Rating the raters: assessing the quality of Hamilton rating scale for depression clinical interviews in two industry-sponsored clinical drug trials.

abstract：:In an open label study, two fixed doses of nifedipine (30 mg and 60 mg daily) were added to the usual antipsychotic drug treatments of 10 patients suffering from chronic schizophrenia. While no patient experienced significant improvements, statistically significant falls in Brief Psychiatric Rating Scales scores were ...

journal_title：Journal of clinical psychopharmacology

authors： Stedman TJ,Whiteford HA,Eyles D,Welham JL,Pond SM

更新日期：1991-02-01 00:00:00

abstract：:In a prospective study of all geriatric patients treated with tricyclic antidepressants over an 18-month period, a lower incidence of adverse psychiatric reactions than literature based on chart reviews has suggested was found. In only three of the 43 patients studied (7%) did a picture consistent with toxic delirium ...

journal_title：Journal of clinical psychopharmacology

authors： Meyers BS,Mei-Tal V

更新日期：1983-02-01 00:00:00

abstract：:The quest for additional effective therapies for bipolar study commenced in the 1960s, even before regulatory approval of lithium. This was driven by the recognition that patient response to lithium varied from excellent to poor; thus, significant numbers of patients faced its frequent adverse effects and risks withou...

journal_title：Journal of clinical psychopharmacology

authors： Bowden CL

更新日期：1996-04-01 00:00:00

abstract：:The reinforcing effects of methylphenidate (20-40 mg), d-amphetamine (10-20 mg), and placebo were assessed in eight healthy, non-sleep-deprived, non-drug-abusing outpatient volunteers. A modified progressive-ratio schedule was used to assess drug reinforcement in which a sampling session always preceded a self-adminis...

journal_title：Journal of clinical psychopharmacology

authors： Rush CR,Essman WD,Simpson CA,Baker RW

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:The present study aimed to assess the level of agreement between clinicians' routine assessments of medication status and plasma levels of commonly prescribed antipsychotic medications in patients presenting to an emergency room with an exacerbation of psychosis. METHODS:We studied 105 patients presenting to a...

journal_title：Journal of clinical psychopharmacology

authors： Lopez LV,Shaikh A,Merson J,Greenberg J,Suckow RF,Kane JM

更新日期：2017-06-01 00:00:00

abstract：:Results of previous studies on the safety of antidepressants during pregnancy have been conflicting. The primary objective of this study was to investigate whether first-trimester exposure to antidepressants, specifically selective serotonin reuptake inhibitors (SSRIs), was associated with increased risk of congenital...

journal_title：Journal of clinical psychopharmacology

authors： Nordeng H,van Gelder MM,Spigset O,Koren G,Einarson A,Eberhard-Gran M

更新日期：2012-04-01 00:00:00

abstract：:This 6-week, double-blind, placebo-controlled study evaluated paliperidone extended-release (ER) as both monotherapy and adjunctive therapy to mood stabilizers and/or antidepressants (MS/ADs) for schizoaffective disorder. Included subjects had a schizoaffective disorder diagnosis; a Positive and Negative Syndrome Scal...

journal_title：Journal of clinical psychopharmacology

authors： Canuso CM,Schooler N,Carothers J,Turkoz I,Kosik-Gonzalez C,Bossie CA,Walling D,Lindenmayer JP

更新日期：2010-10-01 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder (PTSD). This 12-week, multicenter, double-blind study randomized patients to receive either tiagabine or placebo. Tiagabine (administered in divided doses) was initiated at 4 mg/d (2 m...

journal_title：Journal of clinical psychopharmacology

authors： Davidson JR,Brady K,Mellman TA,Stein MB,Pollack MH

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Second-generation antipsychotics (SGAs) are commonly used to treat children with mental health conditions (MHCs) but are associated with adverse effects including obesity, hypertension, dyslipidemia, and type 2 diabetes. The mechanisms underlying these complications are unknown, but it has been suggested tha...

journal_title：Journal of clinical psychopharmacology

authors： Ngai YF,Devlin AM,Panagiotopoulos C

更新日期：2018-12-01 00:00:00

abstract：:Depression is a common disorder in pregnancy and associated with adverse effects for both mother and neonate. Pharmacological treatment and prevention options include mirtazapine. In a series of 56 cases, we investigated neonatal outcome after intrauterine exposure to mirtazapine and exposure through lactation in the ...

