Impairment of working memory by neuronal degeneration with NMDA in rat hippocampal CA-1.

Abstract:

:Rats were trained on a three-panel runway task prior to injections of N-methyl-D-aspartate (NMDA; 40nmoles/µl/side) into the dorsal hippocampus. One week after the treatment, animals did not show any change in the number of errors on the first runway trial (reference memory), with one correct white and two incorrect black panels at each choice point, whereas they showed a marked increase in the number of errors on the following (2nd-6th) trials (working memory) with all black panels. The memory deficit persisted at least for 10 days. After the experiments, histological studies showed neuronal degeneration of hippocampal CA-1 pyramidal cells in all NMDA-treated rats but not in vehicle-treated rats. Pretreatment with the NMDA receptor antagonist MK-801 (3 or 10mg/kg, i.p) before the NMDA injections protected both the neuronal degeneration and the memory deficit. These findings suggest that selective neuronal degeneration induced by excessive stimulation of NMDA receptors in hippocampal CA-1 impaired working memory, but not reference memory.

journal_name

Behav Pharmacol

journal_title

Behavioural pharmacology

authors

Sugimachi K,Izawa K,Nakamura K,Kimura-Iwasaki K,Yamaguchi M,Nakagawa H,Oshino N

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

379-385

issue

4

eissn

0955-8810

issn

1473-5849

journal_volume

3

pub_type

杂志文章
  • The dopamine D2 antagonist eticlopride accelerates extinction and delays reacquisition of food self-administration in rats.

    abstract::Dopamine receptors are implicated in the reinforcing effects of food and drug reinforcement. The purpose of this study was to evaluate whether blocking D2 dopamine receptors during extinction (secondary reinforcement) would affect reacquisition of responding for food pellets (primary reinforcement). Food-restricted ra...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0000000000000002

    authors: Koerber J,Goodman D,Barnes JL,Grimm JW

    更新日期:2013-12-01 00:00:00

  • Changes in gut microbiota during development of compulsive checking and locomotor sensitization induced by chronic treatment with the dopamine agonist quinpirole.

    abstract::Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined wheth...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0000000000000363

    authors: Jung TD,Jung PS,Raveendran L,Farbod Y,Dvorkin-Gheva A,Sakic B,Surette MG,Szechtman H

    更新日期:2018-04-01 00:00:00

  • Sex-specific differences in cannabinoid-induced extracellular-signal-regulated kinase phosphorylation in the cingulate cortex, prefrontal cortex, and nucleus accumbens of Lister Hooded rats.

    abstract::Sex-dependent differences have been consistently described in cannabinoid addiction research. In particular, we recently reported that female Lister Hooded rats display greater self-administration of the cannabinoid CB1 receptor agonist WIN55,212-2 (WIN) and stronger reinstatement of cannabinoid-seeking behavior than ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0000000000000395

    authors: Rosas M,Porru S,Giugliano V,Antinori S,Scheggi S,Fadda P,Fratta W,Acquas E,Fattore L

    更新日期:2018-09-01 00:00:00

  • Daily mirfentanil induces (cross-) tolerance to the rate-decreasing effects of morphine and not mirfentanil.

    abstract::The fentanyl derivative mirfentanil has a novel set of behavioral effects in non-humans including low-efficacy opioid actions and non-opioid antinociceptive actions. This study evaluated the rate-decreasing effects of mirfentanil, morphine, naltrexone and ketamine in pigeons both prior to and during a period of chroni...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/00008877-199909000-00012

    authors: Gauthier CA,Bagley JR,Brockunier LL,France CP

    更新日期:1999-09-01 00:00:00

  • Learning impairment by Δ(9)-tetrahydrocannabinol in adolescence is attributable to deficits in chunking.

    abstract::Cannabis is the most popular illicit drug used by adolescents. Yet, there are only a few studies that have examined the effects of cannabis use on learning and memory during this sensitive and important neurodevelopmental stage. Male adolescent Sprague-Dawley rats were treated with Δ(9)-tetrahydrocannabinol (THC, 6 mg...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0b013e32834dbbb1

    authors: Steel RW,Miller JH,Sim DA,Day DJ

    更新日期:2011-12-01 00:00:00

  • Alterations of acoustic features of 50 kHz vocalizations by nicotine and phencyclidine in rats.

