Select panicogenic drugs and stimuli induce consistent increases in tail skin flushes and decreases in core body temperature.


:Panic attacks (PAs) are episodes of intense fear or discomfort that are accompanied by a variety of both psychological and somatic symptoms. Panic induction in preclinical models (e.g. rats) has largely been assayed through flight and avoidance behavioral tests and cardiorespiratory activity. Yet, the literature pertaining to PAs shows that thermal sensations (hot flushes/heat sensations and chills) are also a common symptom during PAs in humans. Considering that temperature alterations are objectively measurable in rodents, we hypothesized that select panicogenic drugs and stimuli induce consistent changes in thermoregulation related to hot flushes and chills. Specifically, we challenged male rats with intraperitoneal injections of the GABAergic inverse agonist FG-7142; the α2 adrenoceptor antagonist yohimbine; the serotonin agonist D-fenfluramine, and 20% CO2 (an interoceptive homeostatic challenge). We assayed core body temperature and tail skin temperature using implanted radiotelemetry probes and tail thermistors/thermal imaging camera, respectively, and found that all challenges elicited rapid, high-amplitude (~7-9°C) increase in tail skin temperature and delayed decreases (~1-3°C) in core body temperature. We propose that thermal sensations such as these may be an additional indicator of a panic response in rodents and humans, as these panicogenic compounds or stimuli are known to precipitate PAs in persons with panic disorder.


Behav Pharmacol


Behavioural pharmacology


Federici LM,Caliman IF,Fitz SD,Shekhar A,Johnson PL




Has Abstract


2019-06-01 00:00:00












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    abstract::In a modified light-dark exploration test in mice, 5-hydroxytryptophan, at doses (25-50 mg/kg) that approximately doubled the 5-HT content in the cerebral cortex, reduced the time spent by mice in the white compartment, suggesting an anxiogenic effect. Depletion of brain 5-HT content with p-chlorophenylalanine (300 mg...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Artaiz I,Zazpe A,Del Río J

    更新日期:1998-03-01 00:00:00

  • In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis.

    abstract::The pathophysiological role of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) in neuropsychiatric disorders has been highlighted in several recent investigations. For instance, allopregnanolone levels are decreased in the CSF of patients with post-traumatic stress disorder (PTSD) and major un...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,评审


    authors: Pinna G

    更新日期:2010-09-01 00:00:00

  • Triazolam and zolpidem: a comparison of their psychomotor, cognitive, and subjective effects in healthy volunteers.

    abstract::The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) and the imidazopyridine hypnotic zolpidem (5, 10, and 20 mg/70 kg) were compared in 11 volunteers, in a double-blind, placebo-controlled, crosso...

    journal_title:Behavioural pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mintzer MZ,Frey JM,Yingling JE,Griffiths RR

    更新日期:1997-11-01 00:00:00

  • The effects of morphine on clocked fixed-interval performance: stimulus function or strength of stimulus control?

    abstract::The present experiment was conducted to determine whether the modification of the effects of morphine by food deprivation would occur under conditions of strong stimulus control. Four pigeons pecked response keys under a multiple fixed-interval (FI) 5-min and clocked fixed-interval (CFI) 5-min schedule of food present...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Odum AL,Schaal DW

    更新日期:1999-05-01 00:00:00

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    abstract::Relatively little is known about the behavioral effects of the neurosteroids compared with other drugs that modulate the γ-aminobutyric acid A (GABAA) receptor complex. This study examined the acute effects of pregnanolone and dehydroepiandrosterone (DHEA) in male rats responding under a differential-reinforcement-of-...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Amato RJ,Lewis PB,He H,Winsauer PJ

    更新日期:2010-12-01 00:00:00

  • Stress hormones enhance retrieval of fear conditioning acquired either one day or many months before.

    abstract::It has been known for years that systemic administration of the stress hormones, adrenocorticotrophin (ACTH), lysine-vasopressin, adrenaline, or beta-endorphin, enhances retrieval of aversive behaviours acquired one or a few days before. Here we show that the pre-test i.p. injection of the hormones in rats can also en...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Izquierdo LA,Barros DM,Medina JH,Izquierdo I

