Effects of 4-aminopyridine on classical conditioning of the rabbit (Oryctolagus cuniculus) nictitating membrane response.

abstract：:The aim of the present study was to examine a potential mechanism of action of gabapentin to manage cannabis-use disorders by determining the interoceptive effects of gabapentin in cannabis users discriminating [INCREMENT]-tetrahydrocannabinol ([INCREMENT]-THC) using a pharmacologically selective drug-discrimination p...

journal_title：Behavioural pharmacology

authors： Lile JA,Wesley MJ,Kelly TH,Hays LR

更新日期：2016-04-01 00:00:00

abstract：:The strain of spontaneously hypertensive rats (SHR) is considered a genetic model for the study of attention-deficit hyperactivity disorder (ADHD), as it displays hyperactivity, impulsivity and poorly sustained attention. Recently, we have shown the involvement of adenosinergic neuromodulation in the SHR's short-term ...

journal_title：Behavioural pharmacology

authors： Pires VA,Pamplona FA,Pandolfo P,Fernandes D,Prediger RD,Takahashi RN

更新日期：2009-03-01 00:00:00

abstract：:Previous experiments showed that acute administration of the angiotensin converting enzyme (ACE) inhibitor, ceronapril, shares with neuroleptic drugs an ability to enhance latent inhibition (LI), which consists of retardation in conditioning to a stimulus as a consequence of its prior non-reinforced pre-exposure. Expe...

journal_title：Behavioural pharmacology

authors： Weiner I,Tarrasch R,Hasson O,Forian R,Smith AD,Rawlins JN,Feldon J

更新日期：1994-06-01 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter in the brain, produces excitotoxicity through its agonistic action on postsynaptic N-methyl-D-aspartate receptor, resulting in neurodegeneration. We hypothesized that the administration of low doses of glutamate in cerebral ischemia could attenuate the excitotoxicity in neuron...

journal_title：Behavioural pharmacology

authors： Ramanathan M,Abdul KK,Justin A

更新日期：2016-10-01 00:00:00

abstract：:The cannabinoid receptor agonist Δ(9)-tetrahydrocannabinol (THC) enhances the antinociceptive effects of µ-opioid receptor agonists, raising the possibility of using a combination of THC and opioids for treating pain. This study examined the effects of noncontingent and contingent administration of THC on intravenous ...

journal_title：Behavioural pharmacology

authors： Li JX,Koek W,France CP

更新日期：2012-12-01 00:00:00

abstract：:Cannabinoid receptor (CBR) agonists produce antinociception in conventional preclinical assays of pain-stimulated behavior but are not effective in preclinical assays of pain-depressed behavior. Fatty acid amide hydrolase (FAAH) inhibitors increase physiological levels of the endocannabinoid anandamide, which may conf...

journal_title：Behavioural pharmacology

authors： Kwilasz AJ,Abdullah RA,Poklis JL,Lichtman AH,Negus SS

更新日期：2014-04-01 00:00:00

abstract：:This study compared fixed-ratio (FR) and fixed-interval (FI) schedules to investigate the discriminative stimulus properties of μ-opioid and/or κ-opioid receptor agonists. Pigeons were trained to discriminate among morphine (μ agonist), U50488 (κ agonist), the combination, and saline under FR 20-s or FI-300-s schedule...

journal_title：Behavioural pharmacology

authors： Wessinger WD,Li M,McMillan DE

更新日期：2011-09-01 00:00:00

abstract：:Pair-housed, water-deprived rats were trained to run in a two-way shuttle box, using water reinforcement. Animals were tested either singly or in pairs; in the paired condition, the animals were required to shuttle in close physical proximity. Paired performance, but not single performance was severely disrupted by si...

journal_title：Behavioural pharmacology

authors： Willner P,Sampson D,Phillips G,Fichera R,Foxlow P,Muscat R

更新日期：1989-01-01 00:00:00

abstract：:Previous studies have indicated that dopamine D1 receptors in the ventral tegmental area (VTA) may play an important role in the development of sensitization to amphetamine. The present study was designed to determine if D1 receptors are also important in the development of cocaine-induced behavioral and neurochemical...

journal_title：Behavioural pharmacology

authors： Steketee JD

更新日期：1998-02-01 00:00:00

abstract：:Rats were maintained on a daily regimen involving a 2h opportunity to take both water and a sweetened alcoholic beverage (12% ethanol, 0.25% saccharin). After 3 weeks on this regimen, rats regularly take substantial amounts of alcohol. After stabilization, injections of alpha(2)-adrenergic antagonists were administere...

journal_title：Behavioural pharmacology

authors： Reid LD,Delconte JD,Amendola CA,Nichols ML,Krupsky GW,Dharia NS,Hubbell CL

