Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats.


:Cannabinoid receptor (CBR) agonists produce antinociception in conventional preclinical assays of pain-stimulated behavior but are not effective in preclinical assays of pain-depressed behavior. Fatty acid amide hydrolase (FAAH) inhibitors increase physiological levels of the endocannabinoid anandamide, which may confer improved efficacy and safety relative to direct CBR agonists. To further evaluate FAAH inhibitors as candidate analgesics, this study assessed the effects of the FAAH inhibitor URB597 in assays of acute pain-stimulated and pain-depressed behavior in male Sprague-Dawley rats. Intraperitoneal injection of dilute lactic acid served as a noxious stimulus to stimulate a stretching response or depress positively reinforced operant behavior (intracranial self-stimulation), and URB597 was tested 1 and 4 h after administration. Consistent with FAAH inhibitor effects in other assays of pain-stimulated behavior, URB597 (1-10 mg/kg intraperitoneally) produced dose-related and CB1R-mediated decreases in acid-stimulated stretching. Conversely, in the assay of acid-depressed intracranial self-stimulation, URB597 produced a delayed, partial and non-CBR-mediated antinociceptive effect. The antinociceptive dose of URB597 (10 mg/kg) increased plasma and brain anandamide levels. These results suggest that URB597 produces antinociception in these models of 'pain stimulated' and 'pain depressed' behavior, but with different rates of onset and differential involvement of CBRs.


Behav Pharmacol


Behavioural pharmacology


Kwilasz AJ,Abdullah RA,Poklis JL,Lichtman AH,Negus SS




Has Abstract


2014-04-01 00:00:00












  • Changes in gut microbiota during development of compulsive checking and locomotor sensitization induced by chronic treatment with the dopamine agonist quinpirole.

    abstract::Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined wheth...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Jung TD,Jung PS,Raveendran L,Farbod Y,Dvorkin-Gheva A,Sakic B,Surette MG,Szechtman H

    更新日期:2018-04-01 00:00:00

  • A comparison of the predictive therapeutic and undesired side-effects of the NMDA receptor antagonist, memantine, in mice.

    abstract::Memantine (1-amino-3,5-dimethyl-adamantane) is the only clinically used NMDA (N-methyl-D-aspartate) glutamate receptor antagonist. The present experiments were carried out to compare the dose-response for memantine's predictive therapeutic and side-effects in a variety of tests in C57BL/6J/Han mice, and to elucidate i...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Kos T,Popik P

    更新日期:2005-05-01 00:00:00

  • Regulation of emotional behaviour by day length in mice: implication of melatonin.

    abstract::Pineal melatonin secretion occurs at night in all vertebrates and the duration of its secretion is negatively correlated with day length. As short-day exposure was previously shown to decrease emotional behaviour of mice toward an unfamiliar environment, the present study was designed to determine whether such behavio...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Kopp C,Vogel E,Rettori MC,Delagrange P,Renard P,Lesieur D,Misslin R

    更新日期:1999-12-01 00:00:00

  • The antidepressant-like effects of sinomenine in mice: a behavioral and neurobiological characterization.

    abstract::Sinomenine is a bioactive alkaloid extracted from Sinomenium acutum. Here, we investigated the antidepressant effects of sinomenine in mice. The antidepressant actions of sinomenine were first examined in the forced-swim test and the tail-suspension test, and then assessed in the chronic social defeat stress (CSDS) mo...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Li X,Liu C,Jiang B,Chen K,Li W,Wang H

    更新日期:2018-06-01 00:00:00

  • Influence of potassium channel modulators on morphine state-dependent memory of passive avoidance.

    abstract::In a step-down passive avoidance task, the pre-training injection of 1.25-10 mg/kg of morphine impaired memory. This was restored when injection of the same dose of morphine (pre-test treatment) was repeated 24 h later (morphine state-dependent learning: morphine St-D). ATP-dependent potassium (K(ATP)) channels have b...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Zarrindast MR,Jafari MR,Shafaghi B,Djahanguiri B

    更新日期:2004-03-01 00:00:00

  • The predictive validity of the drug-naive bilaterally MPTP-treated monkey as a model of Parkinson's disease: effects of L-DOPA and the D1 agonist SKF 82958.

