Nicol GE,Reynolds CF 3rd,Mulsant BH,Hartz SM,Yingling M,Lenze EJ

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Anxiety symptoms frequently experienced by patients with a major neurocognitive disorder (NCD) are often treated with long-term benzodiazepines despite known adverse effects. Pregabalin has shown efficacy in generalized anxiety disorders but has not been studied in patients with a major NCD. The objective of...

journal_title：Journal of clinical psychopharmacology

authors： Novais T,Doutone A,Gombault C,Krolak-Salmon P,Lepetit A,Mouchoux C

更新日期：2019-05-01 00:00:00

abstract：:Olanzapine therapeutic drug monitoring (TDM) is the measurement of plasma olanzapine to assess adherence and guide dosage. We have audited data from an olanzapine TDM service, 1999-2009. Multiple linear regression analysis was conducted to investigate the contribution of dose, age, sex, body weight, and smoking status...

journal_title：Journal of clinical psychopharmacology

authors： Patel MX,Bowskill S,Couchman L,Lay V,Taylor D,Spencer EP,Flanagan RJ

更新日期：2011-08-01 00:00:00

abstract：PURPOSE/BACKGROUND:For approximately one third of individuals treated for psychosis or schizophrenia, antipsychotic medications will have little or no therapeutic benefit. Clozapine remains the sole medication approved for treatment-resistant schizophrenia, and studies have demonstrated its superior efficacy in reducin...

journal_title：Journal of clinical psychopharmacology

authors： Doyle R,Behan C,OʼKeeffe D,Masterson S,Kinsella A,Kelly A,Sheridan A,Keating D,Hynes C,Madigan K,Lawlor E,Clarke M

更新日期：2017-10-01 00:00:00

abstract：:The aim of this study was to estimate the long-term effectiveness of olanzapine as adjunctive therapy in patients with bipolar disorder who exhibited an inadequate response to mood stabilizers. Twenty-three Research Diagnostic Criteria (RDC) patients with bipolar I and II were assessed by means of the Schedule for Aff...

journal_title：Journal of clinical psychopharmacology

authors： Vieta E,Reinares M,Corbella B,Benabarre A,Gilaberte I,Colom F,Martínez-Arán A,Gastó C,Tohen M

更新日期：2001-10-01 00:00:00

abstract：PURPOSE/BACKGROUND:The aim of this study was to evaluate the effects of quetiapine XR and lithium on actigraphy-measured circadian parameters in patients with bipolar II depression. METHODS/PROCEDURES:This was an 8-week, open-label, prospective, randomized comparative study. The assessments included the 17-item Hamilt...

journal_title：Journal of clinical psychopharmacology

authors： Hwang JY,Choi JW,Kang SG,Hwang SH,Kim SJ,Lee YJ

更新日期：2017-06-01 00:00:00

abstract：:The present study was conducted to derive pediatric mianserin pharmacokinetic parameters, which were compared to those from healthy young adults, and to obtain preliminary information regarding the utility of mianserin for the management of hyperkinesis in children. The sample consisted of six prepubescent children wi...

journal_title：Journal of clinical psychopharmacology

authors： Winsberg BG,Camp-Bruno JA,Vink J,Timmer CJ,Sverd J

更新日期：1987-06-01 00:00:00

abstract：:Although recent treatment guidelines for schizophrenia recommend that the prior antipsychotic agent should remain stable for at least 2 weeks when aripiprazole is introduced, there is no trial-based evidence to support this strategy. This study was designed to compare this strategy with another conventional one in pat...

journal_title：Journal of clinical psychopharmacology

authors： Takeuchi H,Suzuki T,Uchida H,Nakajima S,Nomura K,Kikuchi T,Manki H,Watanabe K,Kashima H

更新日期：2008-10-01 00:00:00

abstract：:Cerebral event-related potentials arise from synchronous neural activity associated with cognitive processing. The P3 is a late positive component that is related to task complexity and is directly proportional to stimulus evaluation time. P3 latency and amplitude were examined after oral administration of diazepam, a...

journal_title：Journal of clinical psychopharmacology

authors： Ray PG,Meador KJ,Loring DW

更新日期：1992-12-01 00:00:00

abstract：:Lithium augmentation, the most studied augmentation strategy for depression, has not been evaluated in patients with a history of non-response to multiple antidepressants. The objective of this study was to assess the efficacy of lithium augmentation for patients with a history of treatment resistant depression who al...

