Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats.


:Cannabinoid receptor (CBR) agonists produce antinociception in conventional preclinical assays of pain-stimulated behavior but are not effective in preclinical assays of pain-depressed behavior. Fatty acid amide hydrolase (FAAH) inhibitors increase physiological levels of the endocannabinoid anandamide, which may confer improved efficacy and safety relative to direct CBR agonists. To further evaluate FAAH inhibitors as candidate analgesics, this study assessed the effects of the FAAH inhibitor URB597 in assays of acute pain-stimulated and pain-depressed behavior in male Sprague-Dawley rats. Intraperitoneal injection of dilute lactic acid served as a noxious stimulus to stimulate a stretching response or depress positively reinforced operant behavior (intracranial self-stimulation), and URB597 was tested 1 and 4 h after administration. Consistent with FAAH inhibitor effects in other assays of pain-stimulated behavior, URB597 (1-10 mg/kg intraperitoneally) produced dose-related and CB1R-mediated decreases in acid-stimulated stretching. Conversely, in the assay of acid-depressed intracranial self-stimulation, URB597 produced a delayed, partial and non-CBR-mediated antinociceptive effect. The antinociceptive dose of URB597 (10 mg/kg) increased plasma and brain anandamide levels. These results suggest that URB597 produces antinociception in these models of 'pain stimulated' and 'pain depressed' behavior, but with different rates of onset and differential involvement of CBRs.


Behav Pharmacol


Behavioural pharmacology


Kwilasz AJ,Abdullah RA,Poklis JL,Lichtman AH,Negus SS




Has Abstract


2014-04-01 00:00:00












  • Dyadic social interaction of C57BL/6 mice versus interaction with a toy mouse: conditioned place preference/aversion, substrain differences, and no development of a hierarchy.

    abstract::Impaired social interaction is a hallmark symptom of many psychiatric diseases, including dependence syndromes (substance use disorders). Helping the addict reorient her/his behavior away from the drug of abuse toward social interaction would be of considerable therapeutic benefit. To study the neural basis of such a ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Pinheiro BS,Seidl SS,Habazettl E,Gruber BE,Bregolin T,Zernig G

    更新日期:2016-04-01 00:00:00

  • Spatial and associative learning deficits induced by neonatal excitotoxic hippocampal damage in rats: further evaluation of an animal model of schizophrenia.

    abstract::Neonatal ventral hippocampal lesions in the rat result in post-pubertal onset of behavioural abnormalities, modelling some aspects of schizophrenia. We further assessed the behavioural effects of neonatal lesions in rats in a variety of cognitive tasks and in the prepulse inhibition (PPI) of startle response paradigm....

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Le Pen G,Grottick AJ,Higgins GA,Martin JR,Jenck F,Moreau JL

    更新日期:2000-06-01 00:00:00

  • An automated learning and memory model in mice: pharmacological and behavioral evaluation of an autoshaped response.

    abstract::The purpose of the present experiments was to develop and validate pharmacologically an automated, relatively rapid, and reproducible behavioral model of learning and memory using an autoshaping procedure in mice. Nose-poke responses into a recessed area were differentiated by response-dependent reinforcement during t...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Vanover KE,Barrett JE

    更新日期:1998-05-01 00:00:00

  • Conditioned hyperkinesia induced by cocaine in mice is dose-dependent but not correlated with the unconditioned response or the contextually-sensitized response.

    abstract::The aims of the study were to test whether drug dose is positively related to the magnitude of the conditioned response following sensitization to the behavioural effects of cocaine and to investigate the relationship between the conditioned response and cocaine-induced sensitization. Male mice (C57BL/6J) were first i...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Michel A,Tirelli E

    更新日期:2002-02-01 00:00:00

  • NMDA antagonists disrupt timing behaviour in rats.

    abstract::The behavioural effects of six compounds with N-methyl-D-aspartate (NMDA) antagonist properties were compared on the responding of rats maintained by a differential reinforcement of low rate 15s (DRL-15s) schedule. This schedule requires that responses be temporally spaced in order to be reinforced (timing behaviour)....

