Does potency determine amnestic effects of benzodiazepines? A dose-response comparison of flunitrazepam and nitrazepam.

abstract：:In light of the adverse side-effects of opioids, cannabinoid receptor agonists may provide an effective alternative for the treatment of cancer pain. This study examined the potency and efficacy of synthetic CB1 and CB2 receptor agonists in a murine model of tumor pain. Intraplantar injection of the CB1 receptor agoni...

journal_title：Behavioural pharmacology

authors： Khasabova IA,Gielissen J,Chandiramani A,Harding-Rose C,Odeh DA,Simone DA,Seybold VS

更新日期：2011-09-01 00:00:00

abstract：:Methylphenidate (MPD) is clinically effective in treating the symptoms of attention-deficit hyperactivity disorder; however, its relatively widespread availability has raised public health concerns on nonmedical use of MPD among certain adult populations. Most preclinical studies investigate whether presumed therapeut...

journal_title：Behavioural pharmacology

authors： Baladi MG,Nielsen SM,Umpierre A,Hanson GR,Fleckenstein AE

更新日期：2014-12-01 00:00:00

abstract：:Previous exposure to a variety of drugs of abuse has been shown to cause long-term impairments in reversal learning and reinforcer devaluation tasks. However, there is mixed evidence in the literature for a long-term effect of ketamine exposure on reversal learning and the long-term effect of ketamine exposure on deva...

journal_title：Behavioural pharmacology

authors： Pickens CL,Aurand L,Hunt J,Fisher H

更新日期：2017-06-01 00:00:00

abstract：:Sensitization induced by repeated drug exposure has been proposed to increase 'wanting' the drug and to facilitate the transition from moderate to excessive drug intake. The present study examined the effects of cocaine-induced sensitization on ethanol-drinking behavior in male and female rats from different strains. ...

journal_title：Behavioural pharmacology

authors： Cailhol S,Mormède P

更新日期：2000-08-01 00:00:00

abstract：:Early-life administration of risperidone, the most widely used antipsychotic drug in children, leads to persistently elevated locomotor activity in adult rats. This study determined whether and when elevated locomotor activity emerges during developmental risperidone administration. Developing and adult rats were admi...

journal_title：Behavioural pharmacology

authors： Stevens RM,Gannon MA,Griffith MS,Bardgett ME

更新日期：2016-08-01 00:00:00

abstract：:Previous studies have indicated that dopamine D1 receptors in the ventral tegmental area (VTA) may play an important role in the development of sensitization to amphetamine. The present study was designed to determine if D1 receptors are also important in the development of cocaine-induced behavioral and neurochemical...

journal_title：Behavioural pharmacology

authors： Steketee JD

更新日期：1998-02-01 00:00:00

abstract：:Synthetic cathinone derivatives are commonly considered quasi-legal alternatives for stimulant drugs, such as cocaine and methamphetamine, but some derivatives are increasingly being detected in club drug formulations of Ecstasy or 'Molly' as substitutes for methylenedioxymethamphetamine (±-MDMA). Although several stu...

journal_title：Behavioural pharmacology

authors： Gatch MB,Dolan SB,Forster MJ

更新日期：2020-06-01 00:00:00

abstract：:Animals neonatally depleted of dopamine show decreases in exploratory behaviour. As latent learning may depend on exploratory behaviour the present study was undertaken to examine the effects of neonatal dopamine depletion on latent learning. In two experiments dopamine was depleted neonatally, using 6-hydroxydopamine...

journal_title：Behavioural pharmacology

authors： Archer T,Beninger RJ,Järbe TU,Seiden LS

更新日期：1989-01-01 00:00:00

abstract：:In previous studies, it was shown that apomorphine-induced stereotyped behaviour could be conditioned when apomorphine was repeatedly paired with sensory stimuli (CS). Since in these experiments, the sum of various sensory stimuli were applied, it seemed of interest to use each sensory stimulus separately in order to ...

journal_title：Behavioural pharmacology

authors： Ferger B,Kuschinsky K

更新日期：1995-01-01 00:00:00

abstract：:The effects on memory of drugs of abuse from several pharmacological classes were examined in four adult male squirrel monkeys responding under a delayed matching-to-sample schedule of food presentation. Subjects were required to emit 20 responses on a sample key transilluminated by either a constant white or a flashi...

journal_title：Behavioural pharmacology

authors： Baron SP,Wenger GR

更新日期：2001-07-01 00:00:00

abstract：:Our earlier study demonstrated that Coeloglossum viride (L.) Hartm. var. bracteatum (Willd.) extract (CE) significantly improved the impaired memory in mice caused by permanent two-vessel occlusion. To investigate whether chronic treatment with CE could influence cerebral ischemia-induced neuronal and cognitive impair...