journal_title：Journal of clinical psychopharmacology

authors： Smit M,Wennink H,Heres M,Dolman KM,Honig A

更新日期：2015-04-01 00:00:00

abstract：:Serotonin 2C and 2A receptor (5-HT2C and 5-HT2A) antagonisms are hypothesized to play a role in the metabolic adverse effects induced by olanzapine and clozapine. Associations between polymorphisms in 5-HT2C and 5-HT2A receptor coding genes, HTR2C and HTR2A, with antipsychotic-induced weight gain have been reported. T...

journal_title：Journal of clinical psychopharmacology

authors： Gunes A,Melkersson KI,Scordo MG,Dahl ML

更新日期：2009-02-01 00:00:00

abstract：:Despite a recognized need for the inclusion of women of childbearing age in drug studies, many such studies include only men. This practice is due mainly to the added risk of teratogenicity and to cyclic variations in the menstrual phase and hormonal state. The methodological and ethical problems associated with drug ...

journal_title：Journal of clinical psychopharmacology

authors： Halbreich U,Carson SW

更新日期：1989-10-01 00:00:00

abstract：:The cholinergic-adrenergic balance hypothesis of affective disorders suggests that, in the areas of the brain that regulate mood, depression may represent a relative predominance of central cholinergic tone over adrenergic tone and that mania may represent the converse. Currently, converging lines of investigation fro...

journal_title：Journal of clinical psychopharmacology

authors： Risch SC,Kalin NH,Janowsky DS

更新日期：1981-07-01 00:00:00

abstract：:This article reports results for patients who completed the 16-week maintenance phase of a double-blind clinical trial comparing buprenorphine (N = 43; average dose = 9.0 mg/day sublingually) with methadone (N = 43; average dose = 54 mg/day orally) in the outpatient treatment of opioid dependence. In addition to pharm...

journal_title：Journal of clinical psychopharmacology

authors： Strain EC,Stitzer ML,Liebson IA,Bigelow GE

更新日期：1996-02-01 00:00:00

abstract：:This 12-week, double-blind, multicenter trial evaluated the efficacy of venlafaxine extended release (ER), sertraline, and placebo in adult outpatients (N = 538) with a primary diagnosis of posttraumatic stress disorder (PTSD), as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, sy...

journal_title：Journal of clinical psychopharmacology

authors： Davidson J,Rothbaum BO,Tucker P,Asnis G,Benattia I,Musgnung JJ

更新日期：2006-06-01 00:00:00

abstract：:The aim of the study was to investigate the use of antidepressant drugs among elderly people in nursing homes. Elderly residents who where found to have been prescribed at least one antidepressant drug according to the specific medication dispensing system were identified in 8 nursing homes in the county of Ostergötla...

journal_title：Journal of clinical psychopharmacology

authors： Chermá MD,Löfgren UB,Almkvist G,Hallert C,Bengtsson F

更新日期：2008-08-01 00:00:00

abstract：:Weight gain is a problem commonly encountered with antipsychotic treatment and has become more apparent with increasing use of the newer atypical antipsychotics. The adipocyte-derived hormone, leptin, has been associated with body weight and energy homeostasis, and abnormal regulation of leptin could play a role in we...

journal_title：Journal of clinical psychopharmacology

authors： Zhang XY,Tan YL,Zhou DF,Haile CN,Cao LY,Xu Q,Shen Y,Kosten TA,Kosten TR

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Anxiety symptoms frequently experienced by patients with a major neurocognitive disorder (NCD) are often treated with long-term benzodiazepines despite known adverse effects. Pregabalin has shown efficacy in generalized anxiety disorders but has not been studied in patients with a major NCD. The objective of...

journal_title：Journal of clinical psychopharmacology

authors： Novais T,Doutone A,Gombault C,Krolak-Salmon P,Lepetit A,Mouchoux C

更新日期：2019-05-01 00:00:00

abstract：:Valproic acid (VPA) has been used for decades in the treatment of epilepsy and psychiatric disorders, and the long-term use of VPA is regularly accompanied by hematological toxicity, including neutropenia. More recently, it has been demonstrated that VPA can be used as a histone deacetylase inhibitor (HDACi) for the t...

journal_title：Journal of clinical psychopharmacology

authors： Bartels M,van Solinge WW,den Breeijen HJ,Bierings MB,Coffer PJ,Egberts TC

更新日期：2012-12-01 00:00:00

abstract：:In this review, the physiologic and pharmacologic effects of tricyclic antidepressants are discussed as they apply to an overdose situation. Systemic arterial hypotension is a frequent occurrence in major overdoses. Occasionally conventional resuscitative measures such as crystalloid or colloid infusion are inadequate...

