Abstract：
:The therapeutic spectrum of nemonapride, a new substituted benzamide, and its relationship with plasma concentrations of the drug and prolactin were investigated by a fixed-dose study (18 mg/day for 3 weeks) in 31 patients with acutely exacerbated schizophrenia. Of 31 patients, 25 (80.6%) were responders who showed a reduction in symptoms (percentage of improvement) of 50% or more after 3 weeks. The mean values of percentage of improvement in scores on the total Brief Psychiatric Rating Scale (BPRS) and the five subscale symptoms were 71.5% for total, 73.2% for Positive, 86.0% for Excitement, 53.9% for Negative, 84.2% for Cognitive, and 67.5% for Anxiety-Depression. Responders had higher percentage of improvement in positive (84.6 +/- 17.0% vs. 25.9 +/- 15.7%; p < 0.001) and anxiety-depression (76.9 +/- 18.8% vs. 28.5 +/- 39.9%; p < 0.005) symptoms than did nonresponders after 3 weeks. The percentage of improvement in total BPRS after 2 weeks was well correlated with that after 3 weeks (Spearman rank correlation coefficient: r(s) = 0.711; p < 0.01). There was an inverted U-shaped relationship between plasma drug concentrations (nemonapride plus desmethylnemonapride) and percentage of improvement in total BPRS symptoms after a 3-week treatment (y = 46.9 + 73.9x - 44.2x2; p < 0.001). These findings suggest that nemonapride has a broad therapeutic spectrum in the treatment of acute schizophrenia. The improvements in scores for the Positive and Anxiety-Depression subscale symptoms are regarded as determinant factors for total response to nemonapride. An assessment of clinical status after 2 weeks and plasma drug monitoring may be useful for the prediction of the final outcome for patients.
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Kondo T,Mihara K,Yasui N,Nagashima U,Ono S,Kaneko S,Ohkubo T,Osanai T,Sugawara K,Otani Kdoi
10.1097/00004714-200008000-00003subject
Has Abstractpub_date
2000-08-01 00:00:00pages
404-9issue
4eissn
0271-0749issn
1533-712Xjournal_volume
20pub_type
临床试验,杂志文章abstract：:Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients and were robustly el...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-10-01 00:00:00
abstract：:The potential for iloperidone, a D2/5-HT2A antipsychotic, to affect the heart rate-corrected QT interval (QTc) was assessed in the absence and presence of metabolic inhibitors in a randomized, open-label, multicenter study. QT interval prolongation by medications, including both conventional and atypical antipsychotic...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/JCP.0b013e31827c0314
更新日期：2013-02-01 00:00:00
abstract：:Age and sex may influence both efficacy and side effects of second-generation antipsychotics. Women and elderly patients tend to have a higher prevalence for several side effects. Higher plasma levels in these groups of patients may be one reason. We studied the hypothesis that steady-state olanzapine plasma concentra...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/01.jcp.0000185427.08268.db
更新日期：2005-12-01 00:00:00
abstract：:Hospital-treated deliberate self-poisoning (DSP) by central nervous system depressant drugs (CNS-D) has been associated with impairments in cognitive and psychomotor functions at the time of discharge. We aimed to replicate this finding and to compare recovery in the first month after discharge for CNS-D and CNS nonde...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000000417
更新日期：2015-12-01 00:00:00
abstract：:Neuropsychiatric side effects have been reported with various systemic betablockers. Data submitted to the National Registry of Drug-Induced Ocular Side Effects appear to indicate similar adverse reactions secondary to topical ophthalmic timolol. One hundred sixty-three of 369 central nervous system cases (44%) report...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：:The aim of this study was to evaluate the efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder (PTSD). This 12-week, multicenter, double-blind study randomized patients to receive either tiagabine or placebo. Tiagabine (administered in divided doses) was initiated at 4 mg/d (2 m...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/JCP.0b013e31802e5115
更新日期：2007-02-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,多中心研究
doi：10.1097/JCP.0000000000000827
更新日期：2018-02-01 00:00:00
abstract：:Twenty-one women with generalized anxiety disorder (GAD) participated in a 6-week, double-blind, placebo-controlled trial to assess the treatment and abrupt withdrawal effects of diazepam on psychic and somatic symptoms of anxiety. The results confirmed those of previous studies reporting that (1) clinical doses of di...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/00004714-199606000-00002
更新日期：1996-06-01 00:00:00
abstract：:Drug delivery systems capable of delivering free (unconjugated) curcuminoids is of great therapeutic significance, since the absorption of bioactive and permeable form plays a key factor in mediating the efficacy of a substance which undergoes rapid biotransformation. Considering the recent understanding on the relati...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1097/JCP.0000000000000508
更新日期：2016-06-01 00:00:00
abstract：:Despite a recognized need for the inclusion of women of childbearing age in drug studies, many such studies include only men. This practice is due mainly to the added risk of teratogenicity and to cyclic variations in the menstrual phase and hormonal state. The methodological and ethical problems associated with drug ...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,评审
