Spatial learning deficit after NMDA receptor blockade and state-dependency.

abstract：:Opioid-maintained volunteers were trained to distinguish between a low dose of the opioid antagonist naloxone (0.15 mg/70 kg, i.m.; i.e. Drug A) and placebo (i.e. Drug B), under an instructed novel-response drug discrimination procedure in which subjects identify the drug condition as 'A', 'B', or 'N' (neither A nor B...

journal_title：Behavioural pharmacology

authors： Oliveto A,Sevarino K,McCance-Katz E,Benios T,Poling J,Feingold A

更新日期：2003-03-01 00:00:00

abstract：:This study compared fixed-ratio (FR) and fixed-interval (FI) schedules to investigate the discriminative stimulus properties of μ-opioid and/or κ-opioid receptor agonists. Pigeons were trained to discriminate among morphine (μ agonist), U50488 (κ agonist), the combination, and saline under FR 20-s or FI-300-s schedule...

journal_title：Behavioural pharmacology

authors： Wessinger WD,Li M,McMillan DE

更新日期：2011-09-01 00:00:00

abstract：:The prototypic cannabinoid CB1 antagonist SR 141716A is one important pharmacologic tool for examining CB1 receptors that mediate the behavioral and physiologic effects of delta9-tetrahydrocannabinol (delta9-THC). This study examined the effects of SR 141716A on the rate-decreasing, hypothermic and discriminative stim...

journal_title：Behavioural pharmacology

authors： McMahon LR,Amin MR,France CP

更新日期：2005-09-01 00:00:00

abstract：:Rats were trained on a three-panel runway task prior to injections of N-methyl-D-aspartate (NMDA; 40nmoles/µl/side) into the dorsal hippocampus. One week after the treatment, animals did not show any change in the number of errors on the first runway trial (reference memory), with one correct white and two incorrect b...

journal_title：Behavioural pharmacology

authors： Sugimachi K,Izawa K,Nakamura K,Kimura-Iwasaki K,Yamaguchi M,Nakagawa H,Oshino N

更新日期：1992-08-01 00:00:00

abstract：:Acetaldehyde has been suggested to mediate a number of the pharmacological and behavioural effects of ethanol. Recently, several studies investigated the role of acetaldehyde in the subjective effects of ethanol, but obtained conflicting results. With the discriminative taste aversion (DTA) procedure, high acetaldehyd...

journal_title：Behavioural pharmacology

authors： Quertemont E

更新日期：2003-07-01 00:00:00

abstract：:There is a growing realization that the severity of the core symptoms of autism spectrum disorders and schizophrenia is associated with gastrointestinal dysfunction. Nonetheless, the mechanisms underlying such comorbidities remain unknown. Several genetic and environmental factors have been linked to a higher suscepti...

journal_title：Behavioural pharmacology

authors： Morais LH,Felice D,Golubeva AV,Moloney G,Dinan TG,Cryan JF

更新日期：2018-04-01 00:00:00

abstract：:This study evaluated the effect of intermittent administration in the development of dependence to diazepam in chronic use of the drug. Gabapentin was used to provide an anxiolytic effect on drug-free days. During a 28-day treatment schedule, rats were given diazepam (15 mg/kg) once daily continuously, or intermittent...

journal_title：Behavioural pharmacology

authors： Açikmeşe B,Haznedar S,Hatipoğlu I,Enginar N

更新日期：2012-04-01 00:00:00

abstract：:Drugs that increase monoamine neurotransmission are effective in both anxiety and depression. The therapeutic effects of monoamine-based antidepressant drugs may involve indirect effects on neurotransmission through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPAR). Thus, chronic antidep...

journal_title：Behavioural pharmacology

authors： Fitzpatrick CM,Larsen M,Madsen LH,Caballero-Puntiverio M,Pickering DS,Clausen RP,Andreasen JT

更新日期：2016-09-01 00:00:00

abstract：:The purpose of this study was to analyse adrenergic and serotonergic interactions in the anxiolytic effects of several 5-HT(1A) agonists including ipsapirone, buspirone, indorenate and 8-OH-DPAT. To this end, the effects of different doses of the adrenergic compounds clonidine (0.015-0.0625mg/kg), yohimbine (0.125-0.5...

journal_title：Behavioural pharmacology

authors： López-Rubalcava C,Fernández-Guasti A

更新日期：1994-02-01 00:00:00

abstract：:Although the dopaminergic pharmacology of the D1 receptor full agonists, dinapsoline, dihydrexidine and the prodrug ABT-431 have been studied, no information is available on the ability of these agonists to substitute for the D1 agonist SKF 38393 in rats trained to discriminate this compound from vehicle. The present ...