    abstract::Ultrasonic vocalizations are widely used to examine affective states in rats, yet relatively few studies explore the acoustic features of vocalizations, especially in relation to drug exposure, and no studies have explored alterations in acoustic features over time. The goal of this study was to examine nicotine- and ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0000000000000463

    authors: Swalve N,Mulholland MM,Li M

    更新日期:2019-08-01 00:00:00

  • Subchronic anesthetic ketamine injections in rats impair choice reversal learning, but have no effect on reinforcer devaluation.

    abstract::Previous exposure to a variety of drugs of abuse has been shown to cause long-term impairments in reversal learning and reinforcer devaluation tasks. However, there is mixed evidence in the literature for a long-term effect of ketamine exposure on reversal learning and the long-term effect of ketamine exposure on deva...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0000000000000289

    authors: Pickens CL,Aurand L,Hunt J,Fisher H

    更新日期:2017-06-01 00:00:00

  • Latent learning in a radial arm maze following neonatal dopamine depletion.

    abstract::Animals neonatally depleted of dopamine show decreases in exploratory behaviour. As latent learning may depend on exploratory behaviour the present study was undertaken to examine the effects of neonatal dopamine depletion on latent learning. In two experiments dopamine was depleted neonatally, using 6-hydroxydopamine...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:

    authors: Archer T,Beninger RJ,Järbe TU,Seiden LS

    更新日期:1989-01-01 00:00:00

  • Blockade of CB1 receptors prevents retention of extinction but does not increase low preincubated conditioned fear in the fear incubation procedure.

    abstract::We recently developed a procedure to study fear incubation, in which rats given 100 tone-shock pairings over 10 days show low fear 2 days after conditioned fear training and high fear after 30 days. Notably, fear 2 days after 10 sessions of fear conditioning is lower than fear seen 2 days after a single session of fea...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0000000000000020

    authors: Pickens CL,Theberge FR

    更新日期:2014-02-01 00:00:00

  • Real-time assessment of alcohol drinking and drug use in opioid-dependent polydrug users.

    abstract::We investigated relationships between drinking, other drug use, and drug craving, using ecological momentary assessment (EMA), in a sample of polydrug users who were not heavy drinkers. In a prospective longitudinal cohort study, 114 heroin and cocaine users on methadone-maintenance treatment carried handheld electron...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0000000000000250

    authors: Preston KL,Jobes ML,Phillips KA,Epstein DH

    更新日期:2016-10-01 00:00:00

  • Object recognition impairment in Fmr1 knockout mice is reversed by amphetamine: involvement of dopamine in the medial prefrontal cortex.

    abstract::Fragile X syndrome is an X-linked form of mental retardation including, among others, symptoms such as stereotypic behaviour, hyperactivity, hyperarousal, and cognitive deficits. We hypothesized that hyperactivity and/or compromised attentional, cognitive functions may lead to impaired performance in cognitive tasks i...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/00008877-200409000-00018

    authors: Ventura R,Pascucci T,Catania MV,Musumeci SA,Puglisi-Allegra S

    更新日期:2004-09-01 00:00:00

  • Delayed yet persistent effects of daily risperidone on activity in developing rats.

    abstract::Early-life administration of risperidone, the most widely used antipsychotic drug in children, leads to persistently elevated locomotor activity in adult rats. This study determined whether and when elevated locomotor activity emerges during developmental risperidone administration. Developing and adult rats were admi...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0000000000000230

    authors: Stevens RM,Gannon MA,Griffith MS,Bardgett ME

    更新日期:2016-08-01 00:00:00

  • Self-reported smoking effects and comparative value between cigarettes and high dose e-cigarettes in nicotine-dependent cigarette smokers.

    abstract::The objective of this experiment was to evaluate the comparative value of cigarettes versus high dose e-cigarettes among nicotine-dependent cigarette smokers when compared with money or use of their usual cigarette brand. The experiment used a within-subject design with four sessions. After baseline assessment, partic...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/FBP.0000000000000226

    authors: McPherson S,Howell D,Lewis J,Barbosa-Leiker C,Bertotti Metoyer P,Roll J

    更新日期:2016-04-01 00:00:00

  • Lithium's effect in forced-swim test is blood level dependent but not dependent on weight loss.

    abstract::The effects of lithium in models of depression are often inconsistent. We aimed to replicate a regimen that induces robust antidepressant effects in the forced-swim test. Mice were treated with three different doses of lithium chloride (LiCl) 0.25, 0.4 or 0.5% in food and the forced-swim test or open field test was pe...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0b013e32801416ed

    authors: Bersudsky Y,Shaldubina A,Belmaker RH

    更新日期:2007-02-01 00:00:00

  • Effects of drugs of abuse on response accuracy and bias under a delayed matching-to-sample procedure in squirrel monkeys.

