Social isolation increases morphine intake: behavioral and psychopharmacological aspects.

abstract：:Both depression and cancer are related to a dysregulation of inflammatory and immune pathways. Indeed, depression is associated with increased expression of interferon-γ, interleukin-1β, and tumor necrosis factor α (TNF-α). In contrast, reductions of the activity of major histocompatibility complex protein molecules -...

journal_title：Behavioural pharmacology

authors： Barreto FS,Chaves Filho AJM,de Araújo MCCR,de Moraes MO,de Moraes MEA,Maes M,de Lucena DF,Macedo DS

更新日期：2018-04-01 00:00:00

abstract：:We investigated relationships between drinking, other drug use, and drug craving, using ecological momentary assessment (EMA), in a sample of polydrug users who were not heavy drinkers. In a prospective longitudinal cohort study, 114 heroin and cocaine users on methadone-maintenance treatment carried handheld electron...

journal_title：Behavioural pharmacology

authors： Preston KL,Jobes ML,Phillips KA,Epstein DH

更新日期：2016-10-01 00:00:00

abstract：:This series of studies provides a behavioural account of dopamine D1-receptor-dependent facilitation and disruption of memory for the single-trial passive avoidance task in the day-old chick. The D1 antagonist, SCH23390, induced memory disruption in a dose-dependent manner from 60 min after training with a strong (100...

journal_title：Behavioural pharmacology

authors： Hale MW,Crowe SF

更新日期：2003-11-01 00:00:00

abstract：:Although the dopaminergic pharmacology of the D1 receptor full agonists, dinapsoline, dihydrexidine and the prodrug ABT-431 have been studied, no information is available on the ability of these agonists to substitute for the D1 agonist SKF 38393 in rats trained to discriminate this compound from vehicle. The present ...

journal_title：Behavioural pharmacology

authors： Gleason SD,Witkin JM

更新日期：2004-02-01 00:00:00

abstract：:Drug-related stimuli seem to contribute to the persistence of drug seeking and relapse. Behavioral momentum theory is a framework for understanding how the discriminative-stimulus context in which operant behavior occurs governs the persistence of that behavior. The theory suggests that both resistance to change and r...

journal_title：Behavioural pharmacology

authors： Pyszczynski AD,Shahan TA

更新日期：2011-02-01 00:00:00

abstract：:Does the effect of amphetamine on behavior (wheel running) differ depending on the functional role (operant, reinforcement) of that behavior? This study addressed this question using a multiple schedule of reinforcement in which wheel running served as reinforcement for lever pressing in one component and as operant b...

journal_title：Behavioural pharmacology

authors： Belke TW,Pierce WD,Sexton CA

更新日期：2019-10-01 00:00:00

abstract：:In spite of the current availability of several pharmacological therapies for the treatment of Parkinson's disease, side effects are invariably manifested during long-term treatment. Dyskinesia, wearing-off and on-off are among the most disabling side effects produced by the dopamine precursor L-dihydroxyphenylalanine...

journal_title：Behavioural pharmacology

authors： Carta AR,Pinna A,Morelli M

更新日期：2006-09-01 00:00:00

abstract：:Different approaches to measuring stimulus generalization in drug discrimination experiments are compared. The main issue, with implications for interpreting partial generalization, has been whether it is preferable to use graded or quantal indices. The first step is to determine whether discriminative drug effects ar...

journal_title：Behavioural pharmacology

authors： Stoleman IP

更新日期：1991-11-01 00:00:00

abstract：:Behavioral sensitization in mammals, including humans, is sensitive to factors such as administration route, testing environment, and pharmacokinetic confounds, unrelated to the drugs themselves that are difficult to eliminate. Simpler animals less susceptible to these confounding influences may be advantageous substi...

journal_title：Behavioural pharmacology

authors： Rawls SM,Patil T,Yuvasheva E,Raffa RB

更新日期：2010-07-01 00:00:00

abstract：:The development of Parkinson's disease (PD) involves the degeneration of dopaminergic neurons caused by oxidative stress. Accumulating clinical evidence indicates that high blood levels of uric acid (UA), an intrinsic antioxidative substance, are associated with reduced risk of PD. However, this hypothesis has not bee...

journal_title：Behavioural pharmacology

authors： Nakashima A,Yamauchi A,Matsumoto J,Dohgu S,Takata F,Koga M,Fukae J,Tsuboi Y,Kataoka Y

