Measures of stimulus generalization in drug discrimination experiments.

abstract：:Dendrosomal nanocurcumin (DNC) is fabricated from esterification of oleic acid and polyethylene glycol residues with curcumin. DNC has shown antioxidant, neuroprotective, and neurogenesis-enhancing effects. In addition, it can attenuate morphine tolerance. Morphine self-administration is associated with neurodegenerat...

journal_title：Behavioural pharmacology

authors： Noroozi J,Hassanpour-Ezatti M,Alaei HA

更新日期：2017-12-01 00:00:00

abstract：:Panic attacks (PAs) are episodes of intense fear or discomfort that are accompanied by a variety of both psychological and somatic symptoms. Panic induction in preclinical models (e.g. rats) has largely been assayed through flight and avoidance behavioral tests and cardiorespiratory activity. Yet, the literature perta...

journal_title：Behavioural pharmacology

authors： Federici LM,Caliman IF,Fitz SD,Shekhar A,Johnson PL

更新日期：2019-06-01 00:00:00

abstract：:The present study estimated the apparent intrinsic activity of the cannabinoid CB1 receptor ligands CP 55,940, Delta9-tetrahydrocannabinol (Delta9-THC) and SR 141716A in a highly sensitive in vivo assay. Rats were trained to discriminate the cannabinoid CB1 receptor agonist CP 55,940 (either 0.03 or 0.014 mg/kg, i.p.,...

journal_title：Behavioural pharmacology

authors： De Vry J,Jentzsch KR

更新日期：2003-09-01 00:00:00

abstract：:Methoxetamine (MXE) is a chemical analogue of ketamine. Originally proposed as a ketamine-like fast-acting antidepressant, owing to similar N-methyl-D-aspartate blocker properties, it is now scheduled for reports of hallucinations and psychosis similar to ketamine and lysergic acid. As little is known about the addict...

journal_title：Behavioural pharmacology

authors： Chiamulera C,Armani F,Mutti A,Fattore L

更新日期：2016-04-01 00:00:00

abstract：:In a double-blind crossover design on 36 male smokers, differences in hormone responses to a serotonergic (citalopram) and dopaminergic (bromocriptine) challenge were tested, to compare transmitter responsivities in addicted and pleasure-motivated smokers with respective controls. A general score of smoking addiction,...

journal_title：Behavioural pharmacology

authors： Netter P,Toll C,Lujic C,Reuter M,Hennig J

更新日期：2002-09-01 00:00:00

abstract：:The stimulus control by morphine under a fixed-interval (FI) 180-s schedule of reinforcement was examined in five pigeons trained to discriminate 5.0mg/kg of i.m. morphine from saline. After training, dose-response relationships were determined for morphine, d-amphetamine, pentobarbital, fentanyl, and MK-801. At low d...

journal_title：Behavioural pharmacology

authors： Massey BW,McMillan DE,Wessinger WD

更新日期：1992-10-01 00:00:00

abstract：:In a step-down passive avoidance task, the pre-training injection of 1.25-10 mg/kg of morphine impaired memory. This was restored when injection of the same dose of morphine (pre-test treatment) was repeated 24 h later (morphine state-dependent learning: morphine St-D). ATP-dependent potassium (K(ATP)) channels have b...

journal_title：Behavioural pharmacology

authors： Zarrindast MR,Jafari MR,Shafaghi B,Djahanguiri B

更新日期：2004-03-01 00:00:00

abstract：:This study compared fixed-ratio (FR) and fixed-interval (FI) schedules to investigate the discriminative stimulus properties of μ-opioid and/or κ-opioid receptor agonists. Pigeons were trained to discriminate among morphine (μ agonist), U50488 (κ agonist), the combination, and saline under FR 20-s or FI-300-s schedule...

journal_title：Behavioural pharmacology

authors： Wessinger WD,Li M,McMillan DE

更新日期：2011-09-01 00:00:00

abstract：:Chronic morphine-induced withdrawal syndrome after morphine cessation remains a severe obstacle in the clinical treatment of morphine. Previous studies have shown that nitric oxide synthetase (NOS) inhibitors may have therapeutic potential in morphine withdrawal in humans. The mechanisms that underlie expression of mo...

journal_title：Behavioural pharmacology

authors： Mori T,Ito S,Matsubayashi K,Sawaguchi T

更新日期：2007-12-01 00:00:00

abstract：:The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) and the imidazopyridine hypnotic zolpidem (5, 10, and 20 mg/70 kg) were compared in 11 volunteers, in a double-blind, placebo-controlled, crosso...

