Investigating complex basal ganglia circuitry in the regulation of motor behaviour, with particular focus on orofacial movement.


:Current concepts of basal ganglia function have evolved from the essentially motoric, to include a range of extramotoric functions that involve not only dopaminergic but also cholinergic, γ-aminobutyric acid (GABA)ergic and glutamatergic mechanisms. We consider these mechanisms and their efferent systems, including spiralling, feed-forward striato-nigro-striatal circuitry, involving the dorsal and ventral striatum and the nucleus accumbens (NAc) core and shell. These processes are illustrated using three behavioural models: turning-pivoting, orofacial movements in rats and orofacial movements in genetically modified mice. Turning-pivoting indicates that dopamine-dependent behaviour elicited from the NAc shell is funnelled through the NAc-nigro-striato-nigro-pedunculopontine pathway, whereas acetylcholine-dependent behaviour elicited from the NAc shell is funnelled through the NAc-ventral pallidum-mediodorsal thalamus pathway. Cooperative/synergistic interactions between striatal D1-like and D2-like dopamine receptors regulate individual topographies of orofacial movements that are funnelled through striatal projection pathways and involve interactions with GABAergic and glutamatergic receptor subtypes. This application of concerted behavioural, neurochemical and neurophysiological techniques implicates a network that is yet broader and interacts with other neurotransmitters and neuropeptides within subcortical, cortical and brainstem regions to 'sculpt' aspects of behaviour into its topographical collective.


Behav Pharmacol


Behavioural pharmacology


Ikeda H,Adachi K,Fujita S,Tomiyama K,Saigusa T,Kobayashi M,Koshikawa N,Waddington JL




Has Abstract


2015-02-01 00:00:00












  • Training dose as a decisive factor for discrimination of a drug mixture in rats.

    abstract::The impact of training dose on the characteristics of a discrimination maintained by a mixture of two dissimilar drugs has been investigated in order to refine this approach to the study of drug interactions. Three groups of rats (n = 10) were trained to discriminate mixtures of (+)-amphetamine (0.2-0.8mg/kg) plus pen...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Mariathasan EA,White JA,Stolerman IP

    更新日期:1996-08-01 00:00:00

  • Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: tests with subtype selective receptor ligands.

    abstract::The interoceptive stimulus induced by clozapine (5 mg/kg, i.p.) has been characterized in an operant drug discrimination procedure in the rat using a wide range of receptor subtype-selective agonists and antagonists. Only the muscarinic receptor antagonist scopolamine generalized fully to clozapine (>80%). Partial gen...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Goudie AJ,Smith JA,Taylor A,Taylor MA,Tricklebank MD

    更新日期:1998-12-01 00:00:00

  • Pimavanserin, a 5-HT2A inverse agonist, reverses psychosis-like behaviors in a rodent model of Parkinson's disease.

    abstract::Parkinson's disease psychosis (PDP) is a condition for which a safe, tolerated, and effective therapy is lacking. Treatment with typical or atypical antipsychotics may be contraindicated in patients with PDP because of the potential for aggravating motor symptoms. This study used a novel animal model with features of ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: McFarland K,Price DL,Bonhaus DW

    更新日期:2011-10-01 00:00:00

  • The effects of home-cage access to a sweet solution on the discriminative stimulus effects of cocaine.

    abstract::This study assessed whether access to a sweet solution in the home cage could change sensitivity to cocaine, using a drug discrimination procedure. Rats were trained to discriminate 10 mg/kg cocaine from saline. After acquisition, rats were tested with a cumulative dose-response procedure (0-18 mg/kg) for 12 consecuti...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Kohut SJ,Riley AL

    更新日期:2010-05-01 00:00:00

  • A comparison of the reinforcing efficacy of PCP, the PCP derivatives TCP and BTCP, and cocaine using a progressive ratio schedule in the rat.

    abstract::This study was designed to compare the reinforcing efficacy of PCP (phencyclidine:phenylcyclohexyl-piperidine) and the PCP-derivatives BTCP (N-[1-(2-benzo(b)thiophenyl) cyclohexyl]piperidine) and TCP (N-[1-(2-thienyl)cyclohexyl]-piperidine) to that of cocaine, using a progressive ratio schedule of reinforcement (PR). ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: French ED,Lopez M,Peper S,Kamenka JM,Roberts DC

