Human behavioral pharmacology, past, present, and future: symposium presented at the 50th annual meeting of the Behavioral Pharmacology Society.

abstract：:The effects of RO-600175, a selective 5-HT2C receptor agonist, were studied in adult rats implanted for chronic sleep recordings. Intraperitoneal administration of RO-600175 (4 mg/kg) during the light phase of the light-dark cycle significantly increased wakefulness and reduced slow wave sleep and rapid-eye-movement s...

journal_title：Behavioural pharmacology

authors： Monti JM,Jantos H

更新日期：2015-08-01 00:00:00

abstract：:Behavioral sensitization in mammals, including humans, is sensitive to factors such as administration route, testing environment, and pharmacokinetic confounds, unrelated to the drugs themselves that are difficult to eliminate. Simpler animals less susceptible to these confounding influences may be advantageous substi...

journal_title：Behavioural pharmacology

authors： Rawls SM,Patil T,Yuvasheva E,Raffa RB

更新日期：2010-07-01 00:00:00

abstract：:Rats were trained on a three-panel runway task prior to injections of N-methyl-D-aspartate (NMDA; 40nmoles/µl/side) into the dorsal hippocampus. One week after the treatment, animals did not show any change in the number of errors on the first runway trial (reference memory), with one correct white and two incorrect b...

journal_title：Behavioural pharmacology

authors： Sugimachi K,Izawa K,Nakamura K,Kimura-Iwasaki K,Yamaguchi M,Nakagawa H,Oshino N

更新日期：1992-08-01 00:00:00

abstract：:The brain endocannabinoid system is a potential target for the treatment of psychiatric and metabolic conditions. Here, a novel CB1 receptor antagonist (ABD459) was synthesized and assayed for pharmacological efficacy in vitro and for modulation of food consumption, vigilance staging and cortical electroencephalograph...

journal_title：Behavioural pharmacology

authors： Goonawardena AV,Plano A,Robinson L,Ross R,Greig I,Pertwee RG,Hampson RE,Platt B,Riedel G

更新日期：2015-04-01 00:00:00

abstract：:Male Syrian hamsters (Mesocricetus auratus) treated with anabolic/androgenic steroids (AAS) during adolescence (P27-P56) display highly escalated and mature forms of offensive aggression correlated with increased γ-aminobutyric acid (GABA) afferent development as well as decreased GABAA receptors in the lateroanterior...

journal_title：Behavioural pharmacology

authors： Morrison TR,Ricci LA,Melloni RH Jr

更新日期：2014-10-01 00:00:00

abstract：:Acetaldehyde has been suggested to mediate a number of the pharmacological and behavioural effects of ethanol. Recently, several studies investigated the role of acetaldehyde in the subjective effects of ethanol, but obtained conflicting results. With the discriminative taste aversion (DTA) procedure, high acetaldehyd...

journal_title：Behavioural pharmacology

authors： Quertemont E

更新日期：2003-07-01 00:00:00

abstract：:This study examined interactions between cocaine and drugs that act as direct agonists at subtypes of "D2-like" dopamine receptors. The drugs 7-OH-DPAT, quinpirole and RU24213 were studied alone and in combination with cocaine for their effects on locomotor activity in non-habituated mice. Locomotor activity was measu...

journal_title：Behavioural pharmacology

authors： Tirelli E,Reggers J,Terry P

更新日期：1997-06-01 00:00:00

abstract：:The impact of training dose on the characteristics of a discrimination maintained by a mixture of two dissimilar drugs has been investigated in order to refine this approach to the study of drug interactions. Three groups of rats (n = 10) were trained to discriminate mixtures of (+)-amphetamine (0.2-0.8mg/kg) plus pen...

journal_title：Behavioural pharmacology

authors： Mariathasan EA,White JA,Stolerman IP

更新日期：1996-08-01 00:00:00

abstract：:Rats were given fixed-time, 1-min food-pellet delivery sessions, for 3 h every day, which resulted in over drinking (schedule-induced polydipsia). In previous research, groups of animals came to prefer solutions of cocaine or lidocaine to concurrently presented water, if the drugs were first offered in a glucose/sacch...

journal_title：Behavioural pharmacology

authors： Falk JL,Yosef E,Schwartz A,Lau CE

更新日期：1999-02-01 00:00:00

abstract：:Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined wheth...

journal_title：Behavioural pharmacology

authors： Jung TD,Jung PS,Raveendran L,Farbod Y,Dvorkin-Gheva A,Sakic B,Surette MG,Szechtman H