    abstract::The aim of this study was twofold: (1) to study the predictive validity of the drug-naive, bilaterally MPTP-treated monkey as an animal model of Parkinson's disease (PD), and (2) to investigate the therapeutic and undesired effects of the D1 agonist SKF 82958 as compared to L-DOPA treatment, in drug-naive and L-DOPA p...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Andringa G,Lubbers L,Drukarch B,Stoof JC,Cools AR

    更新日期:1999-03-01 00:00:00

  • Salvianolic acid B improves motor function after cerebral ischemia in rats.

    abstract::In a previous short-term study, salvianolic acid B was reported to have a protective effect on cerebral ischemia. Here, we investigated whether salvianolic acid B improves the recovery of motor function after cerebral ischemia in a 14-day investigation. Cerebral ischemia was induced by middle cerebral artery occlusion...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Tang M,Feng W,Zhang Y,Zhong J,Zhang J

    更新日期:2006-09-01 00:00:00

  • Spatial and associative learning deficits induced by neonatal excitotoxic hippocampal damage in rats: further evaluation of an animal model of schizophrenia.

    abstract::Neonatal ventral hippocampal lesions in the rat result in post-pubertal onset of behavioural abnormalities, modelling some aspects of schizophrenia. We further assessed the behavioural effects of neonatal lesions in rats in a variety of cognitive tasks and in the prepulse inhibition (PPI) of startle response paradigm....

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Le Pen G,Grottick AJ,Higgins GA,Martin JR,Jenck F,Moreau JL

    更新日期:2000-06-01 00:00:00

  • Stress hormones enhance retrieval of fear conditioning acquired either one day or many months before.

    abstract::It has been known for years that systemic administration of the stress hormones, adrenocorticotrophin (ACTH), lysine-vasopressin, adrenaline, or beta-endorphin, enhances retrieval of aversive behaviours acquired one or a few days before. Here we show that the pre-test i.p. injection of the hormones in rats can also en...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Izquierdo LA,Barros DM,Medina JH,Izquierdo I

    更新日期:2002-05-01 00:00:00

  • Celecoxib potentiates the antianxiety and anticompulsive-like activity of fluoxetine against chronic unpredictable mild stress in experimental animals.

    abstract::Obsessive-compulsive disorder (OCD) is considered a heterogeneous anxiety disorder that includes compulsions. Celecoxib is considered an adjuvant to fluoxetine in the management of OCD in a clinical study. However, the experimental evidence is yet to be established. Therefore, the antianxiety and anticompulsive-like a...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Garabadu D,Kumar V

    更新日期:2019-04-01 00:00:00

  • Delta opioid-like discriminative stimulus effects of mu opioids in pigeons discriminating the delta opioid BW373U86 from saline.

    abstract::The purpose of this experiment was to examine the substitution patterns produced by opioids with activity at the mu receptor in pigeons trained to discriminate the delta opioid BW373U86 from saline. A low dose of naltrindole (0.1 mg/kg) produced at least a 16-fold rightward shift in the dose-effect curve for the stimu...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Picker MJ,Cook CD

    更新日期:1998-07-01 00:00:00

  • Comparison of nitric oxide synthase inhibitors, phospholipase A2 inhibitor and free radical scavengers as attenuators of opioid withdrawal syndrome.

    abstract::Chronic morphine-induced withdrawal syndrome after morphine cessation remains a severe obstacle in the clinical treatment of morphine. Previous studies have shown that nitric oxide synthetase (NOS) inhibitors may have therapeutic potential in morphine withdrawal in humans. The mechanisms that underlie expression of mo...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Mori T,Ito S,Matsubayashi K,Sawaguchi T

    更新日期:2007-12-01 00:00:00

  • Diphenyl diselenide improves scopolamine-induced memory impairment in mice.

    abstract::This study was conducted to evaluate the effects of exposure to diphenyl diselenide (PhSe)2 on cognitive impairment induced by scopolamine, a muscarinic antagonist, using the Y-maze and Morris water maze tests in mice. One hour before the tests, mice were treated with (PhSe)2 (50 mg/kg, oral) and 30 min later memory i...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Souza AC,Brüning CA,Leite MR,Zeni G,Nogueira CW

    更新日期:2010-09-01 00:00:00

  • Environmental influences on behavioural sensitization to the dopamine agonist quinpirole.

