Ultra-low dose naltrexone enhances cannabinoid-induced antinociception.

abstract：:In previous studies, it was shown that apomorphine-induced stereotyped behaviour could be conditioned when apomorphine was repeatedly paired with sensory stimuli (CS). Since in these experiments, the sum of various sensory stimuli were applied, it seemed of interest to use each sensory stimulus separately in order to ...

journal_title：Behavioural pharmacology

authors： Ferger B,Kuschinsky K

更新日期：1995-01-01 00:00:00

abstract：:Drug-addicted individuals show high levels of impulsive choice, characterized by preference for small immediate over larger but delayed rewards. Although the causal relationship between chronic drug use and elevated impulsive choice in humans has been unclear, a small but growing body of literature over the past decad...

journal_title：Behavioural pharmacology

authors： Setlow B,Mendez IA,Mitchell MR,Simon NW

更新日期：2009-09-01 00:00:00

abstract：:Although the dopaminergic pharmacology of the D1 receptor full agonists, dinapsoline, dihydrexidine and the prodrug ABT-431 have been studied, no information is available on the ability of these agonists to substitute for the D1 agonist SKF 38393 in rats trained to discriminate this compound from vehicle. The present ...

journal_title：Behavioural pharmacology

authors： Gleason SD,Witkin JM

更新日期：2004-02-01 00:00:00

abstract：:A runway was used to measure locomotor responses to quinpirole (200µg/kg), in rats. The locomotor stimulant effect of quinpirole increased progressively over successive trials at 3-day intervals. Animals administered quinpirole in the home cage were also sensitized, but to a lesser degree than animals tested in the ru...

journal_title：Behavioural pharmacology

authors： Willner P,Papp M,Cheeta S,Muscat R

更新日期：1992-02-01 00:00:00

abstract：:Ultrasonic vocalizations are widely used to examine affective states in rats, yet relatively few studies explore the acoustic features of vocalizations, especially in relation to drug exposure, and no studies have explored alterations in acoustic features over time. The goal of this study was to examine nicotine- and ...

journal_title：Behavioural pharmacology

authors： Swalve N,Mulholland MM,Li M

更新日期：2019-08-01 00:00:00

abstract：:Previous studies have indicated that dopamine D1 receptors in the ventral tegmental area (VTA) may play an important role in the development of sensitization to amphetamine. The present study was designed to determine if D1 receptors are also important in the development of cocaine-induced behavioral and neurochemical...

journal_title：Behavioural pharmacology

authors： Steketee JD

更新日期：1998-02-01 00:00:00

abstract：:Altered motivation for drugs of abuse is a central feature of most definitions of drug dependence and the impact of drug-related cues on motivation is of current interest. However, since most studies of cue-reactivity have not used behavioural measures of motivation, their results are often difficult to interpret in m...

journal_title：Behavioural pharmacology

authors： Glautier S,Rigney U,Willner P

更新日期：2001-04-01 00:00:00

abstract：:This series of studies provides a behavioural account of dopamine D1-receptor-dependent facilitation and disruption of memory for the single-trial passive avoidance task in the day-old chick. The D1 antagonist, SCH23390, induced memory disruption in a dose-dependent manner from 60 min after training with a strong (100...

journal_title：Behavioural pharmacology

authors： Hale MW,Crowe SF

更新日期：2003-11-01 00:00:00

abstract：:Rats were given fixed-time, 1-min food-pellet delivery sessions, for 3 h every day, which resulted in over drinking (schedule-induced polydipsia). In previous research, groups of animals came to prefer solutions of cocaine or lidocaine to concurrently presented water, if the drugs were first offered in a glucose/sacch...

journal_title：Behavioural pharmacology

authors： Falk JL,Yosef E,Schwartz A,Lau CE

更新日期：1999-02-01 00:00:00

abstract：:We report here that local hippocampal WIN-55,212-2 implants release this cannabinoid agonist for extended periods, the release is restricted to the implanted brain region and is behaviorally active. Radiolabeled WIN-55,212-2 was implanted bilaterally into the CA3 region of the dorsal hippocampus by means of fused sili...

journal_title：Behavioural pharmacology

authors： Barna I,Soproni K,Arszovszki A,Csabai K,Haller J

更新日期：2007-09-01 00:00:00

abstract：:The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in inflammatory pain models. The present study investigated the effect of the intraperitoneal administration of S1RA on the hind paw withdrawal response to thermal and...

