Effects of chronic caffeine pre-exposure on conditioned and unconditioned psychomotor activity induced by nicotine and amphetamine in rats.


:Three experiments examined the effects of chronic pre-exposure to caffeine on the subsequent conditioned and unconditioned locomotor activating effects of nicotine or amphetamine in rats. Rats were given daily intraperitoneal injections of caffeine anhydrous (0, 10 or 30 mg/kg base) for 30 days. Conditioning (environment-drug pairings) began after the last day of caffeine pre-exposure. Pre-exposure to 30 mg/kg of caffeine enhanced the acute and chronic locomotor effects of amphetamine (0.5 mg/kg). A similar enhancement of activity was not seen with the high (0.421 mg/kg base) or low dose (0.175 mg/kg) of nicotine. In a drug-free test, the distinct environment paired with amphetamine and the high dose of nicotine evoked increases in activity relative to controls. Caffeine pre-exposure did not affect expression of this conditioned hyperactivity. These effects of caffeine pre-exposure on amphetamine-induced activity could not be attributed to non-specific effects of caffeine.


Behav Pharmacol


Behavioural pharmacology


Palmatier MI,Fung EY,Bevins RA




Has Abstract


2003-05-01 00:00:00












  • Role of orexin-2 and CB1 receptors within the periaqueductal gray matter in lateral hypothalamic-induced antinociception in rats.

    abstract::Orexin plays an important role in pain modulation. Orexin-1 and orexin-2 receptors (Ox1r and Ox2r) are found at high density in the ventrolateral periaqueductal gray matter (vlPAG). Our previous study showed that chemical stimulation of the lateral hypothalamus with carbachol induces antinociception in the tail-flick ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Esmaeili MH,Reisi Z,Ezzatpanah S,Haghparast A

    更新日期:2017-02-01 00:00:00

  • Environment modifies the expression of behavioral sensitization produced by methamphetamine: behavioral and neurochemical studies.

    abstract::Effects of environmental modulation of methamphetamine (MA)-induced behavior on the establishment and mode of expression of behavioral sensitization were examined. Rats received daily injection of MA for 10 days (1mg/kg, s.c.). Half of them were immediately returned to the home cage (home cage group) and the other hal...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Ohmori T,Abekawa T,Koyama T

    更新日期:1995-03-01 00:00:00

  • Crossover associations of alcohol and smoking, craving and biochemically verified alcohol and nicotine use in heavy drinking smokers.

    abstract::This study examined associations between drinking and smoking prior to treatment (biochemically measured at baseline), alcohol and tobacco craving, and biochemical alcohol and tobacco use during the analog trial period. We conducted a secondary data analysis of a randomized clinical analog trial where participants wit...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Smith CL,Jenkins G,Burduli E,Tham P,Miguel A,Roll J,Mcpherson S

    更新日期:2020-10-01 00:00:00

  • Changes in gut microbiota during development of compulsive checking and locomotor sensitization induced by chronic treatment with the dopamine agonist quinpirole.

    abstract::Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined wheth...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Jung TD,Jung PS,Raveendran L,Farbod Y,Dvorkin-Gheva A,Sakic B,Surette MG,Szechtman H

    更新日期:2018-04-01 00:00:00

  • Intrinsic activity estimation of cannabinoid CB1 receptor ligands in a drug discrimination paradigm.

    abstract::The present study estimated the apparent intrinsic activity of the cannabinoid CB1 receptor ligands CP 55,940, Delta9-tetrahydrocannabinol (Delta9-THC) and SR 141716A in a highly sensitive in vivo assay. Rats were trained to discriminate the cannabinoid CB1 receptor agonist CP 55,940 (either 0.03 or 0.014 mg/kg, i.p.,...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: De Vry J,Jentzsch KR

    更新日期:2003-09-01 00:00:00

  • Prior methylphenidate self-administration alters the subsequent reinforcing effects of methamphetamine in rats.