    abstract::A runway was used to measure locomotor responses to quinpirole (200µg/kg), in rats. The locomotor stimulant effect of quinpirole increased progressively over successive trials at 3-day intervals. Animals administered quinpirole in the home cage were also sensitized, but to a lesser degree than animals tested in the ru...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Willner P,Papp M,Cheeta S,Muscat R

    更新日期:1992-02-01 00:00:00

  • Antidepressant, anxiolytic and procognitive effects of subacute and chronic ketamine in the chronic mild stress model of depression.

    abstract::Ketamine is the prototype of a new generation of antidepressant drugs, which is reported in clinical studies to be effective in treatment-resistant patients, with an effect that appears within hours and lasts for a few days. Chronic mild stress (CMS) is a well-established and widely used animal model of depression, in...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Papp M,Gruca P,Lason-Tyburkiewicz M,Willner P

    更新日期:2017-02-01 00:00:00

  • Pimavanserin, a 5-HT2A inverse agonist, reverses psychosis-like behaviors in a rodent model of Parkinson's disease.

    abstract::Parkinson's disease psychosis (PDP) is a condition for which a safe, tolerated, and effective therapy is lacking. Treatment with typical or atypical antipsychotics may be contraindicated in patients with PDP because of the potential for aggravating motor symptoms. This study used a novel animal model with features of ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: McFarland K,Price DL,Bonhaus DW

    更新日期:2011-10-01 00:00:00

  • Topiramate does not alter nicotine or cocaine discrimination in rats.

    abstract::The effects of topiramate, a potential treatment for drug dependence, were evaluated in two groups of rats trained to discriminate the administration of either 0.4 mg/kg nicotine or 10 mg/kg cocaine from that of saline, under a fixed-ratio 10 schedule of food delivery. Topiramate (1-60 mg/kg, intraperitoneal) did not ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Le Foll B,Justinova Z,Wertheim CE,Barnes C,Goldberg SR

    更新日期:2008-02-01 00:00:00

  • Drug withdrawal conceptualized as a stressor.

    abstract::Drug withdrawal is often conceptualized as an aversive state that motivates drug-seeking and drug-taking behaviors in humans. Stress is more difficult to define, but is also frequently associated with aversive states. Here we describe evidence for the simple theory that drug withdrawal is a stress-like state, on the b...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,评审


    authors: Chartoff EH,Carlezon WA Jr

    更新日期:2014-09-01 00:00:00

  • The effects of chronic administration of ceronapril on the partial reinforcement extinction effect and latent inhibition in rats.

    abstract::Previous experiments showed that acute administration of the angiotensin converting enzyme (ACE) inhibitor, ceronapril, shares with neuroleptic drugs an ability to enhance latent inhibition (LI), which consists of retardation in conditioning to a stimulus as a consequence of its prior non-reinforced pre-exposure. Expe...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Weiner I,Tarrasch R,Hasson O,Forian R,Smith AD,Rawlins JN,Feldon J

    更新日期:1994-06-01 00:00:00

  • Effects of nicotine on active avoidance learning in rats: sex differences.

    abstract::Nicotine, a cognition enhancer and a drug of abuse, exerts its central actions through neuronal nicotinic acetylcholine receptors which show sexual dimorphism. This study tested the effects of nicotine on active avoidance learning in male and female rats. Three month-old Sprague-Dawley rats received varying doses of n...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Yilmaz O,Kanit L,Okur BE,Pöğün S

    更新日期:1997-06-01 00:00:00

  • [INCREMENT]9-Tetrahydrocannabinol discriminative stimulus effects of AM2201 and related aminoalkylindole analogs in rats.

    abstract::The recent recreational use of synthetic cannabinoid ligands, collectively referred to as 'Spice', has raised concerns about their safety and possible differences in their biological effect(s) from marijuana/Δ-tetrahydrocannabinol (THC). AM2201, a highly efficacious, potent cannabinoid receptor 1 (CB1R) agonist, is a ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Järbe TU,Gifford RS,Zvonok A,Makriyannis A

    更新日期:2016-04-01 00:00:00

  • Behavioral effects of acute and chronic cocaine administration in male and female rats: effects of fixed-ratio schedule parameters.

    abstract::Intact and gonadectomized male and female rats pressed a lever to obtain food on different fixed-ratio (FR) schedules in a three-component multiple schedule. The values of a small, intermediate and large FR schedule were individually determined and were higher for intact male rats than for most subjects in the other g...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: van Haaren F,Anderson KG

