Abstract:
:The prefrontal cortex (PFC) plays a critical role in mediating executive functions and orchestrating the way in which we think, decide, and behave. Many studies have shown that PFC neurons not only play a major role in mediating behavioral responses to stress but are also sensitive to stress and undergo remodeling following stress exposure. Activation of the hypothalamic-pituitary-adrenal axis as a result of stress initiates a flood of alterations in prefrontal neurotransmitter release. Dopamine (DA) neurotransmission in the PFC is involved in the modulation of stress responsiveness. Compelling results show that stressful events are associated with increased DA concentrations in the medial PFC. Excessive DA-ergic activity in the medial prefrontal cortex following stress has a negative impact on working memory and executive functions in rodents, monkeys, and humans, making them unable to processing information selectively and impairing cognitive function. Therefore, an exact understanding of these mechanisms may provide important insights into the pathophysiology of executive dysfunction and novel treatment avenues. The present review provides a summary of the neuronal circuitry involved in alterations of PFC dopaminergic neurons under conditions of stress, and then addresses the interaction of PFC DA with glucocorticoids leading to impairment of working memory under conditions of stress.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Bahari Z,Meftahi GH,Meftahi MAdoi
10.1097/FBP.0000000000000429subject
Has Abstractpub_date
2018-10-01 00:00:00pages
584-591issue
7eissn
0955-8810issn
1473-5849pii
00008877-201810000-00005journal_volume
29pub_type
杂志文章,评审abstract::Nitrous oxide (N2O) effects were evaluated, as a behavioural model of inert gas narcosis, in rats performing a vigilance task in which they were required to respond to a slight luminous increment of the house-light. A dose-related decrease of correct responses was produced by the tested range of concentrations of N2O ...
journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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更新日期:1992-08-01 00:00:00
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journal_title:Behavioural pharmacology
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doi:10.1097/00008877-200207000-00006
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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doi:10.1097/00008877-199410000-00006
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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