Abstract:
:It has been reported that, in animals trained to discriminate ethanol, stimulus control generalized to the non-competitive NMDA antagonists phencyclidine, ketamine and dizocilpine. In the present study, rats were trained to discriminate a dose of ethanol (1g/kg, i.p.) and substitution tests were carried out with phencyclidine, dizocilpine, CGS 19755, eliprodil, triazolam, chlordiazepoxide, abecarnil, alpidem and d-amphetamine. Phencyclidine and dizocilpine produce dose-related substitution for ethanol as did the competitive NMDA antagonist, CGS 19755, and the benzodiazepines, triazolam and chlordiazepoxide. Eliprodil, an NMDA antagonist acting through the polyamine modulatory site, neither substituted for ethanol nor modified the ethanol dose-response curve. d-Amphetamine, and the non-benzodiazepine anxiolytics, alpidem and abecarnil, did not substitute for ethanol. The results show that both NMDA antagonists and compounds acting through (GABA receptors (benzodiazepines) can substitute for ethanol, emphasizing that the ethanol cue may involve several mechanisms. As all the drugs substituting for ethanol, like ethanol itself, are known to produce ataxia and muscle relaxation, it is proposed that this property may be an important aspect of the ethanol cue.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Sanger DJsubject
Has Abstractpub_date
1993-10-01 00:00:00pages
523-528issue
5eissn
0955-8810issn
1473-5849journal_volume
4pub_type
杂志文章abstract::We report here that local hippocampal WIN-55,212-2 implants release this cannabinoid agonist for extended periods, the release is restricted to the implanted brain region and is behaviorally active. Radiolabeled WIN-55,212-2 was implanted bilaterally into the CA3 region of the dorsal hippocampus by means of fused sili...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3282d9e9f9
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000429
更新日期:2018-10-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199608000-00008
更新日期:1996-08-01 00:00:00
abstract::Although the role of genetic factors in the response to drugs of abuse has been emphasized, no earlier studies have applied selective breeding to intravenous drug self-administration. Here we report the effects of six generations of selective breeding for rat lines with low or high levels of intravenous drug self-admi...
journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3282feb0ac
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199406000-00008
更新日期:1994-06-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章
doi:10.1097/00008877-199712000-00009
更新日期:1997-12-01 00:00:00
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199903000-00006
更新日期:1999-03-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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更新日期:2020-12-24 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-198900110-00010
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199000140-00009
更新日期:1990-01-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000020
更新日期:2014-02-01 00:00:00
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2016-04-01 00:00:00
abstract::Cannabis is the most popular illicit drug used by adolescents. Yet, there are only a few studies that have examined the effects of cannabis use on learning and memory during this sensitive and important neurodevelopmental stage. Male adolescent Sprague-Dawley rats were treated with Δ(9)-tetrahydrocannabinol (THC, 6 mg...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32834dbbb1
更新日期:2011-12-01 00:00:00
abstract::Given the repeated failure of amyloid-based approaches in Alzheimer's disease, there is increasing interest in tau-based therapeutics. Although methylthioninium (MT) treatment was found to be beneficial in tau transgenic models, the brain concentrations required to inhibit tau aggregation in vivo are unknown. The comp...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000133
更新日期:2015-06-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3283123cc2
更新日期:2008-10-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32833a5bdf
更新日期:2010-05-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200403000-00002
更新日期:2004-03-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0b013e3283305eb4
更新日期:2009-09-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199404000-00003
更新日期:1994-04-01 00:00:00
abstract::The technique of microdialysis was employed to investigate in vivo 5-hydroxytryptamine (5-HT) release in isolation-reared rats compared with socially reared rats. Two methods were employed to stimulate 5-HT release: local KCI injection into the frontal cortex of chloral hydrate anaesthetized rats, and the exposure of ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00