Tolerance and cross-tolerance to the response rate-decreasing effects of µ opioids in morphine-maintained squirrel monkeys.

abstract：:Behavioral flexibility or 'set-shifting' refers to the ability to modify ongoing behavior in response to changing goals or environmental contingencies. Impaired behavioral flexibility is associated with disorders such as schizophrenia and addiction. Hypofunction of N-methyl-D-aspartate (NMDA) receptors has been implic...

journal_title：Behavioural pharmacology

authors： Darrah JM,Stefani MR,Moghaddam B

更新日期：2008-05-01 00:00:00

abstract：:The development of Parkinson's disease (PD) involves the degeneration of dopaminergic neurons caused by oxidative stress. Accumulating clinical evidence indicates that high blood levels of uric acid (UA), an intrinsic antioxidative substance, are associated with reduced risk of PD. However, this hypothesis has not bee...

journal_title：Behavioural pharmacology

authors： Nakashima A,Yamauchi A,Matsumoto J,Dohgu S,Takata F,Koga M,Fukae J,Tsuboi Y,Kataoka Y

更新日期：2019-02-01 00:00:00

abstract：:Insufficient research has been carried out on the effects of repeated treatments with psychostimulants on agonistic behaviour. These effects were studied in mice using different schedules of administration and employing a low dose of amphetamine (1.5 mg/kg) which did not produce significant motor disruptions. After tw...

journal_title：Behavioural pharmacology

authors： Moro M,Salvador A,Simón VM

更新日期：1997-08-01 00:00:00

abstract：:This study was conducted to evaluate the effects of exposure to diphenyl diselenide (PhSe)2 on cognitive impairment induced by scopolamine, a muscarinic antagonist, using the Y-maze and Morris water maze tests in mice. One hour before the tests, mice were treated with (PhSe)2 (50 mg/kg, oral) and 30 min later memory i...

journal_title：Behavioural pharmacology

authors： Souza AC,Brüning CA,Leite MR,Zeni G,Nogueira CW

更新日期：2010-09-01 00:00:00

abstract：:We studied the anxiolytic-like activity of alnespirone and buspirone, two 5-HT(1A) receptor agonists, in a modified Geller-Seifter conflict model, and examined the role of 5-HT(1A) receptors by studying whether WAY-100635, a selective antagonist at these receptors, blocked their effects. Administered s.c. 30 minutes b...

journal_title：Behavioural pharmacology

authors： Cervo L,Munoz C,Bertaglia A,Samanin R

更新日期：2000-04-01 00:00:00

abstract：:Animal models of nicotine dependence are fundamental experimental tools for the understanding of the neurobiological and molecular processes underlying smoking behaviour. Substance use is controlled by four main processes: positive reinforcing effects, aversive effects, discriminative effects and stimulus-conditioned ...

journal_title：Behavioural pharmacology

authors： Merlo Pich E,Chiamulera C,Carboni L

更新日期：1999-11-01 00:00:00

abstract：:There is clinical and experimental evidence that treatment with immunosuppressive and antiproliferative drugs such as the calcineurin inhibitor cyclosporine A (CsA) is associated with mental health problems and neuropsychological disturbances in patients. However, it remains unclear whether and to what extent cognitiv...

journal_title：Behavioural pharmacology

authors： Kahl AL,Kirchhof J,Füting A,Hütter BO,Wilde B,Witzke O,Benson S,Hadamitzky M,Schedlowski M

更新日期：2017-06-01 00:00:00

abstract：:Some reports suggest that older patients are less responsive to antidepressants than young adults, but this idea has not been fully supported. Here, we investigated the role of aging in the behavioral effects of the antidepressants, desipramine (DMI) (5, 10, and 20 mg/kg) and fluoxetine (FLX) (5, 10, and 20 mg/kg) in ...

journal_title：Behavioural pharmacology

authors： Olivares-Nazario M,Fernández-Guasti A,Martínez-Mota L

更新日期：2016-02-01 00:00:00

abstract：:Rats were trained on a three-panel runway task prior to injections of N-methyl-D-aspartate (NMDA; 40nmoles/µl/side) into the dorsal hippocampus. One week after the treatment, animals did not show any change in the number of errors on the first runway trial (reference memory), with one correct white and two incorrect b...

journal_title：Behavioural pharmacology

authors： Sugimachi K,Izawa K,Nakamura K,Kimura-Iwasaki K,Yamaguchi M,Nakagawa H,Oshino N

更新日期：1992-08-01 00:00:00

abstract：:Neuropsychiatric disorders, such as addiction, are associated with cognitive impairment, including learning and memory deficits. Previous research has demonstrated that the chronic use of methamphetamine (METH) induces long-term cognitive impairment and cannabidiol (CBD), as a neuroprotectant, can reverse spatial memo...

