Drug discrimination in pigeons trained to discriminate among morphine, U50488, a combination of these drugs, and saline.

abstract：:The purpose of the present experiment was to assess the degree of tolerance and cross-tolerance to the response rate-decreasing effects of opioids with different degrees of intrinsic efficacy at the mu receptor. The mu opioids included buprenorphine, etorphine, l-methadone, morphine, and sufentanil. Lever pressing of ...

journal_title：Behavioural pharmacology

authors： Hughes CE,Picker MJ,Dykstra LA

更新日期：1995-12-01 00:00:00

abstract：:Both depression and cancer are related to a dysregulation of inflammatory and immune pathways. Indeed, depression is associated with increased expression of interferon-γ, interleukin-1β, and tumor necrosis factor α (TNF-α). In contrast, reductions of the activity of major histocompatibility complex protein molecules -...

journal_title：Behavioural pharmacology

authors： Barreto FS,Chaves Filho AJM,de Araújo MCCR,de Moraes MO,de Moraes MEA,Maes M,de Lucena DF,Macedo DS

更新日期：2018-04-01 00:00:00

abstract：:In a step-down passive avoidance task, the pre-training injection of 1.25-10 mg/kg of morphine impaired memory. This was restored when injection of the same dose of morphine (pre-test treatment) was repeated 24 h later (morphine state-dependent learning: morphine St-D). ATP-dependent potassium (K(ATP)) channels have b...

journal_title：Behavioural pharmacology

authors： Zarrindast MR,Jafari MR,Shafaghi B,Djahanguiri B

更新日期：2004-03-01 00:00:00

abstract：:Panic attacks (PAs) are episodes of intense fear or discomfort that are accompanied by a variety of both psychological and somatic symptoms. Panic induction in preclinical models (e.g. rats) has largely been assayed through flight and avoidance behavioral tests and cardiorespiratory activity. Yet, the literature perta...

journal_title：Behavioural pharmacology

authors： Federici LM,Caliman IF,Fitz SD,Shekhar A,Johnson PL

更新日期：2019-06-01 00:00:00

abstract：:The present study investigated the ability of drug-associated cues to reinstate extinguished responding following an extended period of withdrawal from cocaine self-administration. Rats self-administered cocaine (0.33mg/infusion) for 2 weeks of daily 3-h limited-access sessions under a fixed-interval (FI) schedule of ...

journal_title：Behavioural pharmacology

authors： Meil WM,See RE

更新日期：1996-12-01 00:00:00

abstract：:In a double-blind crossover design on 36 male smokers, differences in hormone responses to a serotonergic (citalopram) and dopaminergic (bromocriptine) challenge were tested, to compare transmitter responsivities in addicted and pleasure-motivated smokers with respective controls. A general score of smoking addiction,...

journal_title：Behavioural pharmacology

authors： Netter P,Toll C,Lujic C,Reuter M,Hennig J

更新日期：2002-09-01 00:00:00

abstract：:In light of the adverse side-effects of opioids, cannabinoid receptor agonists may provide an effective alternative for the treatment of cancer pain. This study examined the potency and efficacy of synthetic CB1 and CB2 receptor agonists in a murine model of tumor pain. Intraplantar injection of the CB1 receptor agoni...

journal_title：Behavioural pharmacology

authors： Khasabova IA,Gielissen J,Chandiramani A,Harding-Rose C,Odeh DA,Simone DA,Seybold VS

更新日期：2011-09-01 00:00:00

abstract：:The present experiments investigated the effects of excitatory amino acid antagonists, infused into core and shell subregions of the nucleus accumbens, on spatial behavior in the rat. A food-search task was used, in which animals learn a specific pattern of food gathering; duration of each trial (time taken to gather ...

journal_title：Behavioural pharmacology

authors： Maldonado-Irizarry CS,Kelley AE

更新日期：1995-08-01 00:00:00

abstract：:A previous study from this laboratory reported an antiaversive effect of the beta-adrenoceptor blocker propranolol microinjected into the dorsal periaqueductal grey (DPAG) of the rat, that was antagonized by the 5-HT(2) receptor blocker ritanserin. The present results show that microinjection into the DPAG of isamolta...

journal_title：Behavioural pharmacology

authors： Nogueira RL,Graeff FG

更新日期：1991-02-01 00:00:00

abstract：:Treatments for the positive and negative symptoms of schizophrenia have been explored for decades, but no completely successful therapy has been found as yet. Metabotropic glutamate receptor 5 (mGluR5), which potentiates N-methyl-D-aspartate receptors in brain regions implicated in schizophrenia, has become a novel dr...