journal_title：Behavioural pharmacology

authors： Gris G,Merlos M,Vela JM,Zamanillo D,Portillo-Salido E

更新日期：2014-06-01 00:00:00

abstract：:Does the effect of amphetamine on behavior (wheel running) differ depending on the functional role (operant, reinforcement) of that behavior? This study addressed this question using a multiple schedule of reinforcement in which wheel running served as reinforcement for lever pressing in one component and as operant b...

journal_title：Behavioural pharmacology

authors： Belke TW,Pierce WD,Sexton CA

更新日期：2019-10-01 00:00:00

abstract：:A previous study from this laboratory reported an antiaversive effect of the beta-adrenoceptor blocker propranolol microinjected into the dorsal periaqueductal grey (DPAG) of the rat, that was antagonized by the 5-HT(2) receptor blocker ritanserin. The present results show that microinjection into the DPAG of isamolta...

journal_title：Behavioural pharmacology

authors： Nogueira RL,Graeff FG

更新日期：1991-02-01 00:00:00

abstract：:Increasing evidence suggests that antagonistic interactions between specific subtypes of adenosine and dopamine receptors in the basal ganglia are involved in the control of motor activity. However, there are few studies investigating this interaction in other brain regions and its role in additional functions. In the...

journal_title：Behavioural pharmacology

authors： Prediger RD,Da Cunha C,Takahashi RN

更新日期：2005-07-01 00:00:00

abstract：:Separate groups of rats were trained to discriminate either 0.1mg/kg (low dose; L) or 2.5mg/kg (high dose; H) of 8-OH-DPAT from saline, in a standard operant task. Both cues were found to be dose, time and route dependent and generalized completely to the 5-HT(1A) agonists ipsapirone and flesinoxan. Buspirone substitu...

journal_title：Behavioural pharmacology

authors： Ybema CE,Slangen JL,Olivier B,Mos J

更新日期：1993-12-01 00:00:00

abstract：:In spite of the current availability of several pharmacological therapies for the treatment of Parkinson's disease, side effects are invariably manifested during long-term treatment. Dyskinesia, wearing-off and on-off are among the most disabling side effects produced by the dopamine precursor L-dihydroxyphenylalanine...

journal_title：Behavioural pharmacology

authors： Carta AR,Pinna A,Morelli M

更新日期：2006-09-01 00:00:00

abstract：:Both depression and cancer are related to a dysregulation of inflammatory and immune pathways. Indeed, depression is associated with increased expression of interferon-γ, interleukin-1β, and tumor necrosis factor α (TNF-α). In contrast, reductions of the activity of major histocompatibility complex protein molecules -...

journal_title：Behavioural pharmacology

authors： Barreto FS,Chaves Filho AJM,de Araújo MCCR,de Moraes MO,de Moraes MEA,Maes M,de Lucena DF,Macedo DS

更新日期：2018-04-01 00:00:00

abstract：:'Active immobility' (AI) is an independent behaviour that can be characterized by behavioural immobility, an increased muscular rigidity and the sustaining of an unusual posture. In previous studies with cocaine we observed, concomitant with hyperlocomotion and increased rearing activity, an increase in AI in well-hab...

journal_title：Behavioural pharmacology

authors： Müller CP,Thönnessen H,Jocham G,Barros M,Tomaz C,Carey RJ,Huston JP

更新日期：2004-11-01 00:00:00

abstract：:Neuropsychiatric disorders, such as addiction, are associated with cognitive impairment, including learning and memory deficits. Previous research has demonstrated that the chronic use of methamphetamine (METH) induces long-term cognitive impairment and cannabidiol (CBD), as a neuroprotectant, can reverse spatial memo...

journal_title：Behavioural pharmacology

authors： Razavi Y,Shabani R,Mehdizadeh M,Haghparast A

更新日期：2020-06-01 00:00:00

abstract：:Much evidence has shown that the inferior colliculus may be part of a brain system commanding defensive behavior. In the present work, evidence is presented for the serotonergic modulation of the neural substrate of aversive states elaborated in this structure. Rats implanted with a cannula in the inferior colliculus ...

journal_title：Behavioural pharmacology

authors： Melo LL,Brando ML

更新日期：1995-06-01 00:00:00

abstract：:The strain of spontaneously hypertensive rats (SHR) is considered a genetic model for the study of attention-deficit hyperactivity disorder (ADHD), as it displays hyperactivity, impulsivity and poorly sustained attention. Recently, we have shown the involvement of adenosinergic neuromodulation in the SHR's short-term ...