    abstract::Methylphenidate (MPD) is clinically effective in treating the symptoms of attention-deficit hyperactivity disorder; however, its relatively widespread availability has raised public health concerns on nonmedical use of MPD among certain adult populations. Most preclinical studies investigate whether presumed therapeut...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Baladi MG,Nielsen SM,Umpierre A,Hanson GR,Fleckenstein AE

    更新日期:2014-12-01 00:00:00

  • Tolerance and cross-tolerance to the response rate-decreasing effects of µ opioids in morphine-maintained squirrel monkeys.

    abstract::The purpose of the present experiment was to assess the degree of tolerance and cross-tolerance to the response rate-decreasing effects of opioids with different degrees of intrinsic efficacy at the mu receptor. The mu opioids included buprenorphine, etorphine, l-methadone, morphine, and sufentanil. Lever pressing of ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Hughes CE,Picker MJ,Dykstra LA

    更新日期:1995-12-01 00:00:00

  • Discriminative stimulus effects of alprazolam and diazepam: generalization to benzodiazepines, antidepressants and buspirone.

    abstract::Rats in one group were trained to discriminate alprazolam (1.0mg/kg, i.p.) and in another group diazepam (3.0mg/kg, i.p.) from saline in a two-lever drug discrimination procedure. Food presentation occurred after 10 consecutive responses on the lever associated either with the training drug or with saline. Alprazolam,...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Wettstein JG,Gauthier B

    更新日期:1992-06-01 00:00:00

  • Selective breeding for intravenous drug self-administration in rats: a pilot study.

    abstract::Although the role of genetic factors in the response to drugs of abuse has been emphasized, no earlier studies have applied selective breeding to intravenous drug self-administration. Here we report the effects of six generations of selective breeding for rat lines with low or high levels of intravenous drug self-admi...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: He S,Yang Y,Mathur D,Grasing K

    更新日期:2008-12-01 00:00:00

  • Drug withdrawal conceptualized as a stressor.

    abstract::Drug withdrawal is often conceptualized as an aversive state that motivates drug-seeking and drug-taking behaviors in humans. Stress is more difficult to define, but is also frequently associated with aversive states. Here we describe evidence for the simple theory that drug withdrawal is a stress-like state, on the b...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,评审


    authors: Chartoff EH,Carlezon WA Jr

    更新日期:2014-09-01 00:00:00

  • Effects of chronic scopolamine administration on spatial working memory and hippocampal receptors related to learning.

    abstract::Scopolamine has been used in neuropsychopharmacology as a standard drug that leads to symptoms mimicking cognitive deficits seen during the aging process in healthy humans and animals. Scopolamine is known to be a nonselective muscarinic receptor blocker, but its chronic effect on the expression of certain hippocampal...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Doguc DK,Delibas N,Vural H,Altuntas I,Sutcu R,Sonmez Y

    更新日期:2012-12-01 00:00:00

  • Influence of beta-adrenoceptor agonists and antagonists on baclofen-induced memory impairment in mice.

    abstract::Post-training administration of different doses of baclofen (a GABAB agonist) has been shown to impair memory retention, in a step-down passive avoidance test in mice. We have studied the effects of beta-adrenergic agonists and antagonists on baclofen-induced memory impairment in mice. Dobutamine (a beta 1-agonist) or...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Zarrindast MR,Haidari H,Jafari MR,Djahanguiri B

    更新日期:2004-07-01 00:00:00

  • Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity.

    abstract::These studies investigated the role of serotonin-1A (5-HT1A) and 5-HT2A receptors in the behavioral effects of dipropyltryptamine (DPT). Eight rats discriminated 0.56 mg/kg 2,5-dimethoxy-4-methylamphetamine (DOM) from saline and responded under a fixed ratio 5 schedule of food presentation; 12 other rats were used for...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Li JX,Rice KC,France CP

    更新日期:2007-07-01 00:00:00

  • Differential involvement of D1 and D2 dopamine receptors in the expression of morphine withdrawal signs in rats.

    abstract::The role of dopamine (DA) receptors in the expression of opioid dependence was examined by use of an unbiased conditioned place preference paradigm. Male Sprague-Dawley rats were implanted s.c. with two pellets containing placebo or 75mg morphine. Animals received one conditioning session with saline and one with the ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Funada M,Shippenberg TS

