Abstract:
:The present experiments investigated the effects of excitatory amino acid antagonists, infused into core and shell subregions of the nucleus accumbens, on spatial behavior in the rat. A food-search task was used, in which animals learn a specific pattern of food gathering; duration of each trial (time taken to gather all four pellets) and number of errors (visits to empty holes) were measured. In experiment 1, animals first underwent training, and subsequently were given microinfusions of either D-2-amino-5 phosphonopentanoic acid (AP-5), an N-methyl-d-aspartate (NMDA) antagonist (0, 0.2, 1.0µg/0.5µl), or 6,7-dinitroquinoxaline-2,3-dione (DNQX), an antagonist of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and kainate receptors (0, 0.075, 0.75µg/0.5µl). AP-5-significantly increased trial duration in both core and shell groups, but increased errors only in the core group. DNQX treatment also impaired performance in both groups, but the effect was greater in the core group compared with the shell group. In experiment 2, animals were treated during acquisition. Rats infused with AP-5 (1µg/0.5µl) took significantly longer to finish trials, made more errors and showed a marked learning impairment across days. AP-5 impaired learning in both core and shell groups, but the disruption was significantly greater in the core group. DNQX (0.75µg/0.5µl) also impaired learning when infused into the core during acquisition; however, the pattern of disruption contrasted markedly with that of AP-5. DNQX in the shell had no effect on trial duration during learning. It is hypothesized that both NMDA and non-NMDA receptors in the nucleus accumbens mediate spatial learning and performance, and that NMDA receptors may have a relatively more important role in memory or retrieval mechanisms. Moreover, the core subregion may be preferentially involved in the control of spatial behavior.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Maldonado-Irizarry CS,Kelley AEsubject
Has Abstractpub_date
1995-08-01 00:00:00pages
527-539issue
5 And 6eissn
0955-8810issn
1473-5849journal_volume
6pub_type
杂志文章abstract::Although the role of genetic factors in the response to drugs of abuse has been emphasized, no earlier studies have applied selective breeding to intravenous drug self-administration. Here we report the effects of six generations of selective breeding for rat lines with low or high levels of intravenous drug self-admi...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32831c3aec
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更新日期:2010-09-01 00:00:00
abstract::Phencyclidine (PCP) can induce a model psychosis in humans that mimics the positive and negative symptoms of schizophrenia. The purpose of the present study was to determine whether PCP can induce similar behavioural effects in rats and whether these effects can be alleviated by neuroleptic drug treatment. Rats were t...
journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000064
更新日期:2014-09-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e328333a267
更新日期:2009-12-01 00:00:00
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journal_title:Behavioural pharmacology
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doi:10.1097/FBP.0000000000000002
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journal_title:Behavioural pharmacology
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更新日期:1991-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3282f3cf84
更新日期:2008-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000172
更新日期:2015-09-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000512
更新日期:2019-12-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3280d3ee83
更新日期:2007-03-01 00:00:00