Abstract:
:The present study investigated the ability of drug-associated cues to reinstate extinguished responding following an extended period of withdrawal from cocaine self-administration. Rats self-administered cocaine (0.33mg/infusion) for 2 weeks of daily 3-h limited-access sessions under a fixed-interval (FI) schedule of reinforcement, in which responding resulted in simultaneous illumination of a stimulus light and drug infusions. Rats were then exposed to 20 daily extinction sessions. Noncontingent presentation of the stimulus light and infusion pump sound on day 21 of extinction resulted in a significant increase in responding. Twenty days later (43 days after cocaine withdrawal), rats returned to the operant chamber and exposed to drug-associated cues responded significantly more than animals exposed to extinction conditions. In a second experiment, using a form of variable-interval schedule in which the stimulus light was presented prior to drug infusions, stimulus-cued recovery of responding was similar to that obtained under the FI schedule. A third experiment showed that noncontingent presentation of the stimulus light alone on day 21 failed to reinstate extinguished responding, suggesting that stimulus-cued reinstatement of responding was due to a compound stimulus or preferential conditioning of the infusion pump sound. The present paradigm may serve as a useful model for the investigation of drug abuse and relapse, since it allows for the independent examination of the reinforcing and conditioned effects of a drug.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Meil WM,See REsubject
Has Abstractpub_date
1996-12-01 00:00:00pages
754-763issue
8eissn
0955-8810issn
1473-5849journal_volume
7pub_type
杂志文章abstract::The prefrontal cortex (PFC) plays a critical role in mediating executive functions and orchestrating the way in which we think, decide, and behave. Many studies have shown that PFC neurons not only play a major role in mediating behavioral responses to stress but are also sensitive to stress and undergo remodeling fol...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000429
更新日期:2018-10-01 00:00:00
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journal_title:Behavioural pharmacology
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更新日期:2004-05-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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更新日期:1995-06-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200202000-00006
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journal_title:Behavioural pharmacology
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更新日期:1997-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1097/FBP.0000000000000230
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journal_title:Behavioural pharmacology
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doi:
更新日期:1989-01-01 00:00:00
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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