Abstract:
:Twenty male Wistar rats were trained under an alternating-lever cyclic-ratio (ALCR) schedule of food reinforcement. When responding showed no trends, each subject was subcutaneously implanted with an Alzet osmotic mini-pump, connected to a chronic indwelling cannula extending into the lateral ventricle of the brain. The mini-pumps were primed to infuse 0.25 microl lipopolysaccharide (LPS) (1.0 microg/0.25 ml) or 0.25 microl artificial cerebrospinal fluid (aCSF) per hour and were implanted for 28 days. LPS infusion produced behavioural deficits which chronic ibuprofen treatment (40 mg/kg every 12 h) alleviated. Infusion of LPS induced R 1282-positive amyloid deposits, and activation of microglia and astrocytes. Ibuprofen treatment reduced the numbers of activated microglia, and withdrawal of ibuprofen resulted in an increase in activated microglia; however, ibuprofen treatment had no effect on numbers of activated astrocytes in the LPS-infused subjects.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Richardson RL,Kim EM,Gardiner T,O'Hare Edoi
10.1097/01.fbp.0000179278.03868.96subject
Has Abstractpub_date
2005-11-01 00:00:00pages
531-41issue
7eissn
0955-8810issn
1473-5849pii
00008877-200511000-00003journal_volume
16pub_type
杂志文章abstract::The present study estimated the apparent intrinsic activity of the cannabinoid CB1 receptor ligands CP 55,940, Delta9-tetrahydrocannabinol (Delta9-THC) and SR 141716A in a highly sensitive in vivo assay. Rats were trained to discriminate the cannabinoid CB1 receptor agonist CP 55,940 (either 0.03 or 0.014 mg/kg, i.p.,...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/01.fbp.0000087739.21047.d8
更新日期:2003-09-01 00:00:00
abstract::Dendrosomal nanocurcumin (DNC) is fabricated from esterification of oleic acid and polyethylene glycol residues with curcumin. DNC has shown antioxidant, neuroprotective, and neurogenesis-enhancing effects. In addition, it can attenuate morphine tolerance. Morphine self-administration is associated with neurodegenerat...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000291
更新日期:2017-12-01 00:00:00
abstract::Impaired social interaction is a hallmark symptom of many psychiatric diseases, including dependence syndromes (substance use disorders). Helping the addict reorient her/his behavior away from the drug of abuse toward social interaction would be of considerable therapeutic benefit. To study the neural basis of such a ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000223
更新日期:2016-04-01 00:00:00
abstract::The behaviour of rats in a novel environment was studied using a rapid time-sampling observation procedure followed by a principal component analysis (PCA) of the data. This approach revealed that novel environment behaviour can be described by two factors or principal components. The first factor comprised rearing, s...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
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更新日期:1993-02-01 00:00:00
abstract::The purpose of the present experiments was to develop and validate pharmacologically an automated, relatively rapid, and reproducible behavioral model of learning and memory using an autoshaping procedure in mice. Nose-poke responses into a recessed area were differentiated by response-dependent reinforcement during t...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
abstract::Previous exposure to a variety of drugs of abuse has been shown to cause long-term impairments in reversal learning and reinforcer devaluation tasks. However, there is mixed evidence in the literature for a long-term effect of ketamine exposure on reversal learning and the long-term effect of ketamine exposure on deva...
journal_title:Behavioural pharmacology
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更新日期:2017-06-01 00:00:00
abstract::Few studies have investigated the effects of chronic cannabinoid exposure on memory performance and whether tolerance occurs to cannabinoid-induced memory impairment. Here, we studied the effects of repeated exposure to Delta-tetrahydrocannabinol (THC: 1 mg/kg) on spatial memory and zif268 expression in mice. One grou...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3283242f6a
更新日期:2009-02-01 00:00:00
abstract::To investigate the role of the nucleus accumbens core (NAc) in the development of quinpirole-induced compulsive checking, rats received an excitotoxic lesion of NAc or sham lesion and were injected with quinpirole (0.5 mg/kg) or saline; development of checking behavior was monitored for 10 biweekly tests. The results ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
abstract::Drug addiction is a progressive, relapsing disease comprised of interlocking stages of disordered motivation. Numerous animal models describing various stages of the addiction process have been developed over the past few decades, providing considerable advantages for the modeling of drug addiction compared with other...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0b013e3283644d15
更新日期:2013-09-01 00:00:00
abstract::Clinical reports and animal experiments indicate that both cocaine administration and cocaine withdrawal increase anxiety. We investigated the ability of a number of putative anxiolytic agents to alleviate these anxiety states using the elevated plus-maze. Rats in the cocaine condition received either saline or cocain...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200211000-00001
更新日期:2002-11-01 00:00:00
abstract::This series of studies provides a behavioural account of dopamine D1-receptor-dependent facilitation and disruption of memory for the single-trial passive avoidance task in the day-old chick. The D1 antagonist, SCH23390, induced memory disruption in a dose-dependent manner from 60 min after training with a strong (100...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200311000-00005
更新日期:2003-11-01 00:00:00
abstract::Flavonoids are natural substances obtained from plants. Most flavonoids cross the blood-brain barrier and exert a wide range of effects on the central nervous system. These actions have been attributed to the modulation of GABA-A receptors. Although motor systems in the central nervous system express a high density of...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000100
更新日期:2015-02-01 00:00:00
abstract::Adult male Wistar rats were bilaterally implanted with indwelling cannulae in the CA1 region of the dorsal hippocampus. Once recovered from surgery, animals were submitted to one session of step-down inhibitory avoidance training (3.0 s, 0.4 mA footshock). Animals received a 0.5-microl infusion of saline, or of LY2940...
