Abstract:
:Post-training administration of different doses of baclofen (a GABAB agonist) has been shown to impair memory retention, in a step-down passive avoidance test in mice. We have studied the effects of beta-adrenergic agonists and antagonists on baclofen-induced memory impairment in mice. Dobutamine (a beta 1-agonist) or salbutamol (a beta 2-agonist) reversed the memory impairment induced by baclofen without exhibiting intrinsic actions on memory when administered alone. The administration of atenolol (a beta 1-antagonist) or propranolol (a beta-antagonist) produced a memory impairment. When co-administered with baclofen, both atenolol and propranolol exacerbated the memory impairment induced by the GABAB agonist. It is concluded that beta-adrenergic mechanisms may be involved in the modulation of memory via GABAB receptors.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Zarrindast MR,Haidari H,Jafari MR,Djahanguiri Bdoi
10.1097/01.fbp.0000137211.95623.07subject
Has Abstractpub_date
2004-07-01 00:00:00pages
293-7issue
4eissn
0955-8810issn
1473-5849pii
00008877-200407000-00006journal_volume
15pub_type
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