Abstract:
:Rats were placed in a circular swimming pool for two 3-min swims separated by 3 days. In the first swim control rats swam initially around the perimeter of the pool and later spent more time in the central region and swam more slowly. The time spent in the centre during min 1 was much higher in the second swim than in the first. This alteration of behaviour by the previous experience suggests that a memory of the first swim was formed. The NMDA antagonists, CPP (10-20mg/kg) or MK-801 (50-100µg/kg), administered before the first swim attenuated or reversed the decline in swimming speed and attenuated the intra-trial increase in the time spent in the centre. The alteration of swimming pattern between the two swims was also reduced. Administering the antagonists immediately after the first swim did not have this effect. Drug administration shortly before the second swim prevented the within-trial decline of swimming speed, but did not significantly reduce the high proportion of time spent in the central region during min 1. The results suggest that in this paradigm NMDA receptors are involved in within-trial habituation of swimming activity and in the initial stages of long-term memory formation, but are not involved in memory consolidation or retrieval.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Venable N,Kelly PHsubject
Has Abstractpub_date
1991-04-01 00:00:00pages
161-169issue
2eissn
0955-8810issn
1473-5849journal_volume
2pub_type
杂志文章abstract::The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) and the imidazopyridine hypnotic zolpidem (5, 10, and 20 mg/70 kg) were compared in 11 volunteers, in a double-blind, placebo-controlled, crosso...
journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00008877-199711000-00014
更新日期:1997-11-01 00:00:00
abstract::Several allosteric modulators (AMs) of the CB1 receptor have been characterized in vitro, including Org27569, which enhances CB1-specific binding of [H]CP55,940, but behaves as an insurmountable CB1-receptor antagonist in several biochemical assays. Although a growing body of research has investigated the molecular ac...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000027
更新日期:2014-04-01 00:00:00
abstract::The aim of this study was to investigate the effects of a mixed dietary intervention on behavioral symptoms in serotonin transporter knockout (5-HTT⁻/⁻) rats modeling the human 5-HTT length polymorphic region short-allele. Twenty female 5-HTT⁻/⁻ and 19 wild-type (5-HTT⁺/⁺) rats were fed for 3 months on a mixed polyuns...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e328347881b
更新日期:2011-08-01 00:00:00
abstract::The recent recreational use of synthetic cannabinoid ligands, collectively referred to as 'Spice', has raised concerns about their safety and possible differences in their biological effect(s) from marijuana/Δ-tetrahydrocannabinol (THC). AM2201, a highly efficacious, potent cannabinoid receptor 1 (CB1R) agonist, is a ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000196
更新日期:2016-04-01 00:00:00
abstract::The dopamine D3/D2 receptor agonists 7-OH-DPAT, quinpirole, quinelorane, and PD128907, the mixed dopamine agonist apomorphine, the D2 agonist bromocriptine, and the D1/D5 agonist SKF38393 were examined in models of hypothermia and prepulse inhibition (PPI) in Wistar rats. As dopamine agonist-induced hypothermia has be...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199809000-00008
更新日期:1998-09-01 00:00:00
abstract::Benzodiazepines are generally reported to be active in tests based on punished responding and in procedures involving exploratory behaviour, but the effects of 5-HT drugs thus far reported are inconsistent. The effects of the two 5-HT(1A) agonists 8-OH-DPAT and buspirone were studied in a passive avoidance test and in...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::Flavonoids are natural substances obtained from plants. Most flavonoids cross the blood-brain barrier and exert a wide range of effects on the central nervous system. These actions have been attributed to the modulation of GABA-A receptors. Although motor systems in the central nervous system express a high density of...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000100
更新日期:2015-02-01 00:00:00
abstract::In a modified light-dark exploration test in mice, 5-hydroxytryptophan, at doses (25-50 mg/kg) that approximately doubled the 5-HT content in the cerebral cortex, reduced the time spent by mice in the white compartment, suggesting an anxiogenic effect. Depletion of brain 5-HT content with p-chlorophenylalanine (300 mg...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::Much evidence has shown that the inferior colliculus may be part of a brain system commanding defensive behavior. In the present work, evidence is presented for the serotonergic modulation of the neural substrate of aversive states elaborated in this structure. Rats implanted with a cannula in the inferior colliculus ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199506000-00012
更新日期:1995-06-01 00:00:00
abstract::Pigeons were trained to discriminate 5mg/kg pentobarbital from saline under several multiple fixed-ratio fixed-interval schedules of food presentation. The following schedules were studied: multiple fixed-ratio 40 fixed-interval 18s (mult FR40 FI18), mult FR10 FI18s, mult FR10 FI180s and mult FR90 FI10s. After respond...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::Few studies have investigated the effects of chronic cannabinoid exposure on memory performance and whether tolerance occurs to cannabinoid-induced memory impairment. Here, we studied the effects of repeated exposure to Delta-tetrahydrocannabinol (THC: 1 mg/kg) on spatial memory and zif268 expression in mice. One grou...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3283242f6a
更新日期:2009-02-01 00:00:00
abstract::Sensitization induced by repeated drug exposure has been proposed to increase 'wanting' the drug and to facilitate the transition from moderate to excessive drug intake. The present study examined the effects of cocaine-induced sensitization on ethanol-drinking behavior in male and female rats from different strains. ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200008000-00004
更新日期:2000-08-01 00:00:00
abstract::This study was designed to explore whether differences in the psychomotor, subjective and memory effects of different benzodiazepines (BDZ) relate to differences in their potencies. Two BDZs with similar kinetics but different potencies were compared. Flunitrazepam (0.5 and 1.0mg, nitrazepam (5 and 10mg) or placebo we...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::With the ever-growing geriatric population, research on brain diseases such as dementia is more imperative now than ever. The most prevalent of all dementias is Alzheimer's disease, a progressive neurodegenerative disease that presents with deficits in memory, cognition, motor skills, and a general decline in the qual...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000284
