Latent learning in a radial arm maze following neonatal dopamine depletion.

abstract：:Obsessive-compulsive disorder (OCD) is considered a heterogeneous anxiety disorder that includes compulsions. Celecoxib is considered an adjuvant to fluoxetine in the management of OCD in a clinical study. However, the experimental evidence is yet to be established. Therefore, the antianxiety and anticompulsive-like a...

journal_title：Behavioural pharmacology

authors： Garabadu D,Kumar V

更新日期：2019-04-01 00:00:00

abstract：:Behavioral sensitization in mammals, including humans, is sensitive to factors such as administration route, testing environment, and pharmacokinetic confounds, unrelated to the drugs themselves that are difficult to eliminate. Simpler animals less susceptible to these confounding influences may be advantageous substi...

journal_title：Behavioural pharmacology

authors： Rawls SM,Patil T,Yuvasheva E,Raffa RB

更新日期：2010-07-01 00:00:00

abstract：:In a previous short-term study, salvianolic acid B was reported to have a protective effect on cerebral ischemia. Here, we investigated whether salvianolic acid B improves the recovery of motor function after cerebral ischemia in a 14-day investigation. Cerebral ischemia was induced by middle cerebral artery occlusion...

journal_title：Behavioural pharmacology

authors： Tang M,Feng W,Zhang Y,Zhong J,Zhang J

更新日期：2006-09-01 00:00:00

abstract：:Both opioids and cannabinoids have inhibitory effects at micromolar doses, which are mediated by activated receptors coupling to Gi/o-proteins. Surprisingly, the analgesic effects of opioids are enhanced by ultra-low doses (nanomolar to picomolar) of the opioid antagonist, naltrexone. As opioid and cannabinoid systems...

journal_title：Behavioural pharmacology

authors： Paquette J,Olmstead MC

更新日期：2005-12-01 00:00:00

abstract：:There is high comorbidity between depression and addiction. Features of addiction relevant to depression have been studied extensively, but less is known about features of depression relevant to addiction. Here, we have studied the effects of chronic mild stress (CMS), a valid animal model of depression, on measures o...

journal_title：Behavioural pharmacology

authors： Papp M,Gruca P,Lason-Tyburkiewicz M,Litwa E,Willner P

更新日期：2014-09-01 00:00:00

abstract：:The present experiment was conducted to determine whether the modification of the effects of morphine by food deprivation would occur under conditions of strong stimulus control. Four pigeons pecked response keys under a multiple fixed-interval (FI) 5-min and clocked fixed-interval (CFI) 5-min schedule of food present...

journal_title：Behavioural pharmacology

authors： Odum AL,Schaal DW

更新日期：1999-05-01 00:00:00

abstract：:Adolescence is one of the most important periods of brain development in mammals. There is increasing evidence that some medicines during this period can affect brain and behavioral functions in adulthood. Silymarin (SM), a mixture of flavonolignans extracted from the milk thistle Silybum marianum, is known as a hepat...

journal_title：Behavioural pharmacology

authors： Kosari-Nasab M,Rabiei A,Doosti MH,Salari AA

更新日期：2014-08-01 00:00:00

abstract：:The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in inflammatory pain models. The present study investigated the effect of the intraperitoneal administration of S1RA on the hind paw withdrawal response to thermal and...

journal_title：Behavioural pharmacology

authors： Gris G,Merlos M,Vela JM,Zamanillo D,Portillo-Salido E

更新日期：2014-06-01 00:00:00

abstract：:Parkinson's disease (PD) affects ∼1-2% of the elderly population. Development of a neuroprotective therapy that may be initiated early in the course of the disease to retard/prevent disease progression is highly desirable. This study aimed to investigate prophylactic treatment with coenzyme Q10 (CoQ10) before paraquat...

journal_title：Behavioural pharmacology

authors： Attia HN,Maklad YA

更新日期：2018-02-01 00:00:00

abstract：:The effects of the competitive NMDA antagonists, 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 12626) and 3-(2-carboxypiperazin-4-yl) propyl-l-phosphonic acid (CPP), were compared to those of the noncompetitive NMDA antagonists, phencyclidine (PCP) and (+)-5-methyl-10, 11-dihydro-5H-dibenzo (a,d) cyclohe...