journal_title:Behavioural pharmacology
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doi:10.1097/00008877-200112000-00007
更新日期:2001-12-01 00:00:00
abstract::Alcohol consumption acutely increases smoking behavior, but the reverse relationship, the acute effects of smoking on alcohol intake, largely has been ignored. We examined whether smoking acutely increases the reinforcing value of alcohol, first in the absence of recent alcohol intake and then following an alcohol pre...
journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-02-01 00:00:00
abstract::The purpose of this study was to examine, in healthy volunteers without histories of extensive sedative use, the acute behavioral effects of doses of alprazolam used in clinical applications. Subjects participated in daily sessions over 12 study days. They consumed a standard breakfast, received an oral drug dose (0, ...
journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-02-01 00:00:00
abstract::A range of selective dopamine D1 and D2 receptor agonists and antagonists was used to characterize to the discriminative stimuli produced by d-amphetamine (0.5mg/kg) and the D1 agonists SKF 81297 (0.1mg/kg). In rats trained to discriminate d-amphetamine (0.5mg/kg) from saline, d-amphetamine produced a dose-related inc...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::This experiment reports on the ability of rimonabant to alter the reinforcing properties of food in the genetically obese Zucker (fa/fa) rat, a strain that exhibits higher levels of endocannabinoids in brain regions that correspond to heightened food intake. We characterized food reinforcement in obese and lean Zucker...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3283123cc2
更新日期:2008-10-01 00:00:00
abstract::Given the repeated failure of amyloid-based approaches in Alzheimer's disease, there is increasing interest in tau-based therapeutics. Although methylthioninium (MT) treatment was found to be beneficial in tau transgenic models, the brain concentrations required to inhibit tau aggregation in vivo are unknown. The comp...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000133
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000512
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abstract::A runway was used to measure locomotor responses to quinpirole (200µg/kg), in rats. The locomotor stimulant effect of quinpirole increased progressively over successive trials at 3-day intervals. Animals administered quinpirole in the home cage were also sensitized, but to a lesser degree than animals tested in the ru...
journal_title:Behavioural pharmacology
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abstract::Scopolamine has been used in neuropsychopharmacology as a standard drug that leads to symptoms mimicking cognitive deficits seen during the aging process in healthy humans and animals. Scopolamine is known to be a nonselective muscarinic receptor blocker, but its chronic effect on the expression of certain hippocampal...
journal_title:Behavioural pharmacology
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doi:10.1097/FBP.0b013e32835a38af
更新日期:2012-12-01 00:00:00
abstract::Different approaches to measuring stimulus generalization in drug discrimination experiments are compared. The main issue, with implications for interpreting partial generalization, has been whether it is preferable to use graded or quantal indices. The first step is to determine whether discriminative drug effects ar...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
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更新日期:1991-11-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000046
更新日期:2014-09-01 00:00:00
abstract::Central nicotinc acetylcholine receptors have been targeted for the development of novel treatments for memory deficits in Alzheimer's disease (AD) and other neurodegenerative disorders. Nicotine itself has been shown to improve memory-related task performance in aged animals and in AD patients. Administration of nico...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199911000-00015
更新日期:1999-11-01 00:00:00
abstract::Adult male Wistar rats were bilaterally implanted with indwelling cannulae in the agranular insular cortex of the prefrontal cortex. After recovery, animals were trained in a step-down inhibitory avoidance task (3.0-s, 0.4-mA footshock) and received, immediately after training, a 0.5-microl infusion of the serotonergi...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200109000-00006
更新日期:2001-09-01 00:00:00
abstract::Some reports suggest that older patients are less responsive to antidepressants than young adults, but this idea has not been fully supported. Here, we investigated the role of aging in the behavioral effects of the antidepressants, desipramine (DMI) (5, 10, and 20 mg/kg) and fluoxetine (FLX) (5, 10, and 20 mg/kg) in ...
journal_title:Behavioural pharmacology
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更新日期:2016-02-01 00:00:00
abstract::The role of dopamine (DA) receptors in the expression of opioid dependence was examined by use of an unbiased conditioned place preference paradigm. Male Sprague-Dawley rats were implanted s.c. with two pellets containing placebo or 75mg morphine. Animals received one conditioning session with saline and one with the ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::The effects of the competitive NMDA antagonists, 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 12626) and 3-(2-carboxypiperazin-4-yl) propyl-l-phosphonic acid (CPP), were compared to those of the noncompetitive NMDA antagonists, phencyclidine (PCP) and (+)-5-methyl-10, 11-dihydro-5H-dibenzo (a,d) cyclohe...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00