更新日期：1994-08-01 00:00:00

abstract：:Alcohol consumption acutely increases smoking behavior, but the reverse relationship, the acute effects of smoking on alcohol intake, largely has been ignored. We examined whether smoking acutely increases the reinforcing value of alcohol, first in the absence of recent alcohol intake and then following an alcohol pre...

journal_title：Behavioural pharmacology

authors： Perkins KA,Fonte C,Grobe JE

更新日期：2000-02-01 00:00:00

abstract：:The purpose of this study was to analyse adrenergic and serotonergic interactions in the anxiolytic effects of several 5-HT(1A) agonists including ipsapirone, buspirone, indorenate and 8-OH-DPAT. To this end, the effects of different doses of the adrenergic compounds clonidine (0.015-0.0625mg/kg), yohimbine (0.125-0.5...

journal_title：Behavioural pharmacology

authors： López-Rubalcava C,Fernández-Guasti A

更新日期：1994-02-01 00:00:00

abstract：:Given the repeated failure of amyloid-based approaches in Alzheimer's disease, there is increasing interest in tau-based therapeutics. Although methylthioninium (MT) treatment was found to be beneficial in tau transgenic models, the brain concentrations required to inhibit tau aggregation in vivo are unknown. The comp...

journal_title：Behavioural pharmacology

authors： Melis V,Magbagbeolu M,Rickard JE,Horsley D,Davidson K,Harrington KA,Goatman K,Goatman EA,Deiana S,Close SP,Zabke C,Stamer K,Dietze S,Schwab K,Storey JM,Harrington CR,Wischik CM,Theuring F,Riedel G

更新日期：2015-06-01 00:00:00

abstract：:Recent examination of the mixed dopamine agonist apomorphine suggests that dopamine inhibits both passive avoidance and response suppression learning. The present study investigated the effects of selective dopamine agonists on memory consolidation using a passive avoidance task in the day-old chick. The dopamine D1 a...

journal_title：Behavioural pharmacology

authors： Hale MW,Crowe SF

更新日期：2002-07-01 00:00:00

abstract：:Neonatal ventral hippocampal lesions in the rat result in post-pubertal onset of behavioural abnormalities, modelling some aspects of schizophrenia. We further assessed the behavioural effects of neonatal lesions in rats in a variety of cognitive tasks and in the prepulse inhibition (PPI) of startle response paradigm....

journal_title：Behavioural pharmacology

authors： Le Pen G,Grottick AJ,Higgins GA,Martin JR,Jenck F,Moreau JL

更新日期：2000-06-01 00:00:00

abstract：:This study examined interactions between cocaine and drugs that act as direct agonists at subtypes of "D2-like" dopamine receptors. The drugs 7-OH-DPAT, quinpirole and RU24213 were studied alone and in combination with cocaine for their effects on locomotor activity in non-habituated mice. Locomotor activity was measu...

journal_title：Behavioural pharmacology

authors： Tirelli E,Reggers J,Terry P

更新日期：1997-06-01 00:00:00

abstract：:Serotonin-selective reuptake inhibitors (SSRIs) have been shown to enhance the locomotor stimulatory, discriminative-stimulus, and convulsive effects of cocaine in rodents. A pharmacokinetic mechanism for the interaction is supported by increases in the brain levels of cocaine by fluoxetine treatment. Furthermore, the...

journal_title：Behavioural pharmacology

authors： Soto PL,Hiranita T,Katz JL

更新日期：2009-12-01 00:00:00

abstract：:Male Syrian hamsters (Mesocricetus auratus) treated with anabolic/androgenic steroids (AAS) during adolescence (P27-P56) display highly escalated and mature forms of offensive aggression correlated with increased γ-aminobutyric acid (GABA) afferent development as well as decreased GABAA receptors in the lateroanterior...

journal_title：Behavioural pharmacology

authors： Morrison TR,Ricci LA,Melloni RH Jr

更新日期：2014-10-01 00:00:00

abstract：:Nitrous oxide (N2O) effects were evaluated, as a behavioural model of inert gas narcosis, in rats performing a vigilance task in which they were required to respond to a slight luminous increment of the house-light. A dose-related decrease of correct responses was produced by the tested range of concentrations of N2O ...

journal_title：Behavioural pharmacology

authors： Courtière A,Hardouin J

更新日期：1997-10-01 00:00:00

abstract：:Synthetic cathinone derivatives are commonly considered quasi-legal alternatives for stimulant drugs, such as cocaine and methamphetamine, but some derivatives are increasingly being detected in club drug formulations of Ecstasy or 'Molly' as substitutes for methylenedioxymethamphetamine (±-MDMA). Although several stu...

