Abstract：
:The acute and chronic effects of certain drugs can often be opposite. For example, in congestive heart failure acute administration of β-adrenoceptor agonists results in beneficial improvement in symptoms of the disease, but their chronic use increases mortality. Conversely, certain β-adrenoceptor antagonists/inverse agonists (β-blockers) initially cause a detrimental response by decreasing cardiac contractility in congestive heart failure, whereas chronic treatment with the same β-blockers improves contractility and survival. Furthermore, this time-dependent reversal of outcomes occurs in nonpharmacological interventions, such as exercise, and can even be observed in the response of plants to pruning or other stressors, with the results being a different short-term versus long-term effect. Here, we review some of these phenomena with a special emphasis on the temporal dissociation of pharmacological effects. Although Francis Colpaert used this knowledge to lead a drug discovery project for an analgesic compound that initially produced hyperalgesia, we focused on examples outside the central nervous system.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Bond RA,Giles Hdoi
10.1097/FBP.0b013e328348ec6fsubject
Has Abstractpub_date
2011-09-01 00:00:00pages
385-9issue
5-6eissn
0955-8810issn
1473-5849journal_volume
22pub_type
杂志文章,评审abstract：:Cocaine addicts very often use different combinations of cocaine and other drugs of abuse such as gamma-hydroxybutyric acid. The objective of the present work was to evaluate the impact of gamma-hydroxybutyric acid administration on the rewarding actions of cocaine, using the conditioned place preference procedure. Co...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/01.fbp.0000190685.84984.ec
更新日期：2006-03-01 00:00:00
abstract：:Previous studies have shown that ethanol produces conditioned place preference (CPP) in mice when injections are given immediately before exposure to the conditioned stimulus (CS). Paradoxically, however, injection of ethanol immediately after the CS produces conditioned place aversion (CPA). Four experiments were con...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/00008877-200011000-00006
更新日期：2000-11-01 00:00:00
abstract：:Treatments for the positive and negative symptoms of schizophrenia have been explored for decades, but no completely successful therapy has been found as yet. Metabotropic glutamate receptor 5 (mGluR5), which potentiates N-methyl-D-aspartate receptors in brain regions implicated in schizophrenia, has become a novel dr...
journal_title：Behavioural pharmacology
pub_type： 杂志文章,评审
doi：10.1097/FBP.0000000000000352
更新日期：2018-02-01 00:00:00
abstract：:Changes in extracellular concentrations of dopamine (DA) were measured in vivo in the nucleus accumbens of the rat during intravenous self-administration of either cocaine (0.25, 0.5, 1.0mg/infusion) or d-amphetamine (0.05, 0.1, 0.2mg/infusion). Drug intake was limited to 12 self-administered infusions per session for...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
abstract：:To investigate the role of the nucleus accumbens core (NAc) in the development of quinpirole-induced compulsive checking, rats received an excitotoxic lesion of NAc or sham lesion and were injected with quinpirole (0.5 mg/kg) or saline; development of checking behavior was monitored for 10 biweekly tests. The results ...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/FBP.0000000000000112
更新日期：2015-02-01 00:00:00
abstract：:Recently, we have described a new model of chronic social stress in rats, based on the resident-intruder paradigm. In this model, rats show behavioural changes that may be considered correlates of depressive symptoms, such as anhedonia and motivational deficits. The present study was designed for pharmacological valid...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/01.fbp.0000186631.53851.71
更新日期：2006-02-01 00:00:00
abstract：:Few studies have investigated the effects of chronic cannabinoid exposure on memory performance and whether tolerance occurs to cannabinoid-induced memory impairment. Here, we studied the effects of repeated exposure to Delta-tetrahydrocannabinol (THC: 1 mg/kg) on spatial memory and zif268 expression in mice. One grou...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/FBP.0b013e3283242f6a
更新日期：2009-02-01 00:00:00
abstract：:There is accumulating evidence that sex plays a critical role in drug abuse. Female sex hormones have been shown to affect central nervous system function and modulate the effects of drugs of abuse. For example, γ-aminobutyric acid type A (GABA(A)) receptor function is positively modulated by progesterone metabolites....
