Investigating complex basal ganglia circuitry in the regulation of motor behaviour, with particular focus on orofacial movement.

abstract：:Relatively little is known about the role of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in extinction of appetitively motivated tasks. The benzodiazepine (BZ) chlordiazepoxide (CDP) was administered during extinction and re-acquisition of lever pressing by mice following food reinforced discrete-tr...

journal_title：Behavioural pharmacology

authors： Shaw D,Dawson GR,Reynolds DS,McCabe C,Leslie JC

更新日期：2004-05-01 00:00:00

abstract：:Clinical reports and animal experiments indicate that both cocaine administration and cocaine withdrawal increase anxiety. We investigated the ability of a number of putative anxiolytic agents to alleviate these anxiety states using the elevated plus-maze. Rats in the cocaine condition received either saline or cocain...

journal_title：Behavioural pharmacology

authors： Paine TA,Jackman SL,Olmstead MC

更新日期：2002-11-01 00:00:00

abstract：:The present study investigated the ability of drug-associated cues to reinstate extinguished responding following an extended period of withdrawal from cocaine self-administration. Rats self-administered cocaine (0.33mg/infusion) for 2 weeks of daily 3-h limited-access sessions under a fixed-interval (FI) schedule of ...

journal_title：Behavioural pharmacology

authors： Meil WM,See RE

更新日期：1996-12-01 00:00:00

abstract：:The purpose of the present experiments was to develop and validate pharmacologically an automated, relatively rapid, and reproducible behavioral model of learning and memory using an autoshaping procedure in mice. Nose-poke responses into a recessed area were differentiated by response-dependent reinforcement during t...

journal_title：Behavioural pharmacology

authors： Vanover KE,Barrett JE

更新日期：1998-05-01 00:00:00

abstract：:This study examined effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 in an assay of pain-related behavioral depression. Adult, male Sprague-Dawley rats responded for electrical brain stimulation in a frequency-rate intracranial self-stimulation (ICSS) procedure. Intraperito...

journal_title：Behavioural pharmacology

authors： Moerke MJ,Li G,Golani LK,Cook J,Negus SS

更新日期：2019-08-01 00:00:00

abstract：:The purpose of this study was to examine, in healthy volunteers without histories of extensive sedative use, the acute behavioral effects of doses of alprazolam used in clinical applications. Subjects participated in daily sessions over 12 study days. They consumed a standard breakfast, received an oral drug dose (0, ...

journal_title：Behavioural pharmacology

authors： Kelly TH,Foltin RW,Serpick E,Fischman MW

更新日期：1997-02-01 00:00:00

abstract：:Drug-addicted individuals show high levels of impulsive choice, characterized by preference for small immediate over larger but delayed rewards. Although the causal relationship between chronic drug use and elevated impulsive choice in humans has been unclear, a small but growing body of literature over the past decad...

journal_title：Behavioural pharmacology

authors： Setlow B,Mendez IA,Mitchell MR,Simon NW

更新日期：2009-09-01 00:00:00

abstract：:Individuals with attention-deficit/hyperactivity disorder tend to make risker choices during probabilistic-discounting procedures. Thus, how common attention-deficit/hyperactivity disorder medications affect probabilistic discounting is of interest. In general, d-amphetamine increases risk-taking while atomoxetine has...

journal_title：Behavioural pharmacology

authors： Ozga-Hess JE,Anderson KG

更新日期：2019-10-01 00:00:00

abstract：:The purpose of this experiment was to examine the substitution patterns produced by opioids with activity at the mu receptor in pigeons trained to discriminate the delta opioid BW373U86 from saline. A low dose of naltrindole (0.1 mg/kg) produced at least a 16-fold rightward shift in the dose-effect curve for the stimu...

journal_title：Behavioural pharmacology

authors： Picker MJ,Cook CD

更新日期：1998-07-01 00:00:00

abstract：:Parkinson's disease psychosis (PDP) is a condition for which a safe, tolerated, and effective therapy is lacking. Treatment with typical or atypical antipsychotics may be contraindicated in patients with PDP because of the potential for aggravating motor symptoms. This study used a novel animal model with features of ...