journal_title：Behavioural pharmacology

authors： Pires VA,Pamplona FA,Pandolfo P,Fernandes D,Prediger RD,Takahashi RN

更新日期：2009-03-01 00:00:00

abstract：:The aim of the present study was to examine a potential mechanism of action of gabapentin to manage cannabis-use disorders by determining the interoceptive effects of gabapentin in cannabis users discriminating [INCREMENT]-tetrahydrocannabinol ([INCREMENT]-THC) using a pharmacologically selective drug-discrimination p...

journal_title：Behavioural pharmacology

authors： Lile JA,Wesley MJ,Kelly TH,Hays LR

更新日期：2016-04-01 00:00:00

abstract：:The purpose of this experiment was to examine the substitution patterns produced by opioids with activity at the mu receptor in pigeons trained to discriminate the delta opioid BW373U86 from saline. A low dose of naltrindole (0.1 mg/kg) produced at least a 16-fold rightward shift in the dose-effect curve for the stimu...

journal_title：Behavioural pharmacology

authors： Picker MJ,Cook CD

更新日期：1998-07-01 00:00:00

abstract：:The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) and the imidazopyridine hypnotic zolpidem (5, 10, and 20 mg/70 kg) were compared in 11 volunteers, in a double-blind, placebo-controlled, crosso...

journal_title：Behavioural pharmacology

authors： Mintzer MZ,Frey JM,Yingling JE,Griffiths RR

更新日期：1997-11-01 00:00:00

abstract：:Behavioral flexibility or 'set-shifting' refers to the ability to modify ongoing behavior in response to changing goals or environmental contingencies. Impaired behavioral flexibility is associated with disorders such as schizophrenia and addiction. Hypofunction of N-methyl-D-aspartate (NMDA) receptors has been implic...

journal_title：Behavioural pharmacology

authors： Darrah JM,Stefani MR,Moghaddam B

更新日期：2008-05-01 00:00:00

abstract：:The impact of training dose on the characteristics of a discrimination maintained by a mixture of two dissimilar drugs has been investigated in order to refine this approach to the study of drug interactions. Three groups of rats (n = 10) were trained to discriminate mixtures of (+)-amphetamine (0.2-0.8mg/kg) plus pen...

journal_title：Behavioural pharmacology

authors： Mariathasan EA,White JA,Stolerman IP

更新日期：1996-08-01 00:00:00

abstract：:Early-life administration of risperidone, the most widely used antipsychotic drug in children, leads to persistently elevated locomotor activity in adult rats. This study determined whether and when elevated locomotor activity emerges during developmental risperidone administration. Developing and adult rats were admi...

journal_title：Behavioural pharmacology

authors： Stevens RM,Gannon MA,Griffith MS,Bardgett ME

更新日期：2016-08-01 00:00:00

abstract：:The present experiments investigated the validity and utility of measuring the habituation of a nose-poke response to assess memory in mice. Mice were placed in an operant chamber equipped with two holes in one wall. Nose-poke responses were recorded by the interruption of a photo-beam across the openings of the holes...

journal_title：Behavioural pharmacology

authors： Brodkin J

更新日期：1999-09-01 00:00:00

abstract：:Previous data indicate that ethanol intoxication (3 g/kg, intragastric) on postnatal day (PD) 7 and 8 increases ethanol acceptance, but on PD 10 and 11 generates an aversion in infant rats. We investigated the participation of the opioid system in these effects. Subcutaneous administration of naloxone (1 or 10 mg/kg) ...

journal_title：Behavioural pharmacology

authors： Gabriela Chotro M,Arias C

更新日期：2007-11-01 00:00:00

abstract：:Few studies have investigated the effects of chronic cannabinoid exposure on memory performance and whether tolerance occurs to cannabinoid-induced memory impairment. Here, we studied the effects of repeated exposure to Delta-tetrahydrocannabinol (THC: 1 mg/kg) on spatial memory and zif268 expression in mice. One grou...

journal_title：Behavioural pharmacology

authors： Boucher AA,Vivier L,Metna-Laurent M,Brayda-Bruno L,Mons N,Arnold JC,Micheau J

更新日期：2009-02-01 00:00:00