Abstract:
:The effects of topiramate, a potential treatment for drug dependence, were evaluated in two groups of rats trained to discriminate the administration of either 0.4 mg/kg nicotine or 10 mg/kg cocaine from that of saline, under a fixed-ratio 10 schedule of food delivery. Topiramate (1-60 mg/kg, intraperitoneal) did not produce any nicotine-like or cocaine-like discriminative effects by itself and did not produce any shift in the dose-response curves for nicotine or cocaine discrimination. Thus, the ability to discriminate the effects of nicotine or cocaine does not appear to be altered by topiramate administration. Furthermore, topiramate, given either alone or in combination with nicotine or cocaine, did not depress rates of responding. These experiments indicate that topiramate does not enhance or reduce the ability of rats to discriminate the effects of nicotine or cocaine.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Le Foll B,Justinova Z,Wertheim CE,Barnes C,Goldberg SRdoi
10.1097/FBP.0b013e3282f3cf84subject
Has Abstractpub_date
2008-02-01 00:00:00pages
13-20issue
1eissn
0955-8810issn
1473-5849pii
00008877-200802000-00002journal_volume
19pub_type
杂志文章abstract::This study was conducted to evaluate the effects of exposure to diphenyl diselenide (PhSe)2 on cognitive impairment induced by scopolamine, a muscarinic antagonist, using the Y-maze and Morris water maze tests in mice. One hour before the tests, mice were treated with (PhSe)2 (50 mg/kg, oral) and 30 min later memory i...
journal_title:Behavioural pharmacology
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doi:10.1097/FBP.0b013e32833befcf
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doi:10.1097/FBP.0b013e3282f00754
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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更新日期:1998-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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pub_type: 临床试验,杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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