Prior methylphenidate self-administration alters the subsequent reinforcing effects of methamphetamine in rats.

abstract：:The brain endocannabinoid system is a potential target for the treatment of psychiatric and metabolic conditions. Here, a novel CB1 receptor antagonist (ABD459) was synthesized and assayed for pharmacological efficacy in vitro and for modulation of food consumption, vigilance staging and cortical electroencephalograph...

journal_title：Behavioural pharmacology

authors： Goonawardena AV,Plano A,Robinson L,Ross R,Greig I,Pertwee RG,Hampson RE,Platt B,Riedel G

更新日期：2015-04-01 00:00:00

abstract：:Fragile X syndrome is an X-linked form of mental retardation including, among others, symptoms such as stereotypic behaviour, hyperactivity, hyperarousal, and cognitive deficits. We hypothesized that hyperactivity and/or compromised attentional, cognitive functions may lead to impaired performance in cognitive tasks i...

journal_title：Behavioural pharmacology

authors： Ventura R,Pascucci T,Catania MV,Musumeci SA,Puglisi-Allegra S

更新日期：2004-09-01 00:00:00

abstract：:Sensorimotor gating disruptions are seen in various psychiatric illnesses with putatively different pathologies, including schizophrenia and bipolar disorder. Interestingly, mice lacking the dopamine (DA) transporter (DAT) gene display markedly increased levels of DA, deficits in sensorimotor gating, and hyperactivity...

journal_title：Behavioural pharmacology

authors： Powell SB,Young JW,Ong JC,Caron MG,Geyer MA

更新日期：2008-09-01 00:00:00

abstract：:The prototypic cannabinoid CB1 antagonist SR 141716A is one important pharmacologic tool for examining CB1 receptors that mediate the behavioral and physiologic effects of delta9-tetrahydrocannabinol (delta9-THC). This study examined the effects of SR 141716A on the rate-decreasing, hypothermic and discriminative stim...

journal_title：Behavioural pharmacology

authors： McMahon LR,Amin MR,France CP

更新日期：2005-09-01 00:00:00

abstract：:A symposium held at the 50th annual meeting of the Behavioral Pharmacology Society in May 2007 reviewed progress in the human behavioral pharmacology of drug abuse. Studies on drug self-administration in humans are reviewed that assessed reinforcing and subjective effects of drugs of abuse. The close parallels observe...

journal_title：Behavioural pharmacology

authors： Comer SD,Bickel WK,Yi R,de Wit H,Higgins ST,Wenger GR,Johanson CE,Kreek MJ

更新日期：2010-07-01 00:00:00

abstract：:The objective of this experiment was to evaluate the comparative value of cigarettes versus high dose e-cigarettes among nicotine-dependent cigarette smokers when compared with money or use of their usual cigarette brand. The experiment used a within-subject design with four sessions. After baseline assessment, partic...

journal_title：Behavioural pharmacology

authors： McPherson S,Howell D,Lewis J,Barbosa-Leiker C,Bertotti Metoyer P,Roll J

更新日期：2016-04-01 00:00:00

abstract：:In a step-down passive avoidance task, the pre-training injection of 1.25-10 mg/kg of morphine impaired memory. This was restored when injection of the same dose of morphine (pre-test treatment) was repeated 24 h later (morphine state-dependent learning: morphine St-D). ATP-dependent potassium (K(ATP)) channels have b...

journal_title：Behavioural pharmacology

authors： Zarrindast MR,Jafari MR,Shafaghi B,Djahanguiri B

更新日期：2004-03-01 00:00:00

abstract：:There is clinical and experimental evidence that treatment with immunosuppressive and antiproliferative drugs such as the calcineurin inhibitor cyclosporine A (CsA) is associated with mental health problems and neuropsychological disturbances in patients. However, it remains unclear whether and to what extent cognitiv...

journal_title：Behavioural pharmacology

authors： Kahl AL,Kirchhof J,Füting A,Hütter BO,Wilde B,Witzke O,Benson S,Hadamitzky M,Schedlowski M

更新日期：2017-06-01 00:00:00

abstract：:Twenty male Wistar rats were trained under an alternating-lever cyclic-ratio (ALCR) schedule of food reinforcement. When responding showed no trends, each subject was subcutaneously implanted with an Alzet osmotic mini-pump, connected to a chronic indwelling cannula extending into the lateral ventricle of the brain. T...

journal_title：Behavioural pharmacology

authors： Richardson RL,Kim EM,Gardiner T,O'Hare E

更新日期：2005-11-01 00:00:00

abstract：:The purpose of the present experiments was to develop and validate pharmacologically an automated, relatively rapid, and reproducible behavioral model of learning and memory using an autoshaping procedure in mice. Nose-poke responses into a recessed area were differentiated by response-dependent reinforcement during t...