更新日期：2018-04-01 00:00:00

abstract：:Nicotine, a cognition enhancer and a drug of abuse, exerts its central actions through neuronal nicotinic acetylcholine receptors which show sexual dimorphism. This study tested the effects of nicotine on active avoidance learning in male and female rats. Three month-old Sprague-Dawley rats received varying doses of n...

journal_title：Behavioural pharmacology

authors： Yilmaz O,Kanit L,Okur BE,Pöğün S

更新日期：1997-06-01 00:00:00

abstract：:The role of dopamine (DA) receptors in the expression of opioid dependence was examined by use of an unbiased conditioned place preference paradigm. Male Sprague-Dawley rats were implanted s.c. with two pellets containing placebo or 75mg morphine. Animals received one conditioning session with saline and one with the ...

journal_title：Behavioural pharmacology

authors： Funada M,Shippenberg TS

更新日期：1996-10-01 00:00:00

abstract：:In light of the adverse side-effects of opioids, cannabinoid receptor agonists may provide an effective alternative for the treatment of cancer pain. This study examined the potency and efficacy of synthetic CB1 and CB2 receptor agonists in a murine model of tumor pain. Intraplantar injection of the CB1 receptor agoni...

journal_title：Behavioural pharmacology

authors： Khasabova IA,Gielissen J,Chandiramani A,Harding-Rose C,Odeh DA,Simone DA,Seybold VS

更新日期：2011-09-01 00:00:00

abstract：:Dendrosomal nanocurcumin (DNC) is fabricated from esterification of oleic acid and polyethylene glycol residues with curcumin. DNC has shown antioxidant, neuroprotective, and neurogenesis-enhancing effects. In addition, it can attenuate morphine tolerance. Morphine self-administration is associated with neurodegenerat...

journal_title：Behavioural pharmacology

authors： Noroozi J,Hassanpour-Ezatti M,Alaei HA

更新日期：2017-12-01 00:00:00

abstract：:Alcohol consumption acutely increases smoking behavior, but the reverse relationship, the acute effects of smoking on alcohol intake, largely has been ignored. We examined whether smoking acutely increases the reinforcing value of alcohol, first in the absence of recent alcohol intake and then following an alcohol pre...

journal_title：Behavioural pharmacology

authors： Perkins KA,Fonte C,Grobe JE

更新日期：2000-02-01 00:00:00

abstract：:The effects of lithium in models of depression are often inconsistent. We aimed to replicate a regimen that induces robust antidepressant effects in the forced-swim test. Mice were treated with three different doses of lithium chloride (LiCl) 0.25, 0.4 or 0.5% in food and the forced-swim test or open field test was pe...

journal_title：Behavioural pharmacology

authors： Bersudsky Y,Shaldubina A,Belmaker RH

更新日期：2007-02-01 00:00:00

abstract：:Serotonin-selective reuptake inhibitors (SSRIs) have been shown to enhance the locomotor stimulatory, discriminative-stimulus, and convulsive effects of cocaine in rodents. A pharmacokinetic mechanism for the interaction is supported by increases in the brain levels of cocaine by fluoxetine treatment. Furthermore, the...

journal_title：Behavioural pharmacology

authors： Soto PL,Hiranita T,Katz JL

更新日期：2009-12-01 00:00:00

abstract：:Rats in one group were trained to discriminate alprazolam (1.0mg/kg, i.p.) and in another group diazepam (3.0mg/kg, i.p.) from saline in a two-lever drug discrimination procedure. Food presentation occurred after 10 consecutive responses on the lever associated either with the training drug or with saline. Alprazolam,...

journal_title：Behavioural pharmacology

authors： Wettstein JG,Gauthier B

更新日期：1992-06-01 00:00:00

abstract：:Orexin plays an important role in pain modulation. Orexin-1 and orexin-2 receptors (Ox1r and Ox2r) are found at high density in the ventrolateral periaqueductal gray matter (vlPAG). Our previous study showed that chemical stimulation of the lateral hypothalamus with carbachol induces antinociception in the tail-flick ...

journal_title：Behavioural pharmacology

authors： Esmaeili MH,Reisi Z,Ezzatpanah S,Haghparast A

更新日期：2017-02-01 00:00:00

abstract：:Inhibitors of phosphodiesterase 10A (PDE10A) represent a novel class of potential antipsychotic compounds. These principles increase the level of cAMP and cGMP in the medium spiny neurons of the striatum and resemble the neurochemical consequences of dopamine D2 receptor inhibition and dopamine D1 receptor stimulation...