    abstract::The effects on memory of drugs of abuse from several pharmacological classes were examined in four adult male squirrel monkeys responding under a delayed matching-to-sample schedule of food presentation. Subjects were required to emit 20 responses on a sample key transilluminated by either a constant white or a flashi...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/00008877-200107000-00003

    authors: Baron SP,Wenger GR

    更新日期:2001-07-01 00:00:00

  • The effects of morphine on clocked fixed-interval performance: stimulus function or strength of stimulus control?

    abstract::The present experiment was conducted to determine whether the modification of the effects of morphine by food deprivation would occur under conditions of strong stimulus control. Four pigeons pecked response keys under a multiple fixed-interval (FI) 5-min and clocked fixed-interval (CFI) 5-min schedule of food present...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/00008877-199905000-00002

    authors: Odum AL,Schaal DW

    更新日期:1999-05-01 00:00:00

  • Intrinsic activity estimation of cannabinoid CB1 receptor ligands in a drug discrimination paradigm.

    abstract::The present study estimated the apparent intrinsic activity of the cannabinoid CB1 receptor ligands CP 55,940, Delta9-tetrahydrocannabinol (Delta9-THC) and SR 141716A in a highly sensitive in vivo assay. Rats were trained to discriminate the cannabinoid CB1 receptor agonist CP 55,940 (either 0.03 or 0.014 mg/kg, i.p.,...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/01.fbp.0000087739.21047.d8

    authors: De Vry J,Jentzsch KR

    更新日期:2003-09-01 00:00:00

  • Prior methylphenidate self-administration alters the subsequent reinforcing effects of methamphetamine in rats.

    abstract::Methylphenidate (MPD) is clinically effective in treating the symptoms of attention-deficit hyperactivity disorder; however, its relatively widespread availability has raised public health concerns on nonmedical use of MPD among certain adult populations. Most preclinical studies investigate whether presumed therapeut...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0000000000000094

    authors: Baladi MG,Nielsen SM,Umpierre A,Hanson GR,Fleckenstein AE

    更新日期:2014-12-01 00:00:00

  • Effects of rimonabant on behavior maintained by progressive ratio schedules of sucrose reinforcement in obese Zucker (fa/fa) rats.

    abstract::This experiment reports on the ability of rimonabant to alter the reinforcing properties of food in the genetically obese Zucker (fa/fa) rat, a strain that exhibits higher levels of endocannabinoids in brain regions that correspond to heightened food intake. We characterized food reinforcement in obese and lean Zucker...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0b013e3283123cc2

    authors: Rasmussen EB,Huskinson SL

    更新日期:2008-10-01 00:00:00

  • Chronic mild stress-induced anhedonia model of depression; sleep abnormalities and curative effects of electroshock treatment.

    abstract::A core symptom of human depressive disorder is anhedonia, the loss of interest or pleasure in daily activities. Anhedonia, measured as subsensitivity to reward, can be induced in rats by a regimen of repeated, mild, unpredictable stressors. Here, the hedonic state of rats was assessed using an intracranial self-stimul...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:

    authors: Moreau JL,Scherschlicht R,Jenck F,Martin JR

    更新日期:1995-11-01 00:00:00

  • Antagonistic interaction between adenosine A2A and dopamine D2 receptors modulates the social recognition memory in reserpine-treated rats.

    abstract::Increasing evidence suggests that antagonistic interactions between specific subtypes of adenosine and dopamine receptors in the basal ganglia are involved in the control of motor activity. However, there are few studies investigating this interaction in other brain regions and its role in additional functions. In the...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/01.fbp.0000166825.62130.9a

    authors: Prediger RD,Da Cunha C,Takahashi RN

    更新日期:2005-07-01 00:00:00

  • Effects of cocaine-induced sensitization on ethanol drinking: sex and strain differences.

    abstract::Sensitization induced by repeated drug exposure has been proposed to increase 'wanting' the drug and to facilitate the transition from moderate to excessive drug intake. The present study examined the effects of cocaine-induced sensitization on ethanol-drinking behavior in male and female rats from different strains. ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/00008877-200008000-00004

    authors: Cailhol S,Mormède P

    更新日期:2000-08-01 00:00:00

  • Gamma-hydroxybutyric acid affects the acquisition and reinstatement of cocaine-induced conditioned place preference in mice.