journal_title：Behavioural pharmacology

authors： Mintzer MZ,Frey JM,Yingling JE,Griffiths RR

更新日期：1997-11-01 00:00:00

abstract：:Behavioural sensitization to the locomotor stimulant effect of (+)-amphetamine or quinpirole was induced in rats by intermittent drug administration. Once established, endogenous dopamine release (DA) was measured in slices containing nucleus accumbens using fast cyclic voltammetry. DA release induced by single pulse ...

journal_title：Behavioural pharmacology

authors： Muscat R,Patel J,Trout SJ,Wieczorek W,Kruk ZL

更新日期：1993-01-01 00:00:00

abstract：:A symposium held at the 50th annual meeting of the Behavioral Pharmacology Society in May 2007 reviewed progress in the human behavioral pharmacology of drug abuse. Studies on drug self-administration in humans are reviewed that assessed reinforcing and subjective effects of drugs of abuse. The close parallels observe...

journal_title：Behavioural pharmacology

authors： Comer SD,Bickel WK,Yi R,de Wit H,Higgins ST,Wenger GR,Johanson CE,Kreek MJ

更新日期：2010-07-01 00:00:00

abstract：:Rats were trained on a three-panel runway task prior to injections of N-methyl-D-aspartate (NMDA; 40nmoles/µl/side) into the dorsal hippocampus. One week after the treatment, animals did not show any change in the number of errors on the first runway trial (reference memory), with one correct white and two incorrect b...

journal_title：Behavioural pharmacology

authors： Sugimachi K,Izawa K,Nakamura K,Kimura-Iwasaki K,Yamaguchi M,Nakagawa H,Oshino N

更新日期：1992-08-01 00:00:00

abstract：:Clinical reports and animal experiments indicate that both cocaine administration and cocaine withdrawal increase anxiety. We investigated the ability of a number of putative anxiolytic agents to alleviate these anxiety states using the elevated plus-maze. Rats in the cocaine condition received either saline or cocain...

journal_title：Behavioural pharmacology

authors： Paine TA,Jackman SL,Olmstead MC

更新日期：2002-11-01 00:00:00

abstract：:We studied the anxiolytic-like activity of alnespirone and buspirone, two 5-HT(1A) receptor agonists, in a modified Geller-Seifter conflict model, and examined the role of 5-HT(1A) receptors by studying whether WAY-100635, a selective antagonist at these receptors, blocked their effects. Administered s.c. 30 minutes b...

journal_title：Behavioural pharmacology

authors： Cervo L,Munoz C,Bertaglia A,Samanin R

更新日期：2000-04-01 00:00:00

abstract：:The recent recreational use of synthetic cannabinoid ligands, collectively referred to as 'Spice', has raised concerns about their safety and possible differences in their biological effect(s) from marijuana/Δ-tetrahydrocannabinol (THC). AM2201, a highly efficacious, potent cannabinoid receptor 1 (CB1R) agonist, is a ...

journal_title：Behavioural pharmacology

authors： Järbe TU,Gifford RS,Zvonok A,Makriyannis A

更新日期：2016-04-01 00:00:00

abstract：:The present experiment was conducted to determine whether the modification of the effects of morphine by food deprivation would occur under conditions of strong stimulus control. Four pigeons pecked response keys under a multiple fixed-interval (FI) 5-min and clocked fixed-interval (CFI) 5-min schedule of food present...

journal_title：Behavioural pharmacology

authors： Odum AL,Schaal DW

更新日期：1999-05-01 00:00:00

abstract：:The present experiments investigated the effects of excitatory amino acid antagonists, infused into core and shell subregions of the nucleus accumbens, on spatial behavior in the rat. A food-search task was used, in which animals learn a specific pattern of food gathering; duration of each trial (time taken to gather ...

journal_title：Behavioural pharmacology

authors： Maldonado-Irizarry CS,Kelley AE

更新日期：1995-08-01 00:00:00

abstract：:Cocaine demand is a behavioral economic measure assessing drug reward value and motivation to use drug. The purpose of the current study was to develop a brief assessment of cocaine demand (BACD). Results from the BACD were compared with self-report measures of cocaine use. Participants consisted of treatment-seeking ...

journal_title：Behavioural pharmacology

authors： Yoon JH,de Dios C,Suchting R,Vincent JN,McKay SA,Lane SD,Schmitz JM

更新日期：2020-12-24 00:00:00

abstract：:Effects of environmental modulation of methamphetamine (MA)-induced behavior on the establishment and mode of expression of behavioral sensitization were examined. Rats received daily injection of MA for 10 days (1mg/kg, s.c.). Half of them were immediately returned to the home cage (home cage group) and the other hal...