journal_title：Behavioural pharmacology

authors： McFarland K,Price DL,Bonhaus DW

更新日期：2011-10-01 00:00:00

abstract：:The impact of training dose on the characteristics of a discrimination maintained by a mixture of two dissimilar drugs has been investigated in order to refine this approach to the study of drug interactions. Three groups of rats (n = 10) were trained to discriminate mixtures of (+)-amphetamine (0.2-0.8mg/kg) plus pen...

journal_title：Behavioural pharmacology

authors： Mariathasan EA,White JA,Stolerman IP

更新日期：1996-08-01 00:00:00

abstract：:In a modified light-dark exploration test in mice, 5-hydroxytryptophan, at doses (25-50 mg/kg) that approximately doubled the 5-HT content in the cerebral cortex, reduced the time spent by mice in the white compartment, suggesting an anxiogenic effect. Depletion of brain 5-HT content with p-chlorophenylalanine (300 mg...

journal_title：Behavioural pharmacology

authors： Artaiz I,Zazpe A,Del Río J

更新日期：1998-03-01 00:00:00

abstract：:Drug-related stimuli seem to contribute to the persistence of drug seeking and relapse. Behavioral momentum theory is a framework for understanding how the discriminative-stimulus context in which operant behavior occurs governs the persistence of that behavior. The theory suggests that both resistance to change and r...

journal_title：Behavioural pharmacology

authors： Pyszczynski AD,Shahan TA

更新日期：2011-02-01 00:00:00

abstract：:The interoceptive stimulus induced by clozapine (5 mg/kg, i.p.) has been characterized in an operant drug discrimination procedure in the rat using a wide range of receptor subtype-selective agonists and antagonists. Only the muscarinic receptor antagonist scopolamine generalized fully to clozapine (>80%). Partial gen...

journal_title：Behavioural pharmacology

authors： Goudie AJ,Smith JA,Taylor A,Taylor MA,Tricklebank MD

更新日期：1998-12-01 00:00:00

abstract：:'Active immobility' (AI) is an independent behaviour that can be characterized by behavioural immobility, an increased muscular rigidity and the sustaining of an unusual posture. In previous studies with cocaine we observed, concomitant with hyperlocomotion and increased rearing activity, an increase in AI in well-hab...

journal_title：Behavioural pharmacology

authors： Müller CP,Thönnessen H,Jocham G,Barros M,Tomaz C,Carey RJ,Huston JP

更新日期：2004-11-01 00:00:00

abstract：:Rats were maintained on a daily regimen involving a 2h opportunity to take both water and a sweetened alcoholic beverage (12% ethanol, 0.25% saccharin). After 3 weeks on this regimen, rats regularly take substantial amounts of alcohol. After stabilization, injections of alpha(2)-adrenergic antagonists were administere...

journal_title：Behavioural pharmacology

authors： Reid LD,Delconte JD,Amendola CA,Nichols ML,Krupsky GW,Dharia NS,Hubbell CL

更新日期：1994-08-01 00:00:00

abstract：:Obsessive-compulsive disorder (OCD) is considered a heterogeneous anxiety disorder that includes compulsions. Celecoxib is considered an adjuvant to fluoxetine in the management of OCD in a clinical study. However, the experimental evidence is yet to be established. Therefore, the antianxiety and anticompulsive-like a...

journal_title：Behavioural pharmacology

authors： Garabadu D,Kumar V

更新日期：2019-04-01 00:00:00

abstract：:Nicotine, a cognition enhancer and a drug of abuse, exerts its central actions through neuronal nicotinic acetylcholine receptors which show sexual dimorphism. This study tested the effects of nicotine on active avoidance learning in male and female rats. Three month-old Sprague-Dawley rats received varying doses of n...

journal_title：Behavioural pharmacology

authors： Yilmaz O,Kanit L,Okur BE,Pöğün S

更新日期：1997-06-01 00:00:00

abstract：:Behavioral sensitization in mammals, including humans, is sensitive to factors such as administration route, testing environment, and pharmacokinetic confounds, unrelated to the drugs themselves that are difficult to eliminate. Simpler animals less susceptible to these confounding influences may be advantageous substi...

journal_title：Behavioural pharmacology

authors： Rawls SM,Patil T,Yuvasheva E,Raffa RB

更新日期：2010-07-01 00:00:00

abstract：:A core symptom of human depressive disorder is anhedonia, the loss of interest or pleasure in daily activities. Anhedonia, measured as subsensitivity to reward, can be induced in rats by a regimen of repeated, mild, unpredictable stressors. Here, the hedonic state of rats was assessed using an intracranial self-stimul...