journal_title：Behavioural pharmacology

authors： Nikiforuk A,Potasiewicz A,Rafa D,Drescher K,Bespalov A,Popik P

更新日期：2016-06-01 00:00:00

abstract：:Human and animal studies provide evidence for vulnerable periods of brain development for deleterious effects of cannabinoids. We have recently shown that pubertal chronic cannabinoid treatment leads to long-lasting behavioral deficits, whereas a comparable treatment in adult rats did not affect the animals' behavior....

journal_title：Behavioural pharmacology

authors： Schneider M,Drews E,Koch M

更新日期：2005-09-01 00:00:00

abstract：:Drug-addicted individuals show high levels of impulsive choice, characterized by preference for small immediate over larger but delayed rewards. Although the causal relationship between chronic drug use and elevated impulsive choice in humans has been unclear, a small but growing body of literature over the past decad...

journal_title：Behavioural pharmacology

authors： Setlow B,Mendez IA,Mitchell MR,Simon NW

更新日期：2009-09-01 00:00:00

abstract：:Drug-related stimuli seem to contribute to the persistence of drug seeking and relapse. Behavioral momentum theory is a framework for understanding how the discriminative-stimulus context in which operant behavior occurs governs the persistence of that behavior. The theory suggests that both resistance to change and r...

journal_title：Behavioural pharmacology

authors： Pyszczynski AD,Shahan TA

更新日期：2011-02-01 00:00:00

abstract：:While previous research has sought to validate the chick separation stress paradigm as an anxiolytic screening assay, it is unknown whether the paradigm better models a nonspecific anxiety-like state or something similar to panic disorder or generalized anxiety disorder. To characterize the anxiety model pharmacologic...

journal_title：Behavioural pharmacology

authors： Warnick JE,Wicks RT,Sufka KJ

更新日期：2006-11-01 00:00:00

abstract：:Male rats form short-term memory for the olfactory characteristics of juvenile conspecifics. Alaptide, a synthetic derivative of the hypothalamic MIF, given subcutaneously at doses of 0.5 and 1.0mg/kg immediately after the initial exposure to an adult male, reduced the time spent by adults in social investigation of t...

journal_title：Behavioural pharmacology

authors： Hlinák Z,Krejcí I

更新日期：1992-04-01 00:00:00

abstract：:Central nicotinc acetylcholine receptors have been targeted for the development of novel treatments for memory deficits in Alzheimer's disease (AD) and other neurodegenerative disorders. Nicotine itself has been shown to improve memory-related task performance in aged animals and in AD patients. Administration of nico...

journal_title：Behavioural pharmacology

authors： Buccafusco JJ,Jackson WJ,Jonnala RR,Terry AV Jr

更新日期：1999-11-01 00:00:00

abstract：:Behavioral flexibility or 'set-shifting' refers to the ability to modify ongoing behavior in response to changing goals or environmental contingencies. Impaired behavioral flexibility is associated with disorders such as schizophrenia and addiction. Hypofunction of N-methyl-D-aspartate (NMDA) receptors has been implic...

journal_title：Behavioural pharmacology

authors： Darrah JM,Stefani MR,Moghaddam B

更新日期：2008-05-01 00:00:00

abstract：:Ultrasonic vocalizations are widely used to examine affective states in rats, yet relatively few studies explore the acoustic features of vocalizations, especially in relation to drug exposure, and no studies have explored alterations in acoustic features over time. The goal of this study was to examine nicotine- and ...

journal_title：Behavioural pharmacology

authors： Swalve N,Mulholland MM,Li M

更新日期：2019-08-01 00:00:00

abstract：:Evidence is mounting that prenatal protein malnutrition affects the physiological properties of the GABAergic neurotransmitter system in rats. To investigate the functional behavioral consequences of these changes, chlordiazepoxide (CDP, a positive modulator of the GABA(A) receptor) was applied directly to the medial ...

journal_title：Behavioural pharmacology

authors： Tonkiss J,Trzcińska M,Shultz P,Vincitore M,Galler JR

更新日期：2000-09-01 00:00:00

abstract：:Rats were maintained on a daily regimen involving a 2h opportunity to take both water and a sweetened alcoholic beverage (12% ethanol, 0.25% saccharin). After 3 weeks on this regimen, rats regularly take substantial amounts of alcohol. After stabilization, injections of alpha(2)-adrenergic antagonists were administere...

journal_title：Behavioural pharmacology

authors： Reid LD,Delconte JD,Amendola CA,Nichols ML,Krupsky GW,Dharia NS,Hubbell CL

更新日期：1994-08-01 00:00:00