    更新日期:2002-05-01 00:00:00

  • Escalation of drug self-administration as a hallmark of persistent addiction liability.

    abstract::Drug addiction is a progressive, relapsing disease comprised of interlocking stages of disordered motivation. Numerous animal models describing various stages of the addiction process have been developed over the past few decades, providing considerable advantages for the modeling of drug addiction compared with other...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,评审


    authors: Edwards S,Koob GF

    更新日期:2013-09-01 00:00:00

  • Prior methylphenidate self-administration alters the subsequent reinforcing effects of methamphetamine in rats.

    abstract::Methylphenidate (MPD) is clinically effective in treating the symptoms of attention-deficit hyperactivity disorder; however, its relatively widespread availability has raised public health concerns on nonmedical use of MPD among certain adult populations. Most preclinical studies investigate whether presumed therapeut...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Baladi MG,Nielsen SM,Umpierre A,Hanson GR,Fleckenstein AE

    更新日期:2014-12-01 00:00:00

  • Personality traits modulate emotional and physiological responses to stress.

    abstract::An individual's susceptibility to psychological and physical disorders associated with chronic stress exposure, for example, cardiovascular and infectious disease, may also be predicted by their reactivity to acute stress. One factor associated with both stress resilience and health outcomes is personality. An underst...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Childs E,White TL,de Wit H

    更新日期:2014-09-01 00:00:00

  • Delayed yet persistent effects of daily risperidone on activity in developing rats.

    abstract::Early-life administration of risperidone, the most widely used antipsychotic drug in children, leads to persistently elevated locomotor activity in adult rats. This study determined whether and when elevated locomotor activity emerges during developmental risperidone administration. Developing and adult rats were admi...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Stevens RM,Gannon MA,Griffith MS,Bardgett ME

    更新日期:2016-08-01 00:00:00

  • Assessing memory in mice using habituation of nose-poke responding.

    abstract::The present experiments investigated the validity and utility of measuring the habituation of a nose-poke response to assess memory in mice. Mice were placed in an operant chamber equipped with two holes in one wall. Nose-poke responses were recorded by the interruption of a photo-beam across the openings of the holes...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Brodkin J

    更新日期:1999-09-01 00:00:00

  • A comparison of the predictive therapeutic and undesired side-effects of the NMDA receptor antagonist, memantine, in mice.

    abstract::Memantine (1-amino-3,5-dimethyl-adamantane) is the only clinically used NMDA (N-methyl-D-aspartate) glutamate receptor antagonist. The present experiments were carried out to compare the dose-response for memantine's predictive therapeutic and side-effects in a variety of tests in C57BL/6J/Han mice, and to elucidate i...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Kos T,Popik P

    更新日期:2005-05-01 00:00:00

  • Behavioral effects in adult rats of chronic prepubertal treatment with the cannabinoid receptor agonist WIN 55,212-2.

    abstract::Human and animal studies provide evidence for vulnerable periods of brain development for deleterious effects of cannabinoids. We have recently shown that pubertal chronic cannabinoid treatment leads to long-lasting behavioral deficits, whereas a comparable treatment in adult rats did not affect the animals' behavior....

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Schneider M,Drews E,Koch M

    更新日期:2005-09-01 00:00:00

  • Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine.

    abstract::Clinical reports and animal experiments indicate that both cocaine administration and cocaine withdrawal increase anxiety. We investigated the ability of a number of putative anxiolytic agents to alleviate these anxiety states using the elevated plus-maze. Rats in the cocaine condition received either saline or cocain...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Paine TA,Jackman SL,Olmstead MC

    更新日期:2002-11-01 00:00:00

  • Pharmacological characterization of the discriminative stimulus properties of the dopamine D1 agonist, SKF 81297.