更新日期:2017-04-01 00:00:00
abstract::Although the role of genetic factors in the response to drugs of abuse has been emphasized, no earlier studies have applied selective breeding to intravenous drug self-administration. Here we report the effects of six generations of selective breeding for rat lines with low or high levels of intravenous drug self-admi...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32831c3aec
更新日期:2008-12-01 00:00:00
abstract::Environmental and situational factors are important determinants of recreational drug use in humans. We aimed to develop a reliable animal model for studying the effects of environmental variables on drug-seeking behavior using the 'social isolation/social restriction' paradigm. Adult Wistar rats housed in short-term ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32833470bd
更新日期:2010-02-01 00:00:00
abstract::Rats in one group were trained to discriminate alprazolam (1.0mg/kg, i.p.) and in another group diazepam (3.0mg/kg, i.p.) from saline in a two-lever drug discrimination procedure. Food presentation occurred after 10 consecutive responses on the lever associated either with the training drug or with saline. Alprazolam,...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::The strain of spontaneously hypertensive rats (SHR) is considered a genetic model for the study of attention-deficit hyperactivity disorder (ADHD), as it displays hyperactivity, impulsivity and poorly sustained attention. Recently, we have shown the involvement of adenosinergic neuromodulation in the SHR's short-term ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32832a80bf
更新日期:2009-03-01 00:00:00
abstract::Sensorimotor gating disruptions are seen in various psychiatric illnesses with putatively different pathologies, including schizophrenia and bipolar disorder. Interestingly, mice lacking the dopamine (DA) transporter (DAT) gene display markedly increased levels of DA, deficits in sensorimotor gating, and hyperactivity...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32830dc110
更新日期:2008-09-01 00:00:00
abstract::Recent examination of the mixed dopamine agonist apomorphine suggests that dopamine inhibits both passive avoidance and response suppression learning. The present study investigated the effects of selective dopamine agonists on memory consolidation using a passive avoidance task in the day-old chick. The dopamine D1 a...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200207000-00006
更新日期:2002-07-01 00:00:00
abstract::Glutamate, an excitatory neurotransmitter in the brain, produces excitotoxicity through its agonistic action on postsynaptic N-methyl-D-aspartate receptor, resulting in neurodegeneration. We hypothesized that the administration of low doses of glutamate in cerebral ischemia could attenuate the excitotoxicity in neuron...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000256
更新日期:2016-10-01 00:00:00
abstract::Pair-housed, water-deprived rats were trained to run in a two-way shuttle box, using water reinforcement. Animals were tested either singly or in pairs; in the paired condition, the animals were required to shuttle in close physical proximity. Paired performance, but not single performance was severely disrupted by si...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-198900110-00010
更新日期:1989-01-01 00:00:00
abstract::The prototypic cannabinoid CB1 antagonist SR 141716A is one important pharmacologic tool for examining CB1 receptors that mediate the behavioral and physiologic effects of delta9-tetrahydrocannabinol (delta9-THC). This study examined the effects of SR 141716A on the rate-decreasing, hypothermic and discriminative stim...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200509000-00008
更新日期:2005-09-01 00:00:00
abstract::The acute and chronic effects of certain drugs can often be opposite. For example, in congestive heart failure acute administration of β-adrenoceptor agonists results in beneficial improvement in symptoms of the disease, but their chronic use increases mortality. Conversely, certain β-adrenoceptor antagonists/inverse ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0b013e328348ec6f
更新日期:2011-09-01 00:00:00
abstract::Ultrasonic vocalizations are widely used to examine affective states in rats, yet relatively few studies explore the acoustic features of vocalizations, especially in relation to drug exposure, and no studies have explored alterations in acoustic features over time. The goal of this study was to examine nicotine- and ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000463
更新日期:2019-08-01 00:00:00
abstract::Mood and anxiety disorders, and rodent phenotypic measures modeling these disorders, have a strong genetic component. Various assays are used to study the neurobiological basis of fear-related and anxiety-related behaviors, phenotype genetically modified mice, and elucidate pharmacological modulation of these behavior...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32830c368c
更新日期:2009-03-01 00:00:00
abstract::Cocaine addicts very often use different combinations of cocaine and other drugs of abuse such as gamma-hydroxybutyric acid. The objective of the present work was to evaluate the impact of gamma-hydroxybutyric acid administration on the rewarding actions of cocaine, using the conditioned place preference procedure. Co...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/01.fbp.0000190685.84984.ec
更新日期:2006-03-01 00:00:00
abstract::The present study investigated the ability of drug-associated cues to reinstate extinguished responding following an extended period of withdrawal from cocaine self-administration. Rats self-administered cocaine (0.33mg/infusion) for 2 weeks of daily 3-h limited-access sessions under a fixed-interval (FI) schedule of ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::Rats were trained on one of two multiple random-interval schedules of reinforcement, which contained both ascending and descending reinforcement density sequences. The design of the schedules made it possible to determine whether performance changes in a particular component depended on the reinforcement density in th...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Eating a diet high in fat can lead to negative health consequences, including obesity and insulin resistance. Omega-3 polyunsaturated fatty acids (such as those found in fish oil) prevent high fat diet-induced obesity and insulin resistance in rats. Eating a high fat diet also enhances sensitivity of rats to the behav...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000322
更新日期:2017-09-01 00:00:00