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Sanger DJ

    更新日期:1992-12-01 00:00:00

  • Training dose as a decisive factor for discrimination of a drug mixture in rats.

    abstract::The impact of training dose on the characteristics of a discrimination maintained by a mixture of two dissimilar drugs has been investigated in order to refine this approach to the study of drug interactions. Three groups of rats (n = 10) were trained to discriminate mixtures of (+)-amphetamine (0.2-0.8mg/kg) plus pen...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Mariathasan EA,White JA,Stolerman IP

    更新日期:1996-08-01 00:00:00

  • Changes in gut microbiota during development of compulsive checking and locomotor sensitization induced by chronic treatment with the dopamine agonist quinpirole.

    abstract::Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined wheth...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Jung TD,Jung PS,Raveendran L,Farbod Y,Dvorkin-Gheva A,Sakic B,Surette MG,Szechtman H

    更新日期:2018-04-01 00:00:00

  • Assessment of executive function using the Tinkertoy test.

    abstract::The Tinkertoy test (TTT) has often been used to assess executive function. Despite its clinical importance, there are few published normative data for it. Thus, the primary aim of this study was to fill this gap. Moreover, as there exists a sex difference in many cognitive abilities and neuropsychological tests, a sec...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Lambert M,Stenger J,Bielajew C

    更新日期:2018-12-01 00:00:00

  • Motivation for alcohol assessed by multiple variable interval schedule behaviour: effects of reward size and alcohol cues.

    abstract::Altered motivation for drugs of abuse is a central feature of most definitions of drug dependence and the impact of drug-related cues on motivation is of current interest. However, since most studies of cue-reactivity have not used behavioural measures of motivation, their results are often difficult to interpret in m...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Glautier S,Rigney U,Willner P

    更新日期:2001-04-01 00:00:00

  • The discriminative stimulus and reinforcing effects of nicotine in humans following nicotine pretreatment.

    abstract::Smokers often report that the first cigarette of the day is the most rewarding, and subsequent smoking is less rewarding. Reduction in smoking enjoyment later in the day may be related to acute tolerance to the discriminative stimulus effects of nicotine. We examined changes in nicotine discrimination behaviour in hum...

    journal_title:Behavioural pharmacology

    pub_type: 临床试验,杂志文章


    authors: Perkins KA,Fonte C,Meeker J,White W,Wilson A

    更新日期:2001-02-01 00:00:00

  • Dopamine agonist-induced hypothermia and disruption of prepulse inhibition: evidence for a role of D3 receptors?

    abstract::The dopamine D3/D2 receptor agonists 7-OH-DPAT, quinpirole, quinelorane, and PD128907, the mixed dopamine agonist apomorphine, the D2 agonist bromocriptine, and the D1/D5 agonist SKF38393 were examined in models of hypothermia and prepulse inhibition (PPI) in Wistar rats. As dopamine agonist-induced hypothermia has be...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Varty GB,Higgins GA

    更新日期:1998-09-01 00:00:00

  • Learning impairment by Δ(9)-tetrahydrocannabinol in adolescence is attributable to deficits in chunking.

    abstract::Cannabis is the most popular illicit drug used by adolescents. Yet, there are only a few studies that have examined the effects of cannabis use on learning and memory during this sensitive and important neurodevelopmental stage. Male adolescent Sprague-Dawley rats were treated with Δ(9)-tetrahydrocannabinol (THC, 6 mg...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Steel RW,Miller JH,Sim DA,Day DJ

    更新日期:2011-12-01 00:00:00

  • Conditioned cued recovery of responding following prolonged withdrawal from self-administered cocaine in rats: an animal model of relapse.

    abstract::The present study investigated the ability of drug-associated cues to reinstate extinguished responding following an extended period of withdrawal from cocaine self-administration. Rats self-administered cocaine (0.33mg/infusion) for 2 weeks of daily 3-h limited-access sessions under a fixed-interval (FI) schedule of ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Meil WM,See RE

    更新日期:1996-12-01 00:00:00

  • Regulation of emotional behaviour by day length in mice: implication of melatonin.

    abstract::Pineal melatonin secretion occurs at night in all vertebrates and the duration of its secretion is negatively correlated with day length. As short-day exposure was previously shown to decrease emotional behaviour of mice toward an unfamiliar environment, the present study was designed to determine whether such behavio...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Kopp C,Vogel E,Rettori MC,Delagrange P,Renard P,Lesieur D,Misslin R