    更新日期:1996-10-01 00:00:00

  • Effects of nicotine on active avoidance learning in rats: sex differences.

    abstract::Nicotine, a cognition enhancer and a drug of abuse, exerts its central actions through neuronal nicotinic acetylcholine receptors which show sexual dimorphism. This study tested the effects of nicotine on active avoidance learning in male and female rats. Three month-old Sprague-Dawley rats received varying doses of n...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Yilmaz O,Kanit L,Okur BE,Pöğün S

    更新日期:1997-06-01 00:00:00

  • Conditioned hyperkinesia induced by cocaine in mice is dose-dependent but not correlated with the unconditioned response or the contextually-sensitized response.

    abstract::The aims of the study were to test whether drug dose is positively related to the magnitude of the conditioned response following sensitization to the behavioural effects of cocaine and to investigate the relationship between the conditioned response and cocaine-induced sensitization. Male mice (C57BL/6J) were first i...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Michel A,Tirelli E

    更新日期:2002-02-01 00:00:00

  • Drug discrimination in pigeons trained to discriminate among morphine, U50488, a combination of these drugs, and saline.

    abstract::This study compared fixed-ratio (FR) and fixed-interval (FI) schedules to investigate the discriminative stimulus properties of μ-opioid and/or κ-opioid receptor agonists. Pigeons were trained to discriminate among morphine (μ agonist), U50488 (κ agonist), the combination, and saline under FR 20-s or FI-300-s schedule...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Wessinger WD,Li M,McMillan DE

    更新日期:2011-09-01 00:00:00

  • Antidepressant, anxiolytic and procognitive effects of subacute and chronic ketamine in the chronic mild stress model of depression.

    abstract::Ketamine is the prototype of a new generation of antidepressant drugs, which is reported in clinical studies to be effective in treatment-resistant patients, with an effect that appears within hours and lasts for a few days. Chronic mild stress (CMS) is a well-established and widely used animal model of depression, in...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Papp M,Gruca P,Lason-Tyburkiewicz M,Willner P

    更新日期:2017-02-01 00:00:00

  • Effects of positive and negative modulators of the γ-aminobutyric acid A receptor complex on responding under a differential-reinforcement-of-low-rate schedule of reinforcement in rats.

    abstract::Relatively little is known about the behavioral effects of the neurosteroids compared with other drugs that modulate the γ-aminobutyric acid A (GABAA) receptor complex. This study examined the acute effects of pregnanolone and dehydroepiandrosterone (DHEA) in male rats responding under a differential-reinforcement-of-...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Amato RJ,Lewis PB,He H,Winsauer PJ

    更新日期:2010-12-01 00:00:00

  • Adolescent silymarin treatment increases anxiety-like behaviors in adult mice.

    abstract::Adolescence is one of the most important periods of brain development in mammals. There is increasing evidence that some medicines during this period can affect brain and behavioral functions in adulthood. Silymarin (SM), a mixture of flavonolignans extracted from the milk thistle Silybum marianum, is known as a hepat...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Kosari-Nasab M,Rabiei A,Doosti MH,Salari AA

    更新日期:2014-08-01 00:00:00

  • An overview on transient receptor potential channels superfamily.

    abstract::The transient receptor potential (TRP) channel superfamily is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of roles in sensory signaling and are involved in plethora of animal behaviors. These channels are activated through a wide variety of mechanisms and participa...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Tsagareli MG,Nozadze I

    更新日期:2020-08-01 00:00:00

  • An automated learning and memory model in mice: pharmacological and behavioral evaluation of an autoshaped response.

    abstract::The purpose of the present experiments was to develop and validate pharmacologically an automated, relatively rapid, and reproducible behavioral model of learning and memory using an autoshaping procedure in mice. Nose-poke responses into a recessed area were differentiated by response-dependent reinforcement during t...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Vanover KE,Barrett JE

    更新日期:1998-05-01 00:00:00

  • A comparison of different sensory stimuli in producing conditioned apomorphine effects.