journal_title：Journal of clinical psychopharmacology

authors： Buchman AL,Dauer J,Geiderman J

更新日期：1990-12-01 00:00:00

abstract：:Case reports of a lithium-ketorolac drug interaction have been published, but no formal investigation of this interaction has been conducted. The objective of the study presented here was to determine significant changes in lithium serum and red blood cell (RBC) concentrations after lithium and ketorolac (oral formula...

journal_title：Journal of clinical psychopharmacology

authors： Cold JA,ZumBrunnen TL,Simpson MA,Augustin BG,Awad E,Jann MW

更新日期：1998-02-01 00:00:00

abstract：PURPOSE/BACKGROUND:Extensive research has been conducted comparing the metabolic characteristics of older second-generation antipsychotics (SGAs); minimal data exist comparing the long-term metabolic effects of SGAs approved in the last 10 years. METHODS/PROCEDURES:A retrospective chart review of patients treated with...

journal_title：Journal of clinical psychopharmacology

authors： Greger J,Aladeen T,Lewandowski E,Wojcik R,Westphal E,Rainka M,Capote H

更新日期：2021-01-01 00:00:00

abstract：:This report notes the incidence and quality of paraesthesiae related to treatment with risperidone, as well as potential implications for treatment. Possible pathophysiologic explanations are offered. ...

journal_title：Journal of clinical psychopharmacology

authors： Heimberg C,Yearian AS

更新日期：1996-12-01 00:00:00

abstract：:Platelet monoamine oxidase (MAO) activity was studied in bipolar and schizophrenic patients treated with lithium and was found to be increased as a nonspecific drug effect. Greater MAO increase in manic patients was correlated with lesser clinical improvement. There was no correlation of MAO activity with short-term o...

journal_title：Journal of clinical psychopharmacology

authors： Huang LG,Bowden CL

更新日期：1984-12-01 00:00:00

abstract：:Four patients with obsessive-compulsive disorder (DSM-III and RDC) were treated in an open trial with alprazolam. Moderate to marked improvement was noted in the degree of obsessionality, anxiety with motor tension, and secondary affective changes. The mixed anxiolytic-antidepressant properties of alprazolam are theor...

journal_title：Journal of clinical psychopharmacology

authors： Tollefson G

更新日期：1985-02-01 00:00:00

abstract：:The evolution of resistance of positive symptoms to antipsychotic therapy may represent a valuable means of subtyping schizophrenia. In contrast, resistance of negative symptoms and cognitive function to antipsychotic agents seems to be present from the first episode of psychotic symptoms and does not evolve over time...

journal_title：Journal of clinical psychopharmacology

authors： Meltzer HY,Lee M,Cola P

更新日期：1998-04-01 00:00:00

abstract：:Depression in the elderly patient may present special challenges for the design of clinical treatment trials due to a complex antidepressant treatment history, individual contraindications to certain medications, medical comorbidity, as well as concurrent medications for other medical conditions. The chronic, relapsin...

journal_title：Journal of clinical psychopharmacology

authors： Lavori PW

更新日期：2005-08-01 00:00:00

abstract：:The present study was conducted to derive pediatric mianserin pharmacokinetic parameters, which were compared to those from healthy young adults, and to obtain preliminary information regarding the utility of mianserin for the management of hyperkinesis in children. The sample consisted of six prepubescent children wi...

journal_title：Journal of clinical psychopharmacology

authors： Winsberg BG,Camp-Bruno JA,Vink J,Timmer CJ,Sverd J

更新日期：1987-06-01 00:00:00

abstract：:To assess the effect of carbamazepine (CBZ) upon total serum cholesterol, we examined 38 inpatients with affective illness and one with multiple personality disorder who received a course of CBZ monotherapy. CBZ therapy yielded significant increases in total serum cholesterol that became evident during the second week...

journal_title：Journal of clinical psychopharmacology

authors： Brown DW,Ketter TA,Crumlish J,Post RM

更新日期：1992-12-01 00:00:00

abstract：:Some of the selective serotonin reuptake inhibitors (SSRI)-induced motor side effects are mediated by stimulating 5-HT2 receptors in the basal ganglia, probably because serotonin inhibits the subsequent neuronal dopamine release. We hypothesized that nefazodone, a serotonin 2 antagonist/reuptake inhibitor (SARI) that ...

journal_title：Journal of clinical psychopharmacology

authors： Avila A,Cardona X,Martin-Baranera M,Maho P,Sastre F,Bello J

更新日期：2003-10-01 00:00:00