    更新日期:1999-12-01 00:00:00

  • Real-time assessment of alcohol drinking and drug use in opioid-dependent polydrug users.

    abstract::We investigated relationships between drinking, other drug use, and drug craving, using ecological momentary assessment (EMA), in a sample of polydrug users who were not heavy drinkers. In a prospective longitudinal cohort study, 114 heroin and cocaine users on methadone-maintenance treatment carried handheld electron...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Preston KL,Jobes ML,Phillips KA,Epstein DH

    更新日期:2016-10-01 00:00:00

  • Effects of drugs of abuse on response accuracy and bias under a delayed matching-to-sample procedure in squirrel monkeys.

    abstract::The effects on memory of drugs of abuse from several pharmacological classes were examined in four adult male squirrel monkeys responding under a delayed matching-to-sample schedule of food presentation. Subjects were required to emit 20 responses on a sample key transilluminated by either a constant white or a flashi...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Baron SP,Wenger GR

    更新日期:2001-07-01 00:00:00

  • The antidepressant-like effects of sinomenine in mice: a behavioral and neurobiological characterization.

    abstract::Sinomenine is a bioactive alkaloid extracted from Sinomenium acutum. Here, we investigated the antidepressant effects of sinomenine in mice. The antidepressant actions of sinomenine were first examined in the forced-swim test and the tail-suspension test, and then assessed in the chronic social defeat stress (CSDS) mo...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Li X,Liu C,Jiang B,Chen K,Li W,Wang H

    更新日期:2018-06-01 00:00:00

  • Ultra-low dose naltrexone enhances cannabinoid-induced antinociception.

    abstract::Both opioids and cannabinoids have inhibitory effects at micromolar doses, which are mediated by activated receptors coupling to Gi/o-proteins. Surprisingly, the analgesic effects of opioids are enhanced by ultra-low doses (nanomolar to picomolar) of the opioid antagonist, naltrexone. As opioid and cannabinoid systems...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Paquette J,Olmstead MC

    更新日期:2005-12-01 00:00:00

  • Triazolam and zolpidem: a comparison of their psychomotor, cognitive, and subjective effects in healthy volunteers.

    abstract::The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) and the imidazopyridine hypnotic zolpidem (5, 10, and 20 mg/70 kg) were compared in 11 volunteers, in a double-blind, placebo-controlled, crosso...

    journal_title:Behavioural pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mintzer MZ,Frey JM,Yingling JE,Griffiths RR

    更新日期:1997-11-01 00:00:00

  • Behavioral momentum and relapse of ethanol seeking: nondrug reinforcement in a context increases relative reinstatement.

    abstract::Drug-related stimuli seem to contribute to the persistence of drug seeking and relapse. Behavioral momentum theory is a framework for understanding how the discriminative-stimulus context in which operant behavior occurs governs the persistence of that behavior. The theory suggests that both resistance to change and r...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Pyszczynski AD,Shahan TA

    更新日期:2011-02-01 00:00:00

  • Differential cross-tolerance to the effects of nicotinic acetylcholine receptor drugs in C57BL/6J mice following chronic varenicline.

    abstract::Varenicline is a smoking cessation pharmacotherapy with a presumed mechanism of action of partial efficacy at the α4β2 nicotinic acetylcholine receptor (nAChR); however, the extent to which daily varenicline use leads to changes in nAChR sensitivity is unclear. This study examined the consequences of daily varenicline...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: de Moura FB,McMahon LR

    更新日期:2019-08-01 00:00:00

  • The effects of PDE10 inhibition on attentional set-shifting do not depend on the activation of dopamine D1 receptors.

    abstract::Inhibitors of phosphodiesterase 10A (PDE10A) represent a novel class of potential antipsychotic compounds. These principles increase the level of cAMP and cGMP in the medium spiny neurons of the striatum and resemble the neurochemical consequences of dopamine D2 receptor inhibition and dopamine D1 receptor stimulation...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Nikiforuk A,Potasiewicz A,Rafa D,Drescher K,Bespalov A,Popik P