    更新日期:1995-04-01 00:00:00

  • First evidence that drugs of abuse produce behavioral sensitization and cross sensitization in planarians.

    abstract::Behavioral sensitization in mammals, including humans, is sensitive to factors such as administration route, testing environment, and pharmacokinetic confounds, unrelated to the drugs themselves that are difficult to eliminate. Simpler animals less susceptible to these confounding influences may be advantageous substi...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Rawls SM,Patil T,Yuvasheva E,Raffa RB

    更新日期:2010-07-01 00:00:00

  • Effects of positive and negative modulators of the γ-aminobutyric acid A receptor complex on responding under a differential-reinforcement-of-low-rate schedule of reinforcement in rats.

    abstract::Relatively little is known about the behavioral effects of the neurosteroids compared with other drugs that modulate the γ-aminobutyric acid A (GABAA) receptor complex. This study examined the acute effects of pregnanolone and dehydroepiandrosterone (DHEA) in male rats responding under a differential-reinforcement-of-...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Amato RJ,Lewis PB,He H,Winsauer PJ

    更新日期:2010-12-01 00:00:00

  • Chronic treatment with Delta(9)-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain.

    abstract::Few studies have investigated the effects of chronic cannabinoid exposure on memory performance and whether tolerance occurs to cannabinoid-induced memory impairment. Here, we studied the effects of repeated exposure to Delta-tetrahydrocannabinol (THC: 1 mg/kg) on spatial memory and zif268 expression in mice. One grou...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Boucher AA,Vivier L,Metna-Laurent M,Brayda-Bruno L,Mons N,Arnold JC,Micheau J

    更新日期:2009-02-01 00:00:00

  • Triazolam and zolpidem: a comparison of their psychomotor, cognitive, and subjective effects in healthy volunteers.

    abstract::The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) and the imidazopyridine hypnotic zolpidem (5, 10, and 20 mg/70 kg) were compared in 11 volunteers, in a double-blind, placebo-controlled, crosso...

    journal_title:Behavioural pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mintzer MZ,Frey JM,Yingling JE,Griffiths RR

    更新日期:1997-11-01 00:00:00

  • Effects of rimonabant on behavior maintained by progressive ratio schedules of sucrose reinforcement in obese Zucker (fa/fa) rats.

    abstract::This experiment reports on the ability of rimonabant to alter the reinforcing properties of food in the genetically obese Zucker (fa/fa) rat, a strain that exhibits higher levels of endocannabinoids in brain regions that correspond to heightened food intake. We characterized food reinforcement in obese and lean Zucker...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Rasmussen EB,Huskinson SL

    更新日期:2008-10-01 00:00:00

  • Involvement of the serotonergic type 1A (5-HT1A) receptor in the agranular insular cortex in the consolidation of memory for inhibitory avoidance in rats.

    abstract::Adult male Wistar rats were bilaterally implanted with indwelling cannulae in the agranular insular cortex of the prefrontal cortex. After recovery, animals were trained in a step-down inhibitory avoidance task (3.0-s, 0.4-mA footshock) and received, immediately after training, a 0.5-microl infusion of the serotonergi...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Mello e Souza T,Rodrigues C,Souza MM,Vinadé E,Coitinho A,Choi H,Izquierdo I

    更新日期:2001-09-01 00:00:00

  • Time-dependent and schedule-dependent effects of dopamine receptor blockade.

    abstract::Rats were trained on one of two multiple random-interval schedules of reinforcement, which contained both ascending and descending reinforcement density sequences. The design of the schedules made it possible to determine whether performance changes in a particular component depended on the reinforcement density in th...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Willner P,Phillips G,Sampson D,Muscat R

    更新日期:1989-01-01 00:00:00

  • Comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine.

    abstract::Changes in extracellular concentrations of dopamine (DA) were measured in vivo in the nucleus accumbens of the rat during intravenous self-administration of either cocaine (0.25, 0.5, 1.0mg/infusion) or d-amphetamine (0.05, 0.1, 0.2mg/infusion). Drug intake was limited to 12 self-administered infusions per session for...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Di Ciano P,Coury A,Depoortere RY,Egilmez Y,Lane JD,Emmett-Oglesby MW,Lepiane FG,Phillips AG,Blaha CD

