Abstract:
:This study assessed whether access to a sweet solution in the home cage could change sensitivity to cocaine, using a drug discrimination procedure. Rats were trained to discriminate 10 mg/kg cocaine from saline. After acquisition, rats were tested with a cumulative dose-response procedure (0-18 mg/kg) for 12 consecutive days. The 12 test days consisted of three 4-day cycles. The first cycle obtained a baseline of responding. During the second cycle, rats were given access to a bottle containing either a glucose/saccharin solution (G+S) or distilled water (dH2O) in addition to having free access to water in their home cage. During the final cycle, the G+S or dH2O bottle was removed. Discriminative control in the first cycle did not differ between pre-G+S and pre-dH2O. When the second bottle was presented, median effective dose values (ED50s) for cocaine in animals with access to G+S were higher than baseline, whereas the ED50s for cocaine in animals that received dH2O remained unchanged. During the final cycle when G+S was removed, ED50 values again did not differ after dH2O but remained increased for the rats with previous access to the G+S solution. Our data suggest that rats were less sensitive to the cocaine cue when a sweet solution was available in the home cage.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Kohut SJ,Riley ALdoi
10.1097/FBP.0b013e32833a5bdfsubject
Has Abstractpub_date
2010-05-01 00:00:00pages
241-5issue
3eissn
0955-8810issn
1473-5849journal_volume
21pub_type
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journal_title:Behavioural pharmacology
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