journal_title：Behavioural pharmacology

authors： Vanover KE,Barrett JE

更新日期：1998-05-01 00:00:00

abstract：:Cannabis is the most popular illicit drug used by adolescents. Yet, there are only a few studies that have examined the effects of cannabis use on learning and memory during this sensitive and important neurodevelopmental stage. Male adolescent Sprague-Dawley rats were treated with Δ(9)-tetrahydrocannabinol (THC, 6 mg...

journal_title：Behavioural pharmacology

authors： Steel RW,Miller JH,Sim DA,Day DJ

更新日期：2011-12-01 00:00:00

abstract：:The aims of the study were to test whether drug dose is positively related to the magnitude of the conditioned response following sensitization to the behavioural effects of cocaine and to investigate the relationship between the conditioned response and cocaine-induced sensitization. Male mice (C57BL/6J) were first i...

journal_title：Behavioural pharmacology

authors： Michel A,Tirelli E

更新日期：2002-02-01 00:00:00

abstract：:Given the repeated failure of amyloid-based approaches in Alzheimer's disease, there is increasing interest in tau-based therapeutics. Although methylthioninium (MT) treatment was found to be beneficial in tau transgenic models, the brain concentrations required to inhibit tau aggregation in vivo are unknown. The comp...

journal_title：Behavioural pharmacology

authors： Melis V,Magbagbeolu M,Rickard JE,Horsley D,Davidson K,Harrington KA,Goatman K,Goatman EA,Deiana S,Close SP,Zabke C,Stamer K,Dietze S,Schwab K,Storey JM,Harrington CR,Wischik CM,Theuring F,Riedel G

更新日期：2015-06-01 00:00:00

abstract：:The dopamine agonist apomorphine (apo) elicits stereotyped pecking bouts in pigeons, a response which increases with successive apo injections. The present study sought, first, to confirm the hypothesis that this sensitization arises through a Pavlovian conditioning driven by both external and internal cues; and, seco...

journal_title：Behavioural pharmacology

authors： Acerbo MJ,Godoy AM,Delius JD

更新日期：2003-12-01 00:00:00

abstract：:The present experiments investigated the effects of excitatory amino acid antagonists, infused into core and shell subregions of the nucleus accumbens, on spatial behavior in the rat. A food-search task was used, in which animals learn a specific pattern of food gathering; duration of each trial (time taken to gather ...

journal_title：Behavioural pharmacology

authors： Maldonado-Irizarry CS,Kelley AE

更新日期：1995-08-01 00:00:00

abstract：:The development of Parkinson's disease (PD) involves the degeneration of dopaminergic neurons caused by oxidative stress. Accumulating clinical evidence indicates that high blood levels of uric acid (UA), an intrinsic antioxidative substance, are associated with reduced risk of PD. However, this hypothesis has not bee...

journal_title：Behavioural pharmacology

authors： Nakashima A,Yamauchi A,Matsumoto J,Dohgu S,Takata F,Koga M,Fukae J,Tsuboi Y,Kataoka Y

更新日期：2019-02-01 00:00:00

abstract：:We studied the anxiolytic-like activity of alnespirone and buspirone, two 5-HT(1A) receptor agonists, in a modified Geller-Seifter conflict model, and examined the role of 5-HT(1A) receptors by studying whether WAY-100635, a selective antagonist at these receptors, blocked their effects. Administered s.c. 30 minutes b...

journal_title：Behavioural pharmacology

authors： Cervo L,Munoz C,Bertaglia A,Samanin R

更新日期：2000-04-01 00:00:00

abstract：:Mood and anxiety disorders, and rodent phenotypic measures modeling these disorders, have a strong genetic component. Various assays are used to study the neurobiological basis of fear-related and anxiety-related behaviors, phenotype genetically modified mice, and elucidate pharmacological modulation of these behavior...

journal_title：Behavioural pharmacology

authors： Brigman JL,Mathur P,Lu L,Williams RW,Holmes A

更新日期：2009-03-01 00:00:00

abstract：:Cocaine demand is a behavioral economic measure assessing drug reward value and motivation to use drug. The purpose of the current study was to develop a brief assessment of cocaine demand (BACD). Results from the BACD were compared with self-report measures of cocaine use. Participants consisted of treatment-seeking ...

journal_title：Behavioural pharmacology

authors： Yoon JH,de Dios C,Suchting R,Vincent JN,McKay SA,Lane SD,Schmitz JM

更新日期：2020-12-24 00:00:00

abstract：:Post-training administration of different doses of baclofen (a GABAB agonist) has been shown to impair memory retention, in a step-down passive avoidance test in mice. We have studied the effects of beta-adrenergic agonists and antagonists on baclofen-induced memory impairment in mice. Dobutamine (a beta 1-agonist) or...