doi：
更新日期：1989-10-01 00:00:00
abstract：:Although many patients with major depressive disorder (MDD) complain of neurocognitive impairment, the effects of antidepressant medications on neurocognitive functions remain unclear. This study compares neurocognitive effects of tianeptine and escitalopram in MDD. Patients with MDD (N = 164) were randomly assigned i...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/JCP.0000000000000072
更新日期：2014-04-01 00:00:00
abstract：:Many factors obscure the diagnosis of psychogenic disorders, especially anxiety and depression. The factors involved include an overlap of symptoms, discrepancies in diagnostic criteria, and the unreliability of self- and observer-reporting. Differentiation among the various personality disorders is, however, extremel...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,评审
doi：10.1097/00004714-199006001-00009
更新日期：1990-06-01 00:00:00
abstract：:Data from evening questionnaires, reports of side effects, laboratory findings, and all-night respiratory measurements were collected on the 99 chronic insomniacs examined in this multicenter study. These data were used to compare the clinical safety and desirability of a benzodiazepine hypnotic with a very short half...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1990-08-01 00:00:00
abstract：:The efficacy of continuation therapy with tricyclic antidepressants has been established in a number of controlled trials. This study investigated the efficacy of continuation therapy with a relatively new antidepressant, amoxapine, using a double-blind controlled comparison with amitriptyline. Subjects met DSM-III cr...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-10-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/JCP.0b013e3181db38bb
更新日期：2010-06-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/01.jcp.0000145340.53417.ca
更新日期：2004-12-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
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更新日期：2003-10-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/00004714-199906000-00007
更新日期：1999-06-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000001174
更新日期：2020-03-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,评审
doi：10.1097/00004714-200212000-00010
更新日期：2002-12-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1097/JCP.0b013e3181ac4839
更新日期：2009-08-01 00:00:00
abstract：:Individual daily dosages of nortriptyline (NT) can be predicted from administration of a 50-mg or 100-mg single test dose, with a determination of the plasma level 24 hours later. Because the 50-mg or 100-mg test dose used in previous studies may cause unmanageable acute side effects in elderly patients, a 25-mg NT te...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1987-10-01 00:00:00
abstract：:Physician-rating scales remain the standard in antidepressant clinical trials. The current study aimed to examine the discrepancies between physician-rating scales and self-rating scales for symptoms and functioning, before and after treatment, in newly hospitalized patients. A total of 131 acutely ill inpatients with...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/JCP.0000000000000229
更新日期：2014-12-01 00:00:00
abstract：:This article reports results for patients who completed the 16-week maintenance phase of a double-blind clinical trial comparing buprenorphine (N = 43; average dose = 9.0 mg/day sublingually) with methadone (N = 43; average dose = 54 mg/day orally) in the outpatient treatment of opioid dependence. In addition to pharm...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-199602000-00010
更新日期：1996-02-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-200002000-00011
更新日期：2000-02-01 00:00:00
abstract：:Consensus guidelines which are applicable in New Zealand and worldwide recommend that the duration of exposure to antipsychotics not exceed 12 weeks, unless justified for mental illnesses like schizophrenia and severe psychotic symptoms which require longer treatment. There has been limited information on time-to-firs...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000000597
更新日期：2016-12-01 00:00:00
abstract：:This is the first placebo-controlled trial evaluating the efficacy of the selective serotonin reuptake inhibitor (SSRI), escitalopram, in the treatment of premenstrual dysphoric disorder (PMDD). Women with PMDD (intention-to-treat population, n = 151) were treated intermittently for 3 months, during luteal phases only...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1097/JCP.0b013e3181678a28
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Sexual dysfunction (SD) is an important underestimated adverse effect of antidepressant drugs. Patients, in fact, if not directly questioned, tend to scarcely report them. The aim of the present meta-analysis was to quantify SD caused by antidepressants on the basis of studies where sexual functioning was pu...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,meta分析,评审
doi：10.1097/JCP.0b013e3181a5233f
更新日期：2009-06-01 00:00:00
abstract：:The objective of this study was to assemble expert clinical experience and judgment regarding the treatment of panic disorder in a systematic, quantitative manner, particularly with respect to changes during the past 5 years. A panel of 73 internationally recognized experts in the field of pharmacotherapy of anxiety a...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/00004714-199812001-00006
更新日期：1998-12-01 00:00:00
