The effects of cannabinoids on contextual conditioned fear in CB1 knockout and CD1 mice.

abstract：:This study was designed to explore whether differences in the psychomotor, subjective and memory effects of different benzodiazepines (BDZ) relate to differences in their potencies. Two BDZs with similar kinetics but different potencies were compared. Flunitrazepam (0.5 and 1.0mg, nitrazepam (5 and 10mg) or placebo we...

journal_title：Behavioural pharmacology

authors： Pompéia S,Gorenstein C,Curran HV

更新日期：1996-11-01 00:00:00

abstract：:A runway was used to measure locomotor responses to quinpirole (200µg/kg), in rats. The locomotor stimulant effect of quinpirole increased progressively over successive trials at 3-day intervals. Animals administered quinpirole in the home cage were also sensitized, but to a lesser degree than animals tested in the ru...

journal_title：Behavioural pharmacology

authors： Willner P,Papp M,Cheeta S,Muscat R

更新日期：1992-02-01 00:00:00

abstract：:The recent recreational use of synthetic cannabinoid ligands, collectively referred to as 'Spice', has raised concerns about their safety and possible differences in their biological effect(s) from marijuana/Δ-tetrahydrocannabinol (THC). AM2201, a highly efficacious, potent cannabinoid receptor 1 (CB1R) agonist, is a ...

journal_title：Behavioural pharmacology

authors： Järbe TU,Gifford RS,Zvonok A,Makriyannis A

更新日期：2016-04-01 00:00:00

abstract：:The strain of spontaneously hypertensive rats (SHR) is considered a genetic model for the study of attention-deficit hyperactivity disorder (ADHD), as it displays hyperactivity, impulsivity and poorly sustained attention. Recently, we have shown the involvement of adenosinergic neuromodulation in the SHR's short-term ...

journal_title：Behavioural pharmacology

authors： Pires VA,Pamplona FA,Pandolfo P,Fernandes D,Prediger RD,Takahashi RN

更新日期：2009-03-01 00:00:00

abstract：:Rats were given fixed-time, 1-min food-pellet delivery sessions, for 3 h every day, which resulted in over drinking (schedule-induced polydipsia). In previous research, groups of animals came to prefer solutions of cocaine or lidocaine to concurrently presented water, if the drugs were first offered in a glucose/sacch...

journal_title：Behavioural pharmacology

authors： Falk JL,Yosef E,Schwartz A,Lau CE

更新日期：1999-02-01 00:00:00

abstract：:Male rats form short-term memory for the olfactory characteristics of juvenile conspecifics. Alaptide, a synthetic derivative of the hypothalamic MIF, given subcutaneously at doses of 0.5 and 1.0mg/kg immediately after the initial exposure to an adult male, reduced the time spent by adults in social investigation of t...

journal_title：Behavioural pharmacology

authors： Hlinák Z,Krejcí I

更新日期：1992-04-01 00:00:00

abstract：:Much evidence has shown that the inferior colliculus may be part of a brain system commanding defensive behavior. In the present work, evidence is presented for the serotonergic modulation of the neural substrate of aversive states elaborated in this structure. Rats implanted with a cannula in the inferior colliculus ...

journal_title：Behavioural pharmacology

authors： Melo LL,Brando ML

更新日期：1995-06-01 00:00:00

abstract：:There is accumulating evidence that sex plays a critical role in drug abuse. Female sex hormones have been shown to affect central nervous system function and modulate the effects of drugs of abuse. For example, γ-aminobutyric acid type A (GABA(A)) receptor function is positively modulated by progesterone metabolites....

journal_title：Behavioural pharmacology

authors： Babalonis S,Lile JA,Martin CA,Kelly TH

更新日期：2011-09-01 00:00:00

abstract：:The present experiments investigated the validity and utility of measuring the habituation of a nose-poke response to assess memory in mice. Mice were placed in an operant chamber equipped with two holes in one wall. Nose-poke responses were recorded by the interruption of a photo-beam across the openings of the holes...

journal_title：Behavioural pharmacology

authors： Brodkin J

更新日期：1999-09-01 00:00:00

abstract：:Human and animal studies provide evidence for vulnerable periods of brain development for deleterious effects of cannabinoids. We have recently shown that pubertal chronic cannabinoid treatment leads to long-lasting behavioral deficits, whereas a comparable treatment in adult rats did not affect the animals' behavior....

