Abstract:
:Behavioral sensitization to amphetamine-like psychostimulants is manifest as a progressive increase in drug-induced anxiety and paranoia which can culminate in psychopathologies, such as paranoid psychosis and panic attacks. Sensitization may also mediate the facilitation of drug relapse in addicts by increasing the reinforcing value of acute drug administration. The primary animal model for psychostimulant-induced psychopathologies involves repeated, non-contingent administration of drug to rodents, which can produce a progressive and enduring augmentation in motor activity and increased susceptibility to drug self-administration. Because of the mature literature implicating mesoaccumbens dopamine transmission in the acute motor and reinforcing effects of amphetamine-like stimulants, investigation into the neural basis of behavioral sensitization has focused on this projection. Over the last decade, with a few exceptions, the neurochemical and molecular literature that has emerged from this effort is replete with inconsistencies. In contrast, the presence of behavioral sensitization is a highly replicable event. It is proposed that behavioral sensitization arises from an alteration in the neural circuitry that subserves the translation of motivationally relevant stimuli into adaptive motor responses. The mesoaccumbens dopamine projection is embedded in this circuit and an enduring change in dopamine transmission may alter the functional state of the circuit to produce behavioral sensitization. However, combinations of alterations in other connections within the circuit can also support behavioral sensitization. The specific changes in the circuit that promote behavioral sensitization are under the control of experimental parameters, such as the drug employed, dosage regimen, withdrawal period and the presence of conditioning cues. Thus, the profile of neurochemical alterations observed after exposure to repeated psychostimulants may vary depending upon the experimental protocol and strain of animals, even though all laboratories report the presence of behavioral sensitization.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Kalivas PW,Sorg BA,Hooks MSsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
315-334issue
4eissn
0955-8810issn
1473-5849journal_volume
4pub_type
杂志文章abstract::The effects of topiramate, a potential treatment for drug dependence, were evaluated in two groups of rats trained to discriminate the administration of either 0.4 mg/kg nicotine or 10 mg/kg cocaine from that of saline, under a fixed-ratio 10 schedule of food delivery. Topiramate (1-60 mg/kg, intraperitoneal) did not ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3282f3cf84
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journal_title:Behavioural pharmacology
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更新日期:2016-06-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0b013e32830c3658
更新日期:2008-09-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000524
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32833b0098
更新日期:2010-07-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199608000-00008
更新日期:1996-08-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/01.fbp.0000236269.87547.9d
更新日期:2006-11-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章
doi:10.1097/00008877-199712000-00009
更新日期:1997-12-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200605000-00003
更新日期:2006-05-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
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更新日期:2018-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32835a3907
更新日期:2012-12-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000142
更新日期:2015-08-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-02-01 00:00:00
abstract::The objective of this experiment was to evaluate the comparative value of cigarettes versus high dose e-cigarettes among nicotine-dependent cigarette smokers when compared with money or use of their usual cigarette brand. The experiment used a within-subject design with four sessions. After baseline assessment, partic...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2016-04-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3282feb0ac
更新日期:2008-07-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199905000-00002
更新日期:1999-05-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200305000-00002
更新日期:2003-05-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199909000-00002
更新日期:1999-09-01 00:00:00
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更新日期:2009-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200104000-00001
更新日期:2001-04-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199911000-00015
更新日期:1999-11-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00008877-200303000-00001
更新日期:2003-03-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199907000-00009
更新日期:1999-07-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000083
更新日期:2014-10-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3282feb0ac
更新日期:2008-05-01 00:00:00
abstract::In a step-down passive avoidance task, the pre-training injection of 1.25-10 mg/kg of morphine impaired memory. This was restored when injection of the same dose of morphine (pre-test treatment) was repeated 24 h later (morphine state-dependent learning: morphine St-D). ATP-dependent potassium (K(ATP)) channels have b...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200403000-00002
更新日期:2004-03-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000544
更新日期:2020-06-01 00:00:00
abstract::The present study used the microdialysis technique to investigate the effect of treadmill running, without the use of an electric grid, on extracellular serotonin in the ventral hippocampus of male Lister hooded rat. Extracellular hippocampal serotonin was measured during 60min of treadmill running at 20m/min and comp...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Animal models of nicotine dependence are fundamental experimental tools for the understanding of the neurobiological and molecular processes underlying smoking behaviour. Substance use is controlled by four main processes: positive reinforcing effects, aversive effects, discriminative effects and stimulus-conditioned ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/00008877-199911000-00005
更新日期:1999-11-01 00:00:00