journal_title：Behavioural pharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1097/FBP.0b013e328349fc02
更新日期：2011-09-01 00:00:00
abstract：:Both opioids and cannabinoids have inhibitory effects at micromolar doses, which are mediated by activated receptors coupling to Gi/o-proteins. Surprisingly, the analgesic effects of opioids are enhanced by ultra-low doses (nanomolar to picomolar) of the opioid antagonist, naltrexone. As opioid and cannabinoid systems...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/00008877-200512000-00001
更新日期：2005-12-01 00:00:00
abstract：:The involvement of adrenoreceptor blocking drugs with the 5-HT(1A)-mediated discriminative stimulus was studied in pigeons trained to discriminate the 5-HT(1A) receptor agonist 8-OH-DPAT (0.3mg/kg) from saline. Cumulative dose-response curves were determined for 8-OH-DPAT, the beta-adrenergic antagonist pindolol, the ...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:The effects of µ agonists fentanyl, methadone and morphine and kappa agonist U50,488 on behavior maintained by negative reinforcement were determined. Rats were trained on concurrent schedules in which pressing one lever postponed shock on a Sidman avoidance schedule and pressing the other lever produced signaled peri...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/00008877-199404000-00003
更新日期：1994-04-01 00:00:00
abstract：:The present study used the microdialysis technique to investigate the effect of treadmill running, without the use of an electric grid, on extracellular serotonin in the ventral hippocampus of male Lister hooded rat. Extracellular hippocampal serotonin was measured during 60min of treadmill running at 20m/min and comp...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Chronic morphine-induced withdrawal syndrome after morphine cessation remains a severe obstacle in the clinical treatment of morphine. Previous studies have shown that nitric oxide synthetase (NOS) inhibitors may have therapeutic potential in morphine withdrawal in humans. The mechanisms that underlie expression of mo...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/FBP.0b013e3282f18da6
更新日期：2007-12-01 00:00:00
abstract：:The technique of microdialysis was employed to investigate in vivo 5-hydroxytryptamine (5-HT) release in isolation-reared rats compared with socially reared rats. Two methods were employed to stimulate 5-HT release: local KCI injection into the frontal cortex of chloral hydrate anaesthetized rats, and the exposure of ...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：:The aim of the present study was to examine a potential mechanism of action of gabapentin to manage cannabis-use disorders by determining the interoceptive effects of gabapentin in cannabis users discriminating [INCREMENT]-tetrahydrocannabinol ([INCREMENT]-THC) using a pharmacologically selective drug-discrimination p...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/FBP.0000000000000187
更新日期：2016-04-01 00:00:00
abstract：:Ultrasonic vocalizations are widely used to examine affective states in rats, yet relatively few studies explore the acoustic features of vocalizations, especially in relation to drug exposure, and no studies have explored alterations in acoustic features over time. The goal of this study was to examine nicotine- and ...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/FBP.0000000000000463
更新日期：2019-08-01 00:00:00
abstract：:The effects of d-amphetamine, chlorpromazine and pentobarbital on single alternation were compared in mice and rats. Chlorpromazine and d-amphetamine produced dose-related decreases in both accuracy and rate of responding with no differences in species sensitivity. Pentobarbital also produced dose-dependent decreases ...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Behavioral sensitization to amphetamine-like psychostimulants is manifest as a progressive increase in drug-induced anxiety and paranoia which can culminate in psychopathologies, such as paranoid psychosis and panic attacks. Sensitization may also mediate the facilitation of drug relapse in addicts by increasing the r...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Adult male Wistar rats were bilaterally implanted with indwelling cannulae in the CA1 region of the dorsal hippocampus. Once recovered from surgery, animals were submitted to one session of step-down inhibitory avoidance training (3.0 s, 0.4 mA footshock). Animals received a 0.5-microl infusion of saline, or of LY2940...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/00008877-200112000-00007
更新日期：2001-12-01 00:00:00