journal_title：Behavioural pharmacology

authors： Schneider M,Drews E,Koch M

更新日期：2005-09-01 00:00:00

abstract：:The present study investigated the ability of drug-associated cues to reinstate extinguished responding following an extended period of withdrawal from cocaine self-administration. Rats self-administered cocaine (0.33mg/infusion) for 2 weeks of daily 3-h limited-access sessions under a fixed-interval (FI) schedule of ...

journal_title：Behavioural pharmacology

authors： Meil WM,See RE

更新日期：1996-12-01 00:00:00

abstract：:Cocaine demand is a behavioral economic measure assessing drug reward value and motivation to use drug. The purpose of the current study was to develop a brief assessment of cocaine demand (BACD). Results from the BACD were compared with self-report measures of cocaine use. Participants consisted of treatment-seeking ...

journal_title：Behavioural pharmacology

authors： Yoon JH,de Dios C,Suchting R,Vincent JN,McKay SA,Lane SD,Schmitz JM

更新日期：2020-12-24 00:00:00

abstract：:The purpose of this experiment was to examine the substitution patterns produced by opioids with activity at the mu receptor in pigeons trained to discriminate the delta opioid BW373U86 from saline. A low dose of naltrindole (0.1 mg/kg) produced at least a 16-fold rightward shift in the dose-effect curve for the stimu...

journal_title：Behavioural pharmacology

authors： Picker MJ,Cook CD

更新日期：1998-07-01 00:00:00

abstract：:Synthetic cathinone derivatives are commonly considered quasi-legal alternatives for stimulant drugs, such as cocaine and methamphetamine, but some derivatives are increasingly being detected in club drug formulations of Ecstasy or 'Molly' as substitutes for methylenedioxymethamphetamine (±-MDMA). Although several stu...

journal_title：Behavioural pharmacology

authors： Gatch MB,Dolan SB,Forster MJ

更新日期：2020-06-01 00:00:00

abstract：:Drug addiction is a progressive, relapsing disease comprised of interlocking stages of disordered motivation. Numerous animal models describing various stages of the addiction process have been developed over the past few decades, providing considerable advantages for the modeling of drug addiction compared with other...

journal_title：Behavioural pharmacology

authors： Edwards S,Koob GF

更新日期：2013-09-01 00:00:00

abstract：:Memantine (1-amino-3,5-dimethyl-adamantane) is the only clinically used NMDA (N-methyl-D-aspartate) glutamate receptor antagonist. The present experiments were carried out to compare the dose-response for memantine's predictive therapeutic and side-effects in a variety of tests in C57BL/6J/Han mice, and to elucidate i...

journal_title：Behavioural pharmacology

authors： Kos T,Popik P

更新日期：2005-05-01 00:00:00

abstract：:Over the last 15 years, genetically modified mice have added important data to our knowledge on psychiatric diseases including anxiety. This has produced many behavioural publications, partially by non-behaviourists, in which differences between mutants and normal wild-type animals were described. The popularity of th...

journal_title：Behavioural pharmacology

authors： Bouwknecht JA,Paylor R

更新日期：2008-09-01 00:00:00

abstract：:The purpose of the present experiment was to assess the degree of tolerance and cross-tolerance to the response rate-decreasing effects of opioids with different degrees of intrinsic efficacy at the mu receptor. The mu opioids included buprenorphine, etorphine, l-methadone, morphine, and sufentanil. Lever pressing of ...

journal_title：Behavioural pharmacology

authors： Hughes CE,Picker MJ,Dykstra LA

更新日期：1995-12-01 00:00:00

abstract：:It has been reported that, in animals trained to discriminate ethanol, stimulus control generalized to the non-competitive NMDA antagonists phencyclidine, ketamine and dizocilpine. In the present study, rats were trained to discriminate a dose of ethanol (1g/kg, i.p.) and substitution tests were carried out with phenc...

journal_title：Behavioural pharmacology

authors： Sanger DJ

更新日期：1993-10-01 00:00:00

abstract：:Impaired social interaction is a hallmark symptom of many psychiatric diseases, including dependence syndromes (substance use disorders). Helping the addict reorient her/his behavior away from the drug of abuse toward social interaction would be of considerable therapeutic benefit. To study the neural basis of such a ...

journal_title：Behavioural pharmacology

authors： Pinheiro BS,Seidl SS,Habazettl E,Gruber BE,Bregolin T,Zernig G

更新日期：2016-04-01 00:00:00

abstract：:The involvement of adrenoreceptor blocking drugs with the 5-HT(1A)-mediated discriminative stimulus was studied in pigeons trained to discriminate the 5-HT(1A) receptor agonist 8-OH-DPAT (0.3mg/kg) from saline. Cumulative dose-response curves were determined for 8-OH-DPAT, the beta-adrenergic antagonist pindolol, the ...

journal_title：Behavioural pharmacology

authors： Zhang L,Barrett JE

更新日期：1991-11-01 00:00:00

abstract：:Animal models of nicotine dependence are fundamental experimental tools for the understanding of the neurobiological and molecular processes underlying smoking behaviour. Substance use is controlled by four main processes: positive reinforcing effects, aversive effects, discriminative effects and stimulus-conditioned ...

journal_title：Behavioural pharmacology

authors： Merlo Pich E,Chiamulera C,Carboni L

更新日期：1999-11-01 00:00:00

abstract：:Behavioral sensitization in mammals, including humans, is sensitive to factors such as administration route, testing environment, and pharmacokinetic confounds, unrelated to the drugs themselves that are difficult to eliminate. Simpler animals less susceptible to these confounding influences may be advantageous substi...

journal_title：Behavioural pharmacology

authors： Rawls SM,Patil T,Yuvasheva E,Raffa RB

更新日期：2010-07-01 00:00:00

abstract：:Three experiments examined the effects of chronic pre-exposure to caffeine on the subsequent conditioned and unconditioned locomotor activating effects of nicotine or amphetamine in rats. Rats were given daily intraperitoneal injections of caffeine anhydrous (0, 10 or 30 mg/kg base) for 30 days. Conditioning (environm...

journal_title：Behavioural pharmacology

authors： Palmatier MI,Fung EY,Bevins RA

更新日期：2003-05-01 00:00:00

abstract：:The prefrontal cortex (PFC) plays a critical role in mediating executive functions and orchestrating the way in which we think, decide, and behave. Many studies have shown that PFC neurons not only play a major role in mediating behavioral responses to stress but are also sensitive to stress and undergo remodeling fol...

journal_title：Behavioural pharmacology

authors： Bahari Z,Meftahi GH,Meftahi MA

更新日期：2018-10-01 00:00:00

abstract：:Although the dopaminergic pharmacology of the D1 receptor full agonists, dinapsoline, dihydrexidine and the prodrug ABT-431 have been studied, no information is available on the ability of these agonists to substitute for the D1 agonist SKF 38393 in rats trained to discriminate this compound from vehicle. The present ...

journal_title：Behavioural pharmacology

authors： Gleason SD,Witkin JM

更新日期：2004-02-01 00:00:00

abstract：:The dopamine agonist apomorphine (apo) elicits stereotyped pecking bouts in pigeons, a response which increases with successive apo injections. The present study sought, first, to confirm the hypothesis that this sensitization arises through a Pavlovian conditioning driven by both external and internal cues; and, seco...

journal_title：Behavioural pharmacology

authors： Acerbo MJ,Godoy AM,Delius JD

更新日期：2003-12-01 00:00:00

abstract：:Cannabinoid receptor (CBR) agonists produce antinociception in conventional preclinical assays of pain-stimulated behavior but are not effective in preclinical assays of pain-depressed behavior. Fatty acid amide hydrolase (FAAH) inhibitors increase physiological levels of the endocannabinoid anandamide, which may conf...

journal_title：Behavioural pharmacology

authors： Kwilasz AJ,Abdullah RA,Poklis JL,Lichtman AH,Negus SS

更新日期：2014-04-01 00:00:00

abstract：:Opioid-maintained volunteers were trained to distinguish between a low dose of the opioid antagonist naloxone (0.15 mg/70 kg, i.m.; i.e. Drug A) and placebo (i.e. Drug B), under an instructed novel-response drug discrimination procedure in which subjects identify the drug condition as 'A', 'B', or 'N' (neither A nor B...

journal_title：Behavioural pharmacology

authors： Oliveto A,Sevarino K,McCance-Katz E,Benios T,Poling J,Feingold A

更新日期：2003-03-01 00:00:00

abstract：:This study examined interactions between cocaine and drugs that act as direct agonists at subtypes of "D2-like" dopamine receptors. The drugs 7-OH-DPAT, quinpirole and RU24213 were studied alone and in combination with cocaine for their effects on locomotor activity in non-habituated mice. Locomotor activity was measu...

journal_title：Behavioural pharmacology

authors： Tirelli E,Reggers J,Terry P

更新日期：1997-06-01 00:00:00