Abstract:
:The cannabinoid receptor agonist Δ(9)-tetrahydrocannabinol (THC) enhances the antinociceptive effects of µ-opioid receptor agonists, raising the possibility of using a combination of THC and opioids for treating pain. This study examined the effects of noncontingent and contingent administration of THC on intravenous heroin self-administration in rhesus monkeys. Self-administration of different unit doses of heroin (0.0001-0.1 mg/kg/infusion) generated a typical inverted U-shaped dose-response curve. In one experiment (n=4), noncontingent THC (0.1-1.0 mg/kg) dose dependently shifted the heroin dose-response curve downward in three monkeys and slightly leftward in one monkey. In a second experiment (n=4), monkeys could self-administer THC alone (0.0032-0.032 mg/kg/infusion), heroin alone, or a mixture of THC and heroin. THC alone did not maintain responding above that obtained with saline; however, increasing the THC dose with heroin dose dependently decreased the number of infusions received and the rate of responding, as compared with data that were obtained with heroin alone. These results indicate that THC does not significantly enhance the positive reinforcing effects of heroin, further supporting the view that combining cannabinoid and opioid receptor agonists (e.g. for treating pain) does not increase, and might decrease, the abuse liability of individual drugs.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Li JX,Koek W,France CPdoi
10.1097/FBP.0b013e32835a3907subject
Has Abstractpub_date
2012-12-01 00:00:00pages
754-61issue
8eissn
0955-8810issn
1473-5849journal_volume
23pub_type
杂志文章abstract::We recently developed a procedure to study fear incubation, in which rats given 100 tone-shock pairings over 10 days show low fear 2 days after conditioned fear training and high fear after 30 days. Notably, fear 2 days after 10 sessions of fear conditioning is lower than fear seen 2 days after a single session of fea...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000020
更新日期:2014-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
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更新日期:2017-04-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200112000-00007
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3282feb0ac
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32834d1385
更新日期:2011-12-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199907000-00009
更新日期:1999-07-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1097/FBP.0b013e328349fc02
更新日期:2011-09-01 00:00:00
abstract::Appetitive behaviours occur in a state of behavioural and physiological activation that allows the optimal performance of these goal-directed behaviours. Here, we tested the hypothesis that histamine neurons under the command of the infralimbic cortex are important to provide behavioural activation. Extracellular hist...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000129
更新日期:2015-06-01 00:00:00
abstract::The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in inflammatory pain models. The present study investigated the effect of the intraperitoneal administration of S1RA on the hind paw withdrawal response to thermal and...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000038
更新日期:2014-06-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000512
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199911000-00015
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-198900110-00010
更新日期:1989-01-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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doi:10.1097/00008877-200609000-00015
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200008000-00004
更新日期:2000-08-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0b013e3283305eb4
更新日期:2009-09-01 00:00:00
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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更新日期:1993-02-01 00:00:00
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journal_title:Behavioural pharmacology
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更新日期:2005-11-01 00:00:00