Abstract:
:Sensorimotor gating disruptions are seen in various psychiatric illnesses with putatively different pathologies, including schizophrenia and bipolar disorder. Interestingly, mice lacking the dopamine (DA) transporter (DAT) gene display markedly increased levels of DA, deficits in sensorimotor gating, and hyperactivity relative to wild-type mice. Atypical antipsychotics are effective treatments of schizophrenia and manic symptoms, presumably in part by antagonizing DA receptors. Here we report that treatment with clozapine (3 mg/kg) or quetiapine (2.5 mg/kg) attenuated prepulse inhibition deficits in male DAT knockout mice. Thus male DAT knockout mice may provide a useful animal model for predicting the efficacy of novel drugs in treating psychiatric illnesses characterized by a dysregulated DA system.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Powell SB,Young JW,Ong JC,Caron MG,Geyer MAdoi
10.1097/FBP.0b013e32830dc110subject
Has Abstractpub_date
2008-09-01 00:00:00pages
562-5issue
5-6eissn
0955-8810issn
1473-5849pii
00008877-200809000-00014journal_volume
19pub_type
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journal_title:Behavioural pharmacology
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