journal_title：Behavioural pharmacology

authors： Gatch MB,Dolan SB,Forster MJ

更新日期：2020-06-01 00:00:00

abstract：:The interoceptive stimulus induced by clozapine (5 mg/kg, i.p.) has been characterized in an operant drug discrimination procedure in the rat using a wide range of receptor subtype-selective agonists and antagonists. Only the muscarinic receptor antagonist scopolamine generalized fully to clozapine (>80%). Partial gen...

journal_title：Behavioural pharmacology

authors： Goudie AJ,Smith JA,Taylor A,Taylor MA,Tricklebank MD

更新日期：1998-12-01 00:00:00

abstract：:Parkinson's disease psychosis (PDP) is a condition for which a safe, tolerated, and effective therapy is lacking. Treatment with typical or atypical antipsychotics may be contraindicated in patients with PDP because of the potential for aggravating motor symptoms. This study used a novel animal model with features of ...

journal_title：Behavioural pharmacology

authors： McFarland K,Price DL,Bonhaus DW

更新日期：2011-10-01 00:00:00

abstract：:Obesity and cigarette smoking are often cited separately as the top two preventable causes of death in the United States; however, little research has explored the factors associated with being both obese and a smoker. Delay discounting is a behavioral characteristic that may underlie both of these conditions/behavior...

journal_title：Behavioural pharmacology

authors： Fields SA,Sabet M,Peal A,Reynolds B

更新日期：2011-06-01 00:00:00

abstract：:Although the dopaminergic pharmacology of the D1 receptor full agonists, dinapsoline, dihydrexidine and the prodrug ABT-431 have been studied, no information is available on the ability of these agonists to substitute for the D1 agonist SKF 38393 in rats trained to discriminate this compound from vehicle. The present ...

journal_title：Behavioural pharmacology

authors： Gleason SD,Witkin JM

更新日期：2004-02-01 00:00:00

abstract：:Cannabis is the most popular illicit drug used by adolescents. Yet, there are only a few studies that have examined the effects of cannabis use on learning and memory during this sensitive and important neurodevelopmental stage. Male adolescent Sprague-Dawley rats were treated with Δ(9)-tetrahydrocannabinol (THC, 6 mg...

journal_title：Behavioural pharmacology

authors： Steel RW,Miller JH,Sim DA,Day DJ

更新日期：2011-12-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder classically associated with motor symptoms, but several nonmotor disturbances appear decades before the clinical diagnosis of the disease. A variety of hypotheses exist to explain the onset of PD, and neuroinflammation is one of the most investigated processes. ...

journal_title：Behavioural pharmacology

authors： Rodrigues LS,Fagotti J,D S Targa A,D Noseda AC,L Ilkiwa J,Chuproski AP,W C Dorieux F,D Dos Santos P,M S Lima M

更新日期：2019-12-01 00:00:00

abstract：:Behavioural sensitization to the locomotor stimulant effect of (+)-amphetamine or quinpirole was induced in rats by intermittent drug administration. Once established, endogenous dopamine release (DA) was measured in slices containing nucleus accumbens using fast cyclic voltammetry. DA release induced by single pulse ...

journal_title：Behavioural pharmacology

authors： Muscat R,Patel J,Trout SJ,Wieczorek W,Kruk ZL

更新日期：1993-01-01 00:00:00

abstract：:The stimulus control by morphine under a fixed-interval (FI) 180-s schedule of reinforcement was examined in five pigeons trained to discriminate 5.0mg/kg of i.m. morphine from saline. After training, dose-response relationships were determined for morphine, d-amphetamine, pentobarbital, fentanyl, and MK-801. At low d...

journal_title：Behavioural pharmacology

authors： Massey BW,McMillan DE,Wessinger WD

更新日期：1992-10-01 00:00:00

abstract：:Flavonoids are natural substances obtained from plants. Most flavonoids cross the blood-brain barrier and exert a wide range of effects on the central nervous system. These actions have been attributed to the modulation of GABA-A receptors. Although motor systems in the central nervous system express a high density of...

journal_title：Behavioural pharmacology

authors： Alatorre A,Oviedo-Chávez A,Villalobos N,Ríos A,Barrientos R,Querejeta E

更新日期：2015-02-01 00:00:00

abstract：:Early-life administration of risperidone, the most widely used antipsychotic drug in children, leads to persistently elevated locomotor activity in adult rats. This study determined whether and when elevated locomotor activity emerges during developmental risperidone administration. Developing and adult rats were admi...

journal_title：Behavioural pharmacology

authors： Stevens RM,Gannon MA,Griffith MS,Bardgett ME

更新日期：2016-08-01 00:00:00