journal_title：Behavioural pharmacology

authors： Gleason SD,Witkin JM

更新日期：2004-02-01 00:00:00

abstract：:Rats were trained on one of two multiple random-interval schedules of reinforcement, which contained both ascending and descending reinforcement density sequences. The design of the schedules made it possible to determine whether performance changes in a particular component depended on the reinforcement density in th...

journal_title：Behavioural pharmacology

authors： Willner P,Phillips G,Sampson D,Muscat R

更新日期：1989-01-01 00:00:00

abstract：:A core symptom of human depressive disorder is anhedonia, the loss of interest or pleasure in daily activities. Anhedonia, measured as subsensitivity to reward, can be induced in rats by a regimen of repeated, mild, unpredictable stressors. Here, the hedonic state of rats was assessed using an intracranial self-stimul...

journal_title：Behavioural pharmacology

authors： Moreau JL,Scherschlicht R,Jenck F,Martin JR

更新日期：1995-11-01 00:00:00

abstract：:Dendrosomal nanocurcumin (DNC) is fabricated from esterification of oleic acid and polyethylene glycol residues with curcumin. DNC has shown antioxidant, neuroprotective, and neurogenesis-enhancing effects. In addition, it can attenuate morphine tolerance. Morphine self-administration is associated with neurodegenerat...

journal_title：Behavioural pharmacology

authors： Noroozi J,Hassanpour-Ezatti M,Alaei HA

更新日期：2017-12-01 00:00:00

abstract：:Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined wheth...

journal_title：Behavioural pharmacology

authors： Jung TD,Jung PS,Raveendran L,Farbod Y,Dvorkin-Gheva A,Sakic B,Surette MG,Szechtman H

更新日期：2018-04-01 00:00:00

abstract：:Does the effect of amphetamine on behavior (wheel running) differ depending on the functional role (operant, reinforcement) of that behavior? This study addressed this question using a multiple schedule of reinforcement in which wheel running served as reinforcement for lever pressing in one component and as operant b...

journal_title：Behavioural pharmacology

authors： Belke TW,Pierce WD,Sexton CA

更新日期：2019-10-01 00:00:00

abstract：:Tolerance develops to the cardiovascular and subjective effects of intravenous cocaine during single self-administration sessions, but diminishes within 3 h after the session ends. To examine whether a similar pattern of tolerance occurs to smoked cocaine, seven adult 'crack' cocaine users completed a protocol investi...

journal_title：Behavioural pharmacology

authors： Ward AS,Haney M,Fischman MW,Foltin RW

更新日期：1997-12-01 00:00:00

abstract：:Previous studies have indicated that dopamine D1 receptors in the ventral tegmental area (VTA) may play an important role in the development of sensitization to amphetamine. The present study was designed to determine if D1 receptors are also important in the development of cocaine-induced behavioral and neurochemical...

journal_title：Behavioural pharmacology

authors： Steketee JD

更新日期：1998-02-01 00:00:00

abstract：:Changes in extracellular concentrations of dopamine (DA) were measured in vivo in the nucleus accumbens of the rat during intravenous self-administration of either cocaine (0.25, 0.5, 1.0mg/infusion) or d-amphetamine (0.05, 0.1, 0.2mg/infusion). Drug intake was limited to 12 self-administered infusions per session for...

journal_title：Behavioural pharmacology

authors： Di Ciano P,Coury A,Depoortere RY,Egilmez Y,Lane JD,Emmett-Oglesby MW,Lepiane FG,Phillips AG,Blaha CD

更新日期：1995-06-01 00:00:00

abstract：:We studied the anxiolytic-like activity of alnespirone and buspirone, two 5-HT(1A) receptor agonists, in a modified Geller-Seifter conflict model, and examined the role of 5-HT(1A) receptors by studying whether WAY-100635, a selective antagonist at these receptors, blocked their effects. Administered s.c. 30 minutes b...

journal_title：Behavioural pharmacology

authors： Cervo L,Munoz C,Bertaglia A,Samanin R

更新日期：2000-04-01 00:00:00

abstract：:Drug-related stimuli seem to contribute to the persistence of drug seeking and relapse. Behavioral momentum theory is a framework for understanding how the discriminative-stimulus context in which operant behavior occurs governs the persistence of that behavior. The theory suggests that both resistance to change and r...