    更新日期:2016-06-01 00:00:00

  • An overview on transient receptor potential channels superfamily.

    abstract::The transient receptor potential (TRP) channel superfamily is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of roles in sensory signaling and are involved in plethora of animal behaviors. These channels are activated through a wide variety of mechanisms and participa...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Tsagareli MG,Nozadze I

    更新日期:2020-08-01 00:00:00

  • Haloperidol blocks the acquisition but not the retrieval of a conditioned sensitization to apomorphine.

    abstract::The dopamine agonist apomorphine (apo) elicits stereotyped pecking bouts in pigeons, a response which increases with successive apo injections. The present study sought, first, to confirm the hypothesis that this sensitization arises through a Pavlovian conditioning driven by both external and internal cues; and, seco...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Acerbo MJ,Godoy AM,Delius JD

    更新日期:2003-12-01 00:00:00

  • Topiramate does not alter nicotine or cocaine discrimination in rats.

    abstract::The effects of topiramate, a potential treatment for drug dependence, were evaluated in two groups of rats trained to discriminate the administration of either 0.4 mg/kg nicotine or 10 mg/kg cocaine from that of saline, under a fixed-ratio 10 schedule of food delivery. Topiramate (1-60 mg/kg, intraperitoneal) did not ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Le Foll B,Justinova Z,Wertheim CE,Barnes C,Goldberg SR

    更新日期:2008-02-01 00:00:00

  • Comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine.

    abstract::Changes in extracellular concentrations of dopamine (DA) were measured in vivo in the nucleus accumbens of the rat during intravenous self-administration of either cocaine (0.25, 0.5, 1.0mg/infusion) or d-amphetamine (0.05, 0.1, 0.2mg/infusion). Drug intake was limited to 12 self-administered infusions per session for...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Di Ciano P,Coury A,Depoortere RY,Egilmez Y,Lane JD,Emmett-Oglesby MW,Lepiane FG,Phillips AG,Blaha CD

    更新日期:1995-06-01 00:00:00

  • Delta opioid-like discriminative stimulus effects of mu opioids in pigeons discriminating the delta opioid BW373U86 from saline.

    abstract::The purpose of this experiment was to examine the substitution patterns produced by opioids with activity at the mu receptor in pigeons trained to discriminate the delta opioid BW373U86 from saline. A low dose of naltrindole (0.1 mg/kg) produced at least a 16-fold rightward shift in the dose-effect curve for the stimu...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Picker MJ,Cook CD

    更新日期:1998-07-01 00:00:00

  • Modification of the discriminative stimulus effects of 8-OH-DPAT, buspirone and the beta-adrenoreceptor antagonist pindolol after chronic administration of the 5-HT(1A) agonist 8-OH-DPAT in the pigeon.

    abstract::The involvement of adrenoreceptor blocking drugs with the 5-HT(1A)-mediated discriminative stimulus was studied in pigeons trained to discriminate the 5-HT(1A) receptor agonist 8-OH-DPAT (0.3mg/kg) from saline. Cumulative dose-response curves were determined for 8-OH-DPAT, the beta-adrenergic antagonist pindolol, the ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Zhang L,Barrett JE

    更新日期:1991-11-01 00:00:00

  • Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the behavioral effects of quinpirole.

    abstract::Eating a diet high in fat can lead to negative health consequences, including obesity and insulin resistance. Omega-3 polyunsaturated fatty acids (such as those found in fish oil) prevent high fat diet-induced obesity and insulin resistance in rats. Eating a high fat diet also enhances sensitivity of rats to the behav...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Hernandez-Casner C,Ramos J,Serafine KM

    更新日期:2017-09-01 00:00:00

  • Involvement of 5-HT(1A) and 5-HT(2) receptors of the inferior colliculus in aversive states induced by exposure of rats to the elevated plus-maze test.

    abstract::Much evidence has shown that the inferior colliculus may be part of a brain system commanding defensive behavior. In the present work, evidence is presented for the serotonergic modulation of the neural substrate of aversive states elaborated in this structure. Rats implanted with a cannula in the inferior colliculus ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Melo LL,Brando ML

    更新日期:1995-06-01 00:00:00