    更新日期:1995-06-01 00:00:00

  • Differential improvement in memory-related task performance with nicotine by aged male and female rhesus monkeys.

    abstract::Central nicotinc acetylcholine receptors have been targeted for the development of novel treatments for memory deficits in Alzheimer's disease (AD) and other neurodegenerative disorders. Nicotine itself has been shown to improve memory-related task performance in aged animals and in AD patients. Administration of nico...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Buccafusco JJ,Jackson WJ,Jonnala RR,Terry AV Jr

    更新日期:1999-11-01 00:00:00

  • A-68930, a novel, potent dopamine D1 receptor agonist: a microstructural analysis of its effects on feeding and other behaviour in the rat.

    abstract::A-68930 [1R, 3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman HCI] is a novel, potent and selective dopamine D1 receptor agonist. Previous reports have shown that the selective D1 partial agonist, SK & F 38393, reduced food consumption in rats and mice. The aim of this study was to undertake a microstructural analys...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: AI-Naser HA,Cooper SJ

    更新日期:1994-04-01 00:00:00

  • Progesterone effects on the discriminative stimulus, subjective and performance effects of triazolam in healthy, premenopausal women.

    abstract::There is accumulating evidence that sex plays a critical role in drug abuse. Female sex hormones have been shown to affect central nervous system function and modulate the effects of drugs of abuse. For example, γ-aminobutyric acid type A (GABA(A)) receptor function is positively modulated by progesterone metabolites....

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Babalonis S,Lile JA,Martin CA,Kelly TH

    更新日期:2011-09-01 00:00:00

  • A mixed polyunsaturated fatty acid diet normalizes hippocampal neurogenesis and reduces anxiety in serotonin transporter knockout rats.

    abstract::The aim of this study was to investigate the effects of a mixed dietary intervention on behavioral symptoms in serotonin transporter knockout (5-HTT⁻/⁻) rats modeling the human 5-HTT length polymorphic region short-allele. Twenty female 5-HTT⁻/⁻ and 19 wild-type (5-HTT⁺/⁺) rats were fed for 3 months on a mixed polyuns...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Schipper P,Kiliaan AJ,Homberg JR

    更新日期:2011-08-01 00:00:00

  • Relationship between weight status and delay discounting in a sample of adolescent cigarette smokers.

    abstract::Obesity and cigarette smoking are often cited separately as the top two preventable causes of death in the United States; however, little research has explored the factors associated with being both obese and a smoker. Delay discounting is a behavioral characteristic that may underlie both of these conditions/behavior...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Fields SA,Sabet M,Peal A,Reynolds B

    更新日期:2011-06-01 00:00:00

  • Latent learning in a radial arm maze following neonatal dopamine depletion.

    abstract::Animals neonatally depleted of dopamine show decreases in exploratory behaviour. As latent learning may depend on exploratory behaviour the present study was undertaken to examine the effects of neonatal dopamine depletion on latent learning. In two experiments dopamine was depleted neonatally, using 6-hydroxydopamine...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Archer T,Beninger RJ,Järbe TU,Seiden LS

    更新日期:1989-01-01 00:00:00

  • Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine.

    abstract::Clinical reports and animal experiments indicate that both cocaine administration and cocaine withdrawal increase anxiety. We investigated the ability of a number of putative anxiolytic agents to alleviate these anxiety states using the elevated plus-maze. Rats in the cocaine condition received either saline or cocain...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Paine TA,Jackman SL,Olmstead MC

    更新日期:2002-11-01 00:00:00

  • Ontogenetic difference in ethanol reinforcing properties: the role of the opioid system.

    abstract::Previous data indicate that ethanol intoxication (3 g/kg, intragastric) on postnatal day (PD) 7 and 8 increases ethanol acceptance, but on PD 10 and 11 generates an aversion in infant rats. We investigated the participation of the opioid system in these effects. Subcutaneous administration of naloxone (1 or 10 mg/kg) ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Gabriela Chotro M,Arias C

    更新日期:2007-11-01 00:00:00

  • NMDA antagonists disrupt timing behaviour in rats.

    abstract::The behavioural effects of six compounds with N-methyl-D-aspartate (NMDA) antagonist properties were compared on the responding of rats maintained by a differential reinforcement of low rate 15s (DRL-15s) schedule. This schedule requires that responses be temporally spaced in order to be reinforced (timing behaviour)....