journal_title：Behavioural pharmacology

authors： Pyszczynski AD,Shahan TA

更新日期：2011-02-01 00:00:00

abstract：:We investigated relationships between drinking, other drug use, and drug craving, using ecological momentary assessment (EMA), in a sample of polydrug users who were not heavy drinkers. In a prospective longitudinal cohort study, 114 heroin and cocaine users on methadone-maintenance treatment carried handheld electron...

journal_title：Behavioural pharmacology

authors： Preston KL,Jobes ML,Phillips KA,Epstein DH

更新日期：2016-10-01 00:00:00

abstract：:Treatments for the positive and negative symptoms of schizophrenia have been explored for decades, but no completely successful therapy has been found as yet. Metabotropic glutamate receptor 5 (mGluR5), which potentiates N-methyl-D-aspartate receptors in brain regions implicated in schizophrenia, has become a novel dr...

journal_title：Behavioural pharmacology

authors： Wu Z,Yang Z,Zhang M,Bao X,Han F,Li L

更新日期：2018-02-01 00:00:00

abstract：:Baclofen has shown promise in treating substance use disorders and also reduced binge frequency in an open-label trial. This placebo-controlled, double-blind, crossover study further assessed the effects of baclofen on binge eating. Twelve individuals who self-reported binge eating completed the study. Data were colle...

journal_title：Behavioural pharmacology

authors： Corwin RL,Boan J,Peters KF,Ulbrecht JS

更新日期：2012-09-01 00:00:00

abstract：:Sensitization induced by repeated drug exposure has been proposed to increase 'wanting' the drug and to facilitate the transition from moderate to excessive drug intake. The present study examined the effects of cocaine-induced sensitization on ethanol-drinking behavior in male and female rats from different strains. ...

journal_title：Behavioural pharmacology

authors： Cailhol S,Mormède P

更新日期：2000-08-01 00:00:00

abstract：:A previous study from this laboratory reported an antiaversive effect of the beta-adrenoceptor blocker propranolol microinjected into the dorsal periaqueductal grey (DPAG) of the rat, that was antagonized by the 5-HT(2) receptor blocker ritanserin. The present results show that microinjection into the DPAG of isamolta...

journal_title：Behavioural pharmacology

authors： Nogueira RL,Graeff FG

更新日期：1991-02-01 00:00:00

abstract：:Synthetic cathinone derivatives are commonly considered quasi-legal alternatives for stimulant drugs, such as cocaine and methamphetamine, but some derivatives are increasingly being detected in club drug formulations of Ecstasy or 'Molly' as substitutes for methylenedioxymethamphetamine (±-MDMA). Although several stu...

journal_title：Behavioural pharmacology

authors： Gatch MB,Dolan SB,Forster MJ

更新日期：2020-06-01 00:00:00

abstract：:Evidence is mounting that prenatal protein malnutrition affects the physiological properties of the GABAergic neurotransmitter system in rats. To investigate the functional behavioral consequences of these changes, chlordiazepoxide (CDP, a positive modulator of the GABA(A) receptor) was applied directly to the medial ...

journal_title：Behavioural pharmacology

authors： Tonkiss J,Trzcińska M,Shultz P,Vincitore M,Galler JR

更新日期：2000-09-01 00:00:00

abstract：:The technique of microdialysis was employed to investigate in vivo 5-hydroxytryptamine (5-HT) release in isolation-reared rats compared with socially reared rats. Two methods were employed to stimulate 5-HT release: local KCI injection into the frontal cortex of chloral hydrate anaesthetized rats, and the exposure of ...

journal_title：Behavioural pharmacology

authors： Bickerdike MJ,Wright IK,Marsden CA

更新日期：1993-06-01 00:00:00

abstract：:Neuropsychiatric disorders, such as addiction, are associated with cognitive impairment, including learning and memory deficits. Previous research has demonstrated that the chronic use of methamphetamine (METH) induces long-term cognitive impairment and cannabidiol (CBD), as a neuroprotectant, can reverse spatial memo...

journal_title：Behavioural pharmacology

authors： Razavi Y,Shabani R,Mehdizadeh M,Haghparast A

更新日期：2020-06-01 00:00:00

abstract：:The behavioural effects of six compounds with N-methyl-D-aspartate (NMDA) antagonist properties were compared on the responding of rats maintained by a differential reinforcement of low rate 15s (DRL-15s) schedule. This schedule requires that responses be temporally spaced in order to be reinforced (timing behaviour)....

journal_title：Behavioural pharmacology

authors： Sanger DJ

更新日期：1992-12-01 00:00:00