更新日期：2019-02-01 00:00:00

abstract：:Behavioral sensitization to amphetamine-like psychostimulants is manifest as a progressive increase in drug-induced anxiety and paranoia which can culminate in psychopathologies, such as paranoid psychosis and panic attacks. Sensitization may also mediate the facilitation of drug relapse in addicts by increasing the r...

journal_title：Behavioural pharmacology

authors： Kalivas PW,Sorg BA,Hooks MS

更新日期：1993-01-01 00:00:00

abstract：:Adolescence is one of the most important periods of brain development in mammals. There is increasing evidence that some medicines during this period can affect brain and behavioral functions in adulthood. Silymarin (SM), a mixture of flavonolignans extracted from the milk thistle Silybum marianum, is known as a hepat...

journal_title：Behavioural pharmacology

authors： Kosari-Nasab M,Rabiei A,Doosti MH,Salari AA

更新日期：2014-08-01 00:00:00

abstract：:Benzodiazepines are generally reported to be active in tests based on punished responding and in procedures involving exploratory behaviour, but the effects of 5-HT drugs thus far reported are inconsistent. The effects of the two 5-HT(1A) agonists 8-OH-DPAT and buspirone were studied in a passive avoidance test and in...

journal_title：Behavioural pharmacology

authors： Klint T

更新日期：1991-12-01 00:00:00

abstract：:Given the repeated failure of amyloid-based approaches in Alzheimer's disease, there is increasing interest in tau-based therapeutics. Although methylthioninium (MT) treatment was found to be beneficial in tau transgenic models, the brain concentrations required to inhibit tau aggregation in vivo are unknown. The comp...

journal_title：Behavioural pharmacology

authors： Melis V,Magbagbeolu M,Rickard JE,Horsley D,Davidson K,Harrington KA,Goatman K,Goatman EA,Deiana S,Close SP,Zabke C,Stamer K,Dietze S,Schwab K,Storey JM,Harrington CR,Wischik CM,Theuring F,Riedel G

更新日期：2015-06-01 00:00:00

abstract：:Some reports suggest that older patients are less responsive to antidepressants than young adults, but this idea has not been fully supported. Here, we investigated the role of aging in the behavioral effects of the antidepressants, desipramine (DMI) (5, 10, and 20 mg/kg) and fluoxetine (FLX) (5, 10, and 20 mg/kg) in ...

journal_title：Behavioural pharmacology

authors： Olivares-Nazario M,Fernández-Guasti A,Martínez-Mota L

更新日期：2016-02-01 00:00:00

abstract：:We recently developed a procedure to study fear incubation, in which rats given 100 tone-shock pairings over 10 days show low fear 2 days after conditioned fear training and high fear after 30 days. Notably, fear 2 days after 10 sessions of fear conditioning is lower than fear seen 2 days after a single session of fea...

journal_title：Behavioural pharmacology

authors： Pickens CL,Theberge FR

更新日期：2014-02-01 00:00:00

abstract：:Altered motivation for drugs of abuse is a central feature of most definitions of drug dependence and the impact of drug-related cues on motivation is of current interest. However, since most studies of cue-reactivity have not used behavioural measures of motivation, their results are often difficult to interpret in m...

journal_title：Behavioural pharmacology

authors： Glautier S,Rigney U,Willner P

更新日期：2001-04-01 00:00:00

abstract：:In a previous short-term study, salvianolic acid B was reported to have a protective effect on cerebral ischemia. Here, we investigated whether salvianolic acid B improves the recovery of motor function after cerebral ischemia in a 14-day investigation. Cerebral ischemia was induced by middle cerebral artery occlusion...

journal_title：Behavioural pharmacology

authors： Tang M,Feng W,Zhang Y,Zhong J,Zhang J

更新日期：2006-09-01 00:00:00

abstract：:The present study used the microdialysis technique to investigate the effect of treadmill running, without the use of an electric grid, on extracellular serotonin in the ventral hippocampus of male Lister hooded rat. Extracellular hippocampal serotonin was measured during 60min of treadmill running at 20m/min and comp...

journal_title：Behavioural pharmacology

authors： Wilson WM,Marsden CA

更新日期：1996-01-01 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter in the brain, produces excitotoxicity through its agonistic action on postsynaptic N-methyl-D-aspartate receptor, resulting in neurodegeneration. We hypothesized that the administration of low doses of glutamate in cerebral ischemia could attenuate the excitotoxicity in neuron...

