Abstract:
:The effects of RO-600175, a selective 5-HT2C receptor agonist, were studied in adult rats implanted for chronic sleep recordings. Intraperitoneal administration of RO-600175 (4 mg/kg) during the light phase of the light-dark cycle significantly increased wakefulness and reduced slow wave sleep and rapid-eye-movement sleep during the first 2 h of the recording period. Direct infusion of RO-600175 into the dorsal raphe nucleus (4 mmol/l), laterodorsal tegmental nucleus (4 mmol/l), or horizontal limb of the diagonal band of Broca (4 mmol/l) also decreased rapid-eye-movement sleep. It is proposed that the activation of γ-aminobutyric acid-ergic cells located in the dorsal raphe nucleus, laterodorsal tegmental nucleus, and horizontal limb of the diagonal band of Broca is responsible, at least in part, for the effects of RO-600175 on rapid-eye-movement sleep. It is suggested that the increased wakefulness observed after systemic injection of the 5-HT2C receptor ligand could be partly related to the increased release of acetylcholine in the frontal cortex and hippocampus. However, additional studies are required to characterize the neurotransmitter systems responsible for the increase in wakefulness.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Monti JM,Jantos Hdoi
10.1097/FBP.0000000000000142subject
Has Abstractpub_date
2015-08-01 00:00:00pages
418-26issue
5eissn
0955-8810issn
1473-5849journal_volume
26pub_type
杂志文章abstract::Pair-housed, water-deprived rats were trained to run in a two-way shuttle box, using water reinforcement. Animals were tested either singly or in pairs; in the paired condition, the animals were required to shuttle in close physical proximity. Paired performance, but not single performance was severely disrupted by si...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::Sensitization induced by repeated drug exposure has been proposed to increase 'wanting' the drug and to facilitate the transition from moderate to excessive drug intake. The present study examined the effects of cocaine-induced sensitization on ethanol-drinking behavior in male and female rats from different strains. ...
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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更新日期:2007-03-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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更新日期:1999-02-01 00:00:00
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journal_title:Behavioural pharmacology
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更新日期:2001-12-01 00:00:00
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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更新日期:1998-12-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0b013e3283305eb4
更新日期:2009-09-01 00:00:00