    abstract::Cocaine addicts very often use different combinations of cocaine and other drugs of abuse such as gamma-hydroxybutyric acid. The objective of the present work was to evaluate the impact of gamma-hydroxybutyric acid administration on the rewarding actions of cocaine, using the conditioned place preference procedure. Co...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/01.fbp.0000190685.84984.ec

    authors: Maldonado C,Rodríguez-Arias M,Castillo A,Aguilar MA,Miñarro J

    更新日期:2006-03-01 00:00:00

  • Modification of the discriminative stimulus effects of 8-OH-DPAT, buspirone and the beta-adrenoreceptor antagonist pindolol after chronic administration of the 5-HT(1A) agonist 8-OH-DPAT in the pigeon.

    abstract::The involvement of adrenoreceptor blocking drugs with the 5-HT(1A)-mediated discriminative stimulus was studied in pigeons trained to discriminate the 5-HT(1A) receptor agonist 8-OH-DPAT (0.3mg/kg) from saline. Cumulative dose-response curves were determined for 8-OH-DPAT, the beta-adrenergic antagonist pindolol, the ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:

    authors: Zhang L,Barrett JE

    更新日期:1991-11-01 00:00:00

  • SR 141716A differentially attenuates the behavioral effects of delta9-THC in rhesus monkeys.

    abstract::The prototypic cannabinoid CB1 antagonist SR 141716A is one important pharmacologic tool for examining CB1 receptors that mediate the behavioral and physiologic effects of delta9-tetrahydrocannabinol (delta9-THC). This study examined the effects of SR 141716A on the rate-decreasing, hypothermic and discriminative stim...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/00008877-200509000-00008

    authors: McMahon LR,Amin MR,France CP

    更新日期:2005-09-01 00:00:00

  • Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats.

    abstract::Cannabinoid receptor (CBR) agonists produce antinociception in conventional preclinical assays of pain-stimulated behavior but are not effective in preclinical assays of pain-depressed behavior. Fatty acid amide hydrolase (FAAH) inhibitors increase physiological levels of the endocannabinoid anandamide, which may conf...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0000000000000023

    authors: Kwilasz AJ,Abdullah RA,Poklis JL,Lichtman AH,Negus SS

    更新日期:2014-04-01 00:00:00

  • Behaviour in the novel environment predicts responsiveness to d-amphetamine in the rat: a multivariate approach.

    abstract::The behaviour of rats in a novel environment was studied using a rapid time-sampling observation procedure followed by a principal component analysis (PCA) of the data. This approach revealed that novel environment behaviour can be described by two factors or principal components. The first factor comprised rearing, s...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:

    authors: Exner M,Clark D

    更新日期:1993-02-01 00:00:00

  • Discriminative-stimulus control by morphine in the pigeon under a fixed-interval schedule of reinforcement.

    abstract::The stimulus control by morphine under a fixed-interval (FI) 180-s schedule of reinforcement was examined in five pigeons trained to discriminate 5.0mg/kg of i.m. morphine from saline. After training, dose-response relationships were determined for morphine, d-amphetamine, pentobarbital, fentanyl, and MK-801. At low d...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:

    authors: Massey BW,McMillan DE,Wessinger WD

    更新日期:1992-10-01 00:00:00

  • Zolpidem is differentiated from triazolam in humans using a three-response drug discrimination procedure.

    abstract::The discriminative stimulus effects of the imidazopyridine hypnotic zolpidem and the classic benzodiazepine hypnotic triazolam were examined in seven healthy volunteers using a three-response drug discrimination procedure and a within-subject design. During an initial sampling phase, the training drug conditions (plac...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/00008877-199811000-00010

    authors: Mintzer MZ,Frey JM,Griffiths RR

    更新日期:1998-11-01 00:00:00

  • Effects of chronic mild stress on the development of drug dependence in rats.

    abstract::There is high comorbidity between depression and addiction. Features of addiction relevant to depression have been studied extensively, but less is known about features of depression relevant to addiction. Here, we have studied the effects of chronic mild stress (CMS), a valid animal model of depression, on measures o...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章

    doi:10.1097/FBP.0000000000000046

    authors: Papp M,Gruca P,Lason-Tyburkiewicz M,Litwa E,Willner P

    更新日期:2014-09-01 00:00:00