journal_title：Behavioural pharmacology

authors： Willetts J,Rice A,Balster RL

更新日期：1990-01-01 00:00:00

abstract：:A symposium held at the 50th annual meeting of the Behavioral Pharmacology Society in May 2007 reviewed progress in the human behavioral pharmacology of drug abuse. Studies on drug self-administration in humans are reviewed that assessed reinforcing and subjective effects of drugs of abuse. The close parallels observe...

journal_title：Behavioural pharmacology

authors： Comer SD,Bickel WK,Yi R,de Wit H,Higgins ST,Wenger GR,Johanson CE,Kreek MJ

更新日期：2010-07-01 00:00:00

abstract：:Scopolamine has been used in neuropsychopharmacology as a standard drug that leads to symptoms mimicking cognitive deficits seen during the aging process in healthy humans and animals. Scopolamine is known to be a nonselective muscarinic receptor blocker, but its chronic effect on the expression of certain hippocampal...

journal_title：Behavioural pharmacology

authors： Doguc DK,Delibas N,Vural H,Altuntas I,Sutcu R,Sonmez Y

更新日期：2012-12-01 00:00:00

abstract：:An individual's susceptibility to psychological and physical disorders associated with chronic stress exposure, for example, cardiovascular and infectious disease, may also be predicted by their reactivity to acute stress. One factor associated with both stress resilience and health outcomes is personality. An underst...

journal_title：Behavioural pharmacology

authors： Childs E,White TL,de Wit H

更新日期：2014-09-01 00:00:00

abstract：:Ultrasonic vocalizations are widely used to examine affective states in rats, yet relatively few studies explore the acoustic features of vocalizations, especially in relation to drug exposure, and no studies have explored alterations in acoustic features over time. The goal of this study was to examine nicotine- and ...

journal_title：Behavioural pharmacology

authors： Swalve N,Mulholland MM,Li M

更新日期：2019-08-01 00:00:00

abstract：:Previous experiments showed that acute administration of the angiotensin converting enzyme (ACE) inhibitor, ceronapril, shares with neuroleptic drugs an ability to enhance latent inhibition (LI), which consists of retardation in conditioning to a stimulus as a consequence of its prior non-reinforced pre-exposure. Expe...

journal_title：Behavioural pharmacology

authors： Weiner I,Tarrasch R,Hasson O,Forian R,Smith AD,Rawlins JN,Feldon J

更新日期：1994-06-01 00:00:00

abstract：:Increasing evidence suggests that antagonistic interactions between specific subtypes of adenosine and dopamine receptors in the basal ganglia are involved in the control of motor activity. However, there are few studies investigating this interaction in other brain regions and its role in additional functions. In the...

journal_title：Behavioural pharmacology

authors： Prediger RD,Da Cunha C,Takahashi RN

更新日期：2005-07-01 00:00:00

abstract：:The purpose of this study was to analyse adrenergic and serotonergic interactions in the anxiolytic effects of several 5-HT(1A) agonists including ipsapirone, buspirone, indorenate and 8-OH-DPAT. To this end, the effects of different doses of the adrenergic compounds clonidine (0.015-0.0625mg/kg), yohimbine (0.125-0.5...

journal_title：Behavioural pharmacology

authors： López-Rubalcava C,Fernández-Guasti A

更新日期：1994-02-01 00:00:00

abstract：:Behavioral flexibility or 'set-shifting' refers to the ability to modify ongoing behavior in response to changing goals or environmental contingencies. Impaired behavioral flexibility is associated with disorders such as schizophrenia and addiction. Hypofunction of N-methyl-D-aspartate (NMDA) receptors has been implic...

journal_title：Behavioural pharmacology

authors： Darrah JM,Stefani MR,Moghaddam B

更新日期：2008-05-01 00:00:00

abstract：:Rats were maintained on a daily regimen involving a 2h opportunity to take both water and a sweetened alcoholic beverage (12% ethanol, 0.25% saccharin). After 3 weeks on this regimen, rats regularly take substantial amounts of alcohol. After stabilization, injections of alpha(2)-adrenergic antagonists were administere...

journal_title：Behavioural pharmacology

authors： Reid LD,Delconte JD,Amendola CA,Nichols ML,Krupsky GW,Dharia NS,Hubbell CL

更新日期：1994-08-01 00:00:00

abstract：:The prefrontal cortex (PFC) plays a critical role in mediating executive functions and orchestrating the way in which we think, decide, and behave. Many studies have shown that PFC neurons not only play a major role in mediating behavioral responses to stress but are also sensitive to stress and undergo remodeling fol...