journal_title：Behavioural pharmacology

authors： Razavi Y,Shabani R,Mehdizadeh M,Haghparast A

更新日期：2020-06-01 00:00:00

abstract：:Pair-housed, water-deprived rats were trained to run in a two-way shuttle box, using water reinforcement. Animals were tested either singly or in pairs; in the paired condition, the animals were required to shuttle in close physical proximity. Paired performance, but not single performance was severely disrupted by si...

journal_title：Behavioural pharmacology

authors： Willner P,Sampson D,Phillips G,Fichera R,Foxlow P,Muscat R

更新日期：1989-01-01 00:00:00

abstract：:Separate groups of rats were trained to discriminate either 0.1mg/kg (low dose; L) or 2.5mg/kg (high dose; H) of 8-OH-DPAT from saline, in a standard operant task. Both cues were found to be dose, time and route dependent and generalized completely to the 5-HT(1A) agonists ipsapirone and flesinoxan. Buspirone substitu...

journal_title：Behavioural pharmacology

authors： Ybema CE,Slangen JL,Olivier B,Mos J

更新日期：1993-12-01 00:00:00

abstract：:Altered motivation for drugs of abuse is a central feature of most definitions of drug dependence and the impact of drug-related cues on motivation is of current interest. However, since most studies of cue-reactivity have not used behavioural measures of motivation, their results are often difficult to interpret in m...

journal_title：Behavioural pharmacology

authors： Glautier S,Rigney U,Willner P

更新日期：2001-04-01 00:00:00

abstract：:Neuroinflammation and β-amyloid (Aβ) deposition in the brain are well known characteristics of neurodegeneration. Diabetes and hypercholesterolemia are the main risk factors leading to memory loss and cognitive impairment. Recently, it was found that statins and thiazolidinediones have promising anti-inflammatory and ...

journal_title：Behavioural pharmacology

authors： Ekladious ST,El Sayed NS

更新日期：2019-02-01 00:00:00

abstract：:Recent examination of the mixed dopamine agonist apomorphine suggests that dopamine inhibits both passive avoidance and response suppression learning. The present study investigated the effects of selective dopamine agonists on memory consolidation using a passive avoidance task in the day-old chick. The dopamine D1 a...

journal_title：Behavioural pharmacology

authors： Hale MW,Crowe SF

更新日期：2002-07-01 00:00:00

abstract：:Mood and anxiety disorders, and rodent phenotypic measures modeling these disorders, have a strong genetic component. Various assays are used to study the neurobiological basis of fear-related and anxiety-related behaviors, phenotype genetically modified mice, and elucidate pharmacological modulation of these behavior...

journal_title：Behavioural pharmacology

authors： Brigman JL,Mathur P,Lu L,Williams RW,Holmes A

更新日期：2009-03-01 00:00:00

abstract：:Acetaldehyde has been suggested to mediate a number of the pharmacological and behavioural effects of ethanol. Recently, several studies investigated the role of acetaldehyde in the subjective effects of ethanol, but obtained conflicting results. With the discriminative taste aversion (DTA) procedure, high acetaldehyd...

journal_title：Behavioural pharmacology

authors： Quertemont E

更新日期：2003-07-01 00:00:00

abstract：:Smokers often report that the first cigarette of the day is the most rewarding, and subsequent smoking is less rewarding. Reduction in smoking enjoyment later in the day may be related to acute tolerance to the discriminative stimulus effects of nicotine. We examined changes in nicotine discrimination behaviour in hum...

journal_title：Behavioural pharmacology

authors： Perkins KA,Fonte C,Meeker J,White W,Wilson A

更新日期：2001-02-01 00:00:00

abstract：:Orexin plays an important role in pain modulation. Orexin-1 and orexin-2 receptors (Ox1r and Ox2r) are found at high density in the ventrolateral periaqueductal gray matter (vlPAG). Our previous study showed that chemical stimulation of the lateral hypothalamus with carbachol induces antinociception in the tail-flick ...

journal_title：Behavioural pharmacology

authors： Esmaeili MH,Reisi Z,Ezzatpanah S,Haghparast A

更新日期：2017-02-01 00:00:00

abstract：:These studies investigated the role of serotonin-1A (5-HT1A) and 5-HT2A receptors in the behavioral effects of dipropyltryptamine (DPT). Eight rats discriminated 0.56 mg/kg 2,5-dimethoxy-4-methylamphetamine (DOM) from saline and responded under a fixed ratio 5 schedule of food presentation; 12 other rats were used for...