journal_title：Behavioural pharmacology

authors： Moreau JL,Scherschlicht R,Jenck F,Martin JR

更新日期：1995-11-01 00:00:00

abstract：:Appetitive behaviours occur in a state of behavioural and physiological activation that allows the optimal performance of these goal-directed behaviours. Here, we tested the hypothesis that histamine neurons under the command of the infralimbic cortex are important to provide behavioural activation. Extracellular hist...

journal_title：Behavioural pharmacology

authors： Riveros ME,Forray MI,Torrealba F

更新日期：2015-06-01 00:00:00

abstract：:The acute and chronic effects of certain drugs can often be opposite. For example, in congestive heart failure acute administration of β-adrenoceptor agonists results in beneficial improvement in symptoms of the disease, but their chronic use increases mortality. Conversely, certain β-adrenoceptor antagonists/inverse ...

journal_title：Behavioural pharmacology

authors： Bond RA,Giles H

更新日期：2011-09-01 00:00:00

abstract：:The present experiments investigated the effects of excitatory amino acid antagonists, infused into core and shell subregions of the nucleus accumbens, on spatial behavior in the rat. A food-search task was used, in which animals learn a specific pattern of food gathering; duration of each trial (time taken to gather ...

journal_title：Behavioural pharmacology

authors： Maldonado-Irizarry CS,Kelley AE

更新日期：1995-08-01 00:00:00

abstract：:The aims of the study were to test whether drug dose is positively related to the magnitude of the conditioned response following sensitization to the behavioural effects of cocaine and to investigate the relationship between the conditioned response and cocaine-induced sensitization. Male mice (C57BL/6J) were first i...

journal_title：Behavioural pharmacology

authors： Michel A,Tirelli E

更新日期：2002-02-01 00:00:00

abstract：:The behavioural effects of six compounds with N-methyl-D-aspartate (NMDA) antagonist properties were compared on the responding of rats maintained by a differential reinforcement of low rate 15s (DRL-15s) schedule. This schedule requires that responses be temporally spaced in order to be reinforced (timing behaviour)....

journal_title：Behavioural pharmacology

authors： Sanger DJ

更新日期：1992-12-01 00:00:00

abstract：:We investigated relationships between drinking, other drug use, and drug craving, using ecological momentary assessment (EMA), in a sample of polydrug users who were not heavy drinkers. In a prospective longitudinal cohort study, 114 heroin and cocaine users on methadone-maintenance treatment carried handheld electron...

journal_title：Behavioural pharmacology

authors： Preston KL,Jobes ML,Phillips KA,Epstein DH

更新日期：2016-10-01 00:00:00

abstract：:The cannabinoid receptor agonist Δ(9)-tetrahydrocannabinol (THC) enhances the antinociceptive effects of µ-opioid receptor agonists, raising the possibility of using a combination of THC and opioids for treating pain. This study examined the effects of noncontingent and contingent administration of THC on intravenous ...

journal_title：Behavioural pharmacology

authors： Li JX,Koek W,France CP

更新日期：2012-12-01 00:00:00

abstract：:The present experiment was conducted to determine whether the modification of the effects of morphine by food deprivation would occur under conditions of strong stimulus control. Four pigeons pecked response keys under a multiple fixed-interval (FI) 5-min and clocked fixed-interval (CFI) 5-min schedule of food present...

journal_title：Behavioural pharmacology

authors： Odum AL,Schaal DW

更新日期：1999-05-01 00:00:00

abstract：:Tolerance develops to the cardiovascular and subjective effects of intravenous cocaine during single self-administration sessions, but diminishes within 3 h after the session ends. To examine whether a similar pattern of tolerance occurs to smoked cocaine, seven adult 'crack' cocaine users completed a protocol investi...

journal_title：Behavioural pharmacology

authors： Ward AS,Haney M,Fischman MW,Foltin RW

更新日期：1997-12-01 00:00:00

abstract：:With the ever-growing geriatric population, research on brain diseases such as dementia is more imperative now than ever. The most prevalent of all dementias is Alzheimer's disease, a progressive neurodegenerative disease that presents with deficits in memory, cognition, motor skills, and a general decline in the qual...

journal_title：Behavioural pharmacology

authors： Caramillo EM,Echevarria DJ

更新日期：2017-04-01 00:00:00