journal_title：Behavioural pharmacology

authors： Bahari Z,Meftahi GH,Meftahi MA

更新日期：2018-10-01 00:00:00

abstract：:The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) and the imidazopyridine hypnotic zolpidem (5, 10, and 20 mg/70 kg) were compared in 11 volunteers, in a double-blind, placebo-controlled, crosso...

journal_title：Behavioural pharmacology

authors： Mintzer MZ,Frey JM,Yingling JE,Griffiths RR

更新日期：1997-11-01 00:00:00

abstract：:Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined wheth...

journal_title：Behavioural pharmacology

authors： Jung TD,Jung PS,Raveendran L,Farbod Y,Dvorkin-Gheva A,Sakic B,Surette MG,Szechtman H

更新日期：2018-04-01 00:00:00

abstract：:Sex-dependent differences have been consistently described in cannabinoid addiction research. In particular, we recently reported that female Lister Hooded rats display greater self-administration of the cannabinoid CB1 receptor agonist WIN55,212-2 (WIN) and stronger reinstatement of cannabinoid-seeking behavior than ...

journal_title：Behavioural pharmacology

authors： Rosas M,Porru S,Giugliano V,Antinori S,Scheggi S,Fadda P,Fratta W,Acquas E,Fattore L

更新日期：2018-09-01 00:00:00

abstract：:A-68930 [1R, 3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman HCI] is a novel, potent and selective dopamine D1 receptor agonist. Previous reports have shown that the selective D1 partial agonist, SK & F 38393, reduced food consumption in rats and mice. The aim of this study was to undertake a microstructural analys...

journal_title：Behavioural pharmacology

authors： AI-Naser HA,Cooper SJ

更新日期：1994-04-01 00:00:00

abstract：:5-HT7 receptors have been linked to a number of psychiatric disorders including anxiety and depression. The localization of 5-HT7 receptors in the thalamus, a key sensory processing center, and the high affinity of many atypical antipsychotic compounds for these receptors have led to the speculation of the utility of ...

journal_title：Behavioural pharmacology

authors： Galici R,Boggs JD,Miller KL,Bonaventure P,Atack JR

更新日期：2008-03-01 00:00:00

abstract：:Drugs that increase monoamine neurotransmission are effective in both anxiety and depression. The therapeutic effects of monoamine-based antidepressant drugs may involve indirect effects on neurotransmission through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPAR). Thus, chronic antidep...

journal_title：Behavioural pharmacology

authors： Fitzpatrick CM,Larsen M,Madsen LH,Caballero-Puntiverio M,Pickering DS,Clausen RP,Andreasen JT

更新日期：2016-09-01 00:00:00

abstract：:Both depression and cancer are related to a dysregulation of inflammatory and immune pathways. Indeed, depression is associated with increased expression of interferon-γ, interleukin-1β, and tumor necrosis factor α (TNF-α). In contrast, reductions of the activity of major histocompatibility complex protein molecules -...

journal_title：Behavioural pharmacology

authors： Barreto FS,Chaves Filho AJM,de Araújo MCCR,de Moraes MO,de Moraes MEA,Maes M,de Lucena DF,Macedo DS

更新日期：2018-04-01 00:00:00

abstract：:The Tinkertoy test (TTT) has often been used to assess executive function. Despite its clinical importance, there are few published normative data for it. Thus, the primary aim of this study was to fill this gap. Moreover, as there exists a sex difference in many cognitive abilities and neuropsychological tests, a sec...

journal_title：Behavioural pharmacology

authors： Lambert M,Stenger J,Bielajew C

更新日期：2018-12-01 00:00:00

abstract：:Mood and anxiety disorders, and rodent phenotypic measures modeling these disorders, have a strong genetic component. Various assays are used to study the neurobiological basis of fear-related and anxiety-related behaviors, phenotype genetically modified mice, and elucidate pharmacological modulation of these behavior...

journal_title：Behavioural pharmacology

authors： Brigman JL,Mathur P,Lu L,Williams RW,Holmes A

更新日期：2009-03-01 00:00:00

abstract：:Drug-related stimuli seem to contribute to the persistence of drug seeking and relapse. Behavioral momentum theory is a framework for understanding how the discriminative-stimulus context in which operant behavior occurs governs the persistence of that behavior. The theory suggests that both resistance to change and r...

journal_title：Behavioural pharmacology

authors： Pyszczynski AD,Shahan TA

更新日期：2011-02-01 00:00:00