journal_title：Journal of clinical psychopharmacology

authors： Nierenberg AA,Papakostas GI,Petersen T,Montoya HD,Worthington JJ,Tedlow J,Alpert JE,Fava M

更新日期：2003-02-01 00:00:00

abstract：:The selection of appropriate subjects is a critical element of successful clinical trials. Failure to properly identify, select, and retain subjects in clinical trials of antidepressant medications may affect the ability to show separation from placebo. Little is known about which type of site, academic or nonacademic...

journal_title：Journal of clinical psychopharmacology

authors： Dording CM,Dalton ED,Pencina MJ,Fava M,Mischoulon D

更新日期：2012-02-01 00:00:00

abstract：:Ahead of Print article withdrawn by publisher. ...

journal_title：Journal of clinical psychopharmacology

authors： Gurrera RJ,Velamoor V,Cernovsky ZZ

更新日期：2013-08-22 00:00:00

abstract：:How do we best teach clinical psychopharmacology to trainees and clinicians, so they not only increase their knowledge base, but even more importantly also learn to practice the most informed, evidence-based practice possible? This article attempts to answer this elusive question by compiling the individual and combin...

journal_title：Journal of clinical psychopharmacology

authors： Zisook S,Glick ID,Jefferson JW,Wagner KD,Salzman C,Peselow ED,Stahl S

更新日期：2008-02-01 00:00:00

abstract：:The aim of the study was to determine whether baseline pain was associated with discernible clinical features and treatment outcomes for patients with major depressive disorder (MDD) receiving 6-week fluoxetine treatment. A total of 131 inpatients with acutely ill MDD were enrolled to receive 20 mg of fluoxetine daily...

journal_title：Journal of clinical psychopharmacology

authors： Lin HS,Wang FC,Lin CH

更新日期：2015-12-01 00:00:00

abstract：:We examined kinetic and dynamic factors to determine the pharmacological and behavioral safety and tolerability of low versus high doses of an opiate antagonist, naltrexone (50 mg/day vs. 100 mg/day), and acamprosate (2 g/day vs. 3 g/day), a functional N-methyl-D-aspartate receptor antagonist, both independently and c...

journal_title：Journal of clinical psychopharmacology

authors： Johnson BA,O'Malley SS,Ciraulo DA,Roache JD,Chambers RA,Sarid-Segal O,Couper D

更新日期：2003-06-01 00:00:00

abstract：:In an open clinical trial, serum concentrations of haloperidol pyridinium (C(HP+)) and reduced haloperidol pyridinium (C(RHP+)), as well as haloperidol (CH) and reduced haloperidol (C(RH)), were measured in 57 schizophrenic and schizoaffective inpatients during 6 weeks of short-term treatment. Psychopathology was moni...

journal_title：Journal of clinical psychopharmacology

authors： Ulrich S,Neuhof S,Braun V,Danos P,Pester U,Hoy L

更新日期：2000-04-01 00:00:00

abstract：:This 6-week, double-blind, placebo-controlled study evaluated paliperidone extended-release (ER) as both monotherapy and adjunctive therapy to mood stabilizers and/or antidepressants (MS/ADs) for schizoaffective disorder. Included subjects had a schizoaffective disorder diagnosis; a Positive and Negative Syndrome Scal...

journal_title：Journal of clinical psychopharmacology

authors： Canuso CM,Schooler N,Carothers J,Turkoz I,Kosik-Gonzalez C,Bossie CA,Walling D,Lindenmayer JP

更新日期：2010-10-01 00:00:00

abstract：:Twenty-four healthy male and female subjects, who participated in this randomized, double-blind, crossover study, received single nighttime doses of zaleplon 10 mg (therapeutic dose), zaleplon 20 mg, zolpidem 10 mg (therapeutic dose), zolpidem 20 mg, triazolam 0.25 mg (positive control), and placebo. Subjective behavi...

journal_title：Journal of clinical psychopharmacology

authors： Troy SM,Lucki I,Unruh MA,Cevallos WH,Leister CA,Martin PT,Furlan PM,Mangano R

更新日期：2000-06-01 00:00:00