journal_title：Behavioural pharmacology

authors： Zarrindast MR,Haidari H,Jafari MR,Djahanguiri B

更新日期：2004-07-01 00:00:00

abstract：:In this experiment we examined the effect of a serotonin receptor (5-HT1A) agonist and antagonist WAY-100635 (N-[2-(4-[2-methoxy-phenyl]-1-piperazinyl)ethyl]-N-2-pyridinylcyclohexane-carboxamide) on temporal differentiation, in intact rats and rats whose serotonergic (5-HTergic) pathways had been destroyed by 5,7-dihy...

journal_title：Behavioural pharmacology

authors： Body S,Kheramin S,Mobini S,Ho MY,Velazquez-Martinez DN,Bradshaw CM,Szabadi E

更新日期：2002-12-01 00:00:00

abstract：:Drug-addicted individuals show high levels of impulsive choice, characterized by preference for small immediate over larger but delayed rewards. Although the causal relationship between chronic drug use and elevated impulsive choice in humans has been unclear, a small but growing body of literature over the past decad...

journal_title：Behavioural pharmacology

authors： Setlow B,Mendez IA,Mitchell MR,Simon NW

更新日期：2009-09-01 00:00:00

abstract：:Does the effect of amphetamine on behavior (wheel running) differ depending on the functional role (operant, reinforcement) of that behavior? This study addressed this question using a multiple schedule of reinforcement in which wheel running served as reinforcement for lever pressing in one component and as operant b...

journal_title：Behavioural pharmacology

authors： Belke TW,Pierce WD,Sexton CA

更新日期：2019-10-01 00:00:00

abstract：:This study compared fixed-ratio (FR) and fixed-interval (FI) schedules to investigate the discriminative stimulus properties of μ-opioid and/or κ-opioid receptor agonists. Pigeons were trained to discriminate among morphine (μ agonist), U50488 (κ agonist), the combination, and saline under FR 20-s or FI-300-s schedule...

journal_title：Behavioural pharmacology

authors： Wessinger WD,Li M,McMillan DE

更新日期：2011-09-01 00:00:00

abstract：:A runway was used to measure locomotor responses to quinpirole (200µg/kg), in rats. The locomotor stimulant effect of quinpirole increased progressively over successive trials at 3-day intervals. Animals administered quinpirole in the home cage were also sensitized, but to a lesser degree than animals tested in the ru...

journal_title：Behavioural pharmacology

authors： Willner P,Papp M,Cheeta S,Muscat R

更新日期：1992-02-01 00:00:00

abstract：:The effects of d-amphetamine, chlorpromazine and pentobarbital on single alternation were compared in mice and rats. Chlorpromazine and d-amphetamine produced dose-related decreases in both accuracy and rate of responding with no differences in species sensitivity. Pentobarbital also produced dose-dependent decreases ...

journal_title：Behavioural pharmacology

authors： Donald JM,McMillan DE

更新日期：1990-01-01 00:00:00

abstract：:Eating a diet high in fat can lead to negative health consequences, including obesity and insulin resistance. Omega-3 polyunsaturated fatty acids (such as those found in fish oil) prevent high fat diet-induced obesity and insulin resistance in rats. Eating a high fat diet also enhances sensitivity of rats to the behav...

journal_title：Behavioural pharmacology

authors： Hernandez-Casner C,Ramos J,Serafine KM

更新日期：2017-09-01 00:00:00

abstract：:Cannabinoid receptor (CBR) agonists produce antinociception in conventional preclinical assays of pain-stimulated behavior but are not effective in preclinical assays of pain-depressed behavior. Fatty acid amide hydrolase (FAAH) inhibitors increase physiological levels of the endocannabinoid anandamide, which may conf...

journal_title：Behavioural pharmacology

authors： Kwilasz AJ,Abdullah RA,Poklis JL,Lichtman AH,Negus SS

更新日期：2014-04-01 00:00:00

abstract：:Both depression and cancer are related to a dysregulation of inflammatory and immune pathways. Indeed, depression is associated with increased expression of interferon-γ, interleukin-1β, and tumor necrosis factor α (TNF-α). In contrast, reductions of the activity of major histocompatibility complex protein molecules -...

journal_title：Behavioural pharmacology

authors： Barreto FS,Chaves Filho AJM,de Araújo MCCR,de Moraes MO,de Moraes MEA,Maes M,de Lucena DF,Macedo DS

更新日期：2018-04-01 00:00:00

abstract：:Pair-housed, water-deprived rats were trained to run in a two-way shuttle box, using water reinforcement. Animals were tested either singly or in pairs; in the paired condition, the animals were required to shuttle in close physical proximity. Paired performance, but not single performance was severely disrupted by si...

journal_title：Behavioural pharmacology

authors： Willner P,Sampson D,Phillips G,Fichera R,Foxlow P,Muscat R

更新日期：1989-01-01 00:00:00