journal_title：Behavioural pharmacology

authors： Ohmori T,Abekawa T,Koyama T

更新日期：1995-03-01 00:00:00

abstract：:Synthetic cathinone derivatives are commonly considered quasi-legal alternatives for stimulant drugs, such as cocaine and methamphetamine, but some derivatives are increasingly being detected in club drug formulations of Ecstasy or 'Molly' as substitutes for methylenedioxymethamphetamine (±-MDMA). Although several stu...

journal_title：Behavioural pharmacology

authors： Gatch MB,Dolan SB,Forster MJ

更新日期：2020-06-01 00:00:00

abstract：:There is clinical and experimental evidence that treatment with immunosuppressive and antiproliferative drugs such as the calcineurin inhibitor cyclosporine A (CsA) is associated with mental health problems and neuropsychological disturbances in patients. However, it remains unclear whether and to what extent cognitiv...

journal_title：Behavioural pharmacology

authors： Kahl AL,Kirchhof J,Füting A,Hütter BO,Wilde B,Witzke O,Benson S,Hadamitzky M,Schedlowski M

更新日期：2017-06-01 00:00:00

abstract：:Dopaminergic (DA) agonist-induced yawning in rats seems to be mediated by DA D3 receptors, and low doses of several DA agonists decrease locomotor activity, an effect attributed to presynaptic D2 receptors. Effects of several DA agonists on yawning and locomotor activity were examined in rats and mice. Yawning was rel...

journal_title：Behavioural pharmacology

authors： Li SM,Collins GT,Paul NM,Grundt P,Newman AH,Xu M,Grandy DK,Woods JH,Katz JL

更新日期：2010-05-01 00:00:00

abstract：:Methylphenidate (MPD) is clinically effective in treating the symptoms of attention-deficit hyperactivity disorder; however, its relatively widespread availability has raised public health concerns on nonmedical use of MPD among certain adult populations. Most preclinical studies investigate whether presumed therapeut...

journal_title：Behavioural pharmacology

authors： Baladi MG,Nielsen SM,Umpierre A,Hanson GR,Fleckenstein AE

更新日期：2014-12-01 00:00:00

abstract：:Behavioral sensitization to amphetamine-like psychostimulants is manifest as a progressive increase in drug-induced anxiety and paranoia which can culminate in psychopathologies, such as paranoid psychosis and panic attacks. Sensitization may also mediate the facilitation of drug relapse in addicts by increasing the r...

journal_title：Behavioural pharmacology

authors： Kalivas PW,Sorg BA,Hooks MS

更新日期：1993-01-01 00:00:00

abstract：:These studies investigated the role of serotonin-1A (5-HT1A) and 5-HT2A receptors in the behavioral effects of dipropyltryptamine (DPT). Eight rats discriminated 0.56 mg/kg 2,5-dimethoxy-4-methylamphetamine (DOM) from saline and responded under a fixed ratio 5 schedule of food presentation; 12 other rats were used for...

journal_title：Behavioural pharmacology

authors： Li JX,Rice KC,France CP

更新日期：2007-07-01 00:00:00

abstract：:This study examined interactions between cocaine and drugs that act as direct agonists at subtypes of "D2-like" dopamine receptors. The drugs 7-OH-DPAT, quinpirole and RU24213 were studied alone and in combination with cocaine for their effects on locomotor activity in non-habituated mice. Locomotor activity was measu...

journal_title：Behavioural pharmacology

authors： Tirelli E,Reggers J,Terry P

更新日期：1997-06-01 00:00:00

abstract：:With the ever-growing geriatric population, research on brain diseases such as dementia is more imperative now than ever. The most prevalent of all dementias is Alzheimer's disease, a progressive neurodegenerative disease that presents with deficits in memory, cognition, motor skills, and a general decline in the qual...

journal_title：Behavioural pharmacology

authors： Caramillo EM,Echevarria DJ

更新日期：2017-04-01 00:00:00

abstract：:Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined wheth...

journal_title：Behavioural pharmacology

authors： Jung TD,Jung PS,Raveendran L,Farbod Y,Dvorkin-Gheva A,Sakic B,Surette MG,Szechtman H

更新日期：2018-04-01 00:00:00

abstract：:Nicotine, a cognition enhancer and a drug of abuse, exerts its central actions through neuronal nicotinic acetylcholine receptors which show sexual dimorphism. This study tested the effects of nicotine on active avoidance learning in male and female rats. Three month-old Sprague-Dawley rats received varying doses of n...

journal_title：Behavioural pharmacology

authors： Yilmaz O,Kanit L,Okur BE,Pöğün S

更新日期：1997-06-01 00:00:00