abstract：:Environmental and situational factors are important determinants of recreational drug use in humans. We aimed to develop a reliable animal model for studying the effects of environmental variables on drug-seeking behavior using the 'social isolation/social restriction' paradigm. Adult Wistar rats housed in short-term ...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/FBP.0b013e32833470bd
更新日期：2010-02-01 00:00:00
abstract：:Effects of environmental modulation of methamphetamine (MA)-induced behavior on the establishment and mode of expression of behavioral sensitization were examined. Rats received daily injection of MA for 10 days (1mg/kg, s.c.). Half of them were immediately returned to the home cage (home cage group) and the other hal...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：:Central nicotinc acetylcholine receptors have been targeted for the development of novel treatments for memory deficits in Alzheimer's disease (AD) and other neurodegenerative disorders. Nicotine itself has been shown to improve memory-related task performance in aged animals and in AD patients. Administration of nico...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/00008877-199911000-00015
更新日期：1999-11-01 00:00:00
abstract：:Sex-dependent differences have been consistently described in cannabinoid addiction research. In particular, we recently reported that female Lister Hooded rats display greater self-administration of the cannabinoid CB1 receptor agonist WIN55,212-2 (WIN) and stronger reinstatement of cannabinoid-seeking behavior than ...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/FBP.0000000000000395
更新日期：2018-09-01 00:00:00
abstract：:Nitrous oxide (N2O) effects were evaluated, as a behavioural model of inert gas narcosis, in rats performing a vigilance task in which they were required to respond to a slight luminous increment of the house-light. A dose-related decrease of correct responses was produced by the tested range of concentrations of N2O ...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:Varenicline is a smoking cessation pharmacotherapy with a presumed mechanism of action of partial efficacy at the α4β2 nicotinic acetylcholine receptor (nAChR); however, the extent to which daily varenicline use leads to changes in nAChR sensitivity is unclear. This study examined the consequences of daily varenicline...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/FBP.0000000000000452
更新日期：2019-08-01 00:00:00
abstract：:The effects of lithium in models of depression are often inconsistent. We aimed to replicate a regimen that induces robust antidepressant effects in the forced-swim test. Mice were treated with three different doses of lithium chloride (LiCl) 0.25, 0.4 or 0.5% in food and the forced-swim test or open field test was pe...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/FBP.0b013e32801416ed
更新日期：2007-02-01 00:00:00
abstract：:Neonatal ventral hippocampal lesions in the rat result in post-pubertal onset of behavioural abnormalities, modelling some aspects of schizophrenia. We further assessed the behavioural effects of neonatal lesions in rats in a variety of cognitive tasks and in the prepulse inhibition (PPI) of startle response paradigm....
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/00008877-200006000-00009
更新日期：2000-06-01 00:00:00
abstract：:Recent examination of the mixed dopamine agonist apomorphine suggests that dopamine inhibits both passive avoidance and response suppression learning. The present study investigated the effects of selective dopamine agonists on memory consolidation using a passive avoidance task in the day-old chick. The dopamine D1 a...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/00008877-200207000-00006
更新日期：2002-07-01 00:00:00
abstract：:Eating a diet high in fat can lead to negative health consequences, including obesity and insulin resistance. Omega-3 polyunsaturated fatty acids (such as those found in fish oil) prevent high fat diet-induced obesity and insulin resistance in rats. Eating a high fat diet also enhances sensitivity of rats to the behav...
journal_title：Behavioural pharmacology
pub_type： 杂志文章
doi：10.1097/FBP.0000000000000322
更新日期：2017-09-01 00:00:00
abstract：:Drug addiction is a progressive, relapsing disease comprised of interlocking stages of disordered motivation. Numerous animal models describing various stages of the addiction process have been developed over the past few decades, providing considerable advantages for the modeling of drug addiction compared with other...
journal_title：Behavioural pharmacology
pub_type： 杂志文章,评审
doi：10.1097/FBP.0b013e3283644d15
更新日期：2013-09-01 00:00:00