    abstract::In previous studies, it was shown that apomorphine-induced stereotyped behaviour could be conditioned when apomorphine was repeatedly paired with sensory stimuli (CS). Since in these experiments, the sum of various sensory stimuli were applied, it seemed of interest to use each sensory stimulus separately in order to ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Ferger B,Kuschinsky K

    更新日期:1995-01-01 00:00:00

  • WIN-55,212-2 chronically implanted into the CA3 region of the dorsal hippocampus impairs learning: a novel method for studying chronic, brain-area-specific effects of cannabinoids.

    abstract::We report here that local hippocampal WIN-55,212-2 implants release this cannabinoid agonist for extended periods, the release is restricted to the implanted brain region and is behaviorally active. Radiolabeled WIN-55,212-2 was implanted bilaterally into the CA3 region of the dorsal hippocampus by means of fused sili...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Barna I,Soproni K,Arszovszki A,Csabai K,Haller J

    更新日期:2007-09-01 00:00:00

  • Relationship between weight status and delay discounting in a sample of adolescent cigarette smokers.

    abstract::Obesity and cigarette smoking are often cited separately as the top two preventable causes of death in the United States; however, little research has explored the factors associated with being both obese and a smoker. Delay discounting is a behavioral characteristic that may underlie both of these conditions/behavior...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Fields SA,Sabet M,Peal A,Reynolds B

    更新日期:2011-06-01 00:00:00

  • Behavioral effects of acute and chronic cocaine administration in male and female rats: effects of fixed-ratio schedule parameters.

    abstract::Intact and gonadectomized male and female rats pressed a lever to obtain food on different fixed-ratio (FR) schedules in a three-component multiple schedule. The values of a small, intermediate and large FR schedule were individually determined and were higher for intact male rats than for most subjects in the other g...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: van Haaren F,Anderson KG

    更新日期:1994-10-01 00:00:00

  • Discriminative stimulus effects of ethanol with a conditioned taste aversion procedure: lack of acetaldehyde substitution.

    abstract::Acetaldehyde has been suggested to mediate a number of the pharmacological and behavioural effects of ethanol. Recently, several studies investigated the role of acetaldehyde in the subjective effects of ethanol, but obtained conflicting results. With the discriminative taste aversion (DTA) procedure, high acetaldehyd...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Quertemont E

    更新日期:2003-07-01 00:00:00

  • Protective effects of extract of Coeloglossum viride var. bracteatum on ischemia-induced neuronal death and cognitive impairment in rats.

    abstract::Our earlier study demonstrated that Coeloglossum viride (L.) Hartm. var. bracteatum (Willd.) extract (CE) significantly improved the impaired memory in mice caused by permanent two-vessel occlusion. To investigate whether chronic treatment with CE could influence cerebral ischemia-induced neuronal and cognitive impair...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Ma B,Li M,Nong H,Shi J,Liu G,Zhang J

    更新日期:2008-07-01 00:00:00

  • Self-reported smoking effects and comparative value between cigarettes and high dose e-cigarettes in nicotine-dependent cigarette smokers.

    abstract::The objective of this experiment was to evaluate the comparative value of cigarettes versus high dose e-cigarettes among nicotine-dependent cigarette smokers when compared with money or use of their usual cigarette brand. The experiment used a within-subject design with four sessions. After baseline assessment, partic...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: McPherson S,Howell D,Lewis J,Barbosa-Leiker C,Bertotti Metoyer P,Roll J

    更新日期:2016-04-01 00:00:00

  • Separate and combined effects of gabapentin and [INCREMENT]9-tetrahydrocannabinol in humans discriminating [INCREMENT]9-tetrahydrocannabinol.

    abstract::The aim of the present study was to examine a potential mechanism of action of gabapentin to manage cannabis-use disorders by determining the interoceptive effects of gabapentin in cannabis users discriminating [INCREMENT]-tetrahydrocannabinol ([INCREMENT]-THC) using a pharmacologically selective drug-discrimination p...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Lile JA,Wesley MJ,Kelly TH,Hays LR

    更新日期:2016-04-01 00:00:00