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Sanger DJ

    更新日期:1992-12-01 00:00:00

  • Impairment of working memory by neuronal degeneration with NMDA in rat hippocampal CA-1.

    abstract::Rats were trained on a three-panel runway task prior to injections of N-methyl-D-aspartate (NMDA; 40nmoles/µl/side) into the dorsal hippocampus. One week after the treatment, animals did not show any change in the number of errors on the first runway trial (reference memory), with one correct white and two incorrect b...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Sugimachi K,Izawa K,Nakamura K,Kimura-Iwasaki K,Yamaguchi M,Nakagawa H,Oshino N

    更新日期:1992-08-01 00:00:00

  • An automated learning and memory model in mice: pharmacological and behavioral evaluation of an autoshaped response.

    abstract::The purpose of the present experiments was to develop and validate pharmacologically an automated, relatively rapid, and reproducible behavioral model of learning and memory using an autoshaping procedure in mice. Nose-poke responses into a recessed area were differentiated by response-dependent reinforcement during t...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Vanover KE,Barrett JE

    更新日期:1998-05-01 00:00:00

  • 5-HT mediation of the antiaversive effect of isamoltane injected into the dorsal periaqueductal grey.

    abstract::A previous study from this laboratory reported an antiaversive effect of the beta-adrenoceptor blocker propranolol microinjected into the dorsal periaqueductal grey (DPAG) of the rat, that was antagonized by the 5-HT(2) receptor blocker ritanserin. The present results show that microinjection into the DPAG of isamolta...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Nogueira RL,Graeff FG

    更新日期:1991-02-01 00:00:00

  • Memantine improves observational learning in day-old chicks.

    abstract::Evidence of observational learning (social learning) is present in many species. One such task is the one-trial taste-avoidance task, in which Actor chicks peck a bead coated with an aversant substance. Observer chicks learn to avoid beads that are similar in appearance to the one presented to the Actors. It has been ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Barber TA,Kimbrough TN

    更新日期:2015-06-01 00:00:00

  • Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the behavioral effects of quinpirole.

    abstract::Eating a diet high in fat can lead to negative health consequences, including obesity and insulin resistance. Omega-3 polyunsaturated fatty acids (such as those found in fish oil) prevent high fat diet-induced obesity and insulin resistance in rats. Eating a high fat diet also enhances sensitivity of rats to the behav...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Hernandez-Casner C,Ramos J,Serafine KM

    更新日期:2017-09-01 00:00:00

  • Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity.

    abstract::5-HT7 receptors have been linked to a number of psychiatric disorders including anxiety and depression. The localization of 5-HT7 receptors in the thalamus, a key sensory processing center, and the high affinity of many atypical antipsychotic compounds for these receptors have led to the speculation of the utility of ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Galici R,Boggs JD,Miller KL,Bonaventure P,Atack JR

    更新日期:2008-03-01 00:00:00

  • Lithium's effect in forced-swim test is blood level dependent but not dependent on weight loss.

    abstract::The effects of lithium in models of depression are often inconsistent. We aimed to replicate a regimen that induces robust antidepressant effects in the forced-swim test. Mice were treated with three different doses of lithium chloride (LiCl) 0.25, 0.4 or 0.5% in food and the forced-swim test or open field test was pe...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Bersudsky Y,Shaldubina A,Belmaker RH

    更新日期:2007-02-01 00:00:00

  • Tolerance and cross-tolerance to the response rate-decreasing effects of µ opioids in morphine-maintained squirrel monkeys.

    abstract::The purpose of the present experiment was to assess the degree of tolerance and cross-tolerance to the response rate-decreasing effects of opioids with different degrees of intrinsic efficacy at the mu receptor. The mu opioids included buprenorphine, etorphine, l-methadone, morphine, and sufentanil. Lever pressing of ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Hughes CE,Picker MJ,Dykstra LA

    更新日期:1995-12-01 00:00:00