Abstract:
:Previous studies have indicated that dopamine D1 receptors in the ventral tegmental area (VTA) may play an important role in the development of sensitization to amphetamine. The present study was designed to determine if D1 receptors are also important in the development of cocaine-induced behavioral and neurochemical sensitization. Animals received intra-VTA injections of saline or the dopamine D1 receptor antagonist SCH 23390 (15 nmol/side) 5 min before receiving systemic injections of saline or cocaine (15 mg/kg) on 4 consecutive days. One week later animals were challenged with cocaine. Motor activity and extracellular dopamine concentrations in the nucleus accumbens were monitored on the day the animals received the first of their four daily treatments and/or on the day animals received their cocaine challenge injection. Intra-VTA SCH 23390 attenuated the acute response, but did not alter development of the sensitized motor-stimulant response to cocaine. In contrast to the behavioral data, intra-VTA SCH 23390 blocked both the acute cocaine-induced increase in extracellular dopamine in the nucleus accumbens and development of the sensitized response. These data provide partial support for the role of dopamine D1 receptors in the VTA in the development of cocaine-induced sensitization. The data also suggest, however, that additional mechanisms may play a role in the development of sensitization.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Steketee JDsubject
Has Abstractpub_date
1998-02-01 00:00:00pages
69-76issue
1eissn
0955-8810issn
1473-5849journal_volume
9pub_type
杂志文章abstract::In the present study, we focused on γ-aminobutyric acid (GABA) signaling through the γ-aminobutyric acid transporter (GAT) in the developing rat cerebral cortex. Tiagabine was used as a GAT inhibitor. The offspring received injections from birth until postnatal day 21 intraperitoneally. Physical development and neurol...
journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200202000-00006
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00008877-200209000-00017
更新日期:2002-09-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200004000-00007
更新日期:2000-04-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200402000-00010
更新日期:2004-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32831c3aec
更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/FBP.0b013e32833befcf
更新日期:2010-09-01 00:00:00
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journal_title:Behavioural pharmacology
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更新日期:1993-01-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200605000-00003
更新日期:2006-05-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199907000-00009
更新日期:1999-07-01 00:00:00
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journal_title:Behavioural pharmacology
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更新日期:2008-09-01 00:00:00