journal_title：Behavioural pharmacology

authors： Li JX,Rice KC,France CP

更新日期：2007-07-01 00:00:00

abstract：:It has been reported that, in animals trained to discriminate ethanol, stimulus control generalized to the non-competitive NMDA antagonists phencyclidine, ketamine and dizocilpine. In the present study, rats were trained to discriminate a dose of ethanol (1g/kg, i.p.) and substitution tests were carried out with phenc...

journal_title：Behavioural pharmacology

authors： Sanger DJ

更新日期：1993-10-01 00:00:00

abstract：:The aim of the present study was to examine a potential mechanism of action of gabapentin to manage cannabis-use disorders by determining the interoceptive effects of gabapentin in cannabis users discriminating [INCREMENT]-tetrahydrocannabinol ([INCREMENT]-THC) using a pharmacologically selective drug-discrimination p...

journal_title：Behavioural pharmacology

authors： Lile JA,Wesley MJ,Kelly TH,Hays LR

更新日期：2016-04-01 00:00:00

abstract：:The effects on memory of drugs of abuse from several pharmacological classes were examined in four adult male squirrel monkeys responding under a delayed matching-to-sample schedule of food presentation. Subjects were required to emit 20 responses on a sample key transilluminated by either a constant white or a flashi...

journal_title：Behavioural pharmacology

authors： Baron SP,Wenger GR

更新日期：2001-07-01 00:00:00

abstract：:The fentanyl derivative mirfentanil has a novel set of behavioral effects in non-humans including low-efficacy opioid actions and non-opioid antinociceptive actions. This study evaluated the rate-decreasing effects of mirfentanil, morphine, naltrexone and ketamine in pigeons both prior to and during a period of chroni...

journal_title：Behavioural pharmacology

authors： Gauthier CA,Bagley JR,Brockunier LL,France CP

更新日期：1999-09-01 00:00:00

abstract：:The technique of microdialysis was employed to investigate in vivo 5-hydroxytryptamine (5-HT) release in isolation-reared rats compared with socially reared rats. Two methods were employed to stimulate 5-HT release: local KCI injection into the frontal cortex of chloral hydrate anaesthetized rats, and the exposure of ...

journal_title：Behavioural pharmacology

authors： Bickerdike MJ,Wright IK,Marsden CA

更新日期：1993-06-01 00:00:00

abstract：:The acute and chronic effects of certain drugs can often be opposite. For example, in congestive heart failure acute administration of β-adrenoceptor agonists results in beneficial improvement in symptoms of the disease, but their chronic use increases mortality. Conversely, certain β-adrenoceptor antagonists/inverse ...

journal_title：Behavioural pharmacology

authors： Bond RA,Giles H

更新日期：2011-09-01 00:00:00

abstract：:Fragile X syndrome is an X-linked form of mental retardation including, among others, symptoms such as stereotypic behaviour, hyperactivity, hyperarousal, and cognitive deficits. We hypothesized that hyperactivity and/or compromised attentional, cognitive functions may lead to impaired performance in cognitive tasks i...

journal_title：Behavioural pharmacology

authors： Ventura R,Pascucci T,Catania MV,Musumeci SA,Puglisi-Allegra S

更新日期：2004-09-01 00:00:00

abstract：:The present study investigated the ability of drug-associated cues to reinstate extinguished responding following an extended period of withdrawal from cocaine self-administration. Rats self-administered cocaine (0.33mg/infusion) for 2 weeks of daily 3-h limited-access sessions under a fixed-interval (FI) schedule of ...

journal_title：Behavioural pharmacology

authors： Meil WM,See RE

更新日期：1996-12-01 00:00:00

abstract：:Sex-dependent differences have been consistently described in cannabinoid addiction research. In particular, we recently reported that female Lister Hooded rats display greater self-administration of the cannabinoid CB1 receptor agonist WIN55,212-2 (WIN) and stronger reinstatement of cannabinoid-seeking behavior than ...

journal_title：Behavioural pharmacology

authors： Rosas M,Porru S,Giugliano V,Antinori S,Scheggi S,Fadda P,Fratta W,Acquas E,Fattore L

更新日期：2018-09-01 00:00:00

abstract：:A core symptom of human depressive disorder is anhedonia, the loss of interest or pleasure in daily activities. Anhedonia, measured as subsensitivity to reward, can be induced in rats by a regimen of repeated, mild, unpredictable stressors. Here, the hedonic state of rats was assessed using an intracranial self-stimul...

journal_title：Behavioural pharmacology

authors： Moreau JL,Scherschlicht R,Jenck F,Martin JR

更新日期：1995-11-01 00:00:00