    abstract::A range of selective dopamine D1 and D2 receptor agonists and antagonists was used to characterize to the discriminative stimuli produced by d-amphetamine (0.5mg/kg) and the D1 agonists SKF 81297 (0.1mg/kg). In rats trained to discriminate d-amphetamine (0.5mg/kg) from saline, d-amphetamine produced a dose-related inc...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Reavill C,B Bond,Overend P,Hunter AJ

    更新日期:1993-04-01 00:00:00

  • Impairment of working memory by neuronal degeneration with NMDA in rat hippocampal CA-1.

    abstract::Rats were trained on a three-panel runway task prior to injections of N-methyl-D-aspartate (NMDA; 40nmoles/µl/side) into the dorsal hippocampus. One week after the treatment, animals did not show any change in the number of errors on the first runway trial (reference memory), with one correct white and two incorrect b...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Sugimachi K,Izawa K,Nakamura K,Kimura-Iwasaki K,Yamaguchi M,Nakagawa H,Oshino N

    更新日期:1992-08-01 00:00:00

  • Does potency determine amnestic effects of benzodiazepines? A dose-response comparison of flunitrazepam and nitrazepam.

    abstract::This study was designed to explore whether differences in the psychomotor, subjective and memory effects of different benzodiazepines (BDZ) relate to differences in their potencies. Two BDZs with similar kinetics but different potencies were compared. Flunitrazepam (0.5 and 1.0mg, nitrazepam (5 and 10mg) or placebo we...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Pompéia S,Gorenstein C,Curran HV

    更新日期:1996-11-01 00:00:00

  • Gamma-hydroxybutyric acid affects the acquisition and reinstatement of cocaine-induced conditioned place preference in mice.

    abstract::Cocaine addicts very often use different combinations of cocaine and other drugs of abuse such as gamma-hydroxybutyric acid. The objective of the present work was to evaluate the impact of gamma-hydroxybutyric acid administration on the rewarding actions of cocaine, using the conditioned place preference procedure. Co...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Maldonado C,Rodríguez-Arias M,Castillo A,Aguilar MA,Miñarro J

    更新日期:2006-03-01 00:00:00

  • Behavioral momentum and relapse of ethanol seeking: nondrug reinforcement in a context increases relative reinstatement.

    abstract::Drug-related stimuli seem to contribute to the persistence of drug seeking and relapse. Behavioral momentum theory is a framework for understanding how the discriminative-stimulus context in which operant behavior occurs governs the persistence of that behavior. The theory suggests that both resistance to change and r...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Pyszczynski AD,Shahan TA

    更新日期:2011-02-01 00:00:00

  • How reliable is the behavioural evaluation of dyskinesia in animal models of Parkinson's disease?

    abstract::In spite of the current availability of several pharmacological therapies for the treatment of Parkinson's disease, side effects are invariably manifested during long-term treatment. Dyskinesia, wearing-off and on-off are among the most disabling side effects produced by the dopamine precursor L-dihydroxyphenylalanine...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,评审


    authors: Carta AR,Pinna A,Morelli M

    更新日期:2006-09-01 00:00:00

  • Noradrenaline-serotonin interactions in the anxiolytic effects of 5-HT(1A) agonists.

    abstract::The purpose of this study was to analyse adrenergic and serotonergic interactions in the anxiolytic effects of several 5-HT(1A) agonists including ipsapirone, buspirone, indorenate and 8-OH-DPAT. To this end, the effects of different doses of the adrenergic compounds clonidine (0.015-0.0625mg/kg), yohimbine (0.125-0.5...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: López-Rubalcava C,Fernández-Guasti A

    更新日期:1994-02-01 00:00:00

  • Alnespirone and buspirone have anxiolytic-like effects in a conflict procedure in rats by stimulating 5-HT(1A) receptors.

    abstract::We studied the anxiolytic-like activity of alnespirone and buspirone, two 5-HT(1A) receptor agonists, in a modified Geller-Seifter conflict model, and examined the role of 5-HT(1A) receptors by studying whether WAY-100635, a selective antagonist at these receptors, blocked their effects. Administered s.c. 30 minutes b...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Cervo L,Munoz C,Bertaglia A,Samanin R