journal_title：Behavioural pharmacology

authors： Wu Z,Yang Z,Zhang M,Bao X,Han F,Li L

更新日期：2018-02-01 00:00:00

abstract：:This study was conducted to evaluate the effects of exposure to diphenyl diselenide (PhSe)2 on cognitive impairment induced by scopolamine, a muscarinic antagonist, using the Y-maze and Morris water maze tests in mice. One hour before the tests, mice were treated with (PhSe)2 (50 mg/kg, oral) and 30 min later memory i...

journal_title：Behavioural pharmacology

authors： Souza AC,Brüning CA,Leite MR,Zeni G,Nogueira CW

更新日期：2010-09-01 00:00:00

abstract：:Behavioral sensitization in mammals, including humans, is sensitive to factors such as administration route, testing environment, and pharmacokinetic confounds, unrelated to the drugs themselves that are difficult to eliminate. Simpler animals less susceptible to these confounding influences may be advantageous substi...

journal_title：Behavioural pharmacology

authors： Rawls SM,Patil T,Yuvasheva E,Raffa RB

更新日期：2010-07-01 00:00:00

abstract：:In a previous short-term study, salvianolic acid B was reported to have a protective effect on cerebral ischemia. Here, we investigated whether salvianolic acid B improves the recovery of motor function after cerebral ischemia in a 14-day investigation. Cerebral ischemia was induced by middle cerebral artery occlusion...

journal_title：Behavioural pharmacology

authors： Tang M,Feng W,Zhang Y,Zhong J,Zhang J

更新日期：2006-09-01 00:00:00

abstract：:We report here that local hippocampal WIN-55,212-2 implants release this cannabinoid agonist for extended periods, the release is restricted to the implanted brain region and is behaviorally active. Radiolabeled WIN-55,212-2 was implanted bilaterally into the CA3 region of the dorsal hippocampus by means of fused sili...

journal_title：Behavioural pharmacology

authors： Barna I,Soproni K,Arszovszki A,Csabai K,Haller J

更新日期：2007-09-01 00:00:00

abstract：:Rats were trained on one of two multiple random-interval schedules of reinforcement, which contained both ascending and descending reinforcement density sequences. The design of the schedules made it possible to determine whether performance changes in a particular component depended on the reinforcement density in th...

journal_title：Behavioural pharmacology

authors： Willner P,Phillips G,Sampson D,Muscat R

更新日期：1989-01-01 00:00:00

abstract：:Previous studies have indicated that dopamine D1 receptors in the ventral tegmental area (VTA) may play an important role in the development of sensitization to amphetamine. The present study was designed to determine if D1 receptors are also important in the development of cocaine-induced behavioral and neurochemical...

journal_title：Behavioural pharmacology

authors： Steketee JD

更新日期：1998-02-01 00:00:00

abstract：:A symposium held at the 50th annual meeting of the Behavioral Pharmacology Society in May 2007 reviewed progress in the human behavioral pharmacology of drug abuse. Studies on drug self-administration in humans are reviewed that assessed reinforcing and subjective effects of drugs of abuse. The close parallels observe...

journal_title：Behavioural pharmacology

authors： Comer SD,Bickel WK,Yi R,de Wit H,Higgins ST,Wenger GR,Johanson CE,Kreek MJ

更新日期：2010-07-01 00:00:00

abstract：:Eating a diet high in fat can lead to negative health consequences, including obesity and insulin resistance. Omega-3 polyunsaturated fatty acids (such as those found in fish oil) prevent high fat diet-induced obesity and insulin resistance in rats. Eating a high fat diet also enhances sensitivity of rats to the behav...

journal_title：Behavioural pharmacology

authors： Hernandez-Casner C,Ramos J,Serafine KM

更新日期：2017-09-01 00:00:00

abstract：:There is a growing realization that the severity of the core symptoms of autism spectrum disorders and schizophrenia is associated with gastrointestinal dysfunction. Nonetheless, the mechanisms underlying such comorbidities remain unknown. Several genetic and environmental factors have been linked to a higher suscepti...

journal_title：Behavioural pharmacology

authors： Morais LH,Felice D,Golubeva AV,Moloney G,Dinan TG,Cryan JF

更新日期：2018-04-01 00:00:00

abstract：:The discriminative stimulus effects of the imidazopyridine hypnotic zolpidem and the classic benzodiazepine hypnotic triazolam were examined in seven healthy volunteers using a three-response drug discrimination procedure and a within-subject design. During an initial sampling phase, the training drug conditions (plac...

journal_title：Behavioural pharmacology

authors： Mintzer MZ,Frey JM,Griffiths RR

更新日期：1998-11-01 00:00:00

abstract：:Post-training administration of different doses of baclofen (a GABAB agonist) has been shown to impair memory retention, in a step-down passive avoidance test in mice. We have studied the effects of beta-adrenergic agonists and antagonists on baclofen-induced memory impairment in mice. Dobutamine (a beta 1-agonist) or...