journal_title：Behavioural pharmacology

authors： Ma B,Li M,Nong H,Shi J,Liu G,Zhang J

更新日期：2008-07-01 00:00:00

abstract：:Relatively little is known about the behavioral effects of the neurosteroids compared with other drugs that modulate the γ-aminobutyric acid A (GABAA) receptor complex. This study examined the acute effects of pregnanolone and dehydroepiandrosterone (DHEA) in male rats responding under a differential-reinforcement-of-...

journal_title：Behavioural pharmacology

authors： Amato RJ,Lewis PB,He H,Winsauer PJ

更新日期：2010-12-01 00:00:00

abstract：:Neonatal ventral hippocampal lesions in the rat result in post-pubertal onset of behavioural abnormalities, modelling some aspects of schizophrenia. We further assessed the behavioural effects of neonatal lesions in rats in a variety of cognitive tasks and in the prepulse inhibition (PPI) of startle response paradigm....

journal_title：Behavioural pharmacology

authors： Le Pen G,Grottick AJ,Higgins GA,Martin JR,Jenck F,Moreau JL

更新日期：2000-06-01 00:00:00

abstract：:The involvement of adrenoreceptor blocking drugs with the 5-HT(1A)-mediated discriminative stimulus was studied in pigeons trained to discriminate the 5-HT(1A) receptor agonist 8-OH-DPAT (0.3mg/kg) from saline. Cumulative dose-response curves were determined for 8-OH-DPAT, the beta-adrenergic antagonist pindolol, the ...

journal_title：Behavioural pharmacology

authors： Zhang L,Barrett JE

更新日期：1991-11-01 00:00:00

abstract：:A symposium held at the 50th annual meeting of the Behavioral Pharmacology Society in May 2007 reviewed progress in the human behavioral pharmacology of drug abuse. Studies on drug self-administration in humans are reviewed that assessed reinforcing and subjective effects of drugs of abuse. The close parallels observe...

journal_title：Behavioural pharmacology

authors： Comer SD,Bickel WK,Yi R,de Wit H,Higgins ST,Wenger GR,Johanson CE,Kreek MJ

更新日期：2010-07-01 00:00:00

abstract：:Drug addiction is a progressive, relapsing disease comprised of interlocking stages of disordered motivation. Numerous animal models describing various stages of the addiction process have been developed over the past few decades, providing considerable advantages for the modeling of drug addiction compared with other...

journal_title：Behavioural pharmacology

authors： Edwards S,Koob GF

更新日期：2013-09-01 00:00:00

abstract：:A large body of data suggests that potassium channels may play an important role in learning and memory. Previous in-vitro research in a number of species including Hermissenda and the rabbit suggests that a 4-aminopyridine-sensitive transient potassium channel may be involved in classical conditioning. We investigate...

journal_title：Behavioural pharmacology

authors： Wang D,Darwish DS,Schreurs BG

更新日期：2006-06-01 00:00:00

abstract：:There is accumulating evidence that sex plays a critical role in drug abuse. Female sex hormones have been shown to affect central nervous system function and modulate the effects of drugs of abuse. For example, γ-aminobutyric acid type A (GABA(A)) receptor function is positively modulated by progesterone metabolites....

journal_title：Behavioural pharmacology

authors： Babalonis S,Lile JA,Martin CA,Kelly TH

更新日期：2011-09-01 00:00:00

abstract：:In this experiment we examined the effect of a serotonin receptor (5-HT1A) agonist and antagonist WAY-100635 (N-[2-(4-[2-methoxy-phenyl]-1-piperazinyl)ethyl]-N-2-pyridinylcyclohexane-carboxamide) on temporal differentiation, in intact rats and rats whose serotonergic (5-HTergic) pathways had been destroyed by 5,7-dihy...

journal_title：Behavioural pharmacology

authors： Body S,Kheramin S,Mobini S,Ho MY,Velazquez-Martinez DN,Bradshaw CM,Szabadi E

更新日期：2002-12-01 00:00:00

abstract：:Drug withdrawal is often conceptualized as an aversive state that motivates drug-seeking and drug-taking behaviors in humans. Stress is more difficult to define, but is also frequently associated with aversive states. Here we describe evidence for the simple theory that drug withdrawal is a stress-like state, on the b...