    更新日期:2000-04-01 00:00:00

  • Differential improvement in memory-related task performance with nicotine by aged male and female rhesus monkeys.

    abstract::Central nicotinc acetylcholine receptors have been targeted for the development of novel treatments for memory deficits in Alzheimer's disease (AD) and other neurodegenerative disorders. Nicotine itself has been shown to improve memory-related task performance in aged animals and in AD patients. Administration of nico...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Buccafusco JJ,Jackson WJ,Jonnala RR,Terry AV Jr

    更新日期:1999-11-01 00:00:00

  • An overview on transient receptor potential channels superfamily.

    abstract::The transient receptor potential (TRP) channel superfamily is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of roles in sensory signaling and are involved in plethora of animal behaviors. These channels are activated through a wide variety of mechanisms and participa...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Tsagareli MG,Nozadze I

    更新日期:2020-08-01 00:00:00

  • Conditioned hyperkinesia induced by cocaine in mice is dose-dependent but not correlated with the unconditioned response or the contextually-sensitized response.

    abstract::The aims of the study were to test whether drug dose is positively related to the magnitude of the conditioned response following sensitization to the behavioural effects of cocaine and to investigate the relationship between the conditioned response and cocaine-induced sensitization. Male mice (C57BL/6J) were first i...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Michel A,Tirelli E

    更新日期:2002-02-01 00:00:00

  • Dissociation of the effects of amphetamine and quinpirole on dopamine release in the nucleus accumbens following behavioural sensitization: an ex vivo voltammetric study.

    abstract::Behavioural sensitization to the locomotor stimulant effect of (+)-amphetamine or quinpirole was induced in rats by intermittent drug administration. Once established, endogenous dopamine release (DA) was measured in slices containing nucleus accumbens using fast cyclic voltammetry. DA release induced by single pulse ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Muscat R,Patel J,Trout SJ,Wieczorek W,Kruk ZL

    更新日期:1993-01-01 00:00:00

  • Early social isolation augments alcohol consumption in rats.

    abstract::There is a considerable degree of individual vulnerability for alcohol use disorder (AUD) as only a subpopulation of individuals who regularly consume alcohol develop AUD. It is therefore very important to understand the factors and mechanisms that contribute towards the individual risk for AUD. In this respect, socia...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Lesscher HM,Spoelder M,Rotte MD,Janssen MJ,Hesseling P,Lozeman-van't Klooster JG,Baars AM,Vanderschuren LJ

    更新日期:2015-10-01 00:00:00

  • Effects of rimonabant on behavior maintained by progressive ratio schedules of sucrose reinforcement in obese Zucker (fa/fa) rats.

    abstract::This experiment reports on the ability of rimonabant to alter the reinforcing properties of food in the genetically obese Zucker (fa/fa) rat, a strain that exhibits higher levels of endocannabinoids in brain regions that correspond to heightened food intake. We characterized food reinforcement in obese and lean Zucker...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Rasmussen EB,Huskinson SL

    更新日期:2008-10-01 00:00:00

  • Effect of pioglitazone and simvastatin in lipopolysaccharide-induced amyloidogenesis and cognitive impairment in mice: possible role of glutamatergic pathway and oxidative stress.

    abstract::Neuroinflammation and β-amyloid (Aβ) deposition in the brain are well known characteristics of neurodegeneration. Diabetes and hypercholesterolemia are the main risk factors leading to memory loss and cognitive impairment. Recently, it was found that statins and thiazolidinediones have promising anti-inflammatory and ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Ekladious ST,El Sayed NS

    更新日期:2019-02-01 00:00:00

  • Lithium's effect in forced-swim test is blood level dependent but not dependent on weight loss.

    abstract::The effects of lithium in models of depression are often inconsistent. We aimed to replicate a regimen that induces robust antidepressant effects in the forced-swim test. Mice were treated with three different doses of lithium chloride (LiCl) 0.25, 0.4 or 0.5% in food and the forced-swim test or open field test was pe...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Bersudsky Y,Shaldubina A,Belmaker RH

    更新日期:2007-02-01 00:00:00