journal_title：Behavioural pharmacology

authors： Zarrindast MR,Haidari H,Jafari MR,Djahanguiri B

更新日期：2004-07-01 00:00:00

abstract：:Few studies have investigated the effects of chronic cannabinoid exposure on memory performance and whether tolerance occurs to cannabinoid-induced memory impairment. Here, we studied the effects of repeated exposure to Delta-tetrahydrocannabinol (THC: 1 mg/kg) on spatial memory and zif268 expression in mice. One grou...

journal_title：Behavioural pharmacology

authors： Boucher AA,Vivier L,Metna-Laurent M,Brayda-Bruno L,Mons N,Arnold JC,Micheau J

更新日期：2009-02-01 00:00:00

abstract：:Drug addiction is a progressive, relapsing disease comprised of interlocking stages of disordered motivation. Numerous animal models describing various stages of the addiction process have been developed over the past few decades, providing considerable advantages for the modeling of drug addiction compared with other...

journal_title：Behavioural pharmacology

authors： Edwards S,Koob GF

更新日期：2013-09-01 00:00:00

abstract：:Adult male Wistar rats were bilaterally implanted with indwelling cannulae in the agranular insular cortex of the prefrontal cortex. After recovery, animals were trained in a step-down inhibitory avoidance task (3.0-s, 0.4-mA footshock) and received, immediately after training, a 0.5-microl infusion of the serotonergi...

journal_title：Behavioural pharmacology

authors： Mello e Souza T,Rodrigues C,Souza MM,Vinadé E,Coitinho A,Choi H,Izquierdo I

更新日期：2001-09-01 00:00:00

abstract：:While previous research has sought to validate the chick separation stress paradigm as an anxiolytic screening assay, it is unknown whether the paradigm better models a nonspecific anxiety-like state or something similar to panic disorder or generalized anxiety disorder. To characterize the anxiety model pharmacologic...

journal_title：Behavioural pharmacology

authors： Warnick JE,Wicks RT,Sufka KJ

更新日期：2006-11-01 00:00:00

abstract：:Neuropsychiatric disorders, such as addiction, are associated with cognitive impairment, including learning and memory deficits. Previous research has demonstrated that the chronic use of methamphetamine (METH) induces long-term cognitive impairment and cannabidiol (CBD), as a neuroprotectant, can reverse spatial memo...

journal_title：Behavioural pharmacology

authors： Razavi Y,Shabani R,Mehdizadeh M,Haghparast A

更新日期：2020-06-01 00:00:00

abstract：:Adult male Wistar rats were bilaterally implanted with indwelling cannulae in the CA1 region of the dorsal hippocampus. Once recovered from surgery, animals were submitted to one session of step-down inhibitory avoidance training (3.0 s, 0.4 mA footshock). Animals received a 0.5-microl infusion of saline, or of LY2940...

journal_title：Behavioural pharmacology

authors： Barros DM,Mello e Souza T,de Souza MM,Choi H,DeDavid e Silva T,Lenz G,Medina JH,Izquierdo I

更新日期：2001-12-01 00:00:00

abstract：:The development of Parkinson's disease (PD) involves the degeneration of dopaminergic neurons caused by oxidative stress. Accumulating clinical evidence indicates that high blood levels of uric acid (UA), an intrinsic antioxidative substance, are associated with reduced risk of PD. However, this hypothesis has not bee...

journal_title：Behavioural pharmacology

authors： Nakashima A,Yamauchi A,Matsumoto J,Dohgu S,Takata F,Koga M,Fukae J,Tsuboi Y,Kataoka Y

更新日期：2019-02-01 00:00:00

abstract：:Although microdialysis is commonly understood as a method of sampling low molecular weight compounds in the extracellular compartment of tissues, this definition appears insufficient to specifically describe brain microdialysis of neurotransmitters. In fact, transmitter overflow from the brain into dialysates is criti...

journal_title：Behavioural pharmacology

authors： Di Chiara G,Tanda G,Carboni E

更新日期：1996-11-01 00:00:00

abstract：:Animals neonatally depleted of dopamine show decreases in exploratory behaviour. As latent learning may depend on exploratory behaviour the present study was undertaken to examine the effects of neonatal dopamine depletion on latent learning. In two experiments dopamine was depleted neonatally, using 6-hydroxydopamine...

journal_title：Behavioural pharmacology

authors： Archer T,Beninger RJ,Järbe TU,Seiden LS

更新日期：1989-01-01 00:00:00