journal_title：Behavioural pharmacology

authors： Chartoff EH,Carlezon WA Jr

更新日期：2014-09-01 00:00:00

abstract：:The development of Parkinson's disease (PD) involves the degeneration of dopaminergic neurons caused by oxidative stress. Accumulating clinical evidence indicates that high blood levels of uric acid (UA), an intrinsic antioxidative substance, are associated with reduced risk of PD. However, this hypothesis has not bee...

journal_title：Behavioural pharmacology

authors： Nakashima A,Yamauchi A,Matsumoto J,Dohgu S,Takata F,Koga M,Fukae J,Tsuboi Y,Kataoka Y

更新日期：2019-02-01 00:00:00

abstract：:Adolescence is one of the most important periods of brain development in mammals. There is increasing evidence that some medicines during this period can affect brain and behavioral functions in adulthood. Silymarin (SM), a mixture of flavonolignans extracted from the milk thistle Silybum marianum, is known as a hepat...

journal_title：Behavioural pharmacology

authors： Kosari-Nasab M,Rabiei A,Doosti MH,Salari AA

更新日期：2014-08-01 00:00:00

abstract：:Both opioids and cannabinoids have inhibitory effects at micromolar doses, which are mediated by activated receptors coupling to Gi/o-proteins. Surprisingly, the analgesic effects of opioids are enhanced by ultra-low doses (nanomolar to picomolar) of the opioid antagonist, naltrexone. As opioid and cannabinoid systems...

journal_title：Behavioural pharmacology

authors： Paquette J,Olmstead MC

更新日期：2005-12-01 00:00:00

abstract：:Mood and anxiety disorders, and rodent phenotypic measures modeling these disorders, have a strong genetic component. Various assays are used to study the neurobiological basis of fear-related and anxiety-related behaviors, phenotype genetically modified mice, and elucidate pharmacological modulation of these behavior...

journal_title：Behavioural pharmacology

authors： Brigman JL,Mathur P,Lu L,Williams RW,Holmes A

更新日期：2009-03-01 00:00:00

abstract：:Flavonoids are natural substances obtained from plants. Most flavonoids cross the blood-brain barrier and exert a wide range of effects on the central nervous system. These actions have been attributed to the modulation of GABA-A receptors. Although motor systems in the central nervous system express a high density of...

journal_title：Behavioural pharmacology

authors： Alatorre A,Oviedo-Chávez A,Villalobos N,Ríos A,Barrientos R,Querejeta E

更新日期：2015-02-01 00:00:00

abstract：:In a step-down passive avoidance task, the pre-training injection of 1.25-10 mg/kg of morphine impaired memory. This was restored when injection of the same dose of morphine (pre-test treatment) was repeated 24 h later (morphine state-dependent learning: morphine St-D). ATP-dependent potassium (K(ATP)) channels have b...

journal_title：Behavioural pharmacology

authors： Zarrindast MR,Jafari MR,Shafaghi B,Djahanguiri B

更新日期：2004-03-01 00:00:00

abstract：:This series of studies provides a behavioural account of dopamine D1-receptor-dependent facilitation and disruption of memory for the single-trial passive avoidance task in the day-old chick. The D1 antagonist, SCH23390, induced memory disruption in a dose-dependent manner from 60 min after training with a strong (100...

journal_title：Behavioural pharmacology

authors： Hale MW,Crowe SF

更新日期：2003-11-01 00:00:00

abstract：:The effects of RO-600175, a selective 5-HT2C receptor agonist, were studied in adult rats implanted for chronic sleep recordings. Intraperitoneal administration of RO-600175 (4 mg/kg) during the light phase of the light-dark cycle significantly increased wakefulness and reduced slow wave sleep and rapid-eye-movement s...

journal_title：Behavioural pharmacology

authors： Monti JM,Jantos H

更新日期：2015-08-01 00:00:00

abstract：:This study examined associations between drinking and smoking prior to treatment (biochemically measured at baseline), alcohol and tobacco craving, and biochemical alcohol and tobacco use during the analog trial period. We conducted a secondary data analysis of a randomized clinical analog trial where participants wit...

journal_title：Behavioural pharmacology

authors： Smith CL,Jenkins G,Burduli E,Tham P,Miguel A,Roll J,Mcpherson S

更新日期：2020-10-01 00:00:00

abstract：:Acute (10mg/kg, i.p.) and chronic (10mg/kg/day, i.p. for 10 days) diazepam treatments decreased hippocampal dialysate 5-HT (but not 5-HIAA) concentrations in freely moving rats, suggesting decreased availability of 5-HT to receptors. Twenty-four hours after the last chronic diazepam injection, hippocampal dialysate 5-...

journal_title：Behavioural pharmacology

authors： Gibson EL,Barnfield AM,Curzon G

更新日期：1996-03-01 00:00:00