    更新日期:1994-10-01 00:00:00

  • How reliable is the behavioural evaluation of dyskinesia in animal models of Parkinson's disease?

    abstract::In spite of the current availability of several pharmacological therapies for the treatment of Parkinson's disease, side effects are invariably manifested during long-term treatment. Dyskinesia, wearing-off and on-off are among the most disabling side effects produced by the dopamine precursor L-dihydroxyphenylalanine...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,评审


    authors: Carta AR,Pinna A,Morelli M

    更新日期:2006-09-01 00:00:00

  • Positive allosteric modulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors differentially modulates the behavioural effects of citalopram in mouse models of antidepressant and anxiolytic action.

    abstract::Drugs that increase monoamine neurotransmission are effective in both anxiety and depression. The therapeutic effects of monoamine-based antidepressant drugs may involve indirect effects on neurotransmission through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPAR). Thus, chronic antidep...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Fitzpatrick CM,Larsen M,Madsen LH,Caballero-Puntiverio M,Pickering DS,Clausen RP,Andreasen JT

    更新日期:2016-09-01 00:00:00

  • Daily mirfentanil induces (cross-) tolerance to the rate-decreasing effects of morphine and not mirfentanil.

    abstract::The fentanyl derivative mirfentanil has a novel set of behavioral effects in non-humans including low-efficacy opioid actions and non-opioid antinociceptive actions. This study evaluated the rate-decreasing effects of mirfentanil, morphine, naltrexone and ketamine in pigeons both prior to and during a period of chroni...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Gauthier CA,Bagley JR,Brockunier LL,France CP

    更新日期:1999-09-01 00:00:00

  • Separate and combined effects of gabapentin and [INCREMENT]9-tetrahydrocannabinol in humans discriminating [INCREMENT]9-tetrahydrocannabinol.

    abstract::The aim of the present study was to examine a potential mechanism of action of gabapentin to manage cannabis-use disorders by determining the interoceptive effects of gabapentin in cannabis users discriminating [INCREMENT]-tetrahydrocannabinol ([INCREMENT]-THC) using a pharmacologically selective drug-discrimination p...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Lile JA,Wesley MJ,Kelly TH,Hays LR

    更新日期:2016-04-01 00:00:00

  • Self-reported smoking effects and comparative value between cigarettes and high dose e-cigarettes in nicotine-dependent cigarette smokers.

    abstract::The objective of this experiment was to evaluate the comparative value of cigarettes versus high dose e-cigarettes among nicotine-dependent cigarette smokers when compared with money or use of their usual cigarette brand. The experiment used a within-subject design with four sessions. After baseline assessment, partic...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: McPherson S,Howell D,Lewis J,Barbosa-Leiker C,Bertotti Metoyer P,Roll J

    更新日期:2016-04-01 00:00:00

  • Spatial learning deficit after NMDA receptor blockade and state-dependency.

    abstract::The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) (0.08 and 0.12 mg/kg, i.p.) was used to examine whether spatial memory is learned state-dependently. Rats pre-treated with drug or saline were trained for 9 days in an eight-arm radial maze, in which four arms were baited. On the ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Kretschmer BD,Fink S

    更新日期:1999-07-01 00:00:00

  • Alnespirone and buspirone have anxiolytic-like effects in a conflict procedure in rats by stimulating 5-HT(1A) receptors.

    abstract::We studied the anxiolytic-like activity of alnespirone and buspirone, two 5-HT(1A) receptor agonists, in a modified Geller-Seifter conflict model, and examined the role of 5-HT(1A) receptors by studying whether WAY-100635, a selective antagonist at these receptors, blocked their effects. Administered s.c. 30 minutes b...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Cervo L,Munoz C,Bertaglia A,Samanin R

    更新日期:2000-04-01 00:00:00

  • Differential effects of d-amphetamine and atomoxetine on risk-based decision making of Lewis and Fischer 344 rats.

    abstract::Individuals with attention-deficit/hyperactivity disorder tend to make risker choices during probabilistic-discounting procedures. Thus, how common attention-deficit/hyperactivity disorder medications affect probabilistic discounting is of interest. In general, d-amphetamine increases risk-taking while atomoxetine has...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Ozga-Hess JE,Anderson KG

    更新日期:2019-10-01 00:00:00