journal_title：Behavioural pharmacology

authors： Ramanathan M,Abdul KK,Justin A

更新日期：2016-10-01 00:00:00

abstract：:The present study estimated the apparent intrinsic activity of the cannabinoid CB1 receptor ligands CP 55,940, Delta9-tetrahydrocannabinol (Delta9-THC) and SR 141716A in a highly sensitive in vivo assay. Rats were trained to discriminate the cannabinoid CB1 receptor agonist CP 55,940 (either 0.03 or 0.014 mg/kg, i.p.,...

journal_title：Behavioural pharmacology

authors： De Vry J,Jentzsch KR

更新日期：2003-09-01 00:00:00

abstract：:Dendrosomal nanocurcumin (DNC) is fabricated from esterification of oleic acid and polyethylene glycol residues with curcumin. DNC has shown antioxidant, neuroprotective, and neurogenesis-enhancing effects. In addition, it can attenuate morphine tolerance. Morphine self-administration is associated with neurodegenerat...

journal_title：Behavioural pharmacology

authors： Noroozi J,Hassanpour-Ezatti M,Alaei HA

更新日期：2017-12-01 00:00:00

abstract：:Previous studies have shown that ethanol produces conditioned place preference (CPP) in mice when injections are given immediately before exposure to the conditioned stimulus (CS). Paradoxically, however, injection of ethanol immediately after the CS produces conditioned place aversion (CPA). Four experiments were con...

journal_title：Behavioural pharmacology

authors： Cunningham CL,Henderson CM

更新日期：2000-11-01 00:00:00

abstract：:The technique of microdialysis was employed to investigate in vivo 5-hydroxytryptamine (5-HT) release in isolation-reared rats compared with socially reared rats. Two methods were employed to stimulate 5-HT release: local KCI injection into the frontal cortex of chloral hydrate anaesthetized rats, and the exposure of ...

journal_title：Behavioural pharmacology

authors： Bickerdike MJ,Wright IK,Marsden CA

更新日期：1993-06-01 00:00:00

abstract：:Previous exposure to a variety of drugs of abuse has been shown to cause long-term impairments in reversal learning and reinforcer devaluation tasks. However, there is mixed evidence in the literature for a long-term effect of ketamine exposure on reversal learning and the long-term effect of ketamine exposure on deva...

journal_title：Behavioural pharmacology

authors： Pickens CL,Aurand L,Hunt J,Fisher H

更新日期：2017-06-01 00:00:00

abstract：:Memantine (1-amino-3,5-dimethyl-adamantane) is the only clinically used NMDA (N-methyl-D-aspartate) glutamate receptor antagonist. The present experiments were carried out to compare the dose-response for memantine's predictive therapeutic and side-effects in a variety of tests in C57BL/6J/Han mice, and to elucidate i...

journal_title：Behavioural pharmacology

authors： Kos T,Popik P

更新日期：2005-05-01 00:00:00

abstract：:With the ever-growing geriatric population, research on brain diseases such as dementia is more imperative now than ever. The most prevalent of all dementias is Alzheimer's disease, a progressive neurodegenerative disease that presents with deficits in memory, cognition, motor skills, and a general decline in the qual...

journal_title：Behavioural pharmacology

authors： Caramillo EM,Echevarria DJ

更新日期：2017-04-01 00:00:00

abstract：:Although the role of genetic factors in the response to drugs of abuse has been emphasized, no earlier studies have applied selective breeding to intravenous drug self-administration. Here we report the effects of six generations of selective breeding for rat lines with low or high levels of intravenous drug self-admi...

journal_title：Behavioural pharmacology

authors： He S,Yang Y,Mathur D,Grasing K

更新日期：2008-12-01 00:00:00

abstract：:Drugs that increase monoamine neurotransmission are effective in both anxiety and depression. The therapeutic effects of monoamine-based antidepressant drugs may involve indirect effects on neurotransmission through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPAR). Thus, chronic antidep...

journal_title：Behavioural pharmacology

authors： Fitzpatrick CM,Larsen M,Madsen LH,Caballero-Puntiverio M,Pickering DS,Clausen RP,Andreasen JT

更新日期：2016-09-01 00:00:00

abstract：:Panic attacks (PAs) are episodes of intense fear or discomfort that are accompanied by a variety of both psychological and somatic symptoms. Panic induction in preclinical models (e.g. rats) has largely been assayed through flight and avoidance behavioral tests and cardiorespiratory activity. Yet, the literature perta...

journal_title：Behavioural pharmacology

authors： Federici LM,Caliman IF,Fitz SD,Shekhar A,Johnson PL

更新日期：2019-06-01 00:00:00