Abstract:
:Male rats form short-term memory for the olfactory characteristics of juvenile conspecifics. Alaptide, a synthetic derivative of the hypothalamic MIF, given subcutaneously at doses of 0.5 and 1.0mg/kg immediately after the initial exposure to an adult male, reduced the time spent by adults in social investigation of the same juvenile upon re-exposure 4h, 24h and 72h after the initial exposure. Oxiracetam (30 and 60mg/kg) had a similar effect. Both drugs were ineffective in animals re-exposed to a novel juvenile. Thus, both alaptide and oxiracetam improved an animal's capacity to recognize the juvenile. The findings may be interpreted in terms of a prolonged retention of memory traces based on olfactory information received during a short social interaction.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Hlinák Z,Krejcí Isubject
Has Abstractpub_date
1992-04-01 00:00:00pages
129-131issue
2eissn
0955-8810issn
1473-5849journal_volume
3pub_type
杂志文章abstract::Relatively little is known about the behavioral effects of the neurosteroids compared with other drugs that modulate the γ-aminobutyric acid A (GABAA) receptor complex. This study examined the acute effects of pregnanolone and dehydroepiandrosterone (DHEA) in male rats responding under a differential-reinforcement-of-...
journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Behavioural pharmacology
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doi:
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
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更新日期:2018-10